Streptomycin |
![]() Last updated: 17/11/2022 |
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(Also known as: streptomycine; streptamine; streptomycin A ; Crop antibiotic) |
Data alerts |
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate | Ecotoxicity | Human health |
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![]() Significant data are missing |
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Streptomycin is used to combat the growth of bacteria, fungi, and algae on a wide range of crops. It also has applications as a drug specifically as a bactericidal antibiotic. | |
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Bacterial shot-hole; Bacterial rots; Bacterial canker; Bacterial wilts; Fire blight | |
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Fruit including apples, pears, stone fruit, citrus; Olives; Vegetables including beans, peppers; Potatoes; Cotton; Ornamentals | |
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1944, first reported; 1958, commericalised USA | |
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UK regulatory status |
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Not approved | ||
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Not applicable | ||
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No UK approval for use |
EC Regulation 1107/2009 (repealing 91/414) |
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Not approved | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Not applicable | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Not applicable | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Not applicable | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Yes | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Additional information |
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USA |
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Chemical structure |
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A chiral molecule | |
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C₂₁H₃₉N₇O₁₂ | |
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CC1C(C(C(O1)OC2C(C(C(C(C2O)O)N=C(N)N)O)N=C(N)N)OC3C(C(C(C(O3)CO)O)O)NC)(C=O)O | |
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C[C@@H]1[C@]([C@@H]([C@H](O1)O[C@@H]2[C@H]([C@@H]([C@H]([C@@H]([C@H]2O)O)N=C(N)N)O)N=C(N)N)O[C@@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)NC)(C=O)O | |
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UCSJYZPVAKXKNQ-APUVXCOVSA-N | |
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InChI=1S/C21H39N7O12/c1-5-21(36,4-30)16(40-17-9(26-2)13(34)10(31)6(3-29)38-17)18(37-5)39-15-8(28-20(24)25)11(32)7(27-19(22)23)12(33)14(15)35/h4-18,26,29,31-36H,3H2,1-2H3,(H4,22,23,27)(H4,24,25,28)/t5-,6-,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,21+/m1/s1 | |
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Yes |
General status |
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Bactericide, Fungicide, Veterinary substance, Crop antibiotic | |
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Micro-organism | |
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Natural | |
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A aminoglycoside that inhibites protein biosynthesis, systemic action | |
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Isolated from the soil actinomycete, Streptomyces griseus | |
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Produced commerically by controlled fermentation | |
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Crop protection | |
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Gram-positive bacterial infections including canker, wilts and fire blight | |
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Top fruit, stone fuit, citrus, olives, vegetables, potatoes, tobacco, ornamentals and others | |
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57-92-1 | |
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200-355-3 | |
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312 | |
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006306 | |
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19649 | |
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581.57 | |
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O-2-deoxy-2-methylamino-α-L-glucopyranosyl-(1-2)-O-5-deoxy-3-C-formyl-α-L-lyxofuranosyl-(1-4)-N1,N3-diamidino-D-streptamine | |
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O-2-deoxy-2-(methylamino)-α-L-glucopyranosyl-(1-2)-O-5-deoxy-3-C-formyl-α-L-lyxofuranosyl-(1-4)-N,N'-bis(aminoiminomethyl)-D-streptamine | |
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Not applicable | |
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Not applicable | |
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Not applicable | |
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BM02 | |
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Resistance is widespread | |
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White powder | |
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Formulations |
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Plantomycin | Aries agro Ltd | ||||
Agrimycin 17 | Nufarm Ltd | |||||
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It is available as a water soluble powder, pellets or as an emulsifiable concentrate. Applied as a foliar spray for crop protetcion. |
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1000000 | V3 V = ChemID online databases / IPCS INCHEM (ChemID; IPCS INCHEM ) at 25 °C3 = Unverified data of known source |
High | ||||||||
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12 | Q3 Q = Miscellaneous internet resources 3 = Unverified data of known source |
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3.16 X 10-08 | Calculated | - | |||||||
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-7.5 | V3 V = ChemID online databases / IPCS INCHEM (ChemID; IPCS INCHEM ) 3 = Unverified data of known source |
Low | ||||||||
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n/a | - | - | ||||||||
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7.76 X 10-23 | V3 V = ChemID online databases / IPCS INCHEM (ChemID; IPCS INCHEM ) at 25 °C3 = Unverified data of known source |
Low volatility | ||||||||
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8.52 X 10-39 | V3 V = ChemID online databases / IPCS INCHEM (ChemID; IPCS INCHEM ) at 25 °C3 = Unverified data of known source |
Non-volatile | ||||||||
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Degradation |
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1.0 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
Non-persistent | ||||||||
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No risks identified | ||||||||||
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Soil adsorption and mobility |
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- | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
Moderately mobile | |||||||
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Known metabolites |
None
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Terrestrial ecotoxicology |
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> 9000 | G3 G = Extension Toxicology network database EXTOXNET (click here ) Rat3 = Unverified data of known source |
Low | ||||||||
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> 4640 | E4 E = Manufacturers safety data sheets Anas platyrhynchos4 = Verified data |
Low | ||||||||
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Aquatic ecotoxicology |
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> 180 | E4 E = Manufacturers safety data sheets Oncorhynchus mykiss4 = Verified data |
Low | ||||||||
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487 | R4 R = Peer reviewed scientific publications Daphnia magna4 = Verified data |
Low | ||||||||
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0.133 | R4 R = Peer reviewed scientific publications Pseudokirchneriella subcapitata4 = Verified data |
Moderate | ||||||||
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General |
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High (class III) | - | - | ||||||||
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> 9000 | G3 G = Extension Toxicology network database EXTOXNET (click here ) Rat3 = Unverified data of known source |
Low | ||||||||
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325 | L3 L = Pesticide manuals and hard copy reference books / other sources Mouse3 = Unverified data of known source |
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Intraperitoneal LD₅₀ = 525 mg kg⁻¹ | V3 V = ChemID online databases / IPCS INCHEM (ChemID; IPCS INCHEM ) Mouse3 = Unverified data of known source |
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Intravenous LDLo = 175 mg kg⁻¹ | V3 V = ChemID online databases / IPCS INCHEM (ChemID; IPCS INCHEM ) Rat3 = Unverified data of known source |
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Majority of oral dose is excreted in the faeces. Parenteral administration leads to urinal elimination. | R4 R = Peer reviewed scientific publications 4 = Verified data |
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Health issues |
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May cause rashes, hives, headache, drop in blood pressure, nausea and vomiting Possible kidney toxicant May cause hearing dysfunction |
Handling issues |
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No information available | |||
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NL (Not listed) | |||
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streptomycin | ||
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streptomycine | ||
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Streptomyzin | ||
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streptomicina | ||
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estreptomicina | ||
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Record last updated: | 17/11/2022 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |