Dicoumarol |

Last updated: 22/01/2023
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(Also known as: melitoxin; dicumarol; bishydroxycoumarin) |
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate |
Ecotoxicity |
Human health |
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A natuirally occurring anticoagulant rodenticide similar to warfarin now considered obsolete |
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Rodents |
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Riodents |
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Obsolete |
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1940, first identified |
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- |
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Not approved |
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Not applicable |
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No UK approval for use |
EC Regulation 1107/2009 (repealing 91/414) |
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Not approved |
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Not applicable |
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Not applicable |
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Not applicable |
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No |
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ATAustria |
BEBelgium |
BGBulgaria |
CYCyprus |
CZCzech Republic |
DEGermany |
DKDenmark |
EEEstonia |
ELGreece |
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ESSpain |
FIFinland |
FRFrance |
HRCroatia |
HUHungary |
IEIreland |
ITItaly |
LTLithuania |
LULuxembourg |
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LVLatvia |
MTMalta |
NLNetherlands |
PLPoland |
PTPortugal |
RORomania |
SESweden |
SISlovenia |
SKSlovakia |
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None |
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C₁₉H₁₂O₆ |
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C1=CC=C2C(=C1)C(=C(C(=O)O2)CC3=C(C4=CC=CC=C4OC3=O)O)O |
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- |
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DOBMPNYZJYQDGZ-UHFFFAOYSA-N |
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InChI=1S/C19H12O6/c20-16-10-5-1-3-7-14(10)24-18(22)12(16)9-13-17(21)11-6-2-4-8-15(11)25-19(13)23/h1-8,20-21H,9H2 |
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Yes |
Cambridge Crystallographic Data Centre diagrams |
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Common Name |
Relationship |
Link |
dicoumarol |
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Rodenticide |
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Coumarin rodenticide |
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- |
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Natural |
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An anticoagulant chemical that is a competitive inhibitor of vitamin K epoxide reductase |
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Has a combined plant and fungal origin - discovered from the spoilage of Melilotus officinalis (L.) Pall |
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- |
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Pest control |
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Rodents |
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- |
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- |
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66-76-2 |
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200-632-9 |
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253 |
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- |
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54676038 |
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607-060-00-2 |
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336.3 |
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3,3′-methylenebis(4-hydroxy-2H-1-benzopyran-2-one) |
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3,3′-methylenebis(4-hydroxy-2H-chromen-2-one) |
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3,3′-methylenebis[4-hydroxy-2H-1-benzopyran-2-one] |
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- |
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- |
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Not applicable |
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Not applicable |
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Not applicable |
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Not applicable |
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- |
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Off-white crystalline powder with slight sweet odour |
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128 |
Q3 Q = Miscellaneous internet resources 3 = Unverified data of known source |
Moderate |
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Insoluble |
Q3 Q = Miscellaneous internet resources 3 = Unverified data of known source Acetone |
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Insoluble |
Q3 Q = Miscellaneous internet resources 3 = Unverified data of known source Ether |
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290 |
Q3 Q = Miscellaneous internet resources 3 = Unverified data of known source |
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1.17 X 1002 |
Calculated |
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2.07 |
Q3 Q = Miscellaneous internet resources 3 = Unverified data of known source |
Low |
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Soil adsorption and mobility |
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None
Terrestrial ecotoxicology |
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233 |
Q3 Q = Miscellaneous internet resources 3 = Unverified data of known source Mouse |
Moderate |
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HUMAN HEALTH AND PROTECTION |
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High (class III) |
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233 |
Q3 Q = Miscellaneous internet resources 3 = Unverified data of known source Mouse |
Moderate |
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Excreted in urine and faeces following hepatic metabolism |
Q4 Q = Miscellaneous internet resources 4 = Verified data |
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Carcinogen |
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Endocrine disruptor |
No data found |
A0 A = Chromosome aberration (EFSA database) 0 = No data ; B0 B = DNA damage/repair (EFSA database) 0 = No data ; C0 C = Gene mutation (EFSA database) 0 = No data ; D0 D = Genome mutation (EFSA database) 0 = No data ; E0 E = Unspecified genotoxicity type (miscellaneous data source) 0 = No data |
No data found |
Reproduction / development effects |
Acetyl cholinesterase inhibitor |
Neurotoxicant |
?Possibly, status not identified |
No data found |
No data found |
Respiratory tract irritant |
Skin irritant |
Skin sensitiser |
No data found |
?Possibly, status not identified |
?Possibly, status not identified |
Eye irritant |
Phototoxicant |
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?Possibly, status not identified |
No data found |
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Highly toxic via the oral route May cause gastrointestinal tract discomfort resulting in nausea and vomiting |
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When heated to decomposition will emit acrid smoke and fumes IMDG Transport Code is 6.1 |
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2811 |
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Packaging Group III (minor danger) |
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dicoumarol |
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dicoumarol |
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Record last updated: |
22/01/2023 |
Contact: |
aeru@herts.ac.uk |
Please cite as: |
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |