Grape seed extract |

Last updated: 30/04/2025
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(Also known as: Vitis vinifera L. seed extract) |
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate |
Ecotoxicity |
Human health |
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A plant derived substance, rich in polyphenols and phenolic acids, used to control various common fungal diseases on a variety of crops |
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Downy mildew; Apple scab; Potato late blight; Downy mildew |
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Grapevines; Apples; Potatoes; Lettuce |
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Current |
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Class Magnoliopsida; Order: Vitales; Family: Vitaceae |
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Not approved |
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Not applicable |
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No UK approval for use (approval may not be required) |
EC Regulation 1107/2009 (repealing 91/414) |
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Approved |
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Not applicable |
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Open ended |
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Not applicable |
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Yes |
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ATAustria |
BEBelgium |
BGBulgaria |
CYCyprus |
CZCzech Republic |
DEGermany |
DKDenmark |
EEEstonia |
ELGreece |
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ESSpain |
FIFinland |
FRFrance |
HRCroatia |
HUHungary |
IEIreland |
ITItaly |
LTLithuania |
LULuxembourg |
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LVLatvia |
MTMalta |
NLNetherlands |
PLPoland |
PTPortugal |
RORomania |
SESweden |
SISlovenia |
SKSlovakia |
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ISIceland |
NONorway |
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Not applicable |
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No |
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Fungicide, Other substance |
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Antimicrobial |
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Plant-derived substance |
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Natural; Complex mixture |
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Sourced from the fruits of the wite wine grape (Vitis vinifera, L.) |
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There are various production methods including: (1) extraction with organic solvents such as acetone, acetonitrile, ethyl acetate or methanol, (2) steam distillation and (3) cold-pressing method |
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Crop protection |
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Downy mildew; Apple scab; Potato late blight; Downy mildew |
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Grapevines; Apples; Potatoes; Lettuce |
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grape seed extract |
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US GRAS; Approved via EU 'Basic substance' legislation (Article 28 of Regulation (EC) No 1107/2009) |
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Not applicable |
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Not applicable |
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Not applicable |
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Not applicable |
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- |
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Orange coloured powder when formulated |
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Enovita |
Indena |
Ecovitis |
Artimis Neutraceuticals |
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Usually forumulated as wettable powder for use as a foliar spray. May also be available as a dustable product. |
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Readily biodegradable |
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Expected to degrade rapidly |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. |
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Soil adsorption and mobility |
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None
Terrestrial ecotoxicology |
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> 4000 |
Rat |
Low |
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Low risk |
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Low risk |
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Low risk |
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Low risk |
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HUMAN HEALTH AND PROTECTION |
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> 4000 |
Rat |
Low |
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2000 |
Rat |
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Carcinogen |
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Endocrine disruptor |
XNo, known not to cause a problem |
A0 A = Chromosome aberration (EFSA database) 0 = No data ; B0 B = DNA damage/repair (EFSA database) 0 = No data ; C0 C = Gene mutation (EFSA database) 0 = No data ; D0 D = Genome mutation (EFSA database) 0 = No data ; E3 E = Unspecified genotoxicity type (miscellaneous data source) 3 = Negative |
XNo, known not to cause a problem |
Reproduction / development effects |
Acetyl cholinesterase inhibitor |
Neurotoxicant |
XNo, known not to cause a problem |
XNo, known not to cause a problem |
XNo, known not to cause a problem |
Respiratory tract irritant |
Skin irritant |
Skin sensitiser |
No data found |
✓Yes, known to cause a problem |
No data found |
Eye irritant |
Phototoxicant |
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✓Yes, known to cause a problem |
No data found |
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Adverse human health effects are not anticipated, Antioxidant |
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grape seed extract |
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Record last updated: |
30/04/2025 |
Contact: |
aeru@herts.ac.uk |
Please cite as: |
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |