piperonyl butoxide (Ref: ENT 14250) ** PBO ** butacide ** butoxide ** Translations

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Further data may be found in the PPDB and VSDB

GENERAL INFORMATION

Description: An unclassified synergist used in a wide variety of insecticides to provide enhanced performance of the active ingredient

Appearance and life cycle: -

Introduction: circa 1950

Taxonomic classification: -

EC Directive 1107/2009 (repealing 91/414):

Status	None - not a ppp
Dossier rapporteur/co-rapporteur	Not applicable
Date inclusion expires	Not applicable

Approved for use () or known to be used () in the following European countries:

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also registered in: Australia, USA

Known to used in the following countries: -

General status:

Biopesticide type	Other product constituent, Veterinary treatment
Other Constituent Type	Performance enhancer, Synergist
Substance group	Cyclic aromatic
Substance origin	Synthetic
Mode of action	Blocks pests natural detoxification system. Synergist. P450-dependent monooxygenase inhibitor.
Substance source	-
Substance production	-
Uses	-
Target pests	-
Target host	-
Farming system suitability	-
CAS RN	51-03-6
EC number	200-076-7
CIPAC number	33
US EPA chemical code	067501
Chemical formula	C19H30O5
SMILES	O1c2cc(c(cc2OC1)COCCOCCOCCCC)CCC
International Chemical Identifier (InChI)	InChI=1/C19H30O5/c1-3-5-7-20-8-9-21-10-11-22-14-17-13-19-18(23-15-24-19)12-16(17)6-4-2/h12-13H,3-11,14-15H2,1-2H3
Structure diagram/image available?	Yes
Molecular mass (g mol-1)	338.44
IUPAC Name	5-[2-(2-butoxyethoxy)ethoxymethyl]-6-propyl-1,3-benzodioxole
CAS Name	5-[[2-(2-butoxyethoxy)ethoxy]methyl]-6-propyl-1,3-benzodioxole
Other status information	Listed on USA Toxic Release Inventory
Herbicide Resistance Classification (HRAC)	Not applicable
Insecticide Resistance Classification (IRAC)	27A
Fungicide Resistance Classification (FRAC)	Not applicable
Physical state	Colourless to yellow oily liquid
Related substances & organisms	-

Formulations:

Property	Product	Manufacturer
Formulation and application details	Available in a range of formulations including dusts, emulsifiable concentrates, foggers, paper coatings, pressurized sprays, wettable powders, shampoos and as impregnated collars.

ENVIRONMENTAL FATE

Property		Value	Source/Quality Score/Other Information	Interpretation
Solubility - In water at 20oC (mg l-1)		14.3	L3	Low
Solubility - In organic solvents at 20oC (mg l-1)		-	-	-
Melting Point (oC)		Not applicable	L3	-
Boiling Point (oC)		-	-	-
Degradation point (oC)		164	E3	-
Flashpoint (oC)		179	E3	-
Octanol-water partition coefficient at pH 7, 20oC	P	5.62 X 1004	Calculated	-
	Log P	4.75	L3	High
Bulk density (g ml-1)/Specific gravity		1.06	L3	-
Dissociation constant (pKa) at 25oC		-	-	-
		Note:
Vapour pressure at 25oC (mPa)		2.00 X 10-02	L3	Non-volatile
Henry's law constant at 25oC (Pa m3 mol-1)		2.30 X 10-06	L3	Non-volatile
Henry's law constant at 20oC (dimensionless)		1.60 X 10-04	K3	Volatile
Maximum UV-vis absorption L mol-1 cm-1		-	-	-
Surface tension (mN m-1)		50.39	E3	-

Degradation:

Property		Value	Source/Quality Score/Other Information	Interpretation
Soil degradation (days) (aerobic)	DT50 (typical)	13	K4	Non-persistent
	DT50 (lab at 20oC)	-	-	-
	DT50 (field)	-	-	-
	DT90 (lab at 20oC)	-	-	-
	DT90 (field)	-	-	-
	Note	Best available data
Aqueous photolysis DT50 (days) at pH 7	Value	-	-	-
	Note	-
Aqueous hydrolysis DT50 (days) at 20oC and pH 7	Value	250	H3	Persistent
	Note	Stable pH 5 to pH 9 at 25 degC
Water-Sediment DT50 (days)		-	-	-
Water phase only DT50 (days)		-	-	-

Soil adsorption and mobility:

Property		Value	Source/Quality Score/Other Information	Interpretation
Linear	Kd	-	W3	Non-mobile
	Koc	89125
	Notes and range	Other data: Koc range 399-830 mL/g (L3)
Freundlich	Kf	-	-	-
	Kfoc	-
	1/n	-
	Notes and range	-
pH sensitivity		-

ECOTOXICOLOGY

Property		Value	Source/Quality Score/Other Information	Interpretation
Bio-concentration factor	BCF	260	E3 Lepomis macrochinis	Threshold for concern
	CT50 (days)	Not available		-
Bioaccumulation potential		-	Calculated	Moderate
Mammals - Acute oral LD50 (mg kg-1)		> 7220	L3 Rat	Low
Mammals - Short term dietary NOEL	(mg kg-1)	30	L2 Rat, 2 year	High
	(ppm diet)	-		-
Birds - Acute LD50 (mg kg-1)		> 2250	L3 Colinus virginianus	Low
Birds - Short term dietary (LC50/LD50)		-	-	-
Fish - Acute 96 hour LC50 (mg l-1)		5.3	L3 Cyprinidae	Moderate
Fish - Chronic 21 day NOEC (mg l-1)		-	-	-
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1)		0.51	J4 Daphnia magna	Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1)		0.12	F3 Daphnia magna, LOEC	-
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1)		-	-	-
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1)		-	-	-
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1)		-	-	-
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1)		-	-	-
Aquatic plants - Acute 7 day EC50, biomass (mg l-1)		-	-	-
Algae - Acute 72 hour EC50, growth (mg l-1)		0.24	K3 Unknown species	Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1)		-	-	-
Honeybees - Acute 48 hour LD50 (µg bee-1)		294	E3 Contact	Low
Earthworms - Acute 14 day LC50 (mg kg-1)		-	-	-
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1)		-	-	-
Other soil macro-organisms - e.g. Collembola	LR50product ha EC50product ha NOECproduct ha % Effect	-	-	-
Other arthropod (1)	LR50 g ha-1	-	-	-
	% Effect	-	-	-
Other arthropod (2)	LR50 g ha-1	-	-	-
	% Effect	-	-	-
Soil micro-organisms		-	-	-
Mesocosm study data	NOEAEC mg l-1	-	-	-
	NOEAEC mg l-1	-	-	-

HUMAN HEALTH AND PROTECTION

General:

Property		Value	Source/Quality Score/Other Information	Interpretation
Mammals - Acute oral LD50 (mg kg-1)		> 7220	L3 Rat	Low
Mammals - Dermal LD50 (mg kg-1 body weight)		> 1880	L3 Rabbit	-
Mammals - Inhalation LC50 (mg l-1)		> 5.9	L3 Rat	-
Other Mammal toxicity endpoints		Intraperitoneal LDLo = 1000 mg kg-1	V3 Mice	-
ADI - Acceptable Daily Intake (mg kg-1bw day-1)		0.2	JMPR 1995	-
ARfD - Acute Reference Dose (mg kg-1bw day-1)		None allocated	JMPR 2002	-
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1)		-	-	-
Dermal penetration studies (%)		-	-	-
Dangerous Substances Directive 76/464		-	-	-
Exposure Limits		-	-	-
Exposure Routes	Public	-
	Occupational	-
Elimination route and rate		Majority of dose eliminated in faeces	R3	-

Health issues:

Carcinogen	Mutagen	Endocrine disrupter	Reproduction / development effects	Acetyl cholinesterase inhibitor	Neurotoxicant	Respiratory tract irritant	Skin irritant	Eye irritant
General human health issues		[Possible liver toxicant], [NB: Some sources dispute carcinogenicity]

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data

Handling issues:

Property		Value	Source/Quality Score/Other Information	Interpretation
General		[Not explosive], [IMDG Transport Code is usually 9]
EC Risk Classification		[Carcinogen category 3: R40], [T - Toxic: R23, R24, R25], [N - Dangerous for the environment: R50/53]
EC Safety Classification		S23, S26, S36, S37, S39, S45
WHO Classification		U	-	Unlikely to present an acute hazard
US EPA Classification (formulation)		IV	-	Caution - Not acutely toxic
UN Number		3082
Waste disposal & packaging		[Usually Packaging Group III (minor danger)]

TRANSLATIONS