methyl isobutyl ketone ** hexone ** MiBK ** isopropyl acetone ** Translations

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GENERAL INFORMATION

Description: Chemical without pesticidal activity that is sometimes used as a solvent in crop protection product formulations

Introduction: -

EC Directive 1107/2009 (repealing 91/414):

Status	None - not a ppp
Dossier rapporteur/co-rapporteur	Not applicable
Date inclusion expires	Not applicable

Approved for use () or known to be used () in the following European countries:

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

General status:

Pesticide type	Other product constituent
Other Constituent Type	Solvent
Substance group	Ketone
Substance origin	Synthetic
Mode of action	Inert
CAS RN	108-10-1
EC number	203-550-1
CIPAC number	-
US EPA chemical code	044105
Chemical formula	C6H12O
SMILES	CC(C)CC(=O)C
International Chemical Identifier (InChI)	InChI=1S/C6H12O/c1-5(2)4-6(3)7/h5H,4H2,1-3H3
Structure diagram/image available?	Yes
Molecular mass (g mol-1)	100.16
IUPAC Name	4-methyl-2-pentanone
CAS Name	isopropylacetone
Other status information	Listed on USA Toxic Release Inventory
Herbicide Resistance Classification (HRAC)	Not applicable
Insecticide Resistance Classification (IRAC)	Not applicable
Fungicide Resistance Classification (FRAC)	Not applicable
Physical state	Colourless liquid
Related substances & organisms	-

Formulations:

Property	Value
Example manufacturers of products using this active	-
Example products using this active	-
UK LERAP status	Not applicable
Formulation and application details	-

ENVIRONMENTAL FATE

Property		Value	Source/Quality Score/Other Information	Interpretation
Solubility - In water at 20oC (mg l-1)		19100	V3 - @ 25 DegC	High
Solubility - In organic solvents at 20oC (mg l-1)		-	-	-
Melting Point (oC)		-84.7	V3	-
Boiling Point (oC)		115.8	P3	-
Degradation point (oC)		-	-	-
Flashpoint (oC)		23	P3 - (closed cup)	-
Octanol-water partition coefficient at pH 7, 20oC	P	2.40 X 1001	Calculated	-
	Log P	1.38	V3	Low
Bulk density (g ml-1)/Specific gravity		0.804	P3	-
Dissociation constant (pKa) at 25oC		-	-	-
		Note:
Vapour pressure at 25oC (mPa)		2100000	V3 - @ 25 degC	Intermediate state
Henry's law constant at 25oC (Pa m3 mol-1)		-	-	-
Henry's law constant at 20oC (dimensionless)		4.52 X 10-03	Calculated	Volatile
GUS leaching potential index		-	-	-
SCI-GROW groundwater index (µg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate	Value	-	-	-
	Note	-
Potential for particle bound transport index		-	-	-
Maximum UV-vis absorption L mol-1 cm-1		-	-	-
Surface tension (mN m-1)		-	-	-

Degradation:

Property		Value	Source/Quality Score/Other Information	Interpretation
Soil degradation (days) (aerobic)	DT50 (typical)	-	-	-
	DT50 (lab at 20oC)	-	-	-
	DT50 (field)	-	-	-
	DT90 (lab at 20oC)	-	-	-
	DT90 (field)	-	-	-
	Note:	-
Aqueous photolysis DT50 (days) at pH 7	Value	-	-	-
	Note	-
Aqueous hydrolysis DT50 (days) at 20oC and pH 7	Value	-	-	-
	Note	-
Water-Sediment DT50 (days)		-	-	-
Water phase only DT50 (days)		-	-	-

Soil adsorption and mobility:

Property		Value	Source/Quality Score/Other Information	Interpretation
Linear	Kd	-	-	-
	Koc	-
	Notes and range	-
Freundlich	Kf	-	-	-
	Kfoc	-
	1/n	-
	Notes and range	-
pH sensitivity		-

ECOTOXICOLOGY

Property		Value	Source/Quality Score/Other Information	Interpretation
Bio-concentration factor	BCF	-	-	-
	CT50 (days)	-		-
Bioaccumulation potential		-	Calculated	Low
Mammals - Acute oral LD50 (mg kg-1)		2080	Q3 Rat	Low
Mammals - Short term dietary NOEL	(mg kg-1)	-	-	-
	(ppm diet)	-		-
Birds - Acute LD50 (mg kg-1)		100	Q3 Agelaius phoeniceus	Moderate
Birds - Short term dietary (LC50/LD50)		-	-	-
Fish - Acute 96 hour LC50 (mg l-1)		600	Q3 Oncorhynchus mykiss	Low
Fish - Chronic 21 day NOEC (mg l-1)		-	-	-
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1)		170	F3 Daphnia magna	Low
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1)		-	-	-
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1)		-	-	-
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1)		-	-	-
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1)		-	-	-
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1)		-	-	-
Aquatic plants - Acute 7 day EC50, biomass (mg l-1)		-	-	-
Algae - Acute 72 hour EC50, growth (mg l-1)		980	F3 Pseudokirchneriella subcapitata	Low
Algae - Chronic 96 hour NOEC, growth (mg l-1)		-	-	-
Honeybees - Acute 48 hour LD50 (µg bee-1)		-	-	-
Earthworms - Acute 14 day LC50 (mg kg-1)		-	-	-
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1)		-	-	-
Other soil macro-organisms - e.g. Collembola	LR50product ha EC50product ha NOECproduct ha % Effect	-	-	-
Other arthropod (1)	LR50 g ha-1	-	-	-
	% Effect	-	-	-
Other arthropod (2)	LR50 g ha-1	-	-	-
	% Effect	-	-	-
Soil micro-organisms		-	-	-
Mesocosm study data	NOEAEC mg l-1	-	-	-
	NOEAEC mg l-1	-	-	-

HUMAN HEALTH AND PROTECTION

General:

Property		Value	Source/Quality Score/Other Information	Interpretation
Mammals - Acute oral LD50 (mg kg-1)		2080	Q3 Rat	Low
Mammals - Dermal LD50 (mg kg-1 body weight)		> 20000	Q3 Rabbit	-
Mammals - Inhalation LC50 (mg l-1)		23300	Q3 Rat	-
Other Mammal toxicity endpoints		-		-
ADI - Acceptable Daily Intake (mg kg-1bw day-1)		-	-	-
ARfD - Acute Reference Dose (mg kg-1bw day-1)		-	-	-
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1)		-	-	-
Dermal penetration studies (%)		-	-	-
Dangerous Substances Directive 76/464		-	-	-
Exposure Limits		[TLV TWA: 50 ppm], [75 ppm as STEL]	Q3	-
Exposure Routes	Public	-
	Occupational	[Major exposure route is through inhalation]
Examples of European MRLs (mg kg-1)	Value	-
	Note	For the EU pesticides database click here
Drinking Water MAC (µg l-1)		-	-	-

Health issues:

Carcinogen	Mutagen	Endocrine disrupter	Reproduction / development effects	Acetyl cholinesterase inhibitor	Neurotoxicant	Respiratory tract irritant	Skin irritant	Eye irritant
	-
General human health issues		[Swallowing may cause chemical pneumonitis], [May cause dermatitis], [Liver and kidney toxicant]

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data

Handling issues:

Property		Value	Source/Quality Score/Other Information	Interpretation
General		[Flammable], [Prevent generation of mists], [Vapour mixes well with air, explosive mixtures are easily formed], [[IMDG Transport Code is usually 3]
EC Risk Classification		[H - Handling risks: R11], [Xn - Harmful: R20], [Xi - Irritant: R36/37, R66]
EC Safety Classification		S2, S9, S16, S29
WHO Classification		None - not a ppp	-	-
US EPA Classification (formulation)		No consensus across products or no products available	-	-
UN Number		1245
Waste disposal & packaging		[Usually Packaging Group II (medium danger)]

TRANSLATIONS