chlorotoluron (Ref: C 2242) ** chlortoluron ** CTU ** Translations

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GENERAL INFORMATION

Description: A contact and residual urea herbicide used to control broad-leaved weeds and grasses

Introduction: 1994

EC Directive 1107/2009 (repealing 91/414):

Status	Annex 1
Dossier rapporteur/co-rapporteur	Spain
Date inclusion expires	28/02/2016

Approved for use () or known to be used () in the following European countries:

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

General status:

Pesticide type	Herbicide
Substance group	Urea
Substance origin	Synthetic
Mode of action	Selective, non-systemic absorbed by roots and foliage. Acts by the inhibition of photosynthetic electron transport.
CAS RN	15545-48-9
EC number	239-592-2
CIPAC number	217
US EPA chemical code	216500
Chemical formula	C10H13ClN2O
SMILES	Clc1cc(NC(=O)N(C)C)ccc1C
International Chemical Identifier (InChI)	InChI=1/C10H13ClN2O/c1-7-4-5-8(6-9(7)11)12-10(14)13(2)3/h4-6H,1-3H3,(H,12,14)
Structure diagram/image available?	Yes
Molecular mass (g mol-1)	212.68
IUPAC Name	3-(3-chloro-p-tolyl)-1,1-dimethylurea
CAS Name	N'-(3-chloro-4-methylphenyl)-N,N-dimethylurea
Other status information	Marine Pollutant
Herbicide Resistance Classification (HRAC)	C2
Insecticide Resistance Classification (IRAC)	Not applicable
Fungicide Resistance Classification (FRAC)	Not applicable
Physical state	Colourless crystalline solid
Related substances & organisms	diflufenican isoproturon

Formulations:

Property	Value
Example manufacturers of products using this active	Clayton Headland Makhteshim-Agan Nufarm UK
Example products using this active	Tolerate Alpha Chlortoluron 500 Tolugan Tolugan Extra Dicurane
UK LERAP status	None
Formulation and application details	Usually supplied as a soluble concentrate or wettable granules that are mixed with water and applied as a spray.

ENVIRONMENTAL FATE

Property		Value	Source/Quality Score/Other Information	Interpretation
Solubility - In water at 20oC (mg l-1)		74	A5	Moderate
Solubility - In organic solvents at 20oC (mg l-1)		21000	A5 - Ethyl acetate	-
		54000	A5 - Acetone	-
		48000	A5 - Ethanol	-
		3000	A5 - Toluene	-
Melting Point (oC)		148.1	L3	-
Boiling Point (oC)		-	-	-
Degradation point (oC)		-	-	-
Flashpoint (oC)		Not highly flammable	A5	-
Octanol-water partition coefficient at pH 7, 20oC	P	3.16 X 1002	Calculated	-
	Log P	2.5	A5	Low
Bulk density (g ml-1)/Specific gravity		1.34	A5	-
Dissociation constant (pKa) at 25oC		Not applicable	A5	-
		Note: No dissociation
Vapour pressure at 25oC (mPa)		0.005	A5	Non-volatile
Henry's law constant at 25oC (Pa m3 mol-1)		1.44 X 10-05	L3	Non-volatile
Henry's law constant at 20oC (dimensionless)		2.10 X 10-08	K3	Non-volatile
GUS leaching potential index		2.82	Calculated	High leachability
SCI-GROW groundwater index (µg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate	Value	2.33 X 10-01	Calculated	-
	Note	-
Potential for particle bound transport index		-	Calculated	Medium
Maximum UV-vis absorption L mol-1 cm-1		Maxima at 241-242nm = 19516	A5	-
Surface tension (mN m-1)		-	-	-

Degradation:

Property		Value	Source/Quality Score/Other Information	Interpretation
Soil degradation (days) (aerobic)	DT50 (typical)	45	A5	Moderately persistent
	DT50 (lab at 20oC)	59	A5	Moderately persistent
	DT50 (field)	34	A5	Moderately persistent
	DT90 (lab at 20oC)	173	A5	-
	DT90 (field)	196	A5	-
	Note	EU dossier Lab studies DT50 range 52-66 days, DT90 range 42-304 days, field studies DT50 range 26-42 days, DT90 range 173-218 days
Aqueous photolysis DT50 (days) at pH 7	Value	0.12	A5	Fast
	Note	-
Aqueous hydrolysis DT50 (days) at 20oC and pH 7	Value	Stable	A5	Very persistent
	Note	pH and temperature sensitive: Stable at 20-30 degC at pH 5 to pH 9, DT50 22 days at pH 5 and 69 days at pH 9 both at 50 degC. DT50 2-3 days at 70 Deg C
Water-Sediment DT50 (days)		352	A5	Slow
Water phase only DT50 (days)		42	A5	Stable

Soil adsorption and mobility:

Property		Value	Source/Quality Score/Other Information	Interpretation
Linear	Kd	5.9	A4	Moderately mobile
	Koc	196
	Notes and range	EU dossier Kd range 1.17-27.21 mL/g, Koc range 108-384 mL/g, Soils=6
Freundlich	Kf	-	-	-
	Kfoc	-
	1/n	-
	Notes and range	-
pH sensitivity		No

Key metabolites:

Metabolite		Formation Medium	Estimated Maximum Occurrence Fraction	91/414 Relevancy
3-(3-chloro-p-tolyl)-1-methylurea		Soil	0.300	Major fraction, Not relevant

Other known metabolites:

Metabolite name and reference	Aliases	Formation Medium / Rate	Estimated Maximum Occurrence Fraction	Metabolising Enzymes
1-(3-chloro-4-p-tolyl)urea	-	Soil	-	-
3-chloro-4-methylaniline	-	Soil	-	-
chlorotoluron benzoic acid	-	Water	0.251	-

ECOTOXICOLOGY

Property		Value	Source/Quality Score/Other Information	Interpretation
Bio-concentration factor	BCF	-	-	-
	CT50 (days)	-		-
Bioaccumulation potential		-	Calculated	Low
Mammals - Acute oral LD50 (mg kg-1)		> 10000	A5 Rat	Low
Mammals - Short term dietary NOEL	(mg kg-1)	> 5	L2 Rat, 2 year	High
	(ppm diet)	> 100		-
Birds - Acute LD50 (mg kg-1)		272	A5 Coturnix japonica	Moderate
Birds - Short term dietary (LC50/LD50)		> 2150 mg kg feed-1	A5 Coturnix japonica	-
Fish - Acute 96 hour LC50 (mg l-1)		20	A5 Oncorhynchus mykiss	Moderate
Fish - Chronic 21 day NOEC (mg l-1)		0.4	A5 Oncorhynchus mykiss	-
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1)		67	A5 Daphnia magna	Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1)		16.7	A5 Daphnia magna	-
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1)		-	-	-
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1)		-	-	-
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1)		-	-	-
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1)		-	-	-
Aquatic plants - Acute 7 day EC50, biomass (mg l-1)		0.038	A5 Lemna gibba	Moderate
Algae - Acute 72 hour EC50, growth (mg l-1)		0.024	A5 Scenedemus subspicatus	Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1)		0.001	J4 Green alaga	Moderate
Honeybees - Acute 48 hour LD50 (µg bee-1)		177.4	A3 Oral as product	Low
Earthworms - Acute 14 day LC50 (mg kg-1)		> 1000	A5	Moderate
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1)		-	-	-
Other soil macro-organisms - e.g. Collembola	LR50product ha EC50product ha NOECproduct ha % Effect	-	-	-
Other arthropod (1)	LR50 g ha-1	-	-	-
	% Effect	No adverse effects	Mortality Dose: 2.45 kg ha-1 A4 Typhlodromus pyri	Harmless
Other arthropod (2)	LR50 g ha-1	-	-	-
	% Effect	No adverse effects	Mortality Dose: 2.45 kg ha-1 A4 Aphidius rhopalosiphi	Harmless
Soil micro-organisms		Nitrogen mineralisation: No significant effect Carbon mineralisation: No significant effect	A5 Dose: 3.5 kg/ha; 83 days	-
Mesocosm study data	NOEAEC mg l-1	-	-	-
	NOEAEC mg l-1	-	-	-

HUMAN HEALTH AND PROTECTION

General:

Property		Value	Source/Quality Score/Other Information	Interpretation
Mammals - Acute oral LD50 (mg kg-1)		> 10000	A5 Rat	Low
Mammals - Dermal LD50 (mg kg-1 body weight)		> 2000	A5 Rat	-
Mammals - Inhalation LC50 (mg l-1)		> 5.3	A5 Rat (nose only)	-
Other Mammal toxicity endpoints		-		-
ADI - Acceptable Daily Intake (mg kg-1bw day-1)		0.04	A5 Rat, SF=100	-
ARfD - Acute Reference Dose (mg kg-1bw day-1)		None allocated	A5	-
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1)		0.215	A5	-
Dermal penetration studies (%)		-	-	-
Dangerous Substances Directive 76/464		-	-	-
Exposure Limits		-	-	-
Exposure Routes	Public	[Acceptable risk to bystanders for proposed uses]
	Occupational	[Acceptable risk to operators and other workers for proposed uses]
Examples of European MRLs (mg kg-1)	Value	-
	Note	For the EU pesticides database click here
Drinking Water MAC (µg l-1)		-	-	-

Health issues:

Carcinogen	Mutagen	Endocrine disrupter	Reproduction / development effects	Acetyl cholinesterase inhibitor	Neurotoxicant	Respiratory tract irritant	Skin irritant	Eye irritant
	-		-
General human health issues		[Kidney and liver tumors have been observed in mice at high doses]

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data

Handling issues:

Property		Value	Source/Quality Score/Other Information	Interpretation
General		[Not explosive], [IMDG Transport Code is usually 9]
EC Risk Classification		[Carcinogen category 3: R40], [Xn - Harmful: R63], [N - Dangerous for the environment: R50, R53]
EC Safety Classification		S2, S26, S36/37, S45, S60, S61
WHO Classification		U	-	Unlikely to present an acute hazard
US EPA Classification (formulation)		No consensus across products or no products available	-	-
UN Number		Variable with product, usually 3077 or 3082
Waste disposal & packaging		[Usually Packaging Group III (minor danger)]

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