cyproconazole (Ref: SAN 619) ** CGA 221949 ** SAN 751 ** A-9898A ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

GENERAL INFORMATION

Description: A broad spectrum fungicide for cereals and other field crops used to control Septoria, rust, powdery mildew and other diseases

Introduction: 1986, first reported; 1989, first introduced France & Switzerland

EC Directive 1107/2009 (repealing 91/414):

Status	Annex 1
Dossier rapporteur/co-rapporteur	Ireland
Date inclusion expires	31/05/2021

Approved for use () or known to be used () in the following European countries:

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also registered in: Australia

General status:

Pesticide type	Fungicide
Substance group	Triazole
Substance origin	Synthetic
Mode of action	Systemic with protective, curative and eradicant action. Disrupts membrane function. An ergosterol-biosynthesis inhibitor.
CAS RN	94361-06-5
EC number	-
CIPAC number	600
US EPA chemical code	128993
Chemical formula	C15H18ClN3O
SMILES	Clc1ccc(cc1)C(O)(C(C)C2CC2)Cn3ncnc3
International Chemical Identifier (InChI)	InChI=1/C15H18ClN3O/c1-11(12-2-3-12)15(20,8-19-10-17-9-18-19)13-4-6-14(16)7-5-13/h4-7,9-12,20H,2-3,8H2,1H3
Structure diagram/image available?	Yes
Molecular mass (g mol-1)	291.78
IUPAC Name	(2RS,3RS;2RS,3SR)-2-(4-chlorophenyl)-3-cyclopropyl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
CAS Name	α-(4-chlorophenyl)-α-(1-cyclopropylethyl)-1H-1,2,4-triazole-1-ethanol
Other status information	-
Herbicide Resistance Classification (HRAC)	Not applicable
Insecticide Resistance Classification (IRAC)	Not applicable
Fungicide Resistance Classification (FRAC)	3
Physical state	Fine white powder
Related substances & organisms	azoxystrobin chlorothalonil cyprodinil quinoxyfen trifloxystrobin

Formulations:

Property	Value
Example manufacturers of products using this active	Bayer CropScience Dow AgroSciences Syngenta
Example products using this active	Alto Elite Cabaret Caddy 240EC Cherokee Excelsior Menara Priori Xtra Quadris Xtra
UK LERAP status	None
Formulation and application details	Often supplied as soluble concentrates that are mixed with water and applied as a spray.

ENVIRONMENTAL FATE

Property		Value	Source/Quality Score/Other Information	Interpretation
Solubility - In water at 20oC (mg l-1)		93	A5	Moderate
Solubility - In organic solvents at 20oC (mg l-1)		360000	A5 - Acetone	-
		240000	A5 - Ethyl acetate	-
		1300	A5 - Hexane	-
		410000	A5 - Methanol	-
Melting Point (oC)		106.5	A5	-
Boiling Point (oC)		Decomposes before boiling	A5	-
Degradation point (oC)		299	A5	-
Flashpoint (oC)		Not highly flammable	A5	-
Octanol-water partition coefficient at pH 7, 20oC	P	1.23 X 1003	Calculated	-
	Log P	3.09	A5	High
Bulk density (g ml-1)/Specific gravity		1.26	L3	-
Dissociation constant (pKa) at 25oC		Not applicable	A5	-
		Note: No dissociation
Vapour pressure at 25oC (mPa)		0.026	A5	Non-volatile
Henry's law constant at 25oC (Pa m3 mol-1)		5.00 X 10-05	A5	Non-volatile
Henry's law constant at 20oC (dimensionless)		2.96 X 10-08	K3	Non-volatile
GUS leaching potential index		3.10	Calculated	High leachability
SCI-GROW groundwater index (µg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate	Value	3.78 X 10-01	Calculated	-
	Note	-
Potential for particle bound transport index		-	Calculated	Medium
Maximum UV-vis absorption L mol-1 cm-1		Neutral solution: 297nm = 0.7; [Acidic solution: 295nm = 0.4; [Basic solution: 295nm = 0.8	A5	-
Surface tension (mN m-1)		65.2	A5	-

Degradation:

Property		Value	Source/Quality Score/Other Information	Interpretation
Soil degradation (days) (aerobic)	DT50 (typical)	142	A5	Persistent
	DT50 (lab at 20oC)	142	A5	Persistent
	DT50 (field)	129	A5	Persistent
	DT90 (lab at 20oC)	422	A5	-
	DT90 (field)	579	A5	-
	Note	EU dossier lab studies DT50 range 44.9-191 days, DT90 range 149-1000 days, field studies DT50 range 62.1-501.2 days, DT90 range 179->1000 days; Other data: DT50 144 days (DW4)
Aqueous photolysis DT50 (days) at pH 7	Value	40	K4	Stable
	Note	-
Aqueous hydrolysis DT50 (days) at 20oC and pH 7	Value	Stable	A5	Very persistent
	Note	Stable pH 4 to pH 9, 50 degC
Water-Sediment DT50 (days)		1000	A5	Stable
Water phase only DT50 (days)		-	-	-

Soil adsorption and mobility:

Property		Value	Source/Quality Score/Other Information	Interpretation
Linear	Kd	-	-	-
	Koc	-
	Notes and range	-
Freundlich	Kf	8.7	A5	Moderately mobile
	Kfoc	364
	1/n	0.862
	Notes and range	EU dossier kf range 4.1-17.0, Kfoc range 173-711 mL/g, 1/n range 0.84-0.90, Soils=5
pH sensitivity		No

Key metabolites:

Metabolite		Formation Medium	Estimated Maximum Occurrence Fraction	91/414 Relevancy
1,2,4-triazole (Ref: CGA 71019)		Soil	0.170	Major fraction, Not relevant
1H-1,2,4-triazol-1-ylacetic acid (Ref: CGA 142856)		Soil	0.067	Micor fraction, Relevant

Other known metabolites:

Metabolite name and reference	Aliases	Formation Medium / Rate	Estimated Maximum Occurrence Fraction	Metabolising Enzymes
-	triazole pyruvic acid	Soil	-	-
-	triazole lactic acid	Soil	-	-
2-amino-3-[1,2,4] triazol-1-yl-propionic acid (Ref: CGA 131013)	triazole alanine; TA	Soil	-	-
(Ref: NOA 142856)	triazole acetic acid	Soil	0.07	-
5-(4-chlorophenyl)-5-hydroxy-4-methyl-6-(1H-1,2,4-triazol-1-yl)-2-hexanoic acid (Ref: NOA 405870)	M21/21a	Rat	-	-
5-(4-chloro-phenyl)-3,5-dihydroxy-4-methyl-6-[1,2,4]triazol-1-yl-hexanoic acid (Ref: NOA 405872)	M36(Z2)	Rat	-	-
(Ref: NOA 421152)	-	Rat (Faeces)	-	-
1-[(E)-2-(4-chloro-phenyl)-3-cyclopropyl-but-1-enyl]-1H-[1,2,4]triazole (Ref: NOA 421155)	M38(Z1)	-	-	-
1H-1,2,4-triazol-3-ol (Ref: NOA 457654)	hydroxy triazole	Soil (Aerobic)	-	-

ECOTOXICOLOGY

Property		Value	Source/Quality Score/Other Information	Interpretation
Bio-concentration factor	BCF	28	A5 Whole fish	Low potential
	CT50 (days)	1		-
Bioaccumulation potential		-	Calculated	Low
Mammals - Acute oral LD50 (mg kg-1)		< 350	A5 Rat	Moderate
Mammals - Short term dietary NOEL	(mg kg-1)	1.84	A5 Mice	High
	(ppm diet)	15		-
Birds - Acute LD50 (mg kg-1)		94	A5 Colinus virginianus	High
Birds - Short term dietary (LC50/LD50)		> 146 mg kg-1	A5 Anas platyrhynchos	-
Fish - Acute 96 hour LC50 (mg l-1)		19.0	A5 Oncorhynchus mykiss	Moderate
Fish - Chronic 21 day NOEC (mg l-1)		0.65	A5 Oncorhynchus mykiss	-
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1)		> 22	A5 Daphnia magna	Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1)		0.29	A5 Daphnia magna	-
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1)		8.3	F3 Americamysis bahia	Moderate
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1)		-	-	-
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1)		-	-	-
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1)		50.0	A4 Chironomus riparius	Moderate
Aquatic plants - Acute 7 day EC50, biomass (mg l-1)		0.059	A5 Lemna gibba	Moderate
Algae - Acute 72 hour EC50, growth (mg l-1)		0.099	A5 Scenedemus subspicatus	Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1)		0.02	Q2 Unknown species	Moderate
Honeybees - Acute 48 hour LD50 (µg bee-1)		> 100	A5 Contact	Moderate
Earthworms - Acute 14 day LC50 (mg kg-1)		168	A5 Eisenia foetida, corr	Moderate
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1)		0.75	A4 Eisenia foetida, corr, formulation	Moderate
Other soil macro-organisms - e.g. Collembola	LR50product ha EC50product ha NOECproduct ha % Effect	55.8	A4 Folsomia candida, 28 day NOEC	-
Other arthropod (1)	LR50 g ha-1	<80	48 hour A5 Aphidius rhopalosiphi, adult	Harmless at 1 kg ha-1
	% Effect	-	-	-
Other arthropod (2)	LR50 g ha-1	35.6	7 day A5 Typhlodromus pyri	Harmless at 1 kg ha-1
	% Effect	-	-	-
Soil micro-organisms		Nitrogen mineralisation: No significant effect Carbon mineralisation: No significant effect	A5 Dose: 2.5 mg/kg soil, 35 days	-
Mesocosm study data	NOEAEC mg l-1	-	-	-
	NOEAEC mg l-1	-	-	-

HUMAN HEALTH AND PROTECTION

General:

Property		Value	Source/Quality Score/Other Information	Interpretation
Mammals - Acute oral LD50 (mg kg-1)		< 350	A5 Rat	Moderate
Mammals - Dermal LD50 (mg kg-1 body weight)		> 2000	A5 Rat	-
Mammals - Inhalation LC50 (mg l-1)		> 5.47	A5 Rat (nose only)	-
Other Mammal toxicity endpoints		-		-
ADI - Acceptable Daily Intake (mg kg-1bw day-1)		0.02	A4 SF=100	-
ARfD - Acute Reference Dose (mg kg-1bw day-1)		0.02	A4 SF=100	-
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1)		0.02	A4 SF=100	-
Dermal penetration studies (%)		1-10	A5 concentration dependant	-
Dangerous Substances Directive 76/464		-	-	-
Exposure Limits		-	-	-
Exposure Routes	Public	[Main route of exposure of bystanders is by spray drify but risk is considered low]
	Occupational	[No unacceptable risks to operators or other workers identified]
Examples of European MRLs (mg kg-1)	Value	-
	Note	For the EU pesticides database click here
Drinking Water MAC (µg l-1)		-	-	-

Health issues:

Carcinogen	Mutagen	Endocrine disrupter	Reproduction / development effects	Acetyl cholinesterase inhibitor	Neurotoxicant	Respiratory tract irritant	Skin irritant	Eye irritant
	-	-
General human health issues		[Possible liver toxicant]

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data

Handling issues:

Property		Value	Source/Quality Score/Other Information	Interpretation
General		[Not explosive or oxidising], [IMDG Transport Code is usually 9]
EC Risk Classification		[Carcinogen category 3: R40], [Reproduction risk category 3: R63], [Xn - Harmful: R22], [N - Dangerous for the environment: R50, R53]
EC Safety Classification		S2, S36/37, S60, S61
WHO Classification		II	-	Moderately hazardous
US EPA Classification (formulation)		III	-	Caution - Slightly toxic
UN Number		Usually 3082
Waste disposal & packaging		[Usually Packaging Group III (minor danger)]

TRANSLATIONS