diazinon (Ref: OMS 469) ** dimpylate ** ENT 19507 ** Translations

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Further data may be found in the VSDB

GENERAL INFORMATION

Description: An insecticide used to control sucking and chewing insects on a wide range of crops including top fruit. Also has livestock applications.

Introduction: 1953, first reported

EC Directive 1107/2009 (repealing 91/414):

Status	Excluded from Annex 1
Dossier rapporteur/co-rapporteur	Portugal
Date inclusion expires	Expired

Approved for use () or known to be used () in the following European countries:

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also registered in: Australia, USA

General status:

Pesticide type	Insecticide, Acaricide, Repellent, Veterinary treatment
Substance group	Organophosphate
Substance origin	Synthetic
Mode of action	Non-systemic with respiratory, contact and stomach action. Acetylcholinesterase (AChE) inhibitor.
CAS RN	333-41-5
EC number	206-373-8
CIPAC number	15
US EPA chemical code	057801
Chemical formula	C12H21N2O3PS
SMILES	S=P(OCC)(OCC)Oc1nc(nc(c1)C)C(C)C
International Chemical Identifier (InChI)	InChI=1/C12H21N2O3PS/c1-6-15-18(19,16-7-2)17-11-8-10(5)13-12(14-11)9(3)4/h8-9H,6-7H2,1-5H3
Structure diagram/image available?	Yes
Molecular mass (g mol-1)	304.35
IUPAC Name	O,O-diethyl O-2-isopropyl-6-methylpyrimidin-4-yl phosphorothioate
CAS Name	O,O-diethyl O-[6-methyl-2-(1-methylethyl)-4-pyrimidinyl] phosphorothioate
Other status information	Potential groundwater contaminant; Severe Marine Pollutant
Herbicide Resistance Classification (HRAC)	Not applicable
Insecticide Resistance Classification (IRAC)	1B
Fungicide Resistance Classification (FRAC)	Not applicable
Physical state	Colourless to dark brown liquid
Related substances & organisms	-

Formulations:

Property	Value
Example manufacturers of products using this active	Makhteshim FCC
Example products using this active	Diazol 60EC Knox-Out DZN Basin
UK LERAP status	No UK approval for use or outside scope
Formulation and application details	Available in a wide variety of formulations including concentrates for dilution and use as a crop spray, powders and impregnated collars for domestic pet use, shampoos, pour-ons and dips.

ENVIRONMENTAL FATE

Property		Value	Source/Quality Score/Other Information	Interpretation
Solubility - In water at 20oC (mg l-1)		60	A5	Moderate
Solubility - In organic solvents at 20oC (mg l-1)		250000	A5 - Ethyl acetate	-
		9000000	A5 - Acetone	-
		9000000	A5 - Methanol	-
		9000000	A5 - Toluene	-
Melting Point (oC)		Not applicable	Q3	-
Boiling Point (oC)		Decomposes before boiling	A5	-
Degradation point (oC)		140	A5	-
Flashpoint (oC)		Not highly flammable	A5	-
Octanol-water partition coefficient at pH 7, 20oC	P	4.90 X 1003	Calculated	-
	Log P	3.69	A5	High
Bulk density (g ml-1)/Specific gravity		1.11	A5	-
Dissociation constant (pKa) at 25oC		2.6	L3	-
		Note: Strong acid
Vapour pressure at 25oC (mPa)		11.97	A5	Volatile
Henry's law constant at 25oC (Pa m3 mol-1)		6.09 X 10-02	L3	Non-volatile
Henry's law constant at 20oC (dimensionless)		6.10 X 10-02	A5	Volatile
GUS leaching potential index		1.14	Calculated	Low leachability
SCI-GROW groundwater index (µg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate	Value	1.42 X 10-02	Calculated	-
	Note	-
Potential for particle bound transport index		-	Calculated	Low
Maximum UV-vis absorption L mol-1 cm-1		Maxima at 246nm = 4050, 290nm = 20.86	A5	-
Surface tension (mN m-1)		49.5	A5 at 20oC	-

Degradation:

Property		Value	Source/Quality Score/Other Information	Interpretation
Soil degradation (days) (aerobic)	DT50 (typical)	9.1	A5	Non-persistent
	DT50 (lab at 20oC)	9.1	A5	Non-persistent
	DT50 (field)	18.4	A5	Non-persistent
	DT90 (lab at 20oC)	209	A5	-
	DT90 (field)	61	A5	-
	Note	EU dossier range lab studies DT50 range 8-23 days, DT90 range 46-372 days; field studies Germany DT50 7.5-29.3 days, DT90 range 24.9-97 days; Other sources: DT50 40 days (DW4)
Aqueous photolysis DT50 (days) at pH 7	Value	50	A5	Stable
	Note	-
Aqueous hydrolysis DT50 (days) at 20oC and pH 7	Value	138	A5	Persistent
	Note	pH variable: DT50 12 days at pH 5, 77 days at pH 9
Water-Sediment DT50 (days)		10.4	A5	Fast
Water phase only DT50 (days)		4.3	A5	Moderately fast

Soil adsorption and mobility:

Property		Value	Source/Quality Score/Other Information	Interpretation
Linear	Kd	27.1	A3	Slightly mobile
	Koc	609
	Notes and range	EU dossier Kd range 3.7-113.5 mL/g, Koc range 430-841 mL/g, Soils=2; Other literature studies: Kd range 0.84-19.72 mL/g; Koc range 254-3779 mL/g, Soils=25
Freundlich	Kf	4.1	A5	Slightly mobile
	Kfoc	643
	1/n	0.860
	Notes and range	EU dossier Kf range1.4-7.6 mL/g, Kfoc range 413-760 mL/g, 1/n range 0.820-0.901, Soils=4; Other literature studies: Kf range 0.70-25.73 mL/g, Kfoc range 259-4175 mL/g, 1/n range 0.79-1.25, Soils = 25
pH sensitivity		No

Key metabolites:

Metabolite		Formation Medium	Estimated Maximum Occurrence Fraction	91/414 Relevancy
pyrimidinol (Ref: GS-27550)		Soil	0.820	Major fraction, Relevant
4-hydroxy-2-isopropyl-6-methylpyrimidine (Ref: CGA 14128)		Animal		Relevant

Other known metabolites:

Metabolite name and reference	Aliases	Formation Medium / Rate	Estimated Maximum Occurrence Fraction	Metabolising Enzymes
O,O,O,O-tetraethyl-thiopyrophosphate	O,S-TEPP	Not applicable	-	-
O,O,O,O-tetraethyl-dithiopyrophosphate	S,S-TEPP	Not applicable	-	-
O,O-diethyl O-(2-isopropyl-4-methylpyrimid-6-yl)phosphate Note: CAS = 962-58-3; Toxic	diazoxon	Animal	-	-
-	diazinon hydroxylate	Animal	-	-
2-(1-hydroxymethyl)-ethyl-4-methyl-6-hydroxypyrimidine (Ref: CL-XIX-29)	-	Animal	-	-
tetraethyl pyrophosphate (Ref: ENT 18771 )	TEPP	Not applicable	-	-
2-(1-hydroxy-1-methyl)-ethyl-4-methyl-6-hydroxpyrimidine (Ref: GS 31144)	-	Rat (Urinary); Animal; Soil	-	-
2-isopropyl-4-hydroxymethyl-6-hydroxypyrimidine (Ref: JAK-III-57)	-	Animal	-	-

ECOTOXICOLOGY

Property		Value	Source/Quality Score/Other Information	Interpretation
Bio-concentration factor	BCF	500	A5	Threshold for concern
	CT50 (days)	2		-
Bioaccumulation potential		-	Calculated	Moderate
Mammals - Acute oral LD50 (mg kg-1)		1139	A5 Rat	Moderate
Mammals - Short term dietary NOEL	(mg kg-1)	5	A5 Rat	High
	(ppm diet)	35		-
Birds - Acute LD50 (mg kg-1)		1.44	A5 Anas platyrhynchos	High
Birds - Short term dietary (LC50/LD50)		8 mg kg bw-1 day-1	A5 Anas platyrhynchos	-
Fish - Acute 96 hour LC50 (mg l-1)		3.1	A5 Oncorhynchus mykiss	Moderate
Fish - Chronic 21 day NOEC (mg l-1)		0.7	A5 Oncorhynchus mykiss	-
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1)		0.001	A5 Daphnia magna	High
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1)		0.00056	A5 Daphnia magna	-
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1)		0.0042	F3 Americamysis bahia	High
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1)		0.023	F4 Chironomus riparius	High
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1)		-	-	-
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1)		-	-	-
Aquatic plants - Acute 7 day EC50, biomass (mg l-1)		-	-	-
Algae - Acute 72 hour EC50, growth (mg l-1)		6.4	A4 Unknown species	Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1)		> 10	Q1 Unknown species	Low
Honeybees - Acute 48 hour LD50 (µg bee-1)		0.09	A5 Oral	High
Earthworms - Acute 14 day LC50 (mg kg-1)		65	A5	Moderate
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1)		-	-	-
Other soil macro-organisms - e.g. Collembola	LR50product ha EC50product ha NOECproduct ha % Effect	-	-	-
Other arthropod (1)	LR50 g ha-1	0.153	48 hour A5 Aphidius rhopalosiphi	Harmful at 1 kg ha-1
	% Effect	-	-	-
Other arthropod (2)	LR50 g ha-1	811	7 day A5 Typhlodromus pyri	Harmful at 1 kg ha-1
	% Effect	-	-	-
Soil micro-organisms		Nitrogen mineralisation: No significant effect Carbon mineralisation: No significant effect	A5 Dose: 80 mg/kg soil, 28 days	-
Mesocosm study data	NOEAEC mg l-1	0.0024	A5 Fish	-
	NOEAEC mg l-1	-	-	-

HUMAN HEALTH AND PROTECTION

General:

Property		Value	Source/Quality Score/Other Information	Interpretation
Mammals - Acute oral LD50 (mg kg-1)		1139	A5 Rat	Moderate
Mammals - Dermal LD50 (mg kg-1 body weight)		> 2000	A5 Rat	-
Mammals - Inhalation LC50 (mg l-1)		> 5.0	A5 Rat	-
Other Mammal toxicity endpoints		Intraperitoneal LD50 = 65.0 mg kg-1	V3 Rat	-
		= 210	V3 Rat	-
ADI - Acceptable Daily Intake (mg kg-1bw day-1)		0.0002	A5 Dog, SF=100	-
ARfD - Acute Reference Dose (mg kg-1bw day-1)		0.025	A5 Rat, SF=100	-
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1)		0.0002	A2 Dog, SF=100	-
Dermal penetration studies (%)		1.7-40.0	A5 concentration dependant	-
Dangerous Substances Directive 76/464		List II	-	-
Exposure Limits		[LT TWA 8hr: 0.1 mg/m3], [ST 15 mins: 0.3 mg/m3]	Occupation Exposure	-
Exposure Routes	Public	[Possible risk to bystanders by inhalation]
	Occupational	[Risk of exposure by dermal and inhalation routes], [Personal protection clothing and equipment must be worn]
Examples of European MRLs (mg kg-1)	Value	Grapefruit and oranges: 1.0; Apples, pears and cherries: 0.3; Carrots, currants, gooseberries and kiwifruit: 0.2; Plums: 0.1; Other vegetables, other fruit and cereal grains: 0.02
	Note	[Current May 2007.] For the EU pesticides database click here
Drinking Water MAC (µg l-1)		-	-	-

Health issues:

Carcinogen	Mutagen	Endocrine disrupter	Reproduction / development effects	Acetyl cholinesterase inhibitor	Neurotoxicant	Respiratory tract irritant	Skin irritant	Eye irritant
General human health issues		[No further information available]

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data

Handling issues:

Property		Value	Source/Quality Score/Other Information	Interpretation
General		[Not explosive], [IMDG Transport Code is usually 6.1]
EC Risk Classification		[Xn - Harmful: R22], [N - Dangerous for the environment: R50, R53]
EC Safety Classification		S2, S24/25, S60, S61
WHO Classification		II	-	Moderately hazardous
US EPA Classification (formulation)		II, III	-	Warning - Moderately toxic, Caution - Slightly toxic
UN Number		Usually 2783 or 2810
Waste disposal & packaging		[Usually Packaging Group III (minor danger)]

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