epoxiconazole (Ref: BAS 480F) ** Translations

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GENERAL INFORMATION

Description: A broad-spectrum fungicide for control of diseases caused by Ascomycetes, Basidiomycetes and Deuteromycetes

Introduction: 1993, first registered

EC Directive 1107/2009 (repealing 91/414):

Status	Annex 1
Dossier rapporteur/co-rapporteur	Germany
Date inclusion expires	30/04/2019

Approved for use () or known to be used () in the following European countries:

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also registered in: Australia

General status:

Pesticide type	Fungicide
Substance group	Triazole
Substance origin	Synthetic
Mode of action	Preventative and curative action
CAS RN	133855-98-8/106325-08-0
EC number	406-850-2
CIPAC number	609
US EPA chemical code	123909
Chemical formula	C17H13ClFN3O
SMILES	Fc1ccc(cc1)C3(OC3c2ccccc2Cl)Cn4ncnc4
International Chemical Identifier (InChI)	InChI=1/C17H13ClFN3O/c18-15-4-2-1-3-14(15)16-17(23-16,9-22-11-20-10-21-22)12-5-7-13(19)8-6-12/h1-8,10-11,16H,9H2/t16-,17-/m1/s1
Structure diagram/image available?	Yes
Molecular mass (g mol-1)	329.76
IUPAC Name	(2RS,3SR)-1-[3-(2-chlorophenyl)-2,3-epoxy-2-(4-fluorophenyl)propyl]-1H-1,2,4-triazole
CAS Name	rel-1-[[(2R,3S)-3-(2-chlorophenyl)-2-(4-fluorophenyl)oxiranyl]methyl]-1H-1,2,4-triazole
Other status information	-
Herbicide Resistance Classification (HRAC)	Not applicable
Insecticide Resistance Classification (IRAC)	Not applicable
Fungicide Resistance Classification (FRAC)	3
Physical state	Colourless crystalline solid
Related substances & organisms	boscalid carbendazim dimoxystrobin kresoxim-methyl metrafenone pyraclostrobin

Formulations:

Property	Value
Example manufacturers of products using this active	AgriGuard BASF Bayer Environ Landgold Standon
Example products using this active	Epic Opus Splice Swing Gold Tango super Venture
UK LERAP status	LERAP Category B
Formulation and application details	Often supplied as a soluble concentrate which is mixed with water and applied as a spray.

ENVIRONMENTAL FATE

Property		Value	Source/Quality Score/Other Information	Interpretation
Solubility - In water at 20oC (mg l-1)		7.1	A5	Low
Solubility - In organic solvents at 20oC (mg l-1)		100000	A5 - Ethyl acetate	-
		140000	A5 - Acetone	-
		28800	C4 - Ethanol	-
		40000	A5 - Toluene	-
Melting Point (oC)		136.7	A5	-
Boiling Point (oC)		Decomposes before boiling	A5	-
Degradation point (oC)		310	A5	-
Flashpoint (oC)		Not highly flammable	A5	-
Octanol-water partition coefficient at pH 7, 20oC	P	2.00 X 1003	Calculated	-
	Log P	3.3	A5	High
Bulk density (g ml-1)/Specific gravity		1.38	A5	-
Dissociation constant (pKa) at 25oC		Not applicable	A5	-
		Note: No dissociation
Vapour pressure at 25oC (mPa)		1.00 X 10-02	A5	Non-volatile
Henry's law constant at 25oC (Pa m3 mol-1)		4.71 X 10-04	A5	Non-volatile
Henry's law constant at 20oC (dimensionless)		2.04 X 10-07	Q2	Non-volatile
GUS leaching potential index		2.47	Calculated	Transition state
SCI-GROW groundwater index (µg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate	Value	1.24 X 10-01	Calculated	-
	Note	-
Potential for particle bound transport index		-	Calculated	High
Maximum UV-vis absorption L mol-1 cm-1		204nm = 32000, 263nm = 390	A5	-
Surface tension (mN m-1)		72.9	A5 at 20oC, 6.4 mg l-1	-

Degradation:

Property		Value	Source/Quality Score/Other Information	Interpretation
Soil degradation (days) (aerobic)	DT50 (typical)	354	B5	Persistent
	DT50 (lab at 20oC)	226	A5	Persistent
	DT50 (field)	120	A5	Persistent
	DT90 (lab at 20oC)	-	-	-
	DT90 (field)	-	-	-
	Note	EU dossier lab studies DT50 range 98-649 days, field studies DT50 range 44-124 days; Other studies: lab DT50 range 224-2236 days, field range 52-226 days
Aqueous photolysis DT50 (days) at pH 7	Value	52	A5	Stable
	Note	-
Aqueous hydrolysis DT50 (days) at 20oC and pH 7	Value	Stable	A5	Very persistent
	Note	Stable pH 5 to pH 9 at 25 degC, some hydrolysis at elevated temperatures
Water-Sediment DT50 (days)		119.8	A5	Slow
Water phase only DT50 (days)		65.8	A5	Stable

Soil adsorption and mobility:

Property		Value	Source/Quality Score/Other Information	Interpretation
Linear	Kd	-	-	-
	Koc	-
	Notes and range	-
Freundlich	Kf	12.18	A5	Slightly mobile
	Kfoc	1073
	1/n	0.836
	Notes and range	EU dossier Kf range 4.79-21.78 mL/g, Kfoc range 280-2647 mL/g, 1/n range 0.766-0.910, Soils=5
pH sensitivity		No

Key metabolites:

Metabolite		Formation Medium	Estimated Maximum Occurrence Fraction	91/414 Relevancy
1,2,4-triazole (Ref: CGA 71019)		Soil	0.066	Minor fraction, Relevant

Other known metabolites:

Metabolite name and reference	Aliases	Formation Medium / Rate	Estimated Maximum Occurrence Fraction	Metabolising Enzymes
triazole alanine	TA	Plant	-	-
triazole acetic acid	-	Plant	-	-
triazoly hydroxyl propionic acid	THPA	Plant	-	-
1-(2-chlorophenyl)-2-(4-fluorophenyl)-1-hydroxy-3-(1H-1,2,4-triazol-1-yl)propane (Ref: BF480-alcohol)	-	Soil	-	-
1-[(2Z)-3-(2-chlorophenyl)-2-(4-fluorophenyl)-2 propenyl]-1H-1,2,4-triazole (Ref: BF480-entriazole)	-	Water/sediment; Soil	-	-
1H-1,2,4-triazol-1-ylacetic acid (Ref: CGA 142856)	TAA	Plant	-	-

ECOTOXICOLOGY

Property		Value	Source/Quality Score/Other Information	Interpretation
Bio-concentration factor	BCF	70	A5 Whole fish	Low potential
	CT50 (days)	0.72		-
Bioaccumulation potential		-	Calculated	Low
Mammals - Acute oral LD50 (mg kg-1)		3160	A5 Rat	Low
Mammals - Short term dietary NOEL	(mg kg-1)	7.5	B5 Rat	High
	(ppm diet)	90		-
Birds - Acute LD50 (mg kg-1)		> 2000	A5 Colinus virginianus	Moderate
Birds - Short term dietary (LC50/LD50)		> 907 mg kg bw-1 day-1	A5 Colinus virginianus	-
Fish - Acute 96 hour LC50 (mg l-1)		3.14	A5 Oncorhynchus mykiss	Moderate
Fish - Chronic 21 day NOEC (mg l-1)		0.01	A5 Oncorhynchus mykiss, 28 day	-
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1)		8.69	A5 Daphnia magna	Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1)		0.63	Q2 Daphnia magna	-
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1)		-	-	-
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1)		0.0625	A5 Chironomus riparius, emergence	High
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1)		0.0625	A4 Chironomus riparius, emergence	Moderate
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1)		-	-	-
Aquatic plants - Acute 7 day EC50, biomass (mg l-1)		0.014	A5 Lemna gibba	Moderate
Algae - Acute 72 hour EC50, growth (mg l-1)		1.19	A5 Pseudokirchneriella subcapitata	Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1)		0.0078	A5 Pseudokirchneriella subcapitata	Moderate
Honeybees - Acute 48 hour LD50 (µg bee-1)		> 83	A5 Oral	Moderate
Earthworms - Acute 14 day LC50 (mg kg-1)		> 500	A5 Eisenia foetida, corr	Moderate
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1)		0.084	A5 Esenia foetida, corr	High
Other soil macro-organisms - e.g. Collembola	LR50product ha EC50product ha NOECproduct ha % Effect	-	-	-
Other arthropod (1)	LR50 g ha-1	246	246A5 Aphidius rhopalosiphi	Moderately harmful at 1 kg ha-1
	% Effect	-	-	-
Other arthropod (2)	LR50 g ha-1	258	A5 Typhlodromus pyri	Moderately harmful at 1 kg ha-1
	% Effect	-	-	-
Soil micro-organisms		Nitrogen mineralisation: No significant effect Carbon mineralisation: No significant effect	A5 Dose: 1.88 kg/ha	-
Mesocosm study data	NOEAEC mg l-1	-	-	-
	NOEAEC mg l-1	-	-	-

HUMAN HEALTH AND PROTECTION

General:

Property		Value	Source/Quality Score/Other Information	Interpretation
Mammals - Acute oral LD50 (mg kg-1)		3160	A5 Rat	Low
Mammals - Dermal LD50 (mg kg-1 body weight)		> 2000	A5 Rat	-
Mammals - Inhalation LC50 (mg l-1)		> 5.3	A5 Rat, 4hr	-
Other Mammal toxicity endpoints		-		-
ADI - Acceptable Daily Intake (mg kg-1bw day-1)		0.008	A5 Mice, SF=100	-
ARfD - Acute Reference Dose (mg kg-1bw day-1)		0.023	A5 Rat, SF=100	-
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1)		0.008	A5 Rat, SF=100	-
Dermal penetration studies (%)		50	A5	-
Dangerous Substances Directive 76/464		List II	-	-
Exposure Limits		-	-	-
Exposure Routes	Public	Acceptable risk for proposed uses
	Occupational	Acceptable risk for proposed uses
Examples of European MRLs (mg kg-1)	Value	Barley, oats: 1.0; Wheat, rye, triticale: 0.2; Sugar beet: 0.05
	Note	A5 EU dossier proposals For the EU pesticides database click here
Drinking Water MAC (µg l-1)		-	-	-

Health issues:

Carcinogen	Mutagen	Endocrine disrupter	Reproduction / development effects	Acetyl cholinesterase inhibitor	Neurotoxicant	Respiratory tract irritant	Skin irritant	Eye irritant
	-	-
General human health issues		Possible liver toxicant

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data

Handling issues:

Property		Value	Source/Quality Score/Other Information	Interpretation
General		Not explosive or oxidising IMDG Transport Code is usually 9
CLP classification 2013		-
EC Risk Classification		Carcinogen category 3: R40 Reproduction risk category 3: R62, R63 N - Dangerous for the environment: R51, R53
EC Safety Classification		S2, S36/37, S46, S61
WHO Classification		NL	-	Not listed
US EPA Classification (formulation)		No consensus across products or no products available	-	-
UN Number		Usually 3077 or 3082
Waste disposal & packaging		Usually Packaging Group III (minor danger)

TRANSLATIONS