ethirimol ** ethyrimol ** Translations

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GENERAL INFORMATION

Description: A pyrimidine fungicide often used as a seed treatment for diseaases such as damping-off. Can also be a pesticide transformation product

Introduction: -

EC Directive 1107/2009 (repealing 91/414):

Status	Excluded from Annex 1
Dossier rapporteur/co-rapporteur	-
Date inclusion expires	Expired

Approved for use () or known to be used () in the following European countries:

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

General status:

Pesticide type	Fungicide, Metabolite
Metabolite Type	Soil
Substance group	Pyrimidinol
Substance origin	Synthetic
Mode of action	Systemic, absorbed by roots and translocated
CAS RN	23947-60-6
EC number	245-949-3
CIPAC number	242
US EPA chemical code	228900
Chemical formula	C11H19N3O
SMILES	O=C/1/N=C(\N\C(=C\1CCCC)C)NCC
International Chemical Identifier (InChI)	InChI=1/C11H19N3O/c1-4-6-7-9-8(3)13-11(12-5-2)14-10(9)15/h4-7H2,1-3H3,(H2,12,13,14,15)
Structure diagram/image available?	Yes
Molecular mass (g mol-1)	209.29
IUPAC Name	5-butyl-2-ethylamino-6-methylpyrimidin-4-ol
CAS Name	5-butyl-2-(ethylamino)-6-methyl-4(1H)-pyrimidinone
Other status information	-
Herbicide Resistance Classification (HRAC)	Not applicable
Insecticide Resistance Classification (IRAC)	Not applicable
Fungicide Resistance Classification (FRAC)	8
Physical state	Colourless crystals
Related substances & organisms	-

Can be a metabolite of:

Parent		Formation Medium	Estimated Maximum Occurrence Fraction	91/414 Relevancy
bupirimate		Soil	0.412	Major fraction, Relevant

Formulations:

Property	Value
Example manufacturers of products using this active	-
Example products using this active	-
UK LERAP status	No UK approval for use or outside scope
Formulation and application details	-

ENVIRONMENTAL FATE

Property		Value	Source/Quality Score/Other Information	Interpretation
Solubility - In water at 20oC (mg l-1)		233	A5	Moderate
Solubility - In organic solvents at 20oC (mg l-1)		-	-	-
Melting Point (oC)		159	Q3	-
Boiling Point (oC)		Decomposes before boiling	V3	-
Degradation point (oC)		-	-	-
Flashpoint (oC)		Not highly flammable	V3	-
Octanol-water partition coefficient at pH 7, 20oC	P	2.00 X 1002	Calculated	-
	Log P	2.3	L3	Low
Bulk density (g ml-1)/Specific gravity		1.21	L3	-
Dissociation constant (pKa) at 25oC		5	L3	-
		Note: Weak base
Vapour pressure at 25oC (mPa)		0.267	L3	Non-volatile
Henry's law constant at 25oC (Pa m3 mol-1)		2.00 X 10-04	L3	Non-volatile
Henry's law constant at 20oC (dimensionless)		9.85 X 10-08	Calculated	Non-volatile
GUS leaching potential index		2.63	Calculated	Transition state
SCI-GROW groundwater index (µg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate	Value	1.93 X 10-01	Calculated	-
	Note	-
Potential for particle bound transport index		-	Calculated	Medium
Maximum UV-vis absorption L mol-1 cm-1		-	-	-
Surface tension (mN m-1)		-	-	-

Degradation:

Property		Value	Source/Quality Score/Other Information	Interpretation
Soil degradation (days) (aerobic)	DT50 (typical)	77	T4	Moderately persistent
	DT50 (lab at 20oC)	53	A5	Moderately persistent
	DT50 (field)	20	A5	Non-persistent
	DT90 (lab at 20oC)	177	A5	-
	DT90 (field)	-	-	-
	Note	EU dosssier (for bupirimate) lab studies DT50 range 19-114 days, DT90 range 63-379 days; field studies DT50 range 13-39 daysT
Aqueous photolysis DT50 (days) at pH 7	Value	-	-	-
	Note	-
Aqueous hydrolysis DT50 (days) at 20oC and pH 7	Value	30	A5	Moderately persistent
	Note	-
Water-Sediment DT50 (days)		-	-	-
Water phase only DT50 (days)		-	-	-

Soil adsorption and mobility:

Property		Value	Source/Quality Score/Other Information	Interpretation
Linear	Kd	-	-	-
	Koc	-
	Notes and range	-
Freundlich	Kf	10.0	A5	Moderately mobile
	Kfoc	402
	1/n	0.849
	Notes and range	EU dossier (for bupirimate) Kf range 1.8-33.0 mL/g, kfoc range 97-950 mL/g, 1/n range 0.808-0.883, Soils=4
pH sensitivity		No

ECOTOXICOLOGY

Property		Value	Source/Quality Score/Other Information	Interpretation
Bio-concentration factor	BCF	-	-	-
	CT50 (days)	-		-
Bioaccumulation potential		-	Calculated	Low
Mammals - Acute oral LD50 (mg kg-1)		> 4000	A5 Rat	Low
Mammals - Short term dietary NOEL	(mg kg-1)	-	L2 Rat, 2 year	-
	(ppm diet)	> 200		-
Birds - Acute LD50 (mg kg-1)		> 3000	A5 Perdix perdix	Low
Birds - Short term dietary (LC50/LD50)		-	-	-
Fish - Acute 96 hour LC50 (mg l-1)		60.8	A5 Oncorhynchus mykiss	Moderate
Fish - Chronic 21 day NOEC (mg l-1)		>= 41.4	A5 Oncorhynchus mykiss	-
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1)		50.0	A5 Daphnia magna	Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1)		7.3	A5 Daphnia magna	-
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1)		-	-	-
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1)		-	-	-
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1)		-	-	-
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1)		-	-	-
Aquatic plants - Acute 7 day EC50, biomass (mg l-1)		-	-	-
Algae - Acute 72 hour EC50, growth (mg l-1)		24	A5 Pseudokirchneriella subcapitata	Low
Algae - Chronic 96 hour NOEC, growth (mg l-1)		-	-	-
Honeybees - Acute 48 hour LD50 (µg bee-1)		1.6	L3 Oral	Moderate
Earthworms - Acute 14 day LC50 (mg kg-1)		-	-	-
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1)		-	-	-
Other soil macro-organisms - e.g. Collembola	LR50product ha EC50product ha NOECproduct ha % Effect	-	-	-
Other arthropod (1)	LR50 g ha-1	Harmless	HarmlessAA2 Typhlodromus pyri	Harmless
	% Effect	-	-	-
Other arthropod (2)	LR50 g ha-1	-	-	-
	% Effect	-	-	-
Soil micro-organisms		-	-	-
Mesocosm study data	NOEAEC mg l-1	-	-	-
	NOEAEC mg l-1	-	-	-

HUMAN HEALTH AND PROTECTION

General:

Property		Value	Source/Quality Score/Other Information	Interpretation
Mammals - Acute oral LD50 (mg kg-1)		> 4000	A5 Rat	Low
Mammals - Dermal LD50 (mg kg-1 body weight)		> 2000	A5 Rat	-
Mammals - Inhalation LC50 (mg l-1)		4.9	A5 Rat	-
Other Mammal toxicity endpoints		-		-
ADI - Acceptable Daily Intake (mg kg-1bw day-1)		0.05	A5	-
ARfD - Acute Reference Dose (mg kg-1bw day-1)		0.05	A5 Rat, SF=100	-
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1)		-	-	-
Dermal penetration studies (%)		-	-	-
Dangerous Substances Directive 76/464		-	-	-
Exposure Limits		-	-	-
Exposure Routes	Public	-
	Occupational	-
Examples of European MRLs (mg kg-1)	Value	-
	Note	For the EU pesticides database click here
Drinking Water MAC (µg l-1)		-	-	-

Health issues:

Carcinogen	Mutagen	Endocrine disrupter	Reproduction / development effects	Acetyl cholinesterase inhibitor	Neurotoxicant	Respiratory tract irritant	Skin irritant	Eye irritant
	-	-	-			-
General human health issues		[No further information available]

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data

Handling issues:

Property		Value	Source/Quality Score/Other Information	Interpretation
General		[No information available]
EC Risk Classification		[Xn - Harmful: R21]
EC Safety Classification		S2, S36/37
WHO Classification		U / O	-	Unlikely to present an acute hazard / Obsolete substance
US EPA Classification (formulation)		No consensus across products or no products available	-	-
UN Number		-
Waste disposal & packaging		-

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