amitrole ** aminotriazole ** amitolamitril ** Translations

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GENERAL INFORMATION

Description: A triazole herbicide used to control a wide range of perennial grasses and broad-leaved weeds.

Introduction: 1953, first reported

EC Directive 1107/2009 (repealing 91/414):

Status	Annex 1
Dossier rapporteur/co-rapporteur	France
Date inclusion expires	31/12/2015

Approved for use () or known to be used () in the following European countries:

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also registered in: Australia

General status:

Pesticide type	Herbicide
Substance group	Triazole
Substance origin	Synthetic
Mode of action	Translocated, foliar-acting, non-selective action. Inhibition of lycopene cyclase.
CAS RN	61-82-5
EC number	200-521-5
CIPAC number	90
US EPA chemical code	004401
Chemical formula	C2H4N4
SMILES	n1cnnc1N
International Chemical Identifier (InChI)	InChI=1/C2H4N4/c3-2-4-1-5-6-2/h1H,(H3,3,4,5,6)
Structure diagram/image available?	Yes
Molecular mass (g mol-1)	84.08
IUPAC Name	1H-1,2,4-triazol-3-amine
CAS Name	1H-1,2,4-triazol-3-amine
Other status information	OSPAR candidate
Herbicide Resistance Classification (HRAC)	F3
Insecticide Resistance Classification (IRAC)	Not applicable
Fungicide Resistance Classification (FRAC)	Not applicable
Physical state	White crystals
Related substances & organisms	-

Formulations:

Property	Value
Example manufacturers of products using this active	NuFarm
Example products using this active	Weedazol TL Herbizole Diurol Amerol
UK LERAP status	None
Formulation and application details	Spray application.

ENVIRONMENTAL FATE

Property		Value	Source/Quality Score/Other Information	Interpretation
Solubility - In water at 20oC (mg l-1)		264000	A5	High
Solubility - In organic solvents at 20oC (mg l-1)		20	A5 - Toluene	-
		27000	A5 - Isopropanol	-
		100	A5 - Dichloromethane	-
Melting Point (oC)		158	L3	-
Boiling Point (oC)		Decomposes before boiling	A5	-
Degradation point (oC)		-	-	-
Flashpoint (oC)		Not highly flammable	A5	-
Octanol-water partition coefficient at pH 7, 20oC	P	1.07 X 10-01	Calculated	-
	Log P	-0.97	A5	Low
Bulk density (g ml-1)/Specific gravity		1.14	A5	-
Dissociation constant (pKa) at 25oC		4.14	A5	-
		Note: Weak acid pKa(2) 10.7
Vapour pressure at 25oC (mPa)		0.033	A5	Non-volatile
Henry's law constant at 25oC (Pa m3 mol-1)		1.76 X 10-08	A5	Non-volatile
Henry's law constant at 20oC (dimensionless)		4.07 X 10-12	Q2	Non-volatile
GUS leaching potential index		2.45	Calculated	Transition state
SCI-GROW groundwater index (µg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate	Value	1.06 X 10-01	Calculated	-
	Note	-
Potential for particle bound transport index		-	Calculated	Low
Maximum UV-vis absorption L mol-1 cm-1		198nm = 4947	A5	-
Surface tension (mN m-1)		-	-	-

Degradation:

Property		Value	Source/Quality Score/Other Information	Interpretation
Soil degradation (days) (aerobic)	DT50 (typical)	18	A5	Non-persistent
	DT50 (lab at 20oC)	5	A5	Non-persistent
	DT50 (field)	18	A5	Non-persistent
	DT90 (lab at 20oC)	22	A5	-
	DT90 (field)	50	A5	-
	Note	DT50 2 studies 21 day median [range 3-56 days], 15 day median [range 3-112 days] Field (UK conditions)
Aqueous photolysis DT50 (days) at pH 7	Value	Stable	A5	Stable
	Note	-
Aqueous hydrolysis DT50 (days) at 20oC and pH 7	Value	Stable	A5	Very persistent
	Note	Not pH sensitive
Water-Sediment DT50 (days)		309	A5	Slow
Water phase only DT50 (days)		71	A5	Stable

Soil adsorption and mobility:

Property		Value	Source/Quality Score/Other Information	Interpretation
Linear	Kd	-	-	-
	Koc	-
	Notes and range	-
Freundlich	Kf	1.97	A5	Moderately mobile
	Kfoc	111
	1/n	-
	Notes and range	Soils=8
pH sensitivity		-

Key metabolites:

Metabolite		Formation Medium	Estimated Maximum Occurrence Fraction	91/414 Relevancy
1,2,4-triazole (Ref: CGA 71019)		Soil		Major fraction

ECOTOXICOLOGY

Property		Value	Source/Quality Score/Other Information	Interpretation
Bio-concentration factor	BCF	2.4	A5	Low potential
	CT50 (days)	7		-
Bioaccumulation potential		-	Calculated	Low
Mammals - Acute oral LD50 (mg kg-1)		> 5000	A5 Rat	Low
Mammals - Short term dietary NOEL	(mg kg-1)	-	-	-
	(ppm diet)	-		-
Birds - Acute LD50 (mg kg-1)		> 2150	A5 Colinus virginianus	Low
Birds - Short term dietary (LC50/LD50)		> 5000 ppm	A3 Colinus virginianus	-
Fish - Acute 96 hour LC50 (mg l-1)		> 1000	A5 Salmonidae	Low
Fish - Chronic 21 day NOEC (mg l-1)		100	A5 Oncorhynchus mykiss	-
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1)		6.1	A5 Daphnia magna	Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1)		0.32	A5 Daphnia magna	-
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1)		2.8	F4 Americamysis bahia	Moderate
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1)		-	-	-
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1)		-	-	-
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1)		-	-	-
Aquatic plants - Acute 7 day EC50, biomass (mg l-1)		2.5	A5 Lemna gibba	Moderate
Algae - Acute 72 hour EC50, growth (mg l-1)		2.3	A4 Scenedemus subspicatus, 72 hour	Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1)		1	J4 Chlorella vulgaris	Moderate
Honeybees - Acute 48 hour LD50 (µg bee-1)		> 100	A5 Contact	Moderate
Earthworms - Acute 14 day LC50 (mg kg-1)		> 448	A5	Moderate
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1)		-	-	-
Other soil macro-organisms - e.g. Collembola	LR50product ha EC50product ha NOECproduct ha % Effect	-	-	-
Other arthropod (1)	LR50 g ha-1	-	-	-
	% Effect	80	Mortality Dose: 4.72 kg ha-1 A5 Aphidius colemani, adult	Harmful
Other arthropod (2)	LR50 g ha-1	-	-	-
	% Effect	100	Mortality Dose: 4.72 kg ha-1 A5 Typhlodromus pyri, protonymph	Harmful
Soil micro-organisms		Nitrogen mineralisation: Transient retardation, recovery after 42 days Carbon mineralisation: No significant effect	A3 Dose: Not stated	-
Mesocosm study data	NOEAEC mg l-1	-	-	-
	NOEAEC mg l-1	-	-	-

HUMAN HEALTH AND PROTECTION

General:

Property		Value	Source/Quality Score/Other Information	Interpretation
Mammals - Acute oral LD50 (mg kg-1)		> 5000	A5 Rat	Low
Mammals - Dermal LD50 (mg kg-1 body weight)		> 2500	A5 Rat	-
Mammals - Inhalation LC50 (mg l-1)		0.439	A5 Rat	-
Other Mammal toxicity endpoints		-		-
ADI - Acceptable Daily Intake (mg kg-1bw day-1)		0.001	A5	-
ARfD - Acute Reference Dose (mg kg-1bw day-1)		None allocated	A5	-
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1)		0.001	A5 Rat, 90 day, SF=100	-
Dermal penetration studies (%)		1	A5	-
Dangerous Substances Directive 76/464		-	-	-
Exposure Limits		-	-	-
Exposure Routes	Public	[Minimal risk of dietary exposure]
	Occupational	-
Examples of European MRLs (mg kg-1)	Value	Vegetables, fruit and cereal grains: 0.01
	Note	[Under review, current until 14 July 2007.] For the EU pesticides database click here
Drinking Water MAC (µg l-1)		-	-	-

Health issues:

Carcinogen	Mutagen	Endocrine disrupter	Reproduction / development effects	Acetyl cholinesterase inhibitor	Neurotoxicant	Respiratory tract irritant	Skin irritant	Eye irritant
General human health issues		[No further information available]

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data

Handling issues:

Property		Value	Source/Quality Score/Other Information	Interpretation
General		[IMDG Transport Code is usually 9]
EC Risk Classification		[Reproduction risk category 3: R63], [Xn - Harmful: R48/22], [N - Dangerous for the environment: R51, R53]
EC Safety Classification		S2, S13, S36/37, S61
WHO Classification		U	-	Unlikely to present an acute hazard
US EPA Classification (formulation)		IV	-	Caution - Not acutely toxic
UN Number		Usually 3077
Waste disposal & packaging		[Usually Packaging Group III (minor danger)]

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