glyphosate (Ref: MON 0573) ** CP 67573 ** sulfosate ** 2-[(phosphonomethyl)amino]acetic acid ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

GENERAL INFORMATION

Description: A herbicide used in a wide range of cropping, utility and industrial situations to control annual and perennial grasses and broad-leaved weeds

Introduction: 1971, first reported

EC Directive 1107/2009 (repealing 91/414):

Status	Annex 1
Dossier rapporteur/co-rapporteur	Germany
Date inclusion expires	31/12/2015

Approved for use () or known to be used () in the following European countries:

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also registered in: Australia, USA

General status:

Pesticide type	Herbicide
Substance group	Phosphonoglycine
Substance origin	Synthetic
Mode of action	Broad-spectrum, systemic, contact action translocated and non-residual. Inhibition of lycopene cyclase.
CAS RN	1071-83-6
EC number	213-997-4
CIPAC number	284
US EPA chemical code	417300
Chemical formula	C3H7NO5P
SMILES	C(C(=O)[O-])NCP(=O)(O)O
International Chemical Identifier (InChI)	InChI=1/C3H8NO5P/c5-3(6)1-4-2-10(7,8)9/h4H,1-2H2,(H,5,6)(H2,7,8,9)
Structure diagram/image available?	Yes
Molecular mass (g mol-1)	168.07
IUPAC Name	N-(phosphonomethyl)glycine
CAS Name	N-(phosphonomethyl)glycine
Other status information	-
Herbicide Resistance Classification (HRAC)	G
Insecticide Resistance Classification (IRAC)	Not applicable
Fungicide Resistance Classification (FRAC)	Not applicable
Physical state	Colourless crystals
Related substances & organisms	diflufenican ethoxylated tallow amine polyacrylamide 8-hydroxyquinoline

Formulations:

Property	Value
Example manufacturers of products using this active	Bayer Environ Dow AgroSciences Headland Makhteshim-Agan Monsanto Nufarm UK Syngenta
Example products using this active	Asteroid Envision Touchdown Glyfos Glyfos Daker Glyphosate 360 Glyphogan Kernel Manifest
UK LERAP status	LERAP Category B
Formulation and application details	Often supplied as a soluble concentrate that is mixed with water and applied as a spray.

ENVIRONMENTAL FATE

Property		Value	Source/Quality Score/Other Information	Interpretation
Solubility - In water at 20oC (mg l-1)		10500	A3	High
Solubility - In organic solvents at 20oC (mg l-1)		78	A5 - Acetone	-
		26	A5 - Hexane	-
		231	A5 - Methanol	-
		12	A5 - Ethyl acetate	-
Melting Point (oC)		189.5	A5	-
Boiling Point (oC)		Decomposes before boiling	A5	-
Degradation point (oC)		200	L3	-
Flashpoint (oC)		Not highly flammable	A5	-
Octanol-water partition coefficient at pH 7, 20oC	P	6.31 X 10-04	Calculated	-
	Log P	-3.2	A5	Low
Bulk density (g ml-1)/Specific gravity		1.71	A5	-
Dissociation constant (pKa) at 25oC		2.34	A5	-
		Note: Strong acid
Vapour pressure at 25oC (mPa)		0.0131	A5	Non-volatile
Henry's law constant at 25oC (Pa m3 mol-1)		2.10 X 10-07	A5	Non-volatile
Henry's law constant at 20oC (dimensionless)		6.60 X 10-19	Q2	Non-volatile
GUS leaching potential index		-0.49	Calculated	Low leachability
SCI-GROW groundwater index (µg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate	Value	5.35 X 10-03	Calculated	-
	Note	Estimated concentrations of chemicals with Koc values greater than 9995 ml g-1 are beyond the scope of the regression data used in SCI-GROW development. If there are concerns for such chemicals, a higher tier groundwater exposure assessment should be considered, regardless of the concentration returned by SCI-GROW
Potential for particle bound transport index		-	Calculated	Medium
Maximum UV-vis absorption L mol-1 cm-1		-	-	-
Surface tension (mN m-1)		-	-	-

Degradation:

Property		Value	Source/Quality Score/Other Information	Interpretation
Soil degradation (days) (aerobic)	DT50 (typical)	12	A5	Non-persistent
	DT50 (lab at 20oC)	49	A5	Moderately persistent
	DT50 (field)	12	A5	Non-persistent
	DT90 (lab at 20oC)	159	A5	-
	DT90 (field)	-	-	-
	Note	EU Dossier Lab studies DT50 range 4-180 days, DT90 range 40-280 days; field study 5-21 days (Germany and Switzerland)
Aqueous photolysis DT50 (days) at pH 7	Value	69	A5	Stable
	Note	pH sensitive: DT50 33 days at pH 5, 77 days at pH 9
Aqueous hydrolysis DT50 (days) at 20oC and pH 7	Value	Stable	A5	Very persistent
	Note	Stable pH 5 to pH 8 at 25 degC
Water-Sediment DT50 (days)		87	A5	Moderately fast
Water phase only DT50 (days)		2.5	A5	Moderately fast

Soil adsorption and mobility:

Property		Value	Source/Quality Score/Other Information	Interpretation
Linear	Kd	222	A5	Slightly mobile
	Koc	1435
	Notes and range	EU dossier Kd range 5.3-810 mL/g, koc range 884- 60000 mL/g, Soils=8
Freundlich	Kf	453	A5	Non-mobile
	Kfoc	28700
	1/n	0.96
	Notes and range	EU dossier Kf range 34.2-900 mL/g, Kfoc range 3800-60000, 1/n range 0.8-1.16, Soils=3
pH sensitivity		No

Key metabolites:

Metabolite		Formation Medium	Estimated Maximum Occurrence Fraction	91/414 Relevancy
aminomethylphosphonic acid		Soil	0.290	Major fraction, Relevant

ECOTOXICOLOGY

Property		Value	Source/Quality Score/Other Information	Interpretation
Bio-concentration factor	BCF	0.5	F4 Whole fish	Low potential
	CT50 (days)	Not available		-
Bioaccumulation potential		-	Calculated	Low
Mammals - Acute oral LD50 (mg kg-1)		> 2000	A5 Rat	Moderate
Mammals - Short term dietary NOEL	(mg kg-1)	150	A5 Rat	Moderate
	(ppm diet)	-		-
Birds - Acute LD50 (mg kg-1)		> 2000	A4 Unknown species	Moderate
Birds - Short term dietary (LC50/LD50)		> 4640 mg kg feed-1	A4 Unknown species	-
Fish - Acute 96 hour LC50 (mg l-1)		38.0	A5 Oncorhynchus mykiss	Moderate
Fish - Chronic 21 day NOEC (mg l-1)		25	A5 Oncorhynchus mykiss	-
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1)		40	A5 Daphnia magna	Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1)		30	A5 Daphnia magna	-
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1)		40.0	F4 Americamysis bahia	Moderate
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1)		-	-	-
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1)		-	-	-
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1)		-	-	-
Aquatic plants - Acute 7 day EC50, biomass (mg l-1)		12	A5 Lemna gibba	Low
Algae - Acute 72 hour EC50, growth (mg l-1)		4.4	F4 Scenedesmus quadricauda	Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1)		2	Q2 Unknown species	Low
Honeybees - Acute 48 hour LD50 (µg bee-1)		100	A5 Oral	Moderate
Earthworms - Acute 14 day LC50 (mg kg-1)		> 480	A5 Eisenia foetida	Moderate
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1)		> 28.8	A5 Eisenia foetida	Moderate
Other soil macro-organisms - e.g. Collembola	LR50product ha EC50product ha NOECproduct ha % Effect	-	-	-
Other arthropod (1)	LR50 g ha-1	-	-	-
	% Effect	25 6	Mortality Fertility Dose: 3.72 kg ha-1 A5 Aphidius rhopalosiphi, adult	Harmless
Other arthropod (2)	LR50 g ha-1	-	-	-
	% Effect	30 0	Mortality Fertility Dose: 3.6 kg ha-1 A5 Typhlodromus pyri, lifecycle	Moderately harmful
Soil micro-organisms		Nitrogen mineralisation: No significant effect Carbon mineralisation: No significant effect	A5 Dose: 18 kg/ha	-
Mesocosm study data	NOEAEC mg l-1	-	-	-
	NOEAEC mg l-1	-	-	-

HUMAN HEALTH AND PROTECTION

General:

Property		Value	Source/Quality Score/Other Information	Interpretation
Mammals - Acute oral LD50 (mg kg-1)		> 2000	A5 Rat	Moderate
Mammals - Dermal LD50 (mg kg-1 body weight)		> 2000	A5 Rat	-
Mammals - Inhalation LC50 (mg l-1)		> 5.0	A5 Rat, 4hr	-
Other Mammal toxicity endpoints		-		-
ADI - Acceptable Daily Intake (mg kg-1bw day-1)		0.3	A5 Rat, SF=100	-
ARfD - Acute Reference Dose (mg kg-1bw day-1)		None allocated	A5	-
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1)		0.2	A3 Rabbit, SF=100	-
Dermal penetration studies (%)		3.0	A5	-
Dangerous Substances Directive 76/464		-	-	-
Exposure Limits		-	-	-
Exposure Routes	Public	-
	Occupational	-
Examples of European MRLs (mg kg-1)	Value	-
	Note	For the EU pesticides database click here
Drinking Water MAC (µg l-1)		-	-	-

Health issues:

Carcinogen	Mutagen	Endocrine disrupter	Reproduction / development effects	Acetyl cholinesterase inhibitor	Neurotoxicant	Respiratory tract irritant	Skin irritant	Eye irritant
		-
General human health issues		[No further information available]

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data

Handling issues:

Property		Value	Source/Quality Score/Other Information	Interpretation
General		[IMDG Transport Code is usually 9]
EC Risk Classification		[Xi - Irritant: R41], [N - Dangerous for the environment: R51, R53]
EC Safety Classification		S2, S26, S39, S61
WHO Classification		III	-	Slightly hazardous
US EPA Classification (formulation)		III	-	Caution - Slightly toxic
UN Number		Variable with product, usually 3077 or 3082
Waste disposal & packaging		[Usually Packaging Group III (minor danger)]

TRANSLATIONS