triadimefon ** triadimefone ** triadimenol metabolite M01 ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

GENERAL INFORMATION

Description: A fungicide used to control powdery mildew, rusts, and other infections in many crops. It is also a pesticide transformation product

Introduction: 1976

EC Directive 1107/2009 (repealing 91/414):

Status	Excluded from Annex 1
Dossier rapporteur/co-rapporteur	-
Date inclusion expires	Expired

Approved for use () or known to be used () in the following European countries:

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also registered in: Australia, USA

General status:

Pesticide type	Fungicide, Metabolite
Metabolite Type	Soil
Substance group	Triazole
Substance origin	Synthetic
Mode of action	Systemic with protective, curative and eradicant action. Disrupts membrane function.
CAS RN	43121-43-3
EC number	256-103-8
CIPAC number	352
US EPA chemical code	109901
Chemical formula	C14H16ClN3O2
SMILES	CC(C)(C)C(=O)C(N1C=NC=N1)OC2=CC=C(C=C2)Cl
International Chemical Identifier (InChI)	InChI=1/C14H16ClN3O2/c1-14(2,3)12(19)13(18-9-16-8-17-18)20-11-6-4-10(15)5-7-11/h4-9,13H,1-3H3
Structure diagram/image available?	Yes
Molecular mass (g mol-1)	293.8
IUPAC Name	(RS)-1-(4-chlorophenoxy)-3,3-dimethyl-1-(1H-1,2,4-triazol-1-yl)butan-2-one
CAS Name	1-(4-chlorophenoxy)-3,3-dimethyl-1-(1H-1,2,4-triazol-1-yl)-2-butanone
Other status information	-
Herbicide Resistance Classification (HRAC)	Not applicable
Insecticide Resistance Classification (IRAC)	Not applicable
Fungicide Resistance Classification (FRAC)	3
Physical state	Colourless crystals
Related substances & organisms	silica

Can be a metabolite of:

Parent		Formation Medium	Estimated Maximum Occurrence Fraction	91/414 Relevancy
triadimenol		Soil	0.0388	Minor fraction, Not relevant

Formulations:

Property	Value
Example manufacturers of products using this active	Bayer CropScience
Example products using this active	-
UK LERAP status	No UK approval for use or outside scope
Formulation and application details	-

ENVIRONMENTAL FATE

Property		Value	Source/Quality Score/Other Information	Interpretation
Solubility - In water at 20oC (mg l-1)		70	H4	Moderate
Solubility - In organic solvents at 20oC (mg l-1)		200000	L3 - Toluene	-
		200000	L3 - Dichloromethane	-
		99000	L3 - Isopropanol	-
		6300	L3 - Hexane	-
Melting Point (oC)		82.3	L3	-
Boiling Point (oC)		Decomposes before boiling	L3	-
Degradation point (oC)		-	-	-
Flashpoint (oC)		72	V3	-
Octanol-water partition coefficient at pH 7, 20oC	P	1.51 X 1003	Calculated	-
	Log P	3.18	G4	High
Bulk density (g ml-1)/Specific gravity		1.28	P4	-
Dissociation constant (pKa) at 25oC		-	-	-
		Note:
Vapour pressure at 25oC (mPa)		0.02	L3	Non-volatile
Henry's law constant at 25oC (Pa m3 mol-1)		9.00 X 10-05	L3	Non-volatile
Henry's law constant at 20oC (dimensionless)		3.37 X 10-09	Q2	Non-volatile
GUS leaching potential index		1.59	Calculated	Low leachability
SCI-GROW groundwater index (µg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate	Value	4.12 X 10-02	Calculated	-
	Note	-
Potential for particle bound transport index		-	Calculated	Low
Maximum UV-vis absorption L mol-1 cm-1		-	-	-
Surface tension (mN m-1)		-	-	-

Degradation:

Property		Value	Source/Quality Score/Other Information	Interpretation
Soil degradation (days) (aerobic)	DT50 (typical)	26	W4	Non-persistent
	DT50 (lab at 20oC)	-	-	-
	DT50 (field)	-	-	-
	DT90 (lab at 20oC)	-	-	-
	DT90 (field)	-	-	-
	Note	Best available data
Aqueous photolysis DT50 (days) at pH 7	Value	0.8	K4	Fast
	Note	-
Aqueous hydrolysis DT50 (days) at 20oC and pH 7	Value	Stable	L3	Very persistent
	Note	Stable pH 3 to pH 9, 22 degC
Water-Sediment DT50 (days)		43	Q2	Moderately fast
Water phase only DT50 (days)		12	Q2	Moderately fast

Soil adsorption and mobility:

Property		Value	Source/Quality Score/Other Information	Interpretation
Linear	Kd	-	G3	Moderately mobile
	Koc	300
	Notes and range	-
Freundlich	Kf	10.16	R4	Slightly mobile
	Kfoc	749
	1/n	0.750
	Notes and range	Literature data: Kf range 1.33-22.0 mL/g, Kfoc range 344-2095 mL/g, 1/n range 0.71-0.77, soils=8
pH sensitivity		No

ECOTOXICOLOGY

Property		Value	Source/Quality Score/Other Information	Interpretation
Bio-concentration factor	BCF	64.0	A5	Low potential
	CT50 (days)	0.6		-
Bioaccumulation potential		-	Calculated	Low
Mammals - Acute oral LD50 (mg kg-1)		300	G4 Rat	Moderate
Mammals - Short term dietary NOEL	(mg kg-1)	-	L2 Rat, 2 year	-
	(ppm diet)	300		-
Birds - Acute LD50 (mg kg-1)		> 2000	A5 Colinus virginianus	Moderate
Birds - Short term dietary (LC50/LD50)		> 880 mg kg bw-1 day-1	A5 Colinus virginianus	-
Fish - Acute 96 hour LC50 (mg l-1)		4.08	A5 Oncorhynchus mykiss	Moderate
Fish - Chronic 21 day NOEC (mg l-1)		0.017	A5 Pimephales promelas	-
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1)		7.16	A5 Daphnia magna	Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1)		0.1	A5 Daphnia magna	-
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1)		-	-	-
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1)		-	-	-
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1)		-	-	-
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1)		-	-	-
Aquatic plants - Acute 7 day EC50, biomass (mg l-1)		-	-	-
Algae - Acute 72 hour EC50, growth (mg l-1)		2.01	A5 Pseudokirchneriella subcapitata	Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1)		-	-	-
Honeybees - Acute 48 hour LD50 (µg bee-1)		25	F4 Oral	Moderate
Earthworms - Acute 14 day LC50 (mg kg-1)		50	P2 Eisenia foetida	Moderate
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1)		-	-	-
Other soil macro-organisms - e.g. Collembola	LR50product ha EC50product ha NOECproduct ha % Effect	-	-	-
Other arthropod (1)	LR50 g ha-1	-	-	-
	% Effect	-	-	-
Other arthropod (2)	LR50 g ha-1	-	-	-
	% Effect	-	-	-
Soil micro-organisms		-	-	-
Mesocosm study data	NOEAEC mg l-1	-	-	-
	NOEAEC mg l-1	-	-	-

HUMAN HEALTH AND PROTECTION

General:

Property		Value	Source/Quality Score/Other Information	Interpretation
Mammals - Acute oral LD50 (mg kg-1)		300	G4 Rat	Moderate
Mammals - Dermal LD50 (mg kg-1 body weight)		> 5000	L3 Rat	-
Mammals - Inhalation LC50 (mg l-1)		3.27	L3 Rat	-
Other Mammal toxicity endpoints		-		-
ADI - Acceptable Daily Intake (mg kg-1bw day-1)		0.03	JMPR 2004	-
ARfD - Acute Reference Dose (mg kg-1bw day-1)		0.08	JMPR 2004	-
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1)		-	-	-
Dermal penetration studies (%)		-	-	-
Dangerous Substances Directive 76/464		-	-	-
Exposure Limits		-	-	-
Exposure Routes	Public	-
	Occupational	-
Examples of European MRLs (mg kg-1)	Value	Grapes: 2.0; Bush fruit: 1.0; Onions, sweet peppers and strawberries: 0.5; Tomatoes: 0.3; Apples, barley grains, oat grains, rye grains and wheat grains: 0.2; Other vegetables, other fruit and other cereal grains: 0.1
	Note	[Current May 2007.] [Limits applies to sum of triadimefon and triadimenol.] For the EU pesticides database click here
Drinking Water MAC (µg l-1)		-	-	-

Health issues:

Carcinogen	Mutagen	Endocrine disrupter	Reproduction / development effects	Acetyl cholinesterase inhibitor	Neurotoxicant	Respiratory tract irritant	Skin irritant	Eye irritant
						-
General human health issues		[Liver and thyroid toxicant]

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data

Handling issues:

Property		Value	Source/Quality Score/Other Information	Interpretation
General		[No information available]
EC Risk Classification		[Xn - Harmful: R22], [Xi - Irritant: R43], [N - Dangerous for the environment: R51, R53]
EC Safety Classification		S2, S24, S37, S61
WHO Classification		II	-	Moderately hazardous
US EPA Classification (formulation)		III	-	Caution - Slightly toxic
UN Number		-
Waste disposal & packaging		-

TRANSLATIONS