triticonazole (Ref: RPA 400727) ** Translations

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GENERAL INFORMATION

Description: A seed treatment fungicide for the control of common bunt, loose smut and covered smut on barley, oats and wheat.

Introduction: 1993, first registered France

EC Directive 1107/2009 (repealing 91/414):

Status	Annex 1
Dossier rapporteur/co-rapporteur	Austria
Date inclusion expires	31/01/2017

Approved for use () or known to be used () in the following European countries:

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also registered in: Australia

General status:

Pesticide type	Fungicide
Substance group	Triazole
Substance origin	Synthetic
Mode of action	Inhibits sterol demethylation
CAS RN	131983-72-7
EC number	603-543-7
CIPAC number	652
US EPA chemical code	-
Chemical formula	C17H20ClN3O
SMILES	CC1(C)CC\C(=C/C2=CC=C(Cl)C=C2)C1(O)CN1C=NC=N1
International Chemical Identifier (InChI)	InChI=1/C17H20ClN3O/c1-16(2)8-7-14(9-13-3-5-15(18)6-4-13)17(16,22)10-21-12-19-11-20-21/h3-6,9,11-12,22H,7-8,10H2,1-2H3/b14-9-
Structure diagram/image available?	Yes
Molecular mass (g mol-1)	317.81
IUPAC Name	(RS)-(E)-5-(4-chlorobenzylidene)-2,2-dimethyl-1-(1H-1,2,4-triazol-1-ylmethyl)cyclopentanol
CAS Name	(5E)-5-[(4-chlorophenyl)methylene]-2,2-dimethyl-1-(1H-1,2,4-triazol-1-ylmethyl)cyclopentanol
Other status information	-
Herbicide Resistance Classification (HRAC)	Not applicable
Insecticide Resistance Classification (IRAC)	Not applicable
Fungicide Resistance Classification (FRAC)	3
Physical state	White powder
Related substances & organisms	propylene glycol prochloraz

Formulations:

Property	Value
Example manufacturers of products using this active	Aventis BASF Bayer CropScience Scotts
Example products using this active	Premis 25 FS Kinto Fungus Clear Ultra
UK LERAP status	None (may vary with mixtures)
Formulation and application details	Often supplied formulated as a flowable concentrate for seed treatment.

ENVIRONMENTAL FATE

Property		Value	Source/Quality Score/Other Information	Interpretation
Solubility - In water at 20oC (mg l-1)		9.3	B5	Low
Solubility - In organic solvents at 20oC (mg l-1)		120	A5 - Hexane	-
		74500	A5 - Acetone	-
		18200	A5 - Methanol	-
		12600	A5 - Toluene	-
Melting Point (oC)		137	A5	-
Boiling Point (oC)		Decomposes before boiling	A5	-
Degradation point (oC)		138	A4	-
Flashpoint (oC)		Not highly flammable	A5	-
Octanol-water partition coefficient at pH 7, 20oC	P	1.95 X 1003	Calculated	-
	Log P	3.29	B5	High
Bulk density (g ml-1)/Specific gravity		1.21	A5	-
Dissociation constant (pKa) at 25oC		Not applicable	A5	-
		Note: No dissociation
Vapour pressure at 25oC (mPa)		1.00 X 10-03	A5	Non-volatile
Henry's law constant at 25oC (Pa m3 mol-1)		3.00 X 10-05	A5	Non-volatile
Henry's law constant at 20oC (dimensionless)		1.65 X 10-08	Q2	Non-volatile
GUS leaching potential index		3.04	Calculated	High leachability
SCI-GROW groundwater index (µg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate	Value	3.57 X 10-01	Calculated	-
	Note	-
Potential for particle bound transport index		-	Calculated	Medium
Maximum UV-vis absorption L mol-1 cm-1		Neutral solution: 212nm = 23879, 263nm = 25731	A5	-
Surface tension (mN m-1)		51.7	A5 at 23.5oC, 13.7 mg l-1	-

Degradation:

Property		Value	Source/Quality Score/Other Information	Interpretation
Soil degradation (days) (aerobic)	DT50 (typical)	237	A5	Persistent
	DT50 (lab at 20oC)	237	A5	Persistent
	DT50 (field)	161	A5	Persistent
	DT90 (lab at 20oC)	788	A5	-
	DT90 (field)	563	A5	-
	Note	EU dossier lab studies DT50 range 151-429 days, DT90 range 501-1425 days; field studies DT50 range 104-247 days, DT90 range 347-857 days
Aqueous photolysis DT50 (days) at pH 7	Value	3.1	A5	Moderately fast
	Note	-
Aqueous hydrolysis DT50 (days) at 20oC and pH 7	Value	Stable	B5	Very persistent
	Note	-
Water-Sediment DT50 (days)		392	A5	Stable
Water phase only DT50 (days)		158	A5	Stable

Soil adsorption and mobility:

Property		Value	Source/Quality Score/Other Information	Interpretation
Linear	Kd	-	DW4	Moderately mobile
	Koc	374
	Notes and range	-
Freundlich	Kf	8.9	A5	Slightly mobile
	Kfoc	523
	1/n	0.856
	Notes and range	EU dossier kf range 4.1-14.4 mL/g, Koc range 344-812 mL/g, 1/n range 0.813-0.890, Soils=5
pH sensitivity		No

Key metabolites:

Metabolite		Formation Medium	Estimated Maximum Occurrence Fraction	91/414 Relevancy
(1R,3R,E)-3-(4-chlorobenzylidene)-5,5-dimethyl-1-((1H)-1,2,4-triazol-1-ylmethyl)-cyclopentan-1,3-diol (Ref: RPA 406341)		Soil	0.202	Major fraction, Relevant
(E)-2-(4-chlorobenzylidene)-5,5-dimethyl-1-((1H)-1,2,4-triazol-1-ylmethyl)-cyclopentan-1,3-diol (Ref: RPA 404766)		Soil	0.123	Major fraction, Relevant
Ref: RPA 407922		Soil	0.128	Major fraction, Relevant

ECOTOXICOLOGY

Property		Value	Source/Quality Score/Other Information	Interpretation
Bio-concentration factor	BCF	94	A5	Low potential
	CT50 (days)	3		-
Bioaccumulation potential		-	Calculated	Low
Mammals - Acute oral LD50 (mg kg-1)		> 2000	B5 Rat	Moderate
Mammals - Short term dietary NOEL	(mg kg-1)	> 21	B5 Rat	High
	(ppm diet)	> 250		-
Birds - Acute LD50 (mg kg-1)		> 2000	A5 Colinus virginianus	Moderate
Birds - Short term dietary (LC50/LD50)		> 693 mg kg bw-1 day-1	A5 Colinus virginianus	-
Fish - Acute 96 hour LC50 (mg l-1)		> 3.6	A5 Oncorhynchus mykiss	Moderate
Fish - Chronic 21 day NOEC (mg l-1)		0.01	A4 Oncorhynchus mykiss, 28 day	-
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1)		9.0	A5 Daphnia magna	Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1)		0.092	A5 Daphnia magna	-
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1)		-	-	-
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1)		-	-	-
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1)		0.08	A5 Chironomus riparius	Moderate
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1)		-	-	-
Aquatic plants - Acute 7 day EC50, biomass (mg l-1)		1.1	A5 Lemna gibba	Moderate
Algae - Acute 72 hour EC50, growth (mg l-1)		> 1.0	B5 Pseudokirchneriella subcapitata	Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1)		-	-	-
Honeybees - Acute 48 hour LD50 (µg bee-1)		> 100	A5 Contact	Moderate
Earthworms - Acute 14 day LC50 (mg kg-1)		> 500	A5 Eisenia foetida, corr	Moderate
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1)		> 250	A5 Eisenia foetida, corr	Low
Other soil macro-organisms - e.g. Collembola	LR50product ha EC50product ha NOECproduct ha % Effect	-	-	-
Other arthropod (1)	LR50 g ha-1	-	-	-
	% Effect	86	Mortality Dose: 0.1 kg ha-1 A5 Aphidius rhopalosiphi, adult	Harmful
Other arthropod (2)	LR50 g ha-1	-	-	-
	% Effect	0 0	Mortality Fecundity Dose: 0.1 kg ha-1 A5 Typhlodromus pyri, protonymph	Harmless
Soil micro-organisms		Nitrogen mineralisation: No significant effect Carbon mineralisation: No significant effect	A5 Dose: 1.6 kg/ha	-
Mesocosm study data	NOEAEC mg l-1	-	-	-
	NOEAEC mg l-1	-	-	-

HUMAN HEALTH AND PROTECTION

General:

Property		Value	Source/Quality Score/Other Information	Interpretation
Mammals - Acute oral LD50 (mg kg-1)		> 2000	B5 Rat	Moderate
Mammals - Dermal LD50 (mg kg-1 body weight)		> 2000	A5 Rat	-
Mammals - Inhalation LC50 (mg l-1)		> 5.61	A5 Rat, 4hr (nose only)	-
Other Mammal toxicity endpoints		-		-
ADI - Acceptable Daily Intake (mg kg-1bw day-1)		0.025	A5 Dog, SF=100	-
ARfD - Acute Reference Dose (mg kg-1bw day-1)		0.05	A5 Dog, SF=100	-
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1)		0.025	A4 Dog, 1 year, SF=100	-
Dermal penetration studies (%)		11	A5	-
Dangerous Substances Directive 76/464		-	-	-
Exposure Limits		-	-	-
Exposure Routes	Public	[No unacceptable risks to bystanders identified]
	Occupational	[No unacceptable risks to operators or other workers identified]
Examples of European MRLs (mg kg-1)	Value	Cereals: 0.01
	Note	[A5 EU dossier proposals] For the EU pesticides database click here
Drinking Water MAC (µg l-1)		0.1	EU Dir 89/778/EC limit; A5	-

Health issues:

Carcinogen	Mutagen	Endocrine disrupter	Reproduction / development effects	Acetyl cholinesterase inhibitor	Neurotoxicant	Respiratory tract irritant	Skin irritant	Eye irritant
-	-	-	-		-
General human health issues		[No further information available]

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data

Handling issues:

Property		Value	Source/Quality Score/Other Information	Interpretation
General		[Not explosive], [IMDG Transport Code is usually 9]
EC Risk Classification		[N - Dangerous for the environment: R51, R53]
EC Safety Classification		S61
WHO Classification		III	-	Slightly hazardous
US EPA Classification (formulation)		III	-	Caution - Slightly toxic
UN Number		Usually 3077
Waste disposal & packaging		[Usually Packaging Group III (minor danger)]

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