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espinetoram (Ref: XDE 175)
** spinetoram ** X574175 ** DE-175 ** GF-1587 ** GF-1640 ** spinotoram J ** Traducciones

Destino ambiental - Ecotoxicología - La salud humana - A a Z Indice - Inicio

INFORMACIÓN GENERAL Click here for an explantaion of the general chemical status information
for spinetoram

Descripción: A mixture of two natural fermentation-derived components with activity against a wide range of common insect pests

Ejemplos de plagas controladas: Apple moth; Grapevine moth; Codling moth; Oriental fruit moth; Western flower thrip; Pear & cherry slug;

Ejemplos de aplicaciones: Fruit including grapes, apples, pears, apricots, cherries, plums, peaches

Eficacia y actividad: -

Availability status: Current

Introduction & key dates: 2007, first registered USA

CEE Regulación 1107/2009 ( 91/414):
Estado Approved
Dossier rapporteur/co-rapporteur UK
Date inclusion expires 30/06/2024
UE Candidatas a sustitución No
Incluido en la base de datos de la UE

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Estados Unidos (pendientes)

Estructura química: Click here for further information on the general chemical status information used on this site
Isomerism Spinetoram technical material is a mixture of XDE-175-J and XDE-175-L in the approximate ratio 3:1 but these substances are not isomers. XDE-175-J contains an extra methyl group. However both substances are complex molecules with multiple chiral centers.
Fórmula química C42H69NO10 / C43H69NO10
Canonical SMILES CCC1CCCC(C(C(=O)C2=CC3C(C2CC(=O)O1)CCC4C3CC(C4)OC5C(C(C(C(O5)C)OC)OCC)OC)C)OC6CCC(C(O6)C)N(C)C
Isomeric SMILES CC[C@H]1CCC[C@@H]([C@H](C(=O)C2=C[C@@H]3[C@H]([C@@H]2CC(=O)O1)CC[C@H]4[C@H]3C[C@@H](C4)O[C@H]5[C@@H]([C@@H]([C@H]([C@@H](O5)C)OC)OCC)OC)C)O[C@H]6CC[C@@H]([C@H](O6)C)N(C)C
International Chemical Identifier Key (InChIKey) GOENIMGKWNZVDA-RWGFPKGXSA-N
International Chemical Identifier (InChI) InChI=1S/C42H69NO10/c1-10-27-13-12-14-35(53-37-18-17-34(43(6)7)24(4)49-37)23(3)38(45)33-21-31-29(32(33)22-36(44)51-27)16-15-26-19-28(20-30(26)31)52-42-41(47-9)40(48-11-2)39(46-8)25(5)50-42/h21,23-32,34-35,37,39-42H,10-20,22H2,1-9H3/t23-,24-,25+,26-,27+,28-,29-,30-,31-,32+,34+,35+,37+,39+,40-,41-,42+/m1/s1
¿Diagrama de estructura 2D / imagen disponible?

Estado general: Click here for further information on the general chemical status information used on this site
Tipo de pesticida Insecticide
Grupo químico Spinosym
Minimum active substance purity 830 g/Kg
Known relevant impurities EU dossier - none declared
Sustancias de origen Sintéticas
Modo de acción Acts through a novel site in the nicotinic receptor. Shows high residual, contact and ingestion activity
CAS RN 935545-74-7
Alternative/old CAS RN 187166-40-1 [J] / 187166-15-0 [L]
CEE número -
Número CIPAC 802
EPA américaine chimiques de code 110008 / 110009
PubChem CID 53297414
Masa molecular (g mol-1) 754.0 (mean)
PIN (Preferred Identification Name) Mixture of 50-90% (2R,3aR,5aR,5bS,9S,13S,14R,16aS,16bR)-2-(6-deoxy-3-O-ethyl-2,4-di-O-methyl-?-L-mannopyranosyloxy)-13-[(2R,5S,6R)-5-(dimethylamino)tetrahydro-6-methylpyran-2-yloxy]-9-ethyl-2,3,3a,4,5,5a,5b,6,9,10,11,12,13,14,16a,16b-hexadecahydro-14-methyl-1H-as-indaceno[3,2-d]oxacyclododecine-7,15-dione
Nombre IUPAC Mixture of 50-90% (2R,3aR,5aR,5bS,9S,13S,14R,16aS,16bR)-2-(6-deoxy-3-O-ethyl-2,4-di-O-methyl-?-L-mannopyranosyloxy)-13-[(2R,5S,6R)-5-(dimethylamino)tetrahydro-6-methylpyran-2-yloxy]-9-ethyl-2,3,3a,4,5,5a,5b,6,9,10,11,12,13,14,16a,16b-hexadecahydro-14-methyl-1H-as-indaceno[3,2-d]oxacyclododecine-7,15-dione
Nombre CAS Mixture of 50-90% (2R,3aR,5aR,5bS,9S,13S,14R,16aS,16bR)-2-((6-deoxy-3-O-ethyl-2,4-di-O-methyl-?-L-mannopyranosyl)oxy)-13-(((2R,5S,6R)-5-(dimethylamino)tetrahydro-6-methyl-2H-pyran-2-yl)oxy)-9-ethyl-2,3,3a,4,5,5a,5b,6,9,10,11,12,13,14,16a,16b-hexadecahydro-14-methyl-1H-as-indaceno(3,2-d)oxacyclododecin-7,15-dione
Otra información de estado PAN listed Highly Hazardous Chemical
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) No aplicable
Herbicide Resistance Classification (WSSA) No aplicable
Insecticide Resistance Classification (IRAC) 5
Fungicide Resistance Classification (FRAC) No aplicable
Examples of recorded resistance -
Estado físico Off-white solid
Related substances & organisms

Formulaciones:
Propiedad Click here for information on the general product and branding information used on this site Valor
Example manufacturers & suppliers of products using this active now or historically
  • Dow AgroSciences
Example products using this active
  • Delegate
  • Radiant
Estado de UK LERAP No UK approval for use as a pesticide under EC Regulation 1107/2009
Formulation and application details -


DESTINO AMBIENTAL

for spinetoram

Propiedad Click here for information on the parameters used to describe environmental fate on this site Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with fate data Interpretación Click here for information on the way in which we interpret environmental fate data
Solubilidad - En aqua en 20oC (mg l-1) 29.0 A4 - (component mean) Bajo
Solubilidad - en solventes organicos en 20oC (mg l-1) 250000 A5 - Metanol -
250000 A5 - Acetona -
250000 A5 - Xileno -
61000 A5 - n-Heptano -
Punto de fusión (oC) 107.1 A4 - 143.4 / 70.8 -
Punto de ebullición (oC) Decomposes before boiling A5 -
El punto de degradación (oC) 293 A5 -
Punto de inflamación (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-aqua coeficiente de particiónat en pH 7, 20oC P 1.58 X 1004 Calculado -
Log P 4.2 A5 - 4.09 / 4.49 Alto
Masa densidad (g ml-1)/Peso específico - - -
Disociación constante (pKa) at 25oC 7.7 A5 -
Nota: 7.86 / 7.59 Weak acid
Presión de vapor en 20oC (mPa) 5.7 X 10-02 A4 Baja volatilidad
Constante de Henry a 25oC (Pa m3 mol-1) 4.0 X 10-03 A5 No volátil
Indice de potencial de lixiviación GUS Click here for a note on the limitations of the GUS index 0.27 Calculado Bajo posibilidad de lixiviación
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Valor 1.05 X 10-03 Calculado -
Nota -
Potencial para transportar de 'particle bound' Click here for a note on the limitations of the potential for particle bound transport index - Calculado Mediano
Maximum UV-vis absorption L mol-1 cm-1 DE-175-J [Neutral soln.: 245nm=12200
Acidic soln.: 247nm=12400
Basic soln.: 247nm=12400; XDE-175-L [Neutral soln.: 243nm=11100
Acidic soln.: 203nm=9800, 245nm=11400
Basic soln.: 244nm=11200
A5 -
Surface tension (mN m-1) 54.0 A5 -

Degradación:
Propiedad Click here for information on the parameters used to describe substance degradation Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with degradation data Interpretación Click here for information on the way in which we interpret substance degradation data
Biodegradabilidad general -
Degradación de suelo (días) (aerobic) DT50 (típico) 16.1 A5 No persistente
DT50 (laboratorio en 20oC) 16.1 A5 No persistente
DT50 (campo) 2.8 A5 No persistente
DT90 (laboratorio en 20oC) 87.0 A4 -
DT90 (campo) 31.1 A5 -
Endpoint de modelado DT50 - - -
Nota EU dossier Lab studies DT50 range 5-86.9 days, DT90 range 27.1-420.0 days, additional study 72881 days; Field studies XDE-175-J: DT50 range 0.03-2.49 days, DT90 1.6-25.7, XDE-175-L: DT50 range 0.07-2.0, DT90 range 0.51-7.91 days; Manufacturer published data gives field studies DT50 3-5 days, lab studies DT50 13-21 days
Dissipation rate RL50 on plant matrix Valor - - -
Nota -
Dissipation rate RL50 on and in plant matrix Valor 2.62 R3 -
Nota Tomato fruit, n=1
Acuoso fotólisis DT50 (días) en pH 7 Valor 0.4 A5 Rápido
Nota DT50 0.3-0.5 days summer sunlight 40 Deg N
Acuoso hidrólisis DT50 (días) en 20oC y pH 7 Valor Estable A5 -
Nota Stable pH 5 to pH 9 at 25 degC
Aqua-Sedimento DT50 (días) 273 A5 Lento
Fase de agua sola DT50 (días) 5.1 A5 Moderado rápido

De absorción del suelo y la movilidad:
Propiedad Click here for information on the parameters used to describe substance adsorption and mobility Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretación Click here for information on the way in which we interpret substance adsorption and mobility
Lineal Kd 37.3 E4 No Móvil
Koc 22836
Notas y rango EU dossier Kd range 12-61 mL/g, Koc range 1470-5490, soils=10; Manufacturer published data Koc = 1800-43873 mL/g
Freundlich Kf 32 A5 Móvil un poco
Kfoc 2544
1/n 0.949
Notas y rango EU dossier Kf range 8.6-43.8 mL/g, Kfoc range 1263-6257 mL/g, 1/n range 0.83-1.11, Soils=10
pH senbsibilidad None

Key metabolites:
Metabolito Medio de formación Maximó Calculado de Fracción Ocurrencia 1107/2009 Importancia Click here for further information on 1107/2009 relevancy
N-demethyl-spinetoram-J This metabolite may cause environmental pollution, click here for further information Suelo   0.697   Major fraction; Relevant
N-demethyl-N-nitroso-spinetoram-J This metabolite may cause environmental pollution, click here for further information Suelo   0.196   Major fraction; Relevant
N-demethyl-spinetoram-L This metabolite may cause environmental pollution, click here for further information Suelo   0.438   Major fraction; Relevant
N-demethyl-N-nitroso-spinetoram-L This metabolite may cause environmental pollution, click here for further information Suelo   0.136   Major fraction; Relevant

Other known metabolites:
Metabolite name and reference Aliases Medio de formación / Rate Maximó Calculado de Fracción Ocurrencia Metabolising enzymes
- N-succinyl-spinetoram-J Soil 0.089 -
- N-succinyl-spinetoram-L Soil 0.163 -
- cysteine-XDE-175--J Rat - -
- cysteine-XDE-175-spinetoram-L Rat - -
- GSH-hydroxy-XDE-175-J Rat - -
- cysteine-hydroxy-XDE-175-J Rat - -
- GSH-N-demethyl-175-J Rat - -
- GSH-N-demethyl-175-J Rat - -
- N-formyl-175-J Plants - -
- N-formyl-175-L Plants - -
- 2-O-demethyl-175-J Sediment; Animals - -
- 2-O-demethyl-175-L Sediment; Animals - -
- 3-O-deethyl-175-J Plants; Rats; Animals - -
- 3-O-deethyl-175-L Plants; Rats; Animals - -
- GSH-3-O-deethyl-175-J Rat - -
- cysteine-3-O-deethyl-175-J Rat - -
- cysteine-3-O-deethyl-175-L Rat - -
- 4-O-demethyl-175-J Sediment; Hens - -
- 4-O-demethyl-175-L Hens - -
- C9-pseudoaglycone-175-J Plants - -
- C17-pseudoaglycone-175-J Plants - -
- C17-pseudoaglycone-175-L Plants - -
- 13,14-beta-dihydro-C17-pseudoaglycone-175-L Water (photolysis) - -
- sulfate-aglycone-175-J Rat - -
- GSH-hydroxy-C9-pseudoaglycone-175-J Rat - -
- N-acetyl-cysteine-C9-ketospseudoaglycone-175-J Rat - -
- glucuronamide-C9-pseudoaglycone-175-L Rat - -


ECOTOXICOLOGÍA

for spinetoram

Propiedad Click here for information on the parameters used to describe substance ecotoxicology Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretación Click here for information on the way in which we interpret substance ecotoxicology
Factor de la bio-concentración BCF (l kg-1) 114 A5 Umbral de importancia
CT50 (días) 4.6 -
Mamíferos - Agudos oral LD50 (mg kg-1) > 5000 A5 Rata Bajo
Mamíferos - a corto plazo NOEL (mg kg-1) - - -
(ppm dieta) - -
Pájaros/aves - Agudos LD50 (mg kg-1) > 2250 A5 Anas platyrhynchos Bajo
Birds - Short term dietary (LC50/LD50) > 5620 mg kg feed-1 A5 Anas platyrhynchos, 32día -
Pez - agudo 96 hora LC50 (mg l-1) 2.69 A5 Lepomis macrochirus Moderado
Pez - Crónico 21 días NOEC (mg l-1) 0.182 A5 Pimephales promelas Moderado
Invertebrados acuáticos - Agudos 48 hora EC50 (mg l-1) 0.228 A5 Daphnia magna Moderado
Invertebrados acuáticos - Crónicos 21 días NOEC (mg l-1) 0.00156 A5 Daphnia magna, crecimiento Alto
Crustáceos acuáticos - Agudos 96 hora LC50 (mg l-1) - - -
Sediment dwelling organisms - Agudos 96 hora LC50 (mg l-1) - - -
Sediment dwelling organisms - Crónicos 28 día NOEC, estático, agua (mg l-1) 0.00075 A5 Chironomus riparius Alto
Sediment dwelling organisms - Crónicos 28 día NOEC, sedimento (mg kg-1) - - -
Plantas acuáticas - Agudos 7 día EC50, biomasa (mg l-1) 14.2 A5 Lemna gibba Bajo
Non-target plants - - -
- - -
Algas - Agudos 72 hora EC50, crecimiento (mg l-1) 0.0779 A5 Navicula pelliculosa Moderado
Algas - Crónicos 96 hora NOEC, crecimiento (mg l-1) - - -
Abejas mielíferas (Apis spp.) Contacto aguda LD50 (peor caso de 24 , 48 y 72 hora valores - μg abeja-1) 0.024 A5 Alto
Oral aguda LD50 (peor caso de 24 , 48 y 72 hora valores - μg abeja-1) 0.14 A5 Alto
Modo desconocido aguda LD50 (peor caso de 24 , 48 y 72 hora valores - μg abeja-1) - - -
Abejorros (Bombus spp.) Contacto aguda LD50 (peor caso de 24 , 48 y 72 hora valores - μg abeja-1) > 120 R4 Bombus terrestris Bajo
-
Oral aguda LD50 (peor caso de 24 , 48 y 72 hora valores - μg abeja-1) 4.97 R4 Bombus terrestris Moderado
-
Abejas albañiles (Osmia spp.) Contacto aguda LD50 (peor caso de 24 , 48 y 72 hora valores - μg abeja-1) - - -
Oral aguda LD50 (peor caso de 24 , 48 y 72 hora valores - μg abeja-1) - - -
Otros polinizadores (1) Agudos LD50 (peor caso de 24 , 48 y 72 hora valores - μg insect-1) - - -
Modo de exposición -
Otros polinizadores (2) Agudos LD50 (peor caso de 24 , 48 y 72 hora valores - μg insect-1) - - -
Modo de exposición -
Lombrices - Agudos 14 día LC50 (mg kg-1) > 500 A5 Eisenia foetida Moderado
Lombrices - Crónicos NOEC, reproducción (mg kg-1) 9.33 A5 Eisenia foetida Moderado
Other soil macro-organisms Agudos LC50 (mg kg-1) - - -
Crónicos NOEC (mg kg-1) - - -
Otro arthropoda (1) LR50 g ha-1 0.132 Mortalidad
A5 Typhlodromus pyri
-
% Causalidad - - -
Otro arthropoda (2) LR50 g ha-1 0.0885 Mortalidad
A5 Aphidius rhopalosiphi
-
% Causalidad - - -
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: 4mg kg-1, 28días
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


LA SALUD HUMANA Y PROTECCIÓN

for spinetoram

General:
Propiedad Click here for information on the parameters used to describe human health and protection issues Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with human health and protection data Interpretación Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class - - -
Mamíferos - Agudos oral LD50 (mg kg-1) > 5000 A5 Rata Bajo
Mammals - Dermal LD50 (mg kg-1 body weight) > 5000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) > 5.0 A5 Rat, 4 hr -
Other Mammal toxicity endpoints - -
Consumo cada día aceptable (mg kg-1p.c. días-1) 0.025 A5 -
ARfD - Acute Reference Dose (mg kg-1p.c. días-1) 0.1 A5 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
El nivel de exposición del operador (AOEL) sistemíco (mg kg-1p.c. días-1) 0.0065 A5 -
Estudios den la absorción cutánea (%) 5-11 A5 Concentration dependent -
Directivo 76/464 Sustancias Peligrosas - - -
Exposure Routes Public Acceptable for proposed uses
Occupational Acceptable for proposed uses
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Genotóxico Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

A3; B0; C3; D0; E3

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

Cuestiones generales de la salud humana Potential for slow accumulation in the body
Possible thyroid toxicant
Weak sensitiser
Clave: Genotoxicidad
A: Aberración cromosómica (base de datos EFSA)
B: Daño/reparación del ADN (base de datos EFSA)
C: Mutación genética (base de datos EFSA)
D: Mutación del genoma (base de datos EFSA)
E: Tipo de genotoxicidad no especificada (fuente de datos diversos)
0: Sin datos
1: Positivo
2: Resultados mixtos/ambiguos
3: Negativo
Clave: Otro
: Sí, se sabe que causa un problema
: No, sabe no causar un problema
: Posiblemente, estado no identificado
- : Datos no encontrados

Handling issues:
Propiedad Click here for information on the parameters used to describe substance handling issues Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with data on handling issues Interpretación Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive or oxidising
CLP classification 2013 Health: H317, H361
Environment: H400, H410
CEE clasificación de riesgos Click here to view information omn the EU risk phrases Reproduction risk category 3: R62
T - Toxic: R48/22
Xn - Harmful: R43
CEE clasificación sin riesgos Click here to view information omn the EU safety phrases -
Clasificación de OSM U - Es poco probable que presente un riesgo agudo
Número de las NU -
Waste disposal & packaging Click here for a description of UN packaging marks -


TRADUCCIONES

for spinetoram

Idioma Nombre
Inglés spinetoram
Francés -
Alemán -
Danés -
Italiano -
Español espinetoram
Griego -
Esloveno -
Polaco -
Sueco -
Húngaro -
Holandés -

Última actualización del registro: Tuesday 29 October 2019
Contacto: aeru@herts.ac.uk