Seleccione la Opción
Inicio
A a Z Indice
Búsqueda
Términos y Condiciones
Información de Asistencia
Compras y Servicios
GET ADDITIONAL DATA HERE!

carboxina (Ref: D 735)
** carboxin ** carboxine ** carbathiin ** vitavax ** Traducciones

Destino ambiental - Ecotoxicología - La salud humana - A a Z Indice - Inicio

RESUMEN

Carboxin is an effective agricultural fungicide that is approved for use in the EU subject to Member State approval. It is moderately soluble in water, is non-volatile and, based on its chemical properties, would not normally be expected to leach to groundwater. It tends not to persist in soil or water systems. Whilst it is an irritant, its mammalian toxicity is low and no significant health effects have been identified. It shows a low or moderate ecotoxicity to most species.

INFORMACIÓN GENERAL Click here for an explantaion of the general chemical status information
for carboxin

Descripción: An anilide fungicide for bunts and smuts normally that is normally used as a seed treatment

Ejemplos de plagas controladas: Smut; Rots; Bunt; Blight; Leaf stripe; Net blotch

Ejemplos de aplicaciones: Rice; Vegetables; Corn; Wheat; Barley; Oats; Turf grass; Cotton

Eficacia y actividad: Carboxin has been shown to be an effective fungicide via field trials and long use globally.

Availability status: Current

Introduction & key dates: 1966, first reported; 1969, first introduced

CEE Regulación 1107/2009 ( 91/414):
Estado Approved
Dossier rapporteur/co-rapporteur UK
Date inclusion expires 31/05/2021
UE Candidatas a sustitución No
Incluido en la base de datos de la UE

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia, Estados Unidos

Estructura química: Click here for further information on the general chemical status information used on this site
Isomerism None
Fórmula química C12H13NO2S
Canonical SMILES CC1=C(SCCO1)C(=O)NC2=CC=CC=C2
Isomeric SMILES No data
International Chemical Identifier Key (InChIKey) GYSSRZJIHXQEHQ-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C12H13NO2S/c1-9-11(16-8-7-15-9)12(14)13-10-5-3-2-4-6-10/h2-6H,7-8H2,1H3,(H,13,14)
¿Diagrama de estructura 2D / imagen disponible?

Estado general: Click here for further information on the general chemical status information used on this site
Tipo de pesticida Fungicide
Grupo químico Oxathiin
Minimum active substance purity 970 g/kg
Known relevant impurities EU dossier - None declared
Sustancias de origen Sintéticas
Modo de acción Systemic, inhibits mitochondrial function. Succinate Dehydrogenase Inhibitor.
CAS RN 5234-68-4
CEE número 226-031-1
Número CIPAC 273
EPA américaine chimiques de code 090201
PubChem CID 21307
Masa molecular (g mol-1) 235.30
PIN (Preferred Identification Name) 2-methyl-N-phenyl-5,6-dihydro-1,4-oxathiine-3-carboxamide
Nombre IUPAC 5,6-dihydro-2-methyl-1,4-oxathiine-3-carboxanilide
Nombre CAS 5,6-dihydro-2-methyl-N-phenyl-1,4-oxathiin-3-carboxamide
Otra información de estado -
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) No aplicable
Herbicide Resistance Classification (WSSA) No aplicable
Insecticide Resistance Classification (IRAC) No aplicable
Fungicide Resistance Classification (FRAC) 7
Examples of recorded resistance -
Estado físico Colourless crystals
Related substances & organisms

Formulaciones:
Propiedad Click here for information on the general product and branding information used on this site Valor
Example manufacturers & suppliers of products using this active now or historically
  • Chemtura Corp
  • Crompton Europe
  • Bayer CropScience
  • Uniroyal
Example products using this active
  • Vitavax 200FF
  • Krisvax
  • Kemikar
Estado de UK LERAP None
Formulation and application details Usually formulated as a flowable concentrate that is diluted with water for use as a seed treament.


DESTINO AMBIENTAL

for carboxin

Propiedad Click here for information on the parameters used to describe environmental fate on this site Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with fate data Interpretación Click here for information on the way in which we interpret environmental fate data
Solubilidad - En aqua en 20oC (mg l-1) 134 A5 Moderado
Solubilidad - en solventes organicos en 20oC (mg l-1) 220000 A5 - Acetona -
110000 A5 - Acetato de etilo -
89000 A5 - Metanol -
53000 A5 - Tolueno -
Punto de fusión (oC) 91.5 A5 -
Punto de ebullición (oC) Decomposes before boiling A5 -
El punto de degradación (oC) 210 A5 -
Punto de inflamación (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-aqua coeficiente de particiónat en pH 7, 20oC P 2.00 X 1002 Calculado -
Log P 2.3 A5 Bajo
Masa densidad (g ml-1)/Peso específico 1.36 L3 -
Disociación constante (pKa) at 25oC 0.5 A5 -
Nota: Ácido fuerte
Presión de vapor en 20oC (mPa) 0.02 A5 Baja volatilidad
Constante de Henry a 25oC (Pa m3 mol-1) 3.20 X 10-05 A5 No volátil
Indice de potencial de lixiviación GUS Click here for a note on the limitations of the GUS index -2.15 Calculado Bajo posibilidad de lixiviación
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Valor 3.83 X 10-03 Calculado -
Nota -
Potencial para transportar de 'particle bound' Click here for a note on the limitations of the potential for particle bound transport index - Calculado Bajo
Maximum UV-vis absorption L mol-1 cm-1 205nm = 17443, 295nm = 6585 A5 -
Surface tension (mN m-1) 61.2 A5 at 20oC -

Degradación:
Propiedad Click here for information on the parameters used to describe substance degradation Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with degradation data Interpretación Click here for information on the way in which we interpret substance degradation data
Biodegradabilidad general -
Degradación de suelo (días) (aerobic) DT50 (típico) 0.5 Click here to see a warning relating to modelling and this active substance A5 No persistente
DT50 (laboratorio en 20oC) 0.28 A5 No persistente
DT50 (campo) 3.3 A5 No persistente
DT90 (laboratorio en 20oC) 1.99 A5 -
DT90 (campo) 11.1 A5 -
Endpoint de modelado DT50 - - -
Nota EU dossier Lab studies DT50 range 0.07-1.68 days, DT90 range 0.23-3.49 days; field studies DT50 range 0.27-11 days, DT90 range 0.9-37 days; Other sources: DT50 1 day (R3)
Dissipation rate RL50 on plant matrix Valor - - -
Nota -
Dissipation rate RL50 on and in plant matrix Valor - - -
Nota -
Acuoso fotólisis DT50 (días) en pH 7 Valor 0.1 A5 Rápido
Nota -
Acuoso hidrólisis DT50 (días) en 20oC y pH 7 Valor Estable A5 -
Nota Stable between pH 4 and pH 9
Aqua-Sedimento DT50 (días) 17.3 A5 Rápido
Fase de agua sola DT50 (días) 13.6 A5 Moderado rápido

De absorción del suelo y la movilidad:
Propiedad Click here for information on the parameters used to describe substance adsorption and mobility Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretación Click here for information on the way in which we interpret substance adsorption and mobility
Lineal Kd 1.3 A5 Móvil moderado
Koc 99.4
Notas y rango EU dossier Kd range 1.03-1.78 mL/g, Koc range 81-124 mL/g, Soils=5
Freundlich Kf 1.95 A5 Móvil muy alta
Kfoc 1.3
1/n 0.80
Notas y rango EU dossier Kf range 1.56-2.71 mL/g, Kfoc range 123-213 mL/g, 1/n range 0.79-0.81, Soils=5
pH senbsibilidad No

Key metabolites:
Metabolito Medio de formación Maximó Calculado de Fracción Ocurrencia 1107/2009 Importancia Click here for further information on 1107/2009 relevancy
carboxin sulfoxide This metabolite may cause environmental pollution, click here for further information Suelo   0.782   Major fraction, Relevant
oxycarboxin (Ref: F 461) This metabolite may cause environmental pollution, click here for further information Suelo   0.170   Major, Relevant
oxathiine amide sulfoxide This metabolite may cause environmental pollution, click here for further information Suelo   0.274   Major fraction, Relevant
oxathiine amide sulfone This metabolite may cause environmental pollution, click here for further information Suelo   0.145   Major fraction, Relevant

Other known metabolites:
Metabolite name and reference Aliases Medio de formación / Rate Maximó Calculado de Fracción Ocurrencia Metabolising enzymes
acetanilide - Plant - -
4-hydroxycarboxin sulfone carboxin Rat M03 Rat (Urine & Bile) - -
4-O-glucuronyl-2-hydroxycarboxin carboxin Rat M04 Rat (Urine) - -
4-hydroxycarboxin carboxin Rat M07 Rat (Urine, Faeces & Bile) - -
monomethoxy dihydroxycarboxin carboxin Rat M09 Rat (Urine & Faeces) - -
2-methoxycarboxin sulfoxide-4-glucuronide carboxin Rat M11 Rat (Bile & Urine) - -
4-O-glucuronyl carboxin carboxin Rat M12 Rat (Bile) - -
- - - - -
2-[2-anilino-2-oxoacetyl)thio]ethyl acetate - Soil; Water; Groundwater - -
2-hydroxy-2-methyl-N-phenyl-1,4-oxathiane-3-carboxamide-4-oxide hydrated carbon sulfoxide; carboxin M09 Soil; Water; Groundwater - -
2-methyl-5,6-dihydro-1,4-oxathiine-3-carboxylic acid-4-oxide PH-3; alpha-vinylsulfinyl acetanilide; P/V-05; M234 Soil; Water; Groundwater - -
4-O-glucuronyl carboxin sulfoxide carboxin Rat M01 Rat (Urine & Bile) - -
4-hydroxycarboxin sulfoxide carboxin Rat M02 Rat (Urine & Bile) - -


ECOTOXICOLOGÍA

for carboxin

Propiedad Click here for information on the parameters used to describe substance ecotoxicology Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretación Click here for information on the way in which we interpret substance ecotoxicology
Factor de la bio-concentración BCF (l kg-1) 13 Q2 Estimado Bajo potencial
CT50 (días) No disponible -
Mamíferos - Agudos oral LD50 (mg kg-1) 2588 A5 Rata Bajo
Mamíferos - a corto plazo NOEL (mg kg-1) 5.5 A5 Rata Alto
(ppm dieta) - -
Pájaros/aves - Agudos LD50 (mg kg-1) > 2150 A5 Colinus virginianus Bajo
Birds - Short term dietary (LC50/LD50) > 5000 mg kg feed-1 A5 Colinus virginianus -
Pez - agudo 96 hora LC50 (mg l-1) 2.3 A5 Oncorhynchus mykiss Moderado
Pez - Crónico 21 días NOEC (mg l-1) 0.32 A5 Cyprinidae Moderado
Invertebrados acuáticos - Agudos 48 hora EC50 (mg l-1) > 57 A5 Daphnia magna Moderado
Invertebrados acuáticos - Crónicos 21 días NOEC (mg l-1) 0.32 A4 Daphnia magna, 17 día Moderado
Crustáceos acuáticos - Agudos 96 hora LC50 (mg l-1) - - -
Sediment dwelling organisms - Agudos 96 hora LC50 (mg l-1) - - -
Sediment dwelling organisms - Crónicos 28 día NOEC, estático, agua (mg l-1) - - -
Sediment dwelling organisms - Crónicos 28 día NOEC, sedimento (mg kg-1) - - -
Plantas acuáticas - Agudos 7 día EC50, biomasa (mg l-1) 0.92 L3 Lemna gibba Moderado
Non-target plants - - -
- - -
Algas - Agudos 72 hora EC50, crecimiento (mg l-1) 0.48 A5 Pseudokirchneriella subcapitata Moderado
Algas - Crónicos 96 hora NOEC, crecimiento (mg l-1) - - -
Abejas mielíferas (Apis spp.) Contacto aguda LD50 (peor caso de 24 , 48 y 72 hora valores - μg abeja-1) > 100 A5 Apis mellifera Bajo
Oral aguda LD50 (peor caso de 24 , 48 y 72 hora valores - μg abeja-1) > 100 A5 Apis mellifera Bajo
Modo desconocido aguda LD50 (peor caso de 24 , 48 y 72 hora valores - μg abeja-1) - - -
Abejorros (Bombus spp.) Contacto aguda LD50 (peor caso de 24 , 48 y 72 hora valores - μg abeja-1) - - -
-
Oral aguda LD50 (peor caso de 24 , 48 y 72 hora valores - μg abeja-1) - - -
-
Abejas albañiles (Osmia spp.) Contacto aguda LD50 (peor caso de 24 , 48 y 72 hora valores - μg abeja-1) - - -
Oral aguda LD50 (peor caso de 24 , 48 y 72 hora valores - μg abeja-1) - - -
Otros polinizadores (1) Agudos LD50 (peor caso de 24 , 48 y 72 hora valores - μg insect-1) - - -
Modo de exposición -
Otros polinizadores (2) Agudos LD50 (peor caso de 24 , 48 y 72 hora valores - μg insect-1) - - -
Modo de exposición -
Lombrices - Agudos 14 día LC50 (mg kg-1) > 250 A5 Eisenia foetida Moderado
Lombrices - Crónicos NOEC, reproducción (mg kg-1) 50 A5 Eisenia foetida Moderado
Other soil macro-organisms Agudos LC50 (mg kg-1) - - -
Crónicos NOEC (mg kg-1) - - -
Otro arthropoda (1) LR50 g ha-1 - - -
% Causalidad - - -
Otro arthropoda (2) LR50 g ha-1 - - -
% Causalidad 0
-21.5
Mortalidad
Reproducción
Dose: 776 mg carboxin + 770 mg thiram/kg seed
A5 Aleochara bilineata, adult/juvenile
-
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: 660 g ha-1
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


LA SALUD HUMANA Y PROTECCIÓN

for carboxin

General:
Propiedad Click here for information on the parameters used to describe human health and protection issues Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with human health and protection data Interpretación Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mamíferos - Agudos oral LD50 (mg kg-1) 2588 A5 Rata Bajo
Mammals - Dermal LD50 (mg kg-1 body weight) > 4000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) > 4.7 A5 Rat, 4 hr -
Other Mammal toxicity endpoints - -
Consumo cada día aceptable (mg kg-1p.c. días-1) 0.008 A3 Rat, 2 year, SF=100 -
ARfD - Acute Reference Dose (mg kg-1p.c. días-1) Ningunos asignaron A4 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
El nivel de exposición del operador (AOEL) sistemíco (mg kg-1p.c. días-1) 0.055 A3 Rat, SF=100 -
Estudios den la absorción cutánea (%) 3.3-5.0 A5 concentration dependent -
Directivo 76/464 Sustancias Peligrosas - - -
Exposure Routes Public Negligible risk to the public due to pattern of use
Occupational Acceptable risks with PPE/PPC
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) 0.1 EU Dir 89/778/EC limit; A5 Calc MAC=4.8 μg l-1 -

Health issues:
Carcinogen Genotóxico Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

A3; D2; C3; D0; E3

-

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

Cuestiones generales de la salud humana Mild skin sensitiser
Possible kidney toxicant
Clave: Genotoxicidad
A: Aberración cromosómica (base de datos EFSA)
B: Daño/reparación del ADN (base de datos EFSA)
C: Mutación genética (base de datos EFSA)
D: Mutación del genoma (base de datos EFSA)
E: Tipo de genotoxicidad no especificada (fuente de datos diversos)
0: Sin datos
1: Positivo
2: Resultados mixtos/ambiguos
3: Negativo
Clave: Otro
: Sí, se sabe que causa un problema
: No, sabe no causar un problema
: Posiblemente, estado no identificado
- : Datos no encontrados

Handling issues:
Propiedad Click here for information on the parameters used to describe substance handling issues Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with data on handling issues Interpretación Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive or oxidising
CLP classification 2013 Health: H302, H312, H317, H332, H373; Environment: H400, H410
CEE clasificación de riesgos Click here to view information omn the EU risk phrases Carcinogen category 3: R40
Xn - Harmful: R43
N - Dangerous for the environment: R50, R53
CEE clasificación sin riesgos Click here to view information omn the EU safety phrases S36/37, S60, S61
Clasificación de OSM III - Peligroso un poco
Número de las NU -
Waste disposal & packaging Click here for a description of UN packaging marks -


TRADUCCIONES

for carboxin

Idioma Nombre
Inglés carboxin
Francés carboxine
Alemán Carboxin
Danés carboxin
Italiano carbossina
Español carboxina
Griego carboxin
Esloveno karboksin
Polaco karboksyna
Sueco karboxin
Húngaro karboxin
Holandés carboxin

Última actualización del registro: Monday 11 November 2019
Contacto: aeru@herts.ac.uk