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clorotalonil (Ref: DS 2787)
** chlorothalonil ** TPN ** tetrachloroisophthalonitrile ** m-TCPN ** HSR002825 ** Traducciones

Destino ambiental - Ecotoxicología - La salud humana - A a Z Indice - Inicio

RESUMEN

Chlorothalonil is a broad spectrum fungicide that is approved for use in the EU and is widely used. It has a low aqueous solubility, is volatile and would not be expected to leach to groundwater. It is slightly mobile. It tends not to be persistent in soil systems but may be persistent in water. It has a low mammalian toxicity but there is some concern regarding its bioaccumulation potential. It is a recognised irritant. Chlorothalonil is moderately toxic to birds, honeybees and earthworms but considered to be more toxic to aquatic organisms.

INFORMACIÓN GENERAL Click here for an explantaion of the general chemical status information
for chlorothalonil

Descripción: A fungicide used to control a wide range of diseases on a broad range of crops. Also used as a wood preservative.

Ejemplos de plagas controladas: Rust; purple spot; Leaf blight; Anthracnose; Downy mildew; Ring spot; Stalk rot; Botrytis rot; Pod & stem blight

Ejemplos de aplicaciones: Cereals; Vegetables including asparagus, beans, cabbage, cauliflower, broccoli, carrot, onions, celery, curcubits; Corn for seed; Fruit including cranberries, melon; Mushrooms; Peanuts; Potatoes

Eficacia y actividad: Can be product specific but generally - Wheat/Mildew=Low; Wheat/Septori tritici=High; Barley/Rhynchosporium=Low; Barley/Ramularia=Moderate

Availability status: Current

Introduction & key dates: 1964, first first reported

CEE Regulación 1107/2009 ( 91/414):
Estado Approved
Dossier rapporteur/co-rapporteur Netherlands/Belgium
Date inclusion expires 31/10/2019
UE Candidatas a sustitución No
Incluido en la base de datos de la UE

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia, Estados Unidos

Estructura química: Click here for further information on the general chemical status information used on this site
Isomerism None
Fórmula química C8Cl4N2
Canonical SMILES C(#N)C1=C(C(=C(C(=C1Cl)Cl)Cl)C#N)Cl
Isomeric SMILES No data
International Chemical Identifier Key (InChIKey) CRQQGFGUEAVUIL-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C8Cl4N2/c9-5-3(1-13)6(10)8(12)7(11)4(5)2-14
¿Diagrama de estructura 2D / imagen disponible?

Click to access the Cambridge Crystallographic Data Centre (CCDC) website
Cambridge Crystallographic Data Centre diagrams:
Nombre Común Relación Vínculo
Chlorothalonil - Click here for the CCDC structure diagram

Estado general: Click here for further information on the general chemical status information used on this site
Tipo de pesticida Fungicide
Grupo químico Chloronitrile
Minimum active substance purity 985 g/kg
Known relevant impurities EU dossier - Hexachlorobenzene 0.04 g/kg; Decachlorobiphenyl 0.03 g/kg
Sustancias de origen Sintéticas
Modo de acción Non-systemic, broad-spectrum, foliar action with some protectant properties. Acts by preventing spore germination and zoospore motility. Multi-site activity.
CAS RN 1897-45-6
CEE número 217-588-1
Número CIPAC 288
EPA américaine chimiques de code 081901
PubChem CID 15910
Masa molecular (g mol-1) 265.91
PIN (Preferred Identification Name) 2,4,5,6-tetrachlorobenzene-1,3-dicarbonitrile
Nombre IUPAC tetrachloroisophthalonitrile
Nombre CAS 2,4,5,6-tetrachloro-1,3-benzenedicarbonitrile
Otra información de estado -
Relevant Environmental Water Quality Standards UK Environment Agency non-statutory standard for the protection of aquatic life: freshwater and saltwater annual average 0.1 ug/L, max acceptable conc 1.0 ug/L
Herbicide Resistance Classification (HRAC) No aplicable
Herbicide Resistance Classification (WSSA) No aplicable
Insecticide Resistance Classification (IRAC) No aplicable
Fungicide Resistance Classification (FRAC) M5
Examples of recorded resistance -
Estado físico White crystalline solid at 99.6% purity
Related substances & organisms

Formulaciones:
Propiedad Click here for information on the general product and branding information used on this site Valor
Example manufacturers & suppliers of products using this active now or historically
  • AgriGuard
  • Certis
  • DuPont
  • Nufarm
  • Scotts
  • Syngenta
  • Teliton
  • Walabi
Example products using this active
  • Alto Elite
  • Amistar Opti
  • Bravo 500
  • Cherokee
  • Credo
  • Folio
  • Joules
  • Merlin
  • Midas
  • Repulse
Estado de UK LERAP Buffer probably required in UK - see product label
Formulation and application details Usually supplied as a soluble concentrate that is mixed with water and applied as a foliar spray.


DESTINO AMBIENTAL

for chlorothalonil

Propiedad Click here for information on the parameters used to describe environmental fate on this site Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with fate data Interpretación Click here for information on the way in which we interpret environmental fate data
Solubilidad - En aqua en 20oC (mg l-1) 0.81 A5 - @25DegC Bajo
Solubilidad - en solventes organicos en 20oC (mg l-1) 13800 A5 - Acetato de etilo -
18000 A5 - Acetone @25DegC -
1700 A5 - Methanol @25DegC -
74400 A5 - Xileno -
Punto de fusión (oC) 252.1 A5 -
Punto de ebullición (oC) 347 A5 -
El punto de degradación (oC) 347 A5 -
Punto de inflamación (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-aqua coeficiente de particiónat en pH 7, 20oC P 8.71 X 1002 Calculado -
Log P 2.94 A5 Moderado
Masa densidad (g ml-1)/Peso específico 1.74 A5 -
Disociación constante (pKa) at 25oC No aplicable A5 -
Nota: Ninguna disociación
Presión de vapor en 20oC (mPa) 0.076 A5 Baja volatilidad
Constante de Henry a 25oC (Pa m3 mol-1) 2.50 X 10-02 A5 No volátil
Indice de potencial de lixiviación GUS Click here for a note on the limitations of the GUS index 0.49 Calculado Bajo posibilidad de lixiviación
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Valor 1.87 X 10-03 Calculado -
Nota -
Potencial para transportar de 'particle bound' Click here for a note on the limitations of the potential for particle bound transport index - Calculado Mediano
Maximum UV-vis absorption L mol-1 cm-1 232nm = 62390, 312nm = 1116, 324nm = 1507 A5 -
Surface tension (mN m-1) 71.5 A5 at 21.5 oC, 99.8% -

Degradación:
Propiedad Click here for information on the parameters used to describe substance degradation Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with degradation data Interpretación Click here for information on the way in which we interpret substance degradation data
Biodegradabilidad general Not readily biodegradable
Degradación de suelo (días) (aerobic) DT50 (típico) 3.53 A5 No persistente
DT50 (laboratorio en 20oC) 3.53 A5 No persistente
DT50 (campo) 17.9 A5 No persistente
DT90 (laboratorio en 20oC) 24.7 A5 -
DT90 (campo) 59.5 - -
Endpoint de modelado DT50 4.29 A5 geometric mean of lab studies -
Nota EU dossier 2018: lab studies DT50 range 0.256-19.0 days, DT90 range 1.46-68.2 days, Soils=18; field studies DT50 range 7.44-28.4 days, DT90 range 24.7-94.2 days; Other sources: 30 days (DW3)
Dissipation rate RL50 on plant matrix Valor 5.5 R4 -
Nota Published literature RL50 range 3.0-12.5 days, 8 field & undercover grown crops, various matrices, n=11
Dissipation rate RL50 on and in plant matrix Valor 5.0 R4 -
Nota Published literature RL50 range 1.7-12.7 days, 11 field & undercover grown crops, various matrices, n=20
Acuoso fotólisis DT50 (días) en pH 7 Valor 0.72 A4 Rápido
Nota In sterile buffer
Acuoso hidrólisis DT50 (días) en 20oC y pH 7 Valor 29.6 A4 - @ 50 degC No persistente
Nota Stable pH 4 to pH 7
Aqua-Sedimento DT50 (días) 0.57 A5 Rápido
Fase de agua sola DT50 (días) 0.82 A5 Rápido

De absorción del suelo y la movilidad:
Propiedad Click here for information on the parameters used to describe substance adsorption and mobility Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretación Click here for information on the way in which we interpret substance adsorption and mobility
Lineal Kd 42.99 A5 Móvil un poco
Koc 2632
Notas y rango EU dossier RAR 2016; Kd range 7.7-153 mL/g, Koc range 300-6154 mL/g, Soils=9
Freundlich Kf 27,2 A5 Móvil un poco
Kfoc 1288
1/n 0.90
Notas y rango EU RAR 2016: Kf range 3.0-74.1 mL/g, Kfoc range 330-7000 mL/g, 1/n range 0.83-0.95, Soils=12; Literature data: Kf range 96.3-1357 mL/g, Kfoc range 13462-52585 mL/g, 1/n range 0.48-0.69, Soils=8
pH senbsibilidad None

Key metabolites:
Metabolito Medio de formación Maximó Calculado de Fracción Ocurrencia 1107/2009 Importancia Click here for further information on 1107/2009 relevancy
4-hydroxy-2,5,6-trichloroisophtalonitrile (Ref: R182281) This metabolite may cause environmental pollution, click here for further information Suelo   0.322   Major fraction, Relevant
2-amido-3,5,6-trichlo-4-cyanobenzenesulphonic acid (Ref: R417888) This metabolite may cause environmental pollution, click here for further information Suelo   0.152   Major fraction, Relevant
3-carbamyl-2,4,5-trichlorobenzoic acid (Ref: R611965) This metabolite may cause environmental pollution, click here for further information Suelo   0.132   Major fraction, Relevant
4-amido-2,5-dichloro-6-cyano benzene-1,3-disulfonic acid (Ref: R419492) This metabolite may cause environmental pollution, click here for further information Suelo   0.124   Major fraction, Relevant

Other known metabolites:
Metabolite name and reference Aliases Medio de formación / Rate Maximó Calculado de Fracción Ocurrencia Metabolising enzymes
2,5 dichloro-4,6 dicyano-benzene-1,3 disulfonic acid
(Ref: R418503)
- Soil; Crop Soil=0.06 -
,4-bis-amido-3,5,6-trichlorobenzenesulfonate
(Ref: R471811)
- Soil; Crop Soil=0.119 -
2,4,5-trichloro-3-cyano benzamid
(Ref: R611966)
Compound 5 Soil; Rat Soil=0.081 -
(Ref: R611967) - Soil; Rat Soil=0.132 -
(Ref: R611968) - Soil 0.065 -
(Ref: R613636) - Soil 0.104 -
2-acetamido-3-[3-(2-acetamido-3-hydroxy-3-oxopropyl)sulfanyl-2,5-dichloro-4,6-dicyano-phenyl]sulfanylpropanoic acid
(Ref: R613823)
- Rat - -
2-acetamido-3-[3,5-bis[(2-acetamido-3-hydroxy-3-oxo-propyl)sulfanyl]-4-chloro-2,6-dicyano-phenyl] sulfanylpropanoic acid
(Ref: R613825)
- Rat - -
2,4,5-trichloro-3-cyano-6-hydroxy-benxamide
(Ref: SYN507900)
SDS66882 Soil 0.058 -


ECOTOXICOLOGÍA

for chlorothalonil

Propiedad Click here for information on the parameters used to describe substance ecotoxicology Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretación Click here for information on the way in which we interpret substance ecotoxicology
Factor de la bio-concentración BCF (l kg-1) 100 A5 Umbral de importancia
CT50 (días) 5 -
Mamíferos - Agudos oral LD50 (mg kg-1) > 5000 A5 Rata Bajo
Mamíferos - a corto plazo NOEL (mg kg-1) 3 B4 Alto
(ppm dieta) 10 -
Pájaros/aves - Agudos LD50 (mg kg-1) > 2000 A5 Coturnix japonica Bajo
Birds - Short term dietary (LC50/LD50) > 5200 mg kg feed-1 A5 Coturnix japonica -
Pez - agudo 96 hora LC50 (mg l-1) 0.017 A5 Oncorhynchus mykiss Alto
Pez - Crónico 21 días NOEC (mg l-1) 0.003 A5 Oncorhynchus mykiss Alto
Invertebrados acuáticos - Agudos 48 hora EC50 (mg l-1) 0.054 A5 Daphnia magna Alto
Invertebrados acuáticos - Crónicos 21 días NOEC (mg l-1) 0.009 A5 Daphnia magna Alto
Crustáceos acuáticos - Agudos 96 hora LC50 (mg l-1) - - -
Sediment dwelling organisms - Agudos 96 hora LC50 (mg l-1) 0.061 A5 Chironomus riparius Alto
Sediment dwelling organisms - Crónicos 28 día NOEC, estático, agua (mg l-1) 0.04 A5 Chironomus riparius Moderado
Sediment dwelling organisms - Crónicos 28 día NOEC, sedimento (mg kg-1) - - -
Plantas acuáticas - Agudos 7 día EC50, biomasa (mg l-1) 0.29 C4 Lemna gibba Moderado
Non-target plants > 4.2 A5 Avena sativa, Allium cepa
Vegetative vigour, ER50
as kg product/ha, product chlorothalonil 75 WG
-
> 8000 A5 maize, onion, oat, radish
Seedling emergence, ER50
as mL/product/ha, product chlorothalonil 500 SC
-
Algas - Agudos 72 hora EC50, crecimiento (mg l-1) 0.21 L2 Raphidocelis subcapitata Moderado
Algas - Crónicos 96 hora NOEC, crecimiento (mg l-1) 0.033 A5 Selenastrum capricornutum Moderado
Abejas mielíferas (Apis spp.) Contacto aguda LD50 (peor caso de 24 , 48 y 72 hora valores - μg abeja-1) > 40 A5 Apis mellifera Moderado
Oral aguda LD50 (peor caso de 24 , 48 y 72 hora valores - μg abeja-1) > 40 A5 Apis mellifera Moderado
Modo desconocido aguda LD50 (peor caso de 24 , 48 y 72 hora valores - μg abeja-1) - - -
Abejorros (Bombus spp.) Contacto aguda LD50 (peor caso de 24 , 48 y 72 hora valores - μg abeja-1) > 100 A5 Bombus terrestris Bajo
-
Oral aguda LD50 (peor caso de 24 , 48 y 72 hora valores - μg abeja-1) > 94 A5 Bombus terrestris Moderado
-
Abejas albañiles (Osmia spp.) Contacto aguda LD50 (peor caso de 24 , 48 y 72 hora valores - μg abeja-1) - - -
Oral aguda LD50 (peor caso de 24 , 48 y 72 hora valores - μg abeja-1) - - -
Otros polinizadores (1) Agudos LD50 (peor caso de 24 , 48 y 72 hora valores - μg insect-1) - - -
Modo de exposición -
Otros polinizadores (2) Agudos LD50 (peor caso de 24 , 48 y 72 hora valores - μg insect-1) - - -
Modo de exposición -
Lombrices - Agudos 14 día LC50 (mg kg-1) 268.5 A4 Eisenia foetida Moderado
Lombrices - Crónicos 14 día NOEC, reproducción (mg kg-1) 50.0 A5 Eisenia foetida Moderado
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Causalidad - - -
Otro arthropoda (1) LR50 g ha-1 18750 48 hora
L3 Aphidius rhopalosiphi
-
% Causalidad - - -
Otro arthropoda (2) LR50 g ha-1 Nocivo Dose: 900 g ha-1
AA3 Typhlodromus pyri
-
% Causalidad - - -
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: 4.8 mg kg-1 soil
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


LA SALUD HUMANA Y PROTECCIÓN

for chlorothalonil

General:
Propiedad Click here for information on the parameters used to describe human health and protection issues Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with human health and protection data Interpretación Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mamíferos - Agudos oral LD50 (mg kg-1) > 5000 A5 Rata Bajo
Mammals - Dermal LD50 (mg kg-1 body weight) > 5000 A5 Rabbit -
Mammals - Inhalation LC50 (mg l-1) 0.1 A5 Rat, 4 hr (nose only) -
Other Mammal toxicity endpoints - -
Consumo cada día aceptable (mg kg-1p.c. días-1) 0.015 A5 Rat, SF=100 -
ARfD - Acute Reference Dose (mg kg-1p.c. días-1) 0.05 A5 Rat, SF=100 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) 0.01 A5 Rat, SF=100 -
El nivel de exposición del operador (AOEL) sistemíco (mg kg-1p.c. días-1) 0.003 A5 Rat, SF=100 -
Estudios den la absorción cutánea (%) 0.02-1.2 A5 concentration dependent -
Directivo 76/464 Sustancias Peligrosas - - -
Exposure Routes Public Low risk for prescribed pattern of use
Occupational PPE/PPC recommended/advised
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Genotóxico Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

A3; B0; C0; D0; E3

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

Cuestiones generales de la salud humana May cause contact dermatitis
IARC group 2B carcinogen; USEPA - probable human carcinogen, formation of tumours shown to form in mice following ingestion
Endocrine issues - Activation of androgen-sensitive cells proliferation
Clave: Genotoxicidad
A: Aberración cromosómica (base de datos EFSA)
B: Daño/reparación del ADN (base de datos EFSA)
C: Mutación genética (base de datos EFSA)
D: Mutación del genoma (base de datos EFSA)
E: Tipo de genotoxicidad no especificada (fuente de datos diversos)
0: Sin datos
1: Positivo
2: Resultados mixtos/ambiguos
3: Negativo
Clave: Otro
: Sí, se sabe que causa un problema
: No, sabe no causar un problema
: Posiblemente, estado no identificado
- : Datos no encontrados

Handling issues:
Propiedad Click here for information on the parameters used to describe substance handling issues Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with data on handling issues Interpretación Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Avoid generating spray mists/dust
Not explosive or oxidising
IMDG Transport Code is usually 9
CLP classification 2013 Health: H317, H318, H330, H335, H351
Environment: H400, H410
CEE clasificación de riesgos Click here to view information omn the EU risk phrases Carcinogen category 3: R40
T+ - Very toxic: R26
Xn - Harmful: R43, R41
Xi - Irritant: R37
N - Dangerous for the environment: R50, R53
CEE clasificación sin riesgos Click here to view information omn the EU safety phrases S1/2, S28, S36/37/39, S45, S60, S61
Clasificación de OSM U - Es poco probable que presente un riesgo agudo
Número de las NU Usually 3082
Waste disposal & packaging Click here for a description of UN packaging marks Packaging Group III (minor danger)


TRADUCCIONES

for chlorothalonil

Idioma Nombre
Inglés chlorothalonil
Francés chlorothalonil
Alemán Chlorthalonil
Danés chlorothalonil
Italiano clorotalonil
Español clorotalonil
Griego chlorothalonil
Esloveno klortalonil
Polaco chlorotalonil
Sueco -
Húngaro chlotalonil
Holandés chloorthalonil

Última actualización del registro: Friday 03 May 2019
Contacto: aeru@herts.ac.uk