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clorpirifos (Ref: OMS 971)
** chlorpyrifos ** ENT 27311 ** chlorpyriphos ** Dowco 179 ** chlorpyrifos ethyl ** Traducciones

Destino ambiental - Ecotoxicología - La salud humana - A a Z Indice - Inicio

RESUMEN

An organophosphate insecticide approved for use in the EU. It has a low aqueous solubility, is quite volatile and is non-mobile. There is a low risk of leaching to groundwater based on its chemical properties. It can be moderately persistent in soil systems but is not usually persistent in water systems. It is highly toxic to mammals, is classified as a reproduction toxicant, an acetyl cholinesterase inhibitor and a neurotoxicant. It is also a skin and eye irritant. It is highly toxic to birds, fish, aquatic inverterbrates and honey bees and moderately toxic to aquatic plants, algae and earthworms

INFORMACIÓN GENERAL Click here for an explantaion of the general chemical status information
for chlorpyrifos

Descripción: A broad spectrum organophosphorus insecticide and acaricide used to control soil and foliage pests

Ejemplos de plagas controladas: Scale; Wooly aphid; Leaf roller; Caterpillars; Corn earworm; Armyworm; Cutworms; Rootworms; Cockroaches; Flea beetles; Flies; Termites; Fire ants

Ejemplos de aplicaciones: Cereals including barley, wheat; Cotton; Fruit including apples, pears, grapes, pineapples, bananas, strawberries, mango; Tomatoes; Nuts; Vegetables inclding carrots, cabbages, cauliflower, Brussel sprouts

Eficacia y actividad: Chlorpyrifos has been used very successfully over a long period of time to control a wide range of foliar pests on agricultural crops.

Availability status: Current

Introduction & key dates: 1965, first reported and introduced

CEE Regulación 1107/2009 ( 91/414):
Estado Approved
Dossier rapporteur/co-rapporteur Spain/Poland
Date inclusion expires 31/01/2020
UE Candidatas a sustitución No
Incluido en la base de datos de la UE

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia, Estados Unidos

Estructura química: Click here for further information on the general chemical status information used on this site
Isomerism -
Fórmula química C9H11Cl3NO3PS
Canonical SMILES CCOP(=S)(OCC)OC1=NC(=C(C=C1Cl)Cl)Cl
Isomeric SMILES No data
International Chemical Identifier Key (InChIKey) SBPBAQFWLVIOKP-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C9H11Cl3NO3PS/c1-3-14-17(18,15-4-2)16-9-7(11)5-6(10)8(12)13-9/h5H,3-4H2,1-2H3
¿Diagrama de estructura 2D / imagen disponible?

Click to access the Cambridge Crystallographic Data Centre (CCDC) website
Cambridge Crystallographic Data Centre diagrams:
Nombre Común Relación Vínculo
Chlorpyrifos - Click here for the CCDC structure diagram

Estado general: Click here for further information on the general chemical status information used on this site
Tipo de pesticida Insecticide
Grupo químico Organophosphate
Minimum active substance purity 970 g/kg
Known relevant impurities EU dossier - Sulfotep <3.0 g/kg, Acetone insolubles <5.0 g/kg
Sustancias de origen Sintéticas
Modo de acción Non-systemic with contact, inhalation and stomach action. Acetylcholinesterase (AChE) inhibitor.
CAS RN 2921-88-2
CEE número 220-864-4
Número CIPAC 221
EPA américaine chimiques de code 059101
PubChem CID 2730
Masa molecular (g mol-1) 350.58
PIN (Preferred Identification Name) O,O-diethyl O-(3,5,6-trichloropyridin-2-yl) phosphorothioate
Nombre IUPAC O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphorothioate
Nombre CAS O,O-diethyl O-(3,5,6-trichloro-2-pyridinyl) phosphorothioate
Otra información de estado OSPAR soc; WFD priority substance; Marine Pollutant
Relevant Environmental Water Quality Standards UK Environment Agency non-statutory standard for the protection of aquatic life: Freshwater annual average 0.002 ug/L, max acceptable conc 0.01 ug/L; Saltwater annual average 0.001 ug/L, max acceptable conc 0.01 ug/L
Herbicide Resistance Classification (HRAC) No aplicable
Herbicide Resistance Classification (WSSA) No aplicable
Insecticide Resistance Classification (IRAC) 1B
Fungicide Resistance Classification (FRAC) No aplicable
Examples of recorded resistance Aedes aegypti
Aedes nigromaculis
Anopheles pharoensis
Bemisia argentifolii
Culex pipiens pipiens
Helicoverpa armigera
Plutella xylostella
Spodoptera litura
Tribolium castaneum
plus others
Estado físico White to light brown coloured crystals
Related substances & organisms -

Formulaciones:
Propiedad Click here for information on the general product and branding information used on this site Valor
Example manufacturers & suppliers of products using this active now or historically
  • Dow AgroSciences
  • Headland
  • Makhteshim-Agan
  • SumiAgro
  • Scotts
Example products using this active
  • Alpha Chlorpyrifos
  • Ballad
  • Cyren
  • Dursban WG
  • Equity
  • Govern
  • Parapet
Estado de UK LERAP Buffer probably required in UK - see product label
Formulation and application details Usually supplied as an emulsifiable concentrates that is mixed with water and applied as a spray. Also supplied as granules for direct application to soil.


DESTINO AMBIENTAL

for chlorpyrifos

Propiedad Click here for information on the parameters used to describe environmental fate on this site Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with fate data Interpretación Click here for information on the way in which we interpret environmental fate data
Solubilidad - En aqua en 20oC (mg l-1) 1.05 A5 Bajo
Solubilidad - en solventes organicos en 20oC (mg l-1) 774000 A5 - Hexano -
290000 A5 - Metanol -
4000000 A5 - Acetato de etilo -
4000000 A5 - Tolueno -
Punto de fusión (oC) 42 A5 -
Punto de ebullición (oC) Decomposes before boiling A5 -
El punto de degradación (oC) 170 A5 -
Punto de inflamación (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-aqua coeficiente de particiónat en pH 7, 20oC P 5.01 X 1004 Calculado -
Log P 4.7 A5 Alto
Masa densidad (g ml-1)/Peso específico 1.51 A5 -
Disociación constante (pKa) at 25oC No aplicable A5 -
Nota: Ninguna disociación
Presión de vapor en 20oC (mPa) 1.43 A5 Baja volatilidad
Constante de Henry a 25oC (Pa m3 mol-1) 0.478 A5 Volátil moderado
Indice de potencial de lixiviación GUS Click here for a note on the limitations of the GUS index 1.04 Calculado Bajo posibilidad de lixiviación
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Valor 1.10 X 10-02 Calculado -
Nota -
Potencial para transportar de 'particle bound' Click here for a note on the limitations of the potential for particle bound transport index - Calculado Alto
Maximum UV-vis absorption L mol-1 cm-1 Neutral soln: 203nm=21174, 230nm=10359, 290nm=5620
Acid soln: 203nm=22223, 230nm=10347, 290nm=5907
Alkaline soln: 242nm=9413, 290nm=1633, 323nm=6701
A5 -
Surface tension (mN m-1) - - -

Degradación:
Propiedad Click here for information on the parameters used to describe substance degradation Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with degradation data Interpretación Click here for information on the way in which we interpret substance degradation data
Biodegradabilidad general Not readily biodegradable
Degradación de suelo (días) (aerobic) DT50 (típico) 386 A5 Persistente muy alta
DT50 (laboratorio en 20oC) 386 A5 Persistente muy alta
DT50 (campo) 27.6 A5 No persistente
DT90 (laboratorio en 20oC) 250 A5 EU 2005 data -
DT90 (campo) 113 A5 -
Endpoint de modelado DT50 23.4 A5 geometric mean -
Nota EU 2017 dossier Lab studies DT50 range 19.8->1000 days, Soils=8, Field - studies DT50 range 0.32-88.9 days, DT90 range 12.2-295 days, Soils =6
Dissipation rate RL50 on plant matrix Valor 3.3 R4 -
Nota Published literature RL50 range 0.7-10.0 days, 11 field & undercover grown crops, various matrices, n=12
Dissipation rate RL50 on and in plant matrix Valor 7.2 R4 -
Nota Published literature RL50 range 0.95-127.0 days, 30 field & undercover grown crops, various matrices, n=77
Acuoso fotólisis DT50 (días) en pH 7 Valor 29.6 A5 Lento
Nota -
Acuoso hidrólisis DT50 (días) en 20oC y pH 7 Valor 53.5 A5 Persistente moderado
Nota pH sensitive 63-73 days @ pH 5, 16-23 days @ pH 8
Aqua-Sedimento DT50 (días) 36.5 A5 Moderado rápido
Fase de agua sola DT50 (días) 5 A5 Moderado rápido

De absorción del suelo y la movilidad:
Propiedad Click here for information on the parameters used to describe substance adsorption and mobility Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretación Click here for information on the way in which we interpret substance adsorption and mobility
Lineal Kd 126.6 A5 No Móvil
Koc 5509
Notas y rango EU 2017 dossier Kd range 55.2-295 mL/g, Koc range 3187-7733 mL/g, Soils=5; Other sources: 6070 mL/g (DW3), >5000 (E4)
Freundlich Kf 91.6 A5 Móvil un poco
Kfoc 3954
1/n 0.92
Notas y rango EU 2017 dossier Kf range 45.2-234 mL/g, Kfoc range 1520-5442 mL./g, 1/n range 0.86-0.97, Soils=5
pH senbsibilidad No

Key metabolites:
Metabolito Medio de formación Maximó Calculado de Fracción Ocurrencia 1107/2009 Importancia Click here for further information on 1107/2009 relevancy
3,5,6-trichloro-2-pyridinol This metabolite may cause environmental pollution, click here for further information Suelo   0.602   Major fraction, Relevant
2,3,5-trichloro-6-methoxypyridine Suelo   0.087   Minor fraction, Relevant

Other known metabolites:
Metabolite name and reference Aliases Medio de formación / Rate Maximó Calculado de Fracción Ocurrencia Metabolising enzymes
O-ethyl-O-(3,5,6-trichloro-2-pyridyl)phosphorothioic acid phosphorothioate Water (Hydrolysis) >0.100 -


ECOTOXICOLOGÍA

for chlorpyrifos

Propiedad Click here for information on the parameters used to describe substance ecotoxicology Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretación Click here for information on the way in which we interpret substance ecotoxicology
Factor de la bio-concentración BCF (l kg-1) 1374 A5 (Other literature log BCF range 0.8-5.4 (R3) Umbral de importancia
CT50 (días) 2.5 -
Mamíferos - Agudos oral LD50 (mg kg-1) 66 A5 Rata Alto
Mamíferos - a corto plazo NOEL (mg kg-1) 1 L2 Rata, 2 año Alto
(ppm dieta) - -
Pájaros/aves - Agudos LD50 (mg kg-1) 39.2 A5 Colinus virginianus Alto
Birds - Short term dietary (LC50/LD50) 203 ppm A5 Anas platyrhynchos -
Pez - agudo 96 hora LC50 (mg l-1) 0.025 A5 Oncorhynchus mykiss Alto
Pez - Crónico 21 días NOEC (mg l-1) 0.00014 A5 Oncorhynchus mykiss Alto
Invertebrados acuáticos - Agudos 48 hora EC50 (mg l-1) 0.00010 A5 Daphnia magna Alto
Invertebrados acuáticos - Crónicos 21 días NOEC (mg l-1) 0.0046 A5 Daphnia magna Alto
Crustáceos acuáticos - Agudos 96 hora LC50 (mg l-1) 0.00004 F4 Americamysis bahia Alto
Sediment dwelling organisms - Agudos 96 hora LC50 (mg l-1) 0.000024 F4 Chironomus riparius Alto
Sediment dwelling organisms - Crónicos 28 día NOEC, estático, agua (mg l-1) 0.0001 F4 Chironomus riparius Alto
Sediment dwelling organisms - Crónicos 28 día NOEC, sedimento (mg kg-1) - - -
Plantas acuáticas - Agudos 7 día EC50, biomasa (mg l-1) 0.53 R4 Lemna minor Moderado
Non-target plants - - -
- - -
Algas - Agudos 72 hora EC50, crecimiento (mg l-1) 0.48 H4 Unknown species Moderado
Algas - Crónicos 96 hora NOEC, crecimiento (mg l-1) 0.043 Q2 Unknown species Moderado
Abejas mielíferas (Apis spp.) Contacto aguda LD50 (peor caso de 24 , 48 y 72 hora valores - μg abeja-1) 0.059 A5 Apis mellifera Alto
Oral aguda LD50 (peor caso de 24 , 48 y 72 hora valores - μg abeja-1) 0.25 A5 Apis mellifera Alto
Modo desconocido aguda LD50 (peor caso de 24 , 48 y 72 hora valores - μg abeja-1) - - -
Abejorros (Bombus spp.) Contacto aguda LD50 (peor caso de 24 , 48 y 72 hora valores - μg abeja-1) > 1.58 R4 Bombus terrestris, 72hr Moderado
Other literature values LD50 range 0.09- 2.39 ug/bee
Oral aguda LD50 (peor caso de 24 , 48 y 72 hora valores - μg abeja-1) 0.23 R4 Bombus terrestris for methyl variant Alto
-
Abejas albañiles (Osmia spp.) Contacto aguda LD50 (peor caso de 24 , 48 y 72 hora valores - μg abeja-1) 4.19 R4 Osmia bicornis Moderado
Oral aguda LD50 (peor caso de 24 , 48 y 72 hora valores - μg abeja-1) - - -
Otros polinizadores (1) Agudos LD50 (peor caso de 24 , 48 y 72 hora valores - μg insect-1) - - -
Modo de exposición -
Otros polinizadores (2) Agudos LD50 (peor caso de 24 , 48 y 72 hora valores - μg insect-1) - - -
Modo de exposición -
Lombrices - Agudos 14 día LC50 (mg kg-1) 129 A5 Eisenia foetida Moderado
Lombrices - Crónicos NOEC, reproducción (mg kg-1) 12.7 A5 Eisenia foetida Moderado
Other soil macro-organisms Agudos LC50 (mg kg-1) 0.2 A5 Folsomia candida, 35d LC50 -
Crónicos NOEC (mg kg-1) - - -
Otro arthropoda (1) LR50 g ha-1 0.2 A5 Aphidius colemani -
% Causalidad 100 Mortalidad
Dose: Field rate
Q2 Galendromus occidentalis
-
Otro arthropoda (2) LR50 g ha-1 1986 A5 Typhlodromus pyri -
% Causalidad 100 Mortalidad
Dose: Field rate
Q2 Neoseiulus fallacis
-
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: 4.8 kg ha-1
-
Mesocosm study data NOEAEC mg l-1 0.1 A5 EAC -
NOEAEC mg l-1 - - -


LA SALUD HUMANA Y PROTECCIÓN

for chlorpyrifos

General:
Propiedad Click here for information on the parameters used to describe human health and protection issues Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with human health and protection data Interpretación Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mamíferos - Agudos oral LD50 (mg kg-1) 66 A5 Rata Alto
Mammals - Dermal LD50 (mg kg-1 body weight) > 1250 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) 0.1 A5 Rat (whole body) -
Other Mammal toxicity endpoints - -
Consumo cada día aceptable (mg kg-1p.c. días-1) 0.001 A5 -
ARfD - Acute Reference Dose (mg kg-1p.c. días-1) 0.005 A5 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
El nivel de exposición del operador (AOEL) sistemíco (mg kg-1p.c. días-1) 0.001 A5 -
Estudios den la absorción cutánea (%) 0.2-25 A5 concentration & product dependent -
Directivo 76/464 Sustancias Peligrosas List I; List II - -
Exposure Routes Public Possible risks of exposure when close to spraying activity
Occupational PPE/PPC required to mitigate any expsoure risks
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards Non-statutory WHO drinking water guideline 0.03 mg/L UK EA QS database, 2018 -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Genotóxico Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

A3; B3; C3; D0; E3

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

Cuestiones generales de la salud humana Highly toxic by ingestion
Some studies indicate a link between chlorpyrifos metabolites and learning difficulties in children
Suspected cardiovascular & blood toxicant
Clave: Genotoxicidad
A: Aberración cromosómica (base de datos EFSA)
B: Daño/reparación del ADN (base de datos EFSA)
C: Mutación genética (base de datos EFSA)
D: Mutación del genoma (base de datos EFSA)
E: Tipo de genotoxicidad no especificada (fuente de datos diversos)
0: Sin datos
1: Positivo
2: Resultados mixtos/ambiguos
3: Negativo
Clave: Otro
: Sí, se sabe que causa un problema
: No, sabe no causar un problema
: Posiblemente, estado no identificado
- : Datos no encontrados

Handling issues:
Propiedad Click here for information on the parameters used to describe substance handling issues Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with data on handling issues Interpretación Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive or oxidising
IMDG Transport Code is 6.1
CLP classification 2013 Health: H301
Environment: H400, H410
CEE clasificación de riesgos Click here to view information omn the EU risk phrases T - Toxic: R25
Xn - Harmful: R21, R43
N - Dangerous for the environment: R50, R53
CEE clasificación sin riesgos Click here to view information omn the EU safety phrases S1/2, S45, S60, S61
Clasificación de OSM II - Peligroso mediano
Número de las NU Active 2783, liquid products usually 3018
Waste disposal & packaging Click here for a description of UN packaging marks Packaging Group III (minor danger)


TRADUCCIONES

for chlorpyrifos

Idioma Nombre
Inglés chlorpyrifos
Francés chlorpyriphos
Alemán Chlorpyrifos
Danés chlorpyrifos
Italiano clorpirifos
Español clorpirifos
Griego chlorpyrifos
Esloveno klorpirifos
Polaco chloropyrifos
Sueco klorpyrifos
Húngaro chlorpyrifos
Holandés chloorpyrifos

Última actualización del registro: Thursday 14 November 2019
Contacto: aeru@herts.ac.uk