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ciprodinil (Ref: CGA 219417)
** cyprodinil ** Traducciones

Destino ambiental - Ecotoxicología - La salud humana - A a Z Indice - Inicio

RESUMEN

Cyprodinil is a systemic, broad-spectrum fungicide that has approval for use in the EU. It has a low solubility, is unlikely to leach to groundwater and is volatile. It soils it is moderately persistent in water systems its persistent depends upon local conditions and it is likely to degrade quickly in daylight. It is moderately toxic to mammals and their is some concern that it may bioaccumulate. Whilst it is a recognised irritant no serious human health concerns have been identified. It is moderately toxic to birds, most aquatic organisms and earthworms. It is not considered toxic to honeybees.

INFORMACIÓN GENERAL Click here for an explantaion of the general chemical status information
for cyprodinil

Descripción: A broad spectrum foliar fungicide used to control a range of pathogens mainly on fruit

Ejemplos de plagas controladas: Grey mould; Scab; Powdery mildew; Botrytis; Eyespot

Ejemplos de aplicaciones: Fruit including grapes, apples, pears, plums, strawberries; Almonds; Ornamentals; Cereals

Eficacia y actividad: Wheat/Eyespot=High; Wheat/Mildew=Low; Barley/Rhynchosporium=Low; Barley/Net blotch=Low; Barley/Ramularia=Low

Availability status: Current

Introduction & key dates: 1994, first reported & marketed

CEE Regulación 1107/2009 ( 91/414):
Estado Approved
Dossier rapporteur/co-rapporteur France/Belgium
Date inclusion expires 30/04/2020
UE Candidatas a sustitución Yes - two 'Persistent-Bioaccumulative-Toxic' criteria
Incluido en la base de datos de la UE Sí

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia, Estados Unidos

Estructura química: Click here for further information on the general chemical status information used on this site
Isomerism -
Fórmula química C14H15N3
Canonical SMILES CC1=NC(=NC(=C1)C2CC2)NC3=CC=CC=C3
Isomeric SMILES No data
International Chemical Identifier Key (InChIKey) HAORKNGNJCEJBX-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C14H15N3/c1-10-9-13(11-7-8-11)17-14(15-10)16-12-5-3-2-4-6-12/h2-6,9,11H,7-8H2,1H3,(H,15,16,17)
¿Diagrama de estructura 2D / imagen disponible? Sí

Click to access the Cambridge Crystallographic Data Centre (CCDC) website
Cambridge Crystallographic Data Centre diagrams:
Nombre Común Relación Vínculo
Cyprodinil - Click here for the CCDC structure diagram

Estado general: Click here for further information on the general chemical status information used on this site
Tipo de pesticida Fungicide
Grupo químico Anilinopyrimidine
Minimum active substance purity 980 g/kg
Known relevant impurities EU dossier - None declared
Sustancias de origen Sintéticas
Modo de acción Systemic, absorbed through foliage. Inhibits protein synthesis.
CAS RN 121552-61-2
CEE número -
Número CIPAC 511
EPA américaine chimiques de code 288202
PubChem CID 86367
Masa molecular (g mol-1) 225.29
PIN (Preferred Identification Name) 4-cyclopropyl-6-methyl-N-phenylpyrimidin-2-amine
Nombre IUPAC 4-cyclopropyl-6-methyl-N-phenylpyrimidin-2-amine
Nombre CAS 4-cyclopropyl-6-methyl-N-phenyl-2-pyrimidinamine
Otra información de estado -
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) No aplicable
Herbicide Resistance Classification (WSSA) No aplicable
Insecticide Resistance Classification (IRAC) No aplicable
Fungicide Resistance Classification (FRAC) 9
Examples of recorded resistance -
Estado físico Beige powder
Related substances & organisms

Formulaciones:
Propiedad Click here for information on the general product and branding information used on this site Valor
Example manufacturers & suppliers of products using this active now or historically
  • DuPont
  • Syngenta
  • Ciba
Example products using this active
  • Acanto Prima
  • Kayak
  • Switch
  • Unix
Estado de UK LERAP Buffer probably required in UK - see product label
Formulation and application details Often supplied as an emulsifiable concentrate or wettable granules which are mixed with water and applied as a spray.


DESTINO AMBIENTAL
for cyprodinil

Propiedad Click here for information on the parameters used to describe environmental fate on this site Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with fate data Interpretación Click here for information on the way in which we interpret environmental fate data
Solubilidad - En aqua en 20oC (mg l-1) 13 B5 Bajo
Solubilidad - en solventes organicos en 20oC (mg l-1) 500000 A5 - Acetona -
440000 A5 - Tolueno -
500000 A5 - Cloruro de metileno -
26000 A5 - n-Hexano -
Punto de fusión (oC) 75.9 A5 -
Punto de ebullición (oC) - - -
El punto de degradación (oC) - - -
Punto de inflamación (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-aqua coeficiente de particiónat en pH 7, 20oC P 1.00 X 1004 Calculado -
Log P 4 B5 Alto
Masa densidad (g ml-1)/Peso específico 1.21 A5 -
Disociación constante (pKa) at 25oC 4.44 B5 -
Nota: Base débil
Presión de vapor en 20oC (mPa) 5.10 X 10-01 B5 Baja volatilidad
Constante de Henry a 25oC (Pa m3 mol-1) 6.60 X 10-03 A5 No volátil
Indice de potencial de lixiviación GUS Click here for a note on the limitations of the GUS index 1.11 Calculado Bajo posibilidad de lixiviación
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Valor 2.33 X 10-02 Calculado -
Nota -
Potencial para transportar de 'particle bound' Click here for a note on the limitations of the potential for particle bound transport index - Calculado Mediano
Maximum UV-vis absorption L mol-1 cm-1 Neutral solution: 270.8nm = 29200; [Acidic solution: 271.6nm = 23400, 316.8nm = 5700; [Basic solution: 270.8nm = 28400 A5 -
Surface tension (mN m-1) 57.7 - 62.6 A5 at 20oC -

Degradación:
Propiedad Click here for information on the parameters used to describe substance degradation Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with degradation data Interpretación Click here for information on the way in which we interpret substance degradation data
Biodegradabilidad general -
Degradación de suelo (días) (aerobic) DT50 (típico) 37 A5 Persistente moderado
DT50 (laboratorio en 20oC) 53 A5 Persistente moderado
DT50 (campo) 45 A5 Persistente moderado
DT90 (laboratorio en 20oC) 120 A5 -
DT90 (campo) - - -
Endpoint de modelado DT50 - - -
Nota EU dossier lab studies DT50 range 31-41 days, DT90 range 103-135 days, field studies DT50 range 11-98 days
Dissipation rate RL50 on plant matrix Valor 8.1 R4 -
Nota Published literature RL50 range 2.6-9.7 days, 6 field & undercover grown crops, various matrices, n=9; Grapes in cold storage RL50=30 days.
Dissipation rate RL50 on and in plant matrix Valor 8.0 R4 -
Nota Published literature RL50 range 2.3-16.7 days, 5 field & undercover grown crops, various matrices, n=9; Peppers in cold storage RL50=49 days.
Acuoso fotólisis DT50 (días) en pH 7 Valor 13.5 A5 Moderado rápido
Nota -
Acuoso hidrólisis DT50 (días) en 20oC y pH 7 Valor Estable A5 -
Nota Stable pH 4 to pH 9
Aqua-Sedimento DT50 (días) 142 A5 Lento
Fase de agua sola DT50 (días) 12.5 A5 Moderado rápido

De absorción del suelo y la movilidad:
Propiedad Click here for information on the parameters used to describe substance adsorption and mobility Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretación Click here for information on the way in which we interpret substance adsorption and mobility
Lineal Kd - - -
Koc -
Notas y rango -
Freundlich Kf 21.27 A5 Móvil un poco
Kfoc 2277
1/n 0.888
Notas y rango EU dossier kf range 12.3-355.55, Kfoc range 1618-4393 mL/g, 1/n range 0.839-0.931, Soils=5
pH senbsibilidad No

Key metabolites:
Metabolito Medio de formación Maximó Calculado de Fracción Ocurrencia 1107/2009 Importancia Click here for further information on 1107/2009 relevancy
4-cyclopropyl-6-methyl-pyrimidine-2-ylamine (Ref: CGA 249287) Suelo   0.098   Minor fraction, Relevant
3-(4-cyclopropyl-6-methylpyrimidin-2-ylamino)phenol (Ref: CGA 275535) This metabolite may cause environmental pollution, click here for further information Suelo   0.230   Major fraction, Relevant
6-cyclopropyl-2-phenylamino-pyrimidin-4-yl)-methanol (Ref: CGA 232449) Plant   -   Non relevant

Other known metabolites:
Metabolite name and reference Aliases Medio de formación / Rate Maximó Calculado de Fracción Ocurrencia Metabolising enzymes
(6-cyclopropyl-2-phenylamino-pyrimidin-4-yl)-methanol
(Ref: CGA 232449) 		- Rat; Plant - -
4-(4-cyclopropyl-6-methyl-pyrimidin-2-yl-amino)-phenol
(Ref: CGA 304075) 		- Plant; Animal; Soil - -
4-cyclopropyl-6-methyl-2-phenylamino-pyrimidin-5-ol
(Ref: CGA 304076) 		- Soil - -
4-cyclopropyl-6-methyl-pyrimidin-2-ol
(Ref: CGA 321915)
Nota: LD50 rat > 2000 mg kg-1 bw 		- Plant; Animal; Soil - -
(2-amino-6-cyclopropyl-pyrimidin-4-yl)-methanol
(Ref: NOA 422054)
Nota: LD50 rat > 2000 mg kg-1 bw 		- Plant; Animal - -


ECOTOXICOLOGÍA
for cyprodinil

Propiedad Click here for information on the parameters used to describe substance ecotoxicology Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretación Click here for information on the way in which we interpret substance ecotoxicology
Factor de la bio-concentración BCF (l kg-1) 393 A5 Whole fish Umbral de importancia
CT50 (días) 0.5 -
Mamíferos - Agudos oral LD50 (mg kg-1) > 2000 B5 Rata Bajo
Mamíferos - a corto plazo NOEL (mg kg-1) 3 L2 Rata, 2 año Alto
(ppm dieta) - -
Pájaros/aves - Agudos LD50 (mg kg-1) > 500 A5 Anas platyrhynchos Moderado
Birds - Short term dietary (LC50/LD50) > 1534 mg kg-1 bw/día A5 Anas platyrhynchos -
Pez - agudo 96 hora LC50 (mg l-1) 2.41 A5 Oncorhynchus mykiss Moderado
Pez - Crónico 21 días NOEC (mg l-1) 0.083 A5 Oncorhynchus mykiss Moderado
Invertebrados acuáticos - Agudos 48 hora EC50 (mg l-1) 0.22 A5 Daphnia magna Moderado
Invertebrados acuáticos - Crónicos 21 días NOEC (mg l-1) 0.0088 A5 Daphnia magna Alto
Crustáceos acuáticos - Agudos 96 hora LC50 (mg l-1) - - -
Sediment dwelling organisms - Agudos 96 hora LC50 (mg l-1) - - -
Sediment dwelling organisms - Crónicos 28 día NOEC, estático, agua (mg l-1) 0.24 A5 Chironomus riparius Moderado
Sediment dwelling organisms - Crónicos 28 día NOEC, sedimento (mg kg-1) - - -
Plantas acuáticas - Agudos 7 día EC50, biomasa (mg l-1) 7.71 A5 Lemna gibba Moderado
Non-target plants - - -
- - -
Algas - Agudos 72 hora EC50, crecimiento (mg l-1) 2.6 A5 Pseudokirchneriella subcapitata Moderado
Algas - Crónicos 96 hora NOEC, crecimiento (mg l-1) - - -
Abejas mielíferas (Apis spp.) Contacto aguda LD50 (peor caso de 24 , 48 y 72 hora valores - μg abeja-1) > 784 A5 Bajo
Oral aguda LD50 (peor caso de 24 , 48 y 72 hora valores - μg abeja-1) 112.5 A5 Bajo
Modo desconocido aguda LD50 (peor caso de 24 , 48 y 72 hora valores - μg abeja-1) - - -
Abejorros (Bombus spp.) Contacto aguda LD50 (peor caso de 24 , 48 y 72 hora valores - μg abeja-1) - - -
-
Oral aguda LD50 (peor caso de 24 , 48 y 72 hora valores - μg abeja-1) - - -
-
Abejas albañiles (Osmia spp.) Contacto aguda LD50 (peor caso de 24 , 48 y 72 hora valores - μg abeja-1) - - -
Oral aguda LD50 (peor caso de 24 , 48 y 72 hora valores - μg abeja-1) - - -
Otros polinizadores (1) Agudos LD50 (peor caso de 24 , 48 y 72 hora valores - μg insect-1) - - -
Modo de exposición -
Otros polinizadores (2) Agudos LD50 (peor caso de 24 , 48 y 72 hora valores - μg insect-1) - - -
Modo de exposición -
Lombrices - Agudos 14 día LC50 (mg kg-1) 192 B5 Moderado
Lombrices - Crónicos 14 día NOEC, reproducción (mg kg-1) - - -
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Causalidad - - -
Otro arthropoda (1) LR50 g ha-1 1470 48 hora
A5 Aphidius rhopalosiphi, adult 		-
% Causalidad 46 Mortalidad
Dose: 0.75 kg ha-1
A5 Aphidius rhopalosiphi, adult 		-
Otro arthropoda (2) LR50 g ha-1 2250 7 día
A5 Typhlodromus pyri, protonymph 		-
% Causalidad 10 Mortalidad
Dose: 0.75 kg ha-1
A5 Typhlodromus pyri, protonymph 		-
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect 		A5
Dose: 26.7 mg kg-1 soil 		-
Mesocosm study data NOEAEC mg l-1 0.013 A5 Aquatic community -
NOEAEC mg l-1 - - -


LA SALUD HUMANA Y PROTECCIÓN
for cyprodinil

General:
Propiedad Click here for information on the parameters used to describe human health and protection issues Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with human health and protection data Interpretación Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mamíferos - Agudos oral LD50 (mg kg-1) > 2000 B5 Rata Bajo
Mammals - Dermal LD50 (mg kg-1 body weight) > 2000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) > 1.2 A5 Rat -
Other Mammal toxicity endpoints - -
Consumo cada día aceptable (mg kg-1p.c. días-1) 0.03 A5 Rat, SF=100 -
ARfD - Acute Reference Dose (mg kg-1p.c. días-1) Ningunos asignaron A5 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
El nivel de exposición del operador (AOEL) sistemíco (mg kg-1p.c. días-1) 0.03 A5 Rat, SF=100 -
Estudios den la absorción cutánea (%) 0.5-6.0 A5 concentration dependent -
Directivo 76/464 Sustancias Peligrosas - - -
Exposure Routes Public No unacceptable risks to bystanders identified
Occupational -
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Genotóxico Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

A3; B3; C3; D0; E3

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

Cuestiones generales de la salud humana No further information available
Clave: Genotoxicidad
A: Aberración cromosómica (base de datos EFSA)
B: Daño/reparación del ADN (base de datos EFSA)
C: Mutación genética (base de datos EFSA)
D: Mutación del genoma (base de datos EFSA)
E: Tipo de genotoxicidad no especificada (fuente de datos diversos)
0: Sin datos
1: Positivo
2: Resultados mixtos/ambiguos
3: Negativo		 Clave: Otro
: Sí, se sabe que causa un problema
: No, sabe no causar un problema
: Posiblemente, estado no identificado
- : Datos no encontrados

Handling issues:
Propiedad Click here for information on the parameters used to describe substance handling issues Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with data on handling issues Interpretación Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive
IMDG Transport Code is usually 9
CLP classification 2013 Health: H317
Environment: H400, H410
CEE clasificación de riesgos Click here to view information omn the EU risk phrases Xn - Harmful: R43
N - Dangerous for the environment: R50, R53
CEE clasificación sin riesgos Click here to view information omn the EU safety phrases S2, S24, S37, S46, S60, S61
Clasificación de OSM III - company classification - Peligroso un poco
Número de las NU Variable with product, usually 3077 or 3082
Waste disposal & packaging Click here for a description of UN packaging marks Packaging Group III (minor danger)


TRADUCCIONES
for cyprodinil

Idioma Nombre
Inglés cyprodinil
Francés cyprodinil
Alemán Cyprodinil
Danés cyprodinil
Italiano cyprodinil
Español ciprodinil
Griego -
Esloveno ciprodinil
Polaco cyprodynil
Sueco cyprodinil
Húngaro cyprodinil
Holandés cyprodinil

Última actualización del registro: Tuesday 25 June 2019
Contacto: aeru@herts.ac.uk