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difetialone (Ref: OMS 3053)
** difethialone ** LM 2219 ** Traducciones

Destino ambiental - Ecotoxicología - La salud humana - A a Z Indice - Inicio

RESUMEN

Difethialone is a rodenticide not approved for use in Europe but is still used elsewhere. It is relatively volatile, has low potential to leach to groundwater but is highly persistent in soils. It is highly toxic to humans and considered to produce adverse effects on the reproduction system. it is also highly toxic to birds and aquatic life.

INFORMACIÓN GENERAL Click here for an explantaion of the general chemical status information
for difethialone

Descripción: A rodenticide for use against warfarin-resistant and warfarin-susceptible strains of Rattus norvegicus and Mus musculus

Ejemplos de plagas controladas: Rats; Mice; Other small rodents

Ejemplos de aplicaciones: -

Eficacia y actividad: -

Availability status: Current

Introduction & key dates: 1989, France

CEE Regulación 1107/2009 ( 91/414):
Estado Not approved
Dossier rapporteur/co-rapporteur Norway
Date inclusion expires Expired
UE Candidatas a sustitución -
Incluido en la base de datos de la UE

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia, Estados Unidos

Estructura química: Click here for further information on the general chemical status information used on this site
Isomerism A molecule with 2 chiral centres
Fórmula química C31H23BrO2S
Canonical SMILES C1C(CC2=CC=CC=C2C1C3=C(SC4=CC=CC=C4C3=O)O)C5=CC=C(C=C5)C6=CC=C(C=C6)Br
Isomeric SMILES No data
International Chemical Identifier Key (InChIKey) JHELOZJAKXYVBE-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C31H23BrO2S/c32-24-15-13-20(14-16-24)19-9-11-21(12-10-19)23-17-22-5-1-2-6-25(22)27(18-23)29-30(33)26-7-3-4-8-28(26)35-31(29)34/h1-16,23,27,33H,17-18H2
¿Diagrama de estructura 2D / imagen disponible?

Estado general: Click here for further information on the general chemical status information used on this site
Tipo de pesticida Rodenticide
Grupo químico Coumarin anticoagulant
Minimum active substance purity 976 g/kg
Known relevant impurities EU dossier - None declared
Sustancias de origen Sintéticas
Modo de acción Anticoagulant, locks onto the rodent's liver enzyme
CAS RN 104653-34-1
CEE número -
Número CIPAC 549
EPA américaine chimiques de code 128967
PubChem CID 91771
Masa molecular (g mol-1) 539.48
PIN (Preferred Identification Name) 3-[(1E,3E)-3-(4'-bromo[1,1'-biphenyl]-4-yl)-1,2,3,4-tetrahydronaphthalen-1-yl]-4-hydroxy-2H-1-benzothiopyran-2-one where the ratios of the racemates (1RS,3RS) to (1RS,3SR) lie within the ranges 015 to 85100 respectively
Nombre IUPAC 3-[3-(4'-bromo[1,1'-biphenyl]-4-yl)-1,2,3,4-tetrahydro-1-naphthalenyl]-4-hydroxy-2H-1-benzothiopyran-2-one
Nombre CAS -
Otra información de estado -
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) No aplicable
Herbicide Resistance Classification (WSSA) No aplicable
Insecticide Resistance Classification (IRAC) No aplicable
Fungicide Resistance Classification (FRAC) No aplicable
Examples of recorded resistance -
Estado físico White-yellow powder
Related substances & organisms -

Formulaciones:
Propiedad Click here for information on the general product and branding information used on this site Valor
Example manufacturers & suppliers of products using this active now or historically
  • Kukbo Science Co. Ltd.
  • Bayer CropScience
Example products using this active
  • Veteran Pellet
  • Veteran Wax Block
  • Rodilon Rat Bait
Estado de UK LERAP No UK approval for use as a pesticide under EC Regulation 1107/2009
Formulation and application details -


DESTINO AMBIENTAL

for difethialone

Propiedad Click here for information on the parameters used to describe environmental fate on this site Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with fate data Interpretación Click here for information on the way in which we interpret environmental fate data
Solubilidad - En aqua en 20oC (mg l-1) 0.392 A5 Bajo
Solubilidad - en solventes organicos en 20oC (mg l-1) 100000 C4 - Acetona -
14000 A5 - Cloruro de metileno -
470 L3 - Metanol -
200 L3 - Hexano -
Punto de fusión (oC) 235 A5 -
Punto de ebullición (oC) - - -
El punto de degradación (oC) - - -
Punto de inflamación (oC) - - -
Octanol-aqua coeficiente de particiónat en pH 7, 20oC P 1.95 X 1006 Calculado -
Log P 6.29 A5 Alto
Masa densidad (g ml-1)/Peso específico 1.36 L3 -
Disociación constante (pKa) at 25oC - - -
Nota:
Presión de vapor en 20oC (mPa) 0.0133 A5 Baja volatilidad
Constante de Henry a 25oC (Pa m3 mol-1) 1.02 X 10-01 L3 Volátil moderado
Indice de potencial de lixiviación GUS Click here for a note on the limitations of the GUS index -10.46 Calculado Bajo posibilidad de lixiviación
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Valor 5.35 X 10-03 Calculado -
Nota Estimated concentrations of chemicals with Koc values greater than 9995 ml g-1 are beyond the scope of the regression data used in SCI-GROW development. If there are concerns for such chemicals, a higher tier groundwater exposure assessment should be considered, regardless of the concentration returned by SCI-GROW
Potencial para transportar de 'particle bound' Click here for a note on the limitations of the potential for particle bound transport index - Calculado Alto
Maximum UV-vis absorption L mol-1 cm-1 Maxima at 234nm, 260nm and 330nm A2 -
Surface tension (mN m-1) - - -

Degradación:
Propiedad Click here for information on the parameters used to describe substance degradation Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with degradation data Interpretación Click here for information on the way in which we interpret substance degradation data
Biodegradabilidad general -
Degradación de suelo (días) (aerobic) DT50 (típico) 635 A3 Persistente muy alta
DT50 (laboratorio en 20oC) 635 A3 Persistente muy alta
DT50 (campo) - - -
DT90 (laboratorio en 20oC) - - -
DT90 (campo) - - -
Endpoint de modelado DT50 - - -
Nota EU dossier lab studies DT50 range 417-976 days, @12 degC
Dissipation rate RL50 on plant matrix Valor - - -
Nota -
Dissipation rate RL50 on and in plant matrix Valor - - -
Nota -
Acuoso fotólisis DT50 (días) en pH 7 Valor - - -
Nota -
Acuoso hidrólisis DT50 (días) en 20oC y pH 7 Valor - - -
Nota -
Aqua-Sedimento DT50 (días) - - -
Fase de agua sola DT50 (días) - - -

De absorción del suelo y la movilidad:
Propiedad Click here for information on the parameters used to describe substance adsorption and mobility Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretación Click here for information on the way in which we interpret substance adsorption and mobility
Lineal Kd - L3 No Móvil
Koc 54000000
Notas y rango -
Freundlich Kf - - -
Kfoc -
1/n -
Notas y rango -
pH senbsibilidad -


ECOTOXICOLOGÍA

for difethialone

Propiedad Click here for information on the parameters used to describe substance ecotoxicology Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretación Click here for information on the way in which we interpret substance ecotoxicology
Factor de la bio-concentración BCF (l kg-1) 39974 A5 Alto potencial
CT50 (días) No disponible -
Mamíferos - Agudos oral LD50 (mg kg-1) 0.56 F4 Rata Alto
Mamíferos - a corto plazo NOEL (mg kg-1) - - -
(ppm dieta) - -
Pájaros/aves - Agudos LD50 (mg kg-1) 0.264 A5 Colinus virginianus Alto
Birds - Short term dietary (LC50/LD50) 0.56 mg kg feed-1 A5 Colinus virginianus -
Pez - agudo 96 hora LC50 (mg l-1) 0.051 A5 Oncorhynchus mykiss Alto
Pez - Crónico 21 días NOEC (mg l-1) - - -
Invertebrados acuáticos - Agudos 48 hora EC50 (mg l-1) 0.0044 A5 Daphnia magna Alto
Invertebrados acuáticos - Crónicos 21 días NOEC (mg l-1) - - -
Crustáceos acuáticos - Agudos 96 hora LC50 (mg l-1) - - -
Sediment dwelling organisms - Agudos 96 hora LC50 (mg l-1) - - -
Sediment dwelling organisms - Crónicos 28 día NOEC, estático, agua (mg l-1) - - -
Sediment dwelling organisms - Crónicos 28 día NOEC, sedimento (mg kg-1) - - -
Plantas acuáticas - Agudos 7 día EC50, biomasa (mg l-1) - - -
Non-target plants - - -
- - -
Algas - Agudos 72 hora EC50, crecimiento (mg l-1) > 0.18 A5 Pseudokirchneriella subcapitata Moderado
Algas - Crónicos 96 hora NOEC, crecimiento (mg l-1) 0.032 A5 Selenastrum capricornutum, Growth Moderado
Abejas mielíferas Contacto aguda 48 hora LD50 (μg abeja-1) - - -
Oral aguda 48 hora LD50 (μg abeja-1) - - -
Modo desconocido aguda 48 hora LD50 (μg abeja-1) - - -
Lombrices - Agudos 14 día LC50 (mg kg-1) > 1000 A4 Bajo
Lombrices - Crónicos 14 día NOEC, reproducción (mg kg-1) - - -
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Causalidad - - -
Otro arthropoda (1) LR50 g ha-1 - - -
% Causalidad - - -
Otro arthropoda (2) LR50 g ha-1 - - -
% Causalidad - - -
Soil micro-organisms - - -
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


LA SALUD HUMANA Y PROTECCIÓN

for difethialone

General:
Propiedad Click here for information on the parameters used to describe human health and protection issues Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with human health and protection data Interpretación Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mamíferos - Agudos oral LD50 (mg kg-1) 0.56 F4 Rata Alto
Mammals - Dermal LD50 (mg kg-1 body weight) 5.3 L3 Rat -
Mammals - Inhalation LC50 (mg l-1) 0.005 L3 Rat -
Other Mammal toxicity endpoints - -
Consumo cada día aceptable (mg kg-1p.c. días-1) - - -
ARfD - Acute Reference Dose (mg kg-1p.c. días-1) - - -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
El nivel de exposición del operador (AOEL) sistemíco (mg kg-1p.c. días-1) - - -
Estudios den la absorción cutánea (%) - - -
Directivo 76/464 Sustancias Peligrosas - - -
Limites de exposiciones - - -
Exposure Routes Public -
Occupational May be absorbed through the skin
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutágeno Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

-

-

-

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

Cuestiones generales de la salud humana Highly toxic
May cause severe haemorrhage leading to death

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Propiedad Click here for information on the parameters used to describe substance handling issues Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with data on handling issues Interpretación Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive or oxidising
CLP classification 2013 None allocated at this time
CEE clasificación de riesgos Click here to view information omn the EU risk phrases Reproduction risk category 2: R61
T+ - Highly toxic: R26/27/28
T - Toxic: R48/23/24/25
N - Dangerous for the environment: R50, R53
CEE clasificación sin riesgos Click here to view information omn the EU safety phrases S45, S53, S60, S61
Clasificación de OSM Ia - Peligroso extremo
US EPA Classification (formulation) I - Danger - Highly toxic
Número de las NU 2588
Waste disposal & packaging Click here for a description of UN packaging marks -


TRADUCCIONES

for difethialone

Idioma Nombre
Inglés difethialone
Francés difethialone
Alemán Difethialone
Danés difethialon
Italiano difetialone
Español difetialone
Griego -
Esloveno difetialon
Polaco difetialon
Sueco -
Húngaro -
Holandés -

Última actualización del registro: Wednesday 23 May 2018
Contacto: aeru@herts.ac.uk