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famoxadona (Ref: JE 874)
** famoxadone ** DPX JE874 ** IN JE874 ** Traducciones

Destino ambiental - Ecotoxicología - La salud humana - A a Z Indice - Inicio

RESUMEN

Famoxadone is an oxazolidinedione fungicide that is approved for use in the EU. It has a low aqueous solubility, low risk of leaching to groundwater and is volatile. It is not persistent in soil or water. Whilst it has a low mammalian toxicity there is a slight concern regarding its ability to bioaccumulate. It is considered to be a neurotoxicant and is a known eye and skin irritant. It is highly toxic to fish and aquatic invertebrates and moderately toxic to other aquatic organisms, earthworms and honeybees.

INFORMACIÓN GENERAL Click here for an explantaion of the general chemical status information
for famoxadone

Descripción: A fungicide used to control a broad spectrum of plant pathogenic fungi including downy mildew and blights

Ejemplos de plagas controladas: Alternaria Leaf Blight, Anthracnose, Downy Mildew, Phytophthora blight

Ejemplos de aplicaciones: Potatoes; Tomatoes; Salad crops; Peppers; Cucurbits; Grapes

Eficacia y actividad: -

Availability status: Current

Introduction & key dates: 1996 first reported; 1998, first introduced

CEE Regulación 1107/2009 ( 91/414):
Estado Approved
Dossier rapporteur/co-rapporteur UK/Finland
Date inclusion expires 30/06/2019
UE Candidatas a sustitución Yes - two 'Persistent-Bioaccumulative-Toxic' criteria
Incluido en la base de datos de la UE

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Estados Unidos

Estructura química: Click here for further information on the general chemical status information used on this site
Isomerism A chiral molecule existing in the R- and S-forms
Fórmula química C22H18N2O4
Canonical SMILES CC1(C(=O)N(C(=O)O1)NC2=CC=CC=C2)C3=CC=C(C=C3)OC4=CC=CC=C4
Isomeric SMILES No data
International Chemical Identifier Key (InChIKey) PCCSBWNGDMYFCW-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C22H18N2O4/c1-22(16-12-14-19(15-13-16)27-18-10-6-3-7-11-18)20(25)24(21(26)28-22)23-17-8-4-2-5-9-17/h2-15,23H,1H3
¿Diagrama de estructura 2D / imagen disponible?

Click to access the Cambridge Crystallographic Data Centre (CCDC) website
Cambridge Crystallographic Data Centre diagrams:
Nombre Común Relación Vínculo
S-famoxadone S-isomer Click here for the CCDC structure diagram

Estado general: Click here for further information on the general chemical status information used on this site
Tipo de pesticida Fungicide
Grupo químico Oxazole
Minimum active substance purity 960 g/kg
Known relevant impurities EU dossier - 1,5-diphenylcarbonohydrazide @ 0.0555 g/kg; 2-phenylacetohydrazide @ 0.3 g/kg; phenylhydazine @ 0.01 g/kg; benzene @ 0.05 g/kg
Sustancias de origen Sintéticas
Modo de acción Protectant with residual activity, interferes with plant respiratory system. Respiration inhibitor (QoL fungicide).
CAS RN 131807-57-3
CEE número 200-835-2
Número CIPAC 594
EPA américaine chimiques de code 113202
PubChem CID 213032
Masa molecular (g mol-1) 374.39
PIN (Preferred Identification Name) rac-(5R)-3-anilino-5-methyl-5-(4-phenoxyphenyl)-1,3-oxazolidine-2,4-dione
Nombre IUPAC (RS)-3-anilino-5-methyl-5-(4-phenoxyphenyl)-1,3-oxazolidine-2,4-dione
Nombre CAS 5-methyl-5-(4-phenoxyphenyl)-3-(phenylamino)-2,4-oxazolidinedione
Otra información de estado -
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) No aplicable
Herbicide Resistance Classification (WSSA) No aplicable
Insecticide Resistance Classification (IRAC) No aplicable
Fungicide Resistance Classification (FRAC) 11
Examples of recorded resistance -
Estado físico Pale cream powder
Related substances & organisms

Formulaciones:
Propiedad Click here for information on the general product and branding information used on this site Valor
Example manufacturers & suppliers of products using this active now or historically
  • DuPont
  • Syngenta
Example products using this active
  • Medley
  • Tanos
  • Famoxate
  • Equation Pro
Estado de UK LERAP Buffer probably required in UK - see product label
Formulation and application details -


DESTINO AMBIENTAL

for famoxadone

Propiedad Click here for information on the parameters used to describe environmental fate on this site Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with fate data Interpretación Click here for information on the way in which we interpret environmental fate data
Solubilidad - En aqua en 20oC (mg l-1) 0.059 A5 Bajo
Solubilidad - en solventes organicos en 20oC (mg l-1) 274000 A5 - Acetona -
13300 A5 - Tolueno -
48 A5 - Hexano -
125000 A5 - Acetato de etilo -
Punto de fusión (oC) 141.3 A5 -
Punto de ebullición (oC) Decomposes before boiling A5 -
El punto de degradación (oC) 275 A5 -
Punto de inflamación (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-aqua coeficiente de particiónat en pH 7, 20oC P 4.47 X 1004 Calculado -
Log P 4.65 A5 Alto
Masa densidad (g ml-1)/Peso específico 1.31 A5 -
Disociación constante (pKa) at 25oC No aplicable A5 -
Nota: Ninguna disociación
Presión de vapor en 20oC (mPa) 0.00064 A5 Baja volatilidad
Constante de Henry a 25oC (Pa m3 mol-1) 4.06 X 10-03 A5 No volátil
Indice de potencial de lixiviación GUS Click here for a note on the limitations of the GUS index 1.35 Calculado Bajo posibilidad de lixiviación
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Valor 3.19 X 10-02 Calculado -
Nota -
Potencial para transportar de 'particle bound' Click here for a note on the limitations of the potential for particle bound transport index - Calculado Alto
Maximum UV-vis absorption L mol-1 cm-1 231nm = 553, shoulder at 275-280nm, no absorption after 290nm A5 -
Surface tension (mN m-1) 73.0 A5 -

Degradación:
Propiedad Click here for information on the parameters used to describe substance degradation Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with degradation data Interpretación Click here for information on the way in which we interpret substance degradation data
Biodegradabilidad general -
Degradación de suelo (días) (aerobic) DT50 (típico) 41.1 A5 Persistente moderado
DT50 (laboratorio en 20oC) 41.1 A5 Persistente moderado
DT50 (campo) 20 F4 No persistente
DT90 (laboratorio en 20oC) 152 A5 -
DT90 (campo) - - -
Endpoint de modelado DT50 - - -
Nota 2015 EU Dossier Lab studies DT50 range 8.0-104.3 days, DT90 range 27.5-214 days
Dissipation rate RL50 on plant matrix Valor 12.3 R3 -
Nota Grape berries, n=1
Dissipation rate RL50 on and in plant matrix Valor 10.0 R4 -
Nota Published literature RL50 range 6.3-18.0 days, 4 field & undercover grown crops, various matrices, n=5
Acuoso fotólisis DT50 (días) en pH 7 Valor 1.9 A5 Moderado rápido
Nota -
Acuoso hidrólisis DT50 (días) en 20oC y pH 7 Valor 2 A5 No persistente
Nota pH sensitive: DT50 41 days at pH 5, 1.5 hours at pH 9 all at 25 deg C
Aqua-Sedimento DT50 (días) 0.7 A5 Rápido
Fase de agua sola DT50 (días) 0.1 A5 Rápido

De absorción del suelo y la movilidad:
Propiedad Click here for information on the parameters used to describe substance adsorption and mobility Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretación Click here for information on the way in which we interpret substance adsorption and mobility
Lineal Kd 52.2 A5 Móvil un poco
Koc 3847
Notas y rango 2015 EU dossier Kd range 23.4-89.1 mL/g, Koc range 3307-4950 mL/g, soils=3
Freundlich Kf 40.98 A5 (2015 EU dossier) Móvil un poco
Kfoc 1455
1/n 0.832
Notas y rango 2015 EU dossier Kf range 4.5-127.0 mL/g, Kfoc range 587-3414 mL/g, Soils=4
pH senbsibilidad No

Key metabolites:
Metabolito Medio de formación Maximó Calculado de Fracción Ocurrencia 1107/2009 Importancia Click here for further information on 1107/2009 relevancy
alpha-hydroxy-alpha-methyl-4-phenoxybenzene acetic acid (Ref: IN-JS940) This metabolite may cause environmental pollution, click here for further information Suelo   0.278   Major fraction, Relevancy unknown
5-[4-(4-hydroxyphenoxy)phenyl-5-methyl-3-(phenylamino)-2,4-oxazolidine dione (Ref: IN-KZ007) This metabolite may cause environmental pollution, click here for further information Suelo   0.162   Minor fraction, Relevancy unknown

Other known metabolites:
Metabolite name and reference Aliases Medio de formación / Rate Maximó Calculado de Fracción Ocurrencia Metabolising enzymes
N-(4-hydroxyphenol)acetamide
(Ref: IN-00915)
- Animal - -
fumaric acid
(Ref: IN-02162)
- Water (Photolysis) - -
formic acid
(Ref: IN-02317)
- Water (Photolysis) - -
1,2-benzenediol
(Ref: IN-03492)
- Hydrolysis; Water (Photolysis); Rat - -
4-aminophenyl acetate
(Ref: IN-BY759)
- Rat - -
4-aminophenyl
(Ref: IN-CH490)
- Animal - -
oxalic acid
(Ref: IN-DI994)
- Water (Photolysis) - -
benzenamine
(Ref: IN-E0933)
- Animal - -
3-aminophenol
(Ref: IN-EK332)
- Hen - -
1-(4-phenoxyphenyl_ethanone
(Ref: IN-H3310)
- Water (Hydrolysis); Water-Sediment systems; Plant; Animal - -
(Ref: IN-H3310)
Nota: DT50 soil = 0.6 days; Kfoc=2157 mL/g
- Water (Hydrolysis) - -
benzeneacetic acid
(Ref: IN-JL856)
- Water (Hydrolysis, Photolysis); Plant; Animal - -
5-methyl-5-(4-phenoxyphenyl)-2,4-oxazolidinedione
(Ref: IN-KF015)
Nota: DT50 soil = 0.7 days
- Water (Photolysis); Soil (Photolysis); Plant; Hen - -
potassium 2-phenylhydrazinecarboxylate
(Ref: IN-KT983)
- Hydrolysis - -
3-[(4-hydroxyphenyl)amino]-5-methyl-5-(4-phenoxyphenyl)-2,4-oxazoldinediol
(Ref: IN-KZ532)
- Plant; Animal - -
(Ref: IN-KZ534) - Plant; Animal - -
(Ref: IN-LM815) - Plant; Animal - -
N-phyenylacetamide
(Ref: IN-M0278)
- Goat - -
Phenol
(Ref: IN-M0371)
- Hydrolysis; Water (Photolysis) - -
(Ref: IN-ME338) - Hen - -
(Ref: IN-ML436) - Rat; Hen - -
(Ref: IN-MN467)
Nota: DT50 soil =10.6 days; Kfoc=31320 mL/g
- Soil - -
(Ref: IN-MN468)
Nota: DT50 soil = 13.0 days; Kfoc=22482 mL/g
- Soil - -
(Ref: IN-MN967) - Rat - -
(Ref: IN-MN968) - Hydrolysis - -
(Ref: IN-MP821) - Plant; Hen - -
(Ref: IN-MQ607) - Goat - -
(Ref: IN-MQ608) - Hen - -
(Ref: IN-MQ609) - Hen - -
(Ref: IN-MQ610) - Hen - -
(Ref: IN-MQ613) - Plant - -
5-{4-)4-hydroxyphenoxy)phenyl]-5-methyl-2,4-oxazolidinedione
(Ref: IN-ZK007)
- Animal - -


ECOTOXICOLOGÍA

for famoxadone

Propiedad Click here for information on the parameters used to describe substance ecotoxicology Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretación Click here for information on the way in which we interpret substance ecotoxicology
Factor de la bio-concentración BCF (l kg-1) 3000 A5 Umbral de importancia
CT50 (días) No disponible -
Mamíferos - Agudos oral LD50 (mg kg-1) > 5000 A5 Rata Bajo
Mamíferos - a corto plazo NOEL (mg kg-1) 3.3 F4 Rata Alto
(ppm dieta) - -
Pájaros/aves - Agudos LD50 (mg kg-1) > 2250 A5 Colinus virginianus Bajo
Birds - Short term dietary (LC50/LD50) > 5620 mg kg feed-1 A5 Colinus virginianus -
Pez - agudo 96 hora LC50 (mg l-1) 0.011 A5 Oncorhynchus mykiss Alto
Pez - Crónico 21 días NOEC (mg l-1) 0.0014 A5 Oncorhynchus mykiss Alto
Invertebrados acuáticos - Agudos 48 hora EC50 (mg l-1) 0.033 A5 Daphnia magna Alto
Invertebrados acuáticos - Crónicos 21 días NOEC (mg l-1) 0.0037 A5 Daphnia magna Alto
Crustáceos acuáticos - Agudos 96 hora LC50 (mg l-1) - - -
Sediment dwelling organisms - Agudos 96 hora LC50 (mg l-1) - - -
Sediment dwelling organisms - Crónicos 28 día NOEC, estático, agua (mg l-1) > 0.007 A5 Chironomus riparius Alto
Sediment dwelling organisms - Crónicos 28 día NOEC, sedimento (mg kg-1) - - -
Plantas acuáticas - Agudos 7 día EC50, biomasa (mg l-1) 0.0081 A5 Lemna gibba Alto
Non-target plants > 300 A5 Blackgrass, Lambsquarter, Chickweed, Velvetleaf & others
Vegetative vigour, ER50
as g/ha
-
> 201 A5 Corn, Onion, Soybean, Sugarbeet & others
Seedling emergence, ER50
as g/ha
-
Algas - Agudos 72 hora EC50, crecimiento (mg l-1) 0.00308 A5 Pseudokirchneriella subcapitata Alto
Algas - Crónicos 96 hora NOEC, crecimiento (mg l-1) - - -
Abejas mielíferas Contacto aguda 48 hora LD50 (μg abeja-1) > 25 A5 Moderado
Oral aguda 48 hora LD50 (μg abeja-1) > 1.0 A4 [Max conc due to solubility limit] Moderado
Modo desconocido aguda 48 hora LD50 (μg abeja-1) - - -
Lombrices - Agudos 14 día LC50 (mg kg-1) 235 A5 Eisenia foetida, corr Moderado
Lombrices - Crónicos 14 día NOEC, reproducción (mg kg-1) 8.15 A5 Eisenia foetida, corr Moderado
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Causalidad - - -
Otro arthropoda (1) LR50 g ha-1 2240 >
A5 Aphidius rhopalosiphi
-
% Causalidad 100 Mortalidad
Dose: 0.3 kg ha-1
A5 Aphidius rhopalosiphi, adult
-
Otro arthropoda (2) LR50 g ha-1 2240 >
A5 Typhlodromus pyri
-
% Causalidad 99 Mortalidad
Dose: 0.099 kg ha-1
A5 Typhlodromus pyri, protonymph
-
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: 1.44 mg kg-1 soil
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


LA SALUD HUMANA Y PROTECCIÓN

for famoxadone

General:
Propiedad Click here for information on the parameters used to describe human health and protection issues Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with human health and protection data Interpretación Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mamíferos - Agudos oral LD50 (mg kg-1) > 5000 A5 Rata Bajo
Mammals - Dermal LD50 (mg kg-1 body weight) > 2000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) > 5.3 A5 Rat, 4 hr -
Other Mammal toxicity endpoints - -
Consumo cada día aceptable (mg kg-1p.c. días-1) 0.012 A5 Dog, SF=100 -
ARfD - Acute Reference Dose (mg kg-1p.c. días-1) 0.2 A5 Mouse, SF=100 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
El nivel de exposición del operador (AOEL) sistemíco (mg kg-1p.c. días-1) 0.0048 A4 Dog, 1 year, SF=100 -
Estudios den la absorción cutánea (%) 0.4-2.0 A5 concentration dependent -
Directivo 76/464 Sustancias Peligrosas - - -
Limites de exposiciones - - -
Exposure Routes Public Minimal risk from dietary exposure
Risk assessment indicates ARfD would not normally be execeeded
Occupational Risk of exposure acceptable under label recommendations for use for personal protection clothing and equipment
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutágeno Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

-

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

-

Cuestiones generales de la salud humana Splene, liver & red blood cell toxicant
May cause long term eye damage from repeated exposure

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Propiedad Click here for information on the parameters used to describe substance handling issues Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with data on handling issues Interpretación Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive or oxidising
CLP classification 2013 Health: H373
Environment: H400, H410
CEE clasificación de riesgos Click here to view information omn the EU risk phrases Xn - Harmful: R48/22
N - Dangerous for the environment: R50, R53
CEE clasificación sin riesgos Click here to view information omn the EU safety phrases S2, S46, S60, S61
Clasificación de OSM U - Es poco probable que presente un riesgo agudo
US EPA Classification (formulation) III - Caution - Slightly toxic
Número de las NU Usually 1648
Waste disposal & packaging Click here for a description of UN packaging marks Packaging Group II (medium danger)


TRADUCCIONES

for famoxadone

Idioma Nombre
Inglés famoxadone
Francés famoxadone
Alemán Famoxadone
Danés famoxadon
Italiano famoxadone
Español famoxadona
Griego famoxadone
Esloveno famoksadon
Polaco famoksadon
Sueco famoxadon
Húngaro famoxadon
Holandés famoxadon

Última actualización del registro: Wednesday 31 October 2018
Contacto: aeru@herts.ac.uk