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fenpicoxamid (Ref: XDE 777)
** fenpicoxamid ** X772777 ** XR-777 ** UK 2A procide ** Antibiotic UK 2A procide ** GF-2925 ** lyserphenvalpyr ** Traducciones

Destino ambiental - Ecotoxicología - La salud humana - A a Z Indice - Inicio

RESUMEN

A novel antibiotic fungicide with a new class of chemistry that is currently progressing through the EU regulatory system. It has a low human health risk with no major concerns being identified in the initial data set. It appears to degrade quickly in soils and is unstable in water. It also has a low toxicity to birds but is a much higher risk to aquatic organisms.

INFORMACIÓN GENERAL Click here for an explantaion of the general chemical status information
for fenpicoxamid

Descripción: A pre-emergence antibiotic fungicide for use on cereals to control a range of foliar diseases

Ejemplos de plagas controladas: Foliar diseases including Mycosphaerella graminicola (Septoria tritici), Black Slgatoka

Ejemplos de aplicaciones: Spring and winter cereals including soft wheat, durum wheat, rye and tritical; Rice; Bananas

Eficacia y actividad: Based on manufacturers information products are considered to be sufficiently effective and have no unacceptable effects on plant or plant products

Availability status: Current

Introduction & key dates: 2016

CEE Regulación 1107/2009 ( 91/414):
Estado Approved
Dossier rapporteur/co-rapporteur UK/France
Date inclusion expires 11/10/2028
UE Candidatas a sustitución No
Incluido en la base de datos de la UE

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Estructura química: Click here for further information on the general chemical status information used on this site
Isomerism Isomeric
Fórmula química C31H38N2O11
Canonical SMILES CC1C(C(C(=O)OCC(C(=O)O1)NC(=O)C2=NC=CC(=C2OCOC(=O)C(C)C)OC)CC3=CC=CC=C3)OC(=O)C(C)C
Isomeric SMILES C[C@H]1[C@@H]([C@H](C(=O)OC[C@H](C(=O)O1)NC(=O)C2=NC=CC(=C2OCOC(=O)C(C)C)OC)CC3=CC=CC=C3)OC(=O)C(C)C
International Chemical Identifier Key (InChIKey) QGTOTYJSCYHYFK-XSARVHFWSA-N
International Chemical Identifier (InChI) InChI=1S/C31H38N2O11/c1-17(2)28(35)42-16-41-26-23(39-6)12-13-32-24(26)27(34)33-22-15-40-30(37)21(14-20-10-8-7-9-11-20)25(19(5)43-31(22)38)44-29(36)18(3)4/h7-13,17-19,21-22,25H,14-16H2,1-6H3,(H,33,34)/t19-,21+,22+,25-/m0/s1
¿Diagrama de estructura 2D / imagen disponible?

Estado general: Click here for further information on the general chemical status information used on this site
Tipo de pesticida Fungicide
Grupo químico Antibiotic
Minimum active substance purity 750 g/kg
Known relevant impurities EFSA DAR: None declared
Sustancias de origen Sintéticas
Modo de acción A Qi inhibitor fungicide
CAS RN 517875-34-2
CEE número Ningunos asignaron
Número CIPAC 991
EPA américaine chimiques de code -
PubChem CID 121494114
Masa molecular (g mol-1) 614.64
PIN (Preferred Identification Name) (3S,6S,7R,8R)-8-benzyl-3-(4-methoxy-3-(((2-methylpropanoyl)oxy)methoxy)pyridine-2-carboxamido)-6-methyl-4,9-dioxo-1,5-dioxonan-7-yl 2-methylpropanoate
Nombre IUPAC (2-(((3R,7R,8R,9S)-7-benzyl-9-methyl-8-(2-methylpropanoyloxy)-2,6-dioxo-1,5-dioxonan-3-yl)carbamoyl)-4-methoxypyridin-3-yl)oxymethyl 2-methylpropanoate
Nombre CAS propanoic acid, 2-methyl-, ((4-methoxy-2-((((3S,7R,8R,9S)-9-methyl-8-(2-methyl-1-oxopropoxy)-2,6-dioxo-7-(phenylmethyl)-1,5-dioxonan-3-yl)amino)carbonyl)-3-pyridinyl)oxy)methyl ester
Otra información de estado -
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) No aplicable
Herbicide Resistance Classification (WSSA) No aplicable
Insecticide Resistance Classification (IRAC) No aplicable
Fungicide Resistance Classification (FRAC) No data
Examples of recorded resistance -
Estado físico White powdery solid
Related substances & organisms -

Formulaciones:
Propiedad Click here for information on the general product and branding information used on this site Valor
Example manufacturers & suppliers of products using this active now or historically
  • Dow Agrosciences
Example products using this active -
Estado de UK LERAP No UK authorisation for use
Formulation and application details Supplied as a suspension concentrate.


DESTINO AMBIENTAL

for fenpicoxamid

Propiedad Click here for information on the parameters used to describe environmental fate on this site Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with fate data Interpretación Click here for information on the way in which we interpret environmental fate data
Solubilidad - En aqua en 20oC (mg l-1) 0.041 A5 - unstable Bajo
Solubilidad - en solventes organicos en 20oC (mg l-1) 250000 A5 - 1,2-dichloroethane -
180000 A5 - Acetona -
18000 A5 - Xileno -
130000 A5 - Acetato de etilo -
Punto de fusión (oC) 158.3 A5 -
Punto de ebullición (oC) Decomposes before boiling A5 -
El punto de degradación (oC) 246 A5 -
Punto de inflamación (oC) Not expected to self ignite; Not highly flammable - -
Octanol-aqua coeficiente de particiónat en pH 7, 20oC P 2.51 X 1004 Calculado -
Log P 4.4 A5 Alto
Masa densidad (g ml-1)/Peso específico - - -
Disociación constante (pKa) at 25oC 4.4 A5 -
Nota:
Presión de vapor en 20oC (mPa) 1.2 X 10-04 A5 Baja volatilidad
Constante de Henry a 25oC (Pa m3 mol-1) 2.38 X 10-03 A5 No volátil
Indice de potencial de lixiviación GUS Click here for a note on the limitations of the GUS index -0.29 Calculado Bajo posibilidad de lixiviación
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Valor 5.35 X 10-03 Calculado -
Nota Estimated concentrations of chemicals with Koc values greater than 9995 ml g-1 are beyond the scope of the regression data used in SCI-GROW development. If there are concerns for such chemicals, a higher tier groundwater exposure assessment should be considered, regardless of the concentration returned by SCI-GROW
Potencial para transportar de 'particle bound' Click here for a note on the limitations of the potential for particle bound transport index - Calculado Mediano
Maximum UV-vis absorption L mol-1 cm-1 pH 2: maxima at 2.09nm and 245nm
pH 7: maxima at 214nm and 276nm
pH 10: maxima at 211nm and 327nm
- -
Surface tension (mN m-1) - - -

Degradación:
Propiedad Click here for information on the parameters used to describe substance degradation Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with degradation data Interpretación Click here for information on the way in which we interpret substance degradation data
Biodegradabilidad general Generally considered not to be readily biodegradable
Degradación de suelo (días) (aerobic) DT50 (típico) 3.5 A5 No persistente
DT50 (laboratorio en 20oC) 3.5 A5 No persistente
DT50 (campo) 9.91 A5 No persistente
DT90 (laboratorio en 20oC) 12.7 A5 -
DT90 (campo) 68.4 A5 -
Endpoint de modelado DT50 3.5 A5 -
Nota EU 2018 dossier: Lab studies DT50 range 2.0-6.0 days, DT90 range 6.8-19.8 days, Soils=4; Field studies DT50 range 4.1-50.9 days, DT90 range 17.8-194.0 days, Soils =5
Dissipation rate RL50 on plant matrix Valor - - -
Nota -
Dissipation rate RL50 on and in plant matrix Valor - - -
Nota -
Acuoso fotólisis DT50 (días) en pH 7 Valor 0.35 A5 Rápido
Nota -
Acuoso hidrólisis DT50 (días) en 20oC y pH 7 Valor 0.92 A4 - @25 degC No persistente
Nota pH 4: 7.1 days @ 25 degC, pH 9: 0.024 days @ 25 degC
Aqua-Sedimento DT50 (días) 0.76 A5 Rápido
Fase de agua sola DT50 (días) 0.26 A5 Rápido

De absorción del suelo y la movilidad:
Propiedad Click here for information on the parameters used to describe substance adsorption and mobility Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretación Click here for information on the way in which we interpret substance adsorption and mobility
Lineal Kd 786 A5 No Móvil
Koc 53233
Notas y rango EU 2018 dossier: Kd range 349-1278 mL/g, Kdoc range 8961-134720 mL/g, Soils=7
Freundlich Kf 470.8 A5 No Móvil
Kfoc 19731
1/n 0.820
Notas y rango EU 2018 dossier: Kf range 9.36-2472 mL/g, Kfoc range 936-63394 mL/g, 1/n range 0.608-1.066, Soils=7
pH senbsibilidad None

Key metabolites:
Metabolito Medio de formación Maximó Calculado de Fracción Ocurrencia 1107/2009 Importancia Click here for further information on 1107/2009 relevancy
3-hydroxy-4-methoxypyridine-2-carboxylic acid (Ref: X696476) This metabolite may cause environmental pollution, click here for further information Suelo   0.434   Major fraction; Relevant
(3S,6S,7R,8R)-8-benzyl-3-(((3-hydroxy-4-methoxypyridin-2-yl)carbonyl)amino)-6-methyl-4,9-dioxo-1,5-dioxonan-7-yl 2-methylpropanoate (Ref: X642188) This metabolite may cause environmental pollution, click here for further information Suelo   0.389   Major fraction; Relevant
N-((3-hydroxy-4-methoxypyridin-2-yl)carbonyl)serine (Ref: X12264475) This metabolite may cause environmental pollution, click here for further information Suelo   0.354   Major fraction; Relevant
N-((3S,7R,8R,9S)-7-benzyl-8-hydroxy-9-methyl-2,6-dioxo-1,5-dioxonan-3-yl)-3-hydroxy-4-methoxypyridine-2-carboxamide (Ref: X696872) This metabolite may cause environmental pollution, click here for further information Suelo   0.160   Major fraction; Relevant
3-hydroxy-4-methoxypyridine-2-carboximide (Ref: X12313581) This metabolite may cause environmental pollution, click here for further information Suelo   0.101   Major fraction; Relevant
(3R,4R,5S)-3-benzyl-4-hydroxy-5-methyldihydrofuran-2(3H)-one (Ref: X119634522) This metabolite may cause environmental pollution, click here for further information Suelo   0.107   Major fraction; Relevant

Other known metabolites:
Metabolite name and reference Aliases Medio de formación / Rate Maximó Calculado de Fracción Ocurrencia Metabolising enzymes
- X763024 Soil - -
(3R,4R,5S)-3-benzyl-4-hydroxy-5-methyldihydrofuran-2(3H)-one
Nota: Transient metabolite
X11963422 Soil - -


ECOTOXICOLOGÍA

for fenpicoxamid

Propiedad Click here for information on the parameters used to describe substance ecotoxicology Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretación Click here for information on the way in which we interpret substance ecotoxicology
Factor de la bio-concentración BCF (l kg-1) 18.36 A4 Bajo potencial
CT50 (días) No data -
Mamíferos - Agudos oral LD50 (mg kg-1) > 2000 A5 Rata Bajo
Mamíferos - a corto plazo NOEL (mg kg-1) - - -
(ppm dieta) - -
Pájaros/aves - Agudos LD50 (mg kg-1) > 2000 A5 Colinus virginianus Bajo
Birds - Short term dietary (LC50/LD50) - - -
Pez - agudo 96 hora LC50 (mg l-1) 0.0022 A5 Oncorhynchus mykiss Alto
Pez - Crónico 21 días NOEC (mg l-1) 0.00037 A4 Pimephales promelas, 32 día Alto
Invertebrados acuáticos - Agudos 48 hora EC50 (mg l-1) 0.00093 A5 Daphnia magna Alto
Invertebrados acuáticos - Crónicos 21 días NOEC (mg l-1) - - -
Crustáceos acuáticos - Agudos 96 hora LC50 (mg l-1) - - -
Sediment dwelling organisms - Agudos 96 hora LC50 (mg l-1) 0.15 A4 Chironomus riparius, 48 hr Moderado
Sediment dwelling organisms - Crónicos 28 día NOEC, estático, agua (mg l-1) - - -
Sediment dwelling organisms - Crónicos 28 día NOEC, sedimento (mg kg-1) - - -
Plantas acuáticas - Agudos 7 día EC50, biomasa (mg l-1) - - -
Non-target plants > 2.0 A5 Oats
Vegetative vigour, ER50
as g/ha
-
> 2.0 A5 Sunflower
Seedling emergence, ER50
as g/ha
-
Algas - Agudos 72 hora EC50, crecimiento (mg l-1) > 0.522 A5 Pseudokirchneriella subcapitata Moderado
Algas - Crónicos 96 hora NOEC, crecimiento (mg l-1) - - -
Abejas mielíferas (Apis spp.) Contacto aguda LD50 (peor caso de 24 , 48 y 72 hora valores - μg abeja-1) > 202.4 A5 Apis mellifera Bajo
Oral aguda LD50 (peor caso de 24 , 48 y 72 hora valores - μg abeja-1) > 303 A5 Apis mellifera Bajo
Modo desconocido aguda LD50 (peor caso de 24 , 48 y 72 hora valores - μg abeja-1) - - -
Abejorros (Bombus spp.) Contacto aguda LD50 (peor caso de 24 , 48 y 72 hora valores - μg abeja-1) - - -
-
Oral aguda LD50 (peor caso de 24 , 48 y 72 hora valores - μg abeja-1) - - -
-
Abejas albañiles (Osmia spp.) Contacto aguda LD50 (peor caso de 24 , 48 y 72 hora valores - μg abeja-1) - - -
Oral aguda LD50 (peor caso de 24 , 48 y 72 hora valores - μg abeja-1) - - -
Otros polinizadores (1) Agudos LD50 (peor caso de 24 , 48 y 72 hora valores - μg insect-1) - - -
Modo de exposición -
Otros polinizadores (2) Agudos LD50 (peor caso de 24 , 48 y 72 hora valores - μg insect-1) - - -
Modo de exposición -
Lombrices - Agudos 14 día LC50 (mg kg-1) - - -
Lombrices - Crónicos NOEC, reproducción (mg kg-1) 9.93 A5 Eisenia foetida, corr Moderado
Other soil macro-organisms Agudos LC50 (mg kg-1) - 3.97 -
Crónicos NOEC (mg kg-1) A5 Folsomia candida, corr = - -
Otro arthropoda (1) LR50 g ha-1 400 >
A5 Typhlodromus pyri
-
% Causalidad - - -
Otro arthropoda (2) LR50 g ha-1 129 =
A5 Aphidius rhopalosiphi
-
% Causalidad - - -
Soil micro-organisms Nitrogen transformation: No significant adverse effect A5
Dose: 0.438 mg kg-1 soil, 28 días
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


LA SALUD HUMANA Y PROTECCIÓN

for fenpicoxamid

General:
Propiedad Click here for information on the parameters used to describe human health and protection issues Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with human health and protection data Interpretación Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mamíferos - Agudos oral LD50 (mg kg-1) > 2000 A5 Rata Bajo
Mammals - Dermal LD50 (mg kg-1 body weight) > 5000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) > 0.53 A5 Rat, 4 hr (nose only) -
Other Mammal toxicity endpoints - -
Consumo cada día aceptable (mg kg-1p.c. días-1) 0.05 A5 Mice, SF=100 -
ARfD - Acute Reference Dose (mg kg-1p.c. días-1) 1.8 A5 Rabbit, SF=100 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) 0.2 A5 Rabbit, SF=833 corr -
El nivel de exposición del operador (AOEL) sistemíco (mg kg-1p.c. días-1) 0.05 A5 Mice, SF=833 corr -
Estudios den la absorción cutánea (%) 0.2-6.0 A5 concentration dependent -
Directivo 76/464 Sustancias Peligrosas - - -
Exposure Routes Public No significant risks anticipated for proposed patterns of use
Occupational Estimated risks acceptable, PPE/PPC recommended
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Genotóxico Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

A3; B0; C0; D0; E3

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

Cuestiones generales de la salud humana Possible liver and kidney toxicant
Clave: Genotoxicidad
A: Aberración cromosómica (base de datos EFSA)
B: Daño/reparación del ADN (base de datos EFSA)
C: Mutación genética (base de datos EFSA)
D: Mutación del genoma (base de datos EFSA)
E: Tipo de genotoxicidad no especificada (fuente de datos diversos)
0: Sin datos
1: Positivo
2: Resultados mixtos/ambiguos
3: Negativo
Clave: Otro
: Sí, se sabe que causa un problema
: No, sabe no causar un problema
: Posiblemente, estado no identificado
- : Datos no encontrados

Handling issues:
Propiedad Click here for information on the parameters used to describe substance handling issues Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with data on handling issues Interpretación Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive or oxidising
CLP classification 2013 Environment: H400, H410
CEE clasificación de riesgos Click here to view information omn the EU risk phrases -
CEE clasificación sin riesgos Click here to view information omn the EU safety phrases -
Clasificación de OSM - -
Número de las NU -
Waste disposal & packaging Click here for a description of UN packaging marks -


TRADUCCIONES

for fenpicoxamid

Idioma Nombre
Inglés fenpicoxamid
Francés -
Alemán -
Danés -
Italiano -
Español -
Griego -
Esloveno -
Polaco -
Sueco -
Húngaro -
Holandés -

Última actualización del registro: Wednesday 27 November 2019
Contacto: aeru@herts.ac.uk