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flufenoxuron (Ref: BAS 3071)
** flufenoxuron ** AC 811678 ** WL 115110 ** Traducciones

Destino ambiental - Ecotoxicología - La salud humana - A a Z Indice - Inicio

RESUMEN

Flufenoxuron is an insectide no longer approved for use in the EU. It has a low aqueous solubility, is non-volatile and is not expected to leach to groundwater. It is moderately persistent in soils but will degrade quickly in aquatic systems in the presence of sunlight. Whilst it has a low mammalian toxicity it does have a high potential to bioaccumulate. It is a know respiratory tract irritant but no other significant human health issues have been identified. It is highly toxic to most aquatic organisms and moderately toxic to birds, honeybees and earthworms.

INFORMACIÓN GENERAL Click here for an explantaion of the general chemical status information
for flufenoxuron

Descripción: An insecticide used to control immature stages of phytophagous mites and other insect pests

Ejemplos de plagas controladas: Phytophagous mites (including Aculus, Brevipalpus, Panonychus, Phyllocoptruta, Tetranychus spp.)

Ejemplos de aplicaciones: Fruit including apples, cherry, grape, citrus, strawberry; Vegetables including brassicas, onions, leeks, eggplant; Cotton; Ornamentals

Eficacia y actividad: -

Availability status: Current

Introduction & key dates: 1986, first reported

CEE Regulación 1107/2009 ( 91/414):
Estado Not approved
Dossier rapporteur/co-rapporteur France
Date inclusion expires No aplicable
UE Candidatas a sustitución No aplicable
Incluido en la base de datos de la UE

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia, Japón, Philippines, Sudáfrica

Estructura química: Click here for further information on the general chemical status information used on this site
Isomerism None
Fórmula química C21H11ClF6N2O3
Canonical SMILES C1=CC(=C(C(=C1)F)C(=O)NC(=O)NC2=C(C=C(C=C2)OC3=C(C=C(C=C3)C(F)(F)F)Cl)F)F
Isomeric SMILES No data
International Chemical Identifier Key (InChIKey) RYLHNOVXKPXDIP-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C21H11ClF6N2O3/c22-12-8-10(21(26,27)28)4-7-17(12)33-11-5-6-16(15(25)9-11)29-20(32)30-19(31)18-13(23)2-1-3-14(18)24/h1-9H,(H2,29,30,31,32)
¿Diagrama de estructura 2D / imagen disponible?

Click to access the Cambridge Crystallographic Data Centre (CCDC) website
Cambridge Crystallographic Data Centre diagrams:
Nombre Común Relación Vínculo
Flufenoxuron - Click here for the CCDC structure diagram

Estado general: Click here for further information on the general chemical status information used on this site
Tipo de pesticida Insecticide, Acaricide
Grupo químico Benzoylurea
Minimum active substance purity 960 g/kg
Known relevant impurities EU Dossier - 4-(2-chloro-4-(trifluoromethyl)phenoxy)-2-fluoroaniline hydrochloride <1g/Kg; Toluene <2 g/kg
Sustancias de origen Sintéticas
Modo de acción Growth regulator with contact and stomach action. Inhibitors of chitin biosynthesis.
CAS RN 101463-69-8
CEE número 417-680-3
Número CIPAC 470
EPA américaine chimiques de code 108203
PubChem CID 91766
Masa molecular (g mol-1) 488.77
PIN (Preferred Identification Name) -
Nombre IUPAC 1-[4-(2-chloro-α,α,α-trifluoro-p-tolyloxy)-2-fluorophenyl]-3-(2,6-difluorobenzoyl)urea
Nombre CAS N-(((4-(2-chloro-4-(trifluoromethyl)phenoxy)-2-fluorophenyl)amino)carbonyl)-2,6-difluorobenzamide
Otra información de estado Chemical subject to PIC regulations, Banned 2011; PAN listed Highly Hazardous Chemical
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) No aplicable
Herbicide Resistance Classification (WSSA) No aplicable
Insecticide Resistance Classification (IRAC) 15
Fungicide Resistance Classification (FRAC) No aplicable
Examples of recorded resistance None recorded
Estado físico White crystalline solid
Related substances & organisms

Formulaciones:
Propiedad Click here for information on the general product and branding information used on this site Valor
Example manufacturers & suppliers of products using this active now or historically
  • BASF
  • Agro-Care Chemical Industry Group Limited
  • American Cyanamid
Example products using this active
  • Tenopa
  • BAS 307 02I
  • Casette
  • Cascade
Estado de UK LERAP None
Formulation and application details Available in a variety of formulations including dispersible powders, emulsifiable concentrates and suspension concentrates.


DESTINO AMBIENTAL

for flufenoxuron

Propiedad Click here for information on the parameters used to describe environmental fate on this site Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with fate data Interpretación Click here for information on the way in which we interpret environmental fate data
Solubilidad - En aqua en 20oC (mg l-1) 0.0043 A5 Bajo
Solubilidad - en solventes organicos en 20oC (mg l-1) 83000 A5 - Acetona -
3500 A5 - Tolueno -
6000 L3 - Xileno -
16000 A5 - Cloruro de metileno -
Punto de fusión (oC) 167 A5 -
Punto de ebullición (oC) Decomposes before boiling A5 -
El punto de degradación (oC) 184 A5 -
Punto de inflamación (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-aqua coeficiente de particiónat en pH 7, 20oC P 1.29 X 1005 Calculado -
Log P 5.11 A5 - @ 25 DegC Alto
Masa densidad (g ml-1)/Peso específico 1.58 B5 -
Disociación constante (pKa) at 25oC 10.1 A5 -
Nota: Ácido muy débil
Presión de vapor en 20oC (mPa) 6.52 X 10-09 A5 Baja volatilidad
Constante de Henry a 25oC (Pa m3 mol-1) 2.64 X 10-06 A5 No volátil
Indice de potencial de lixiviación GUS Click here for a note on the limitations of the GUS index -2.75 Calculado Bajo posibilidad de lixiviación
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Valor 5.35 X 10-03 Calculado -
Nota Estimated concentrations of chemicals with Koc values greater than 9995 ml g-1 are beyond the scope of the regression data used in SCI-GROW development. If there are concerns for such chemicals, a higher tier groundwater exposure assessment should be considered, regardless of the concentration returned by SCI-GROW
Potencial para transportar de 'particle bound' Click here for a note on the limitations of the potential for particle bound transport index - Calculado Alto
Maximum UV-vis absorption L mol-1 cm-1 Neutral solution: 206nm = 31741, 252nm = 17403, 274nm = 18589; [Acidic solution: 220nm = 12073, 258nm = 9424, 297nm = 1064; [Basic solution: 224nm = 19830, 237nm = 19571 A5 -
Surface tension (mN m-1) 49.4 A5 at 20oC -

Degradación:
Propiedad Click here for information on the parameters used to describe substance degradation Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with degradation data Interpretación Click here for information on the way in which we interpret substance degradation data
Biodegradabilidad general -
Degradación de suelo (días) (aerobic) DT50 (típico) 42 B5 Persistente moderado
DT50 (laboratorio en 20oC) 72.5 A5 Persistente moderado
DT50 (campo) 42.9 A5 Persistente moderado
DT90 (laboratorio en 20oC) 363 A5 -
DT90 (campo) 2052 A3 -
Endpoint de modelado DT50 - - -
Nota EU dossier lab studies DT50 range 28-130 days, DT90 range 138-477 days, Field studies DT50 5.8-91.6 days, DT90 range 84.5-8547 days
Dissipation rate RL50 on plant matrix Valor - - -
Nota -
Dissipation rate RL50 on and in plant matrix Valor 21.1 R4 -
Nota Published literature RL50 range 2.1-64.2 days, 4 field & undercover grown crops, various matrices, n=4
Acuoso fotólisis DT50 (días) en pH 7 Valor 6 A5 Moderado rápido
Nota Continuous irradiation
Acuoso hidrólisis DT50 (días) en 20oC y pH 7 Valor 267 B5 Persistente
Nota pH sensitive: DT50 112 days at pH 5, 104 days at pH 7, 36.7 days at pH 9, 2.7 days at pH 12, all at 25 degC (L3)
Aqua-Sedimento DT50 (días) 53 A5 Moderado rápido
Fase de agua sola DT50 (días) 0.7 A5 Rápido

De absorción del suelo y la movilidad:
Propiedad Click here for information on the parameters used to describe substance adsorption and mobility Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretación Click here for information on the way in which we interpret substance adsorption and mobility
Lineal Kd 3078 A5 No Móvil
Koc 157643
Notas y rango EU dossier Kd range 1738-4250 mL/g, Koc range 88240-289747 mL/g, Soils=5
Freundlich Kf 9743 A5 No Móvil
Kfoc 486092
1/n 1.07
Notas y rango EU dossier Kf range 3021-22898 mL/g, kfoc range 167874-738650 mL/g, 1/n range 0.99-1.156, Soils=3
pH senbsibilidad No

Key metabolites:
Metabolito Medio de formación Maximó Calculado de Fracción Ocurrencia 1107/2009 Importancia Click here for further information on 1107/2009 relevancy
N-(4-(2-chloro-4-(trifluoromethyl)phenoxy)-2-fluorophenyl) urea (Ref: CL 932338) This metabolite may cause environmental pollution, click here for further information Suelo   0.156   Major fraction, Relevant

Other known metabolites:
Metabolite name and reference Aliases Medio de formación / Rate Maximó Calculado de Fracción Ocurrencia Metabolising enzymes
unknown
(Ref: Reg. no 4110958; WL 132612)
Nota: Minor metabolite
- Rat - -
2,6-difluorobenzamide
(Ref: Registration no: 102719; CL 21558)
Nota: Mol wt = 157.12; Log P = -0.86; Kow = 0.138
- Rat; Surface Water - -
difluorobenzoic acid
(Ref: Registration no: 206925; CL 245508)
Nota: Mol Wt = 158.1
- Rat: Surface water; Groundwater - -
4-[2-chloro-4-(trifluoromethyl]phenoxy]-2-fluorobenzenamine
(Ref: Registration no: 241208, CL 359882)
Nota: Mol Wt = 305.6; Log P = 3.32; Kow = 4169; Toxicologically relevant
- Rat; Soil; Water - -


ECOTOXICOLOGÍA

for flufenoxuron

Propiedad Click here for information on the parameters used to describe substance ecotoxicology Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretación Click here for information on the way in which we interpret substance ecotoxicology
Factor de la bio-concentración BCF (l kg-1) 700500 A5 Alto potencial
CT50 (días) 21 -
Mamíferos - Agudos oral LD50 (mg kg-1) > 3000 A5 Rata Bajo
Mamíferos - a corto plazo NOEL (mg kg-1) 5 B5 Rata Alto
(ppm dieta) 50 -
Pájaros/aves - Agudos LD50 (mg kg-1) > 2000 A5 Colinus virginianus Bajo
Birds - Short term dietary (LC50/LD50) > 1243 mg kg-1 bw/día A5 Colinus virginianus -
Pez - agudo 96 hora LC50 (mg l-1) > 0.0049 A5 Oncorhynchus mykiss Alto
Pez - Crónico 21 días NOEC (mg l-1) 0.00082 A5 Pimephales promelas Alto
Invertebrados acuáticos - Agudos 48 hora EC50 (mg l-1) 0.000043 A5 Daphnia magna Alto
Invertebrados acuáticos - Crónicos 21 días NOEC (mg l-1) 0.00007 A5 Daphnia magna Alto
Crustáceos acuáticos - Agudos 96 hora LC50 (mg l-1) - - -
Sediment dwelling organisms - Agudos 96 hora LC50 (mg l-1) - - -
Sediment dwelling organisms - Crónicos 28 día NOEC, estático, agua (mg l-1) 0.000036 A5 Chironomus riparius Alto
Sediment dwelling organisms - Crónicos 28 día NOEC, sedimento (mg kg-1) - - -
Plantas acuáticas - Agudos 7 día EC50, biomasa (mg l-1) - - -
Non-target plants > 80 A5 Avena sativa, Allium cepa, Pisum sativum, Brassica oleracea
Vegetative vigour, ER50
as g/ha
-
> 40 A5 Brassica napus, Cucumis sativus, Pisum sativum, Allium cepa
Seedling emergence, ER50
as g/ha
-
Algas - Agudos 72 hora EC50, crecimiento (mg l-1) 5.11 A5 Pseudokirchneriella subcapitata, Biomass Moderado
Algas - Crónicos 96 hora NOEC, crecimiento (mg l-1) - - -
Abejas mielíferas (Apis spp.) Contacto aguda LD50 (peor caso de 24 , 48 y 72 hora valores - μg abeja-1) > 100 A5 Bajo
Oral aguda LD50 (peor caso de 24 , 48 y 72 hora valores - μg abeja-1) > 109.1 A5 Bajo
Modo desconocido aguda LD50 (peor caso de 24 , 48 y 72 hora valores - μg abeja-1) - - -
Abejorros (Bombus spp.) Contacto aguda LD50 (peor caso de 24 , 48 y 72 hora valores - μg abeja-1) - - -
-
Oral aguda LD50 (peor caso de 24 , 48 y 72 hora valores - μg abeja-1) - - -
-
Abejas albañiles (Osmia spp.) Contacto aguda LD50 (peor caso de 24 , 48 y 72 hora valores - μg abeja-1) - - -
Oral aguda LD50 (peor caso de 24 , 48 y 72 hora valores - μg abeja-1) - - -
Otros polinizadores (1) Agudos LD50 (peor caso de 24 , 48 y 72 hora valores - μg insect-1) - - -
Modo de exposición -
Otros polinizadores (2) Agudos LD50 (peor caso de 24 , 48 y 72 hora valores - μg insect-1) - - -
Modo de exposición -
Lombrices - Agudos 14 día LC50 (mg kg-1) > 500 A5 Eisenia foetida, corr Moderado
Lombrices - Crónicos NOEC, reproducción (mg kg-1) - - -
Other soil macro-organisms Agudos LC50 (mg kg-1) - - -
Crónicos NOEC (mg kg-1) 0.055 A5 Folsomia candida, 28d corr -
Otro arthropoda (1) LR50 g ha-1 73 Mortalidad
A5 Typhlodromus pyri
-
% Causalidad - - -
Otro arthropoda (2) LR50 g ha-1 386 >, Mortality
A5 Aphidius rhopalosiphi
-
% Causalidad - - -
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: 1.28 kg ha-1, 28 días
-
Mesocosm study data NOEAEC mg l-1 0.000025 A5 Aquatic insects and zooplankton -
NOEAEC mg l-1 0.000010 A5 Aquatic insects and zooplankton -


LA SALUD HUMANA Y PROTECCIÓN

for flufenoxuron

General:
Propiedad Click here for information on the parameters used to describe human health and protection issues Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with human health and protection data Interpretación Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mamíferos - Agudos oral LD50 (mg kg-1) > 3000 A5 Rata Bajo
Mammals - Dermal LD50 (mg kg-1 body weight) > 2000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) > 3.3 A5 Rat -
Other Mammal toxicity endpoints - -
Consumo cada día aceptable (mg kg-1p.c. días-1) 0.01 A5 Dog, SF=300 Provisional -
ARfD - Acute Reference Dose (mg kg-1p.c. días-1) Ningunos asignaron A5 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
El nivel de exposición del operador (AOEL) sistemíco (mg kg-1p.c. días-1) 0.01 A5 Dog, SF=250 Provisional -
Estudios den la absorción cutánea (%) 0.02-2.0 A5 concentration dependent -
Directivo 76/464 Sustancias Peligrosas - - -
Exposure Routes Public Acceptable for proposed uses
Occupational Acceptable for proposed uses
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Genotóxico Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

A3; B3; C3; D0; E3

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

Cuestiones generales de la salud humana Bioaccumulates
May cause anemia
Possible blood, liver, kidney and spleen toxicant
Clave: Genotoxicidad
A: Aberración cromosómica (base de datos EFSA)
B: Daño/reparación del ADN (base de datos EFSA)
C: Mutación genética (base de datos EFSA)
D: Mutación del genoma (base de datos EFSA)
E: Tipo de genotoxicidad no especificada (fuente de datos diversos)
0: Sin datos
1: Positivo
2: Resultados mixtos/ambiguos
3: Negativo
Clave: Otro
: Sí, se sabe que causa un problema
: No, sabe no causar un problema
: Posiblemente, estado no identificado
- : Datos no encontrados

Handling issues:
Propiedad Click here for information on the parameters used to describe substance handling issues Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with data on handling issues Interpretación Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive or oxidising however fine dust clouds may present an explosive mix
IMDG Transport Code is usually 9
CLP classification 2013 Health: H362
Environment: H400, H410
CEE clasificación de riesgos Click here to view information omn the EU risk phrases Xn - Harmful: R20
N - Dangerous for the environment: R50, R53
CEE clasificación sin riesgos Click here to view information omn the EU safety phrases S22
Clasificación de OSM III - Peligroso un poco
Número de las NU Usually 3077
Waste disposal & packaging Click here for a description of UN packaging marks Packaging Group III (minor danger)


TRADUCCIONES

for flufenoxuron

Idioma Nombre
Inglés flufenoxuron
Francés flufenoxuron
Alemán Flufenoxuron
Danés flufenoxuron
Italiano flufenoxuron
Español flufenoxuron
Griego -
Esloveno flufenoksuron
Polaco flufenoksuron
Sueco -
Húngaro flufenoxuron
Holandés -

Última actualización del registro: Tuesday 03 March 2020
Contacto: aeru@herts.ac.uk