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indoxacarb (Ref: DPX KN128)
** indoxacarb ** DPX KN127 ** DPX MP062 ** Traducciones

Destino ambiental - Ecotoxicología - La salud humana - A a Z Indice - Inicio

INFORMACIÓN GENERAL Click here for an explantaion of the general chemical status information
for indoxacarb

Descripción: An insecticide for use on a wide range of crops to control certain Lepidoptera, cockroaches and ants

Ejemplos de plagas controladas: Beet armyworm, Fire ants; Cockroaches

Ejemplos de aplicaciones: Cotton; Brassicas; Sweet corn; Lettuce; Fruiting vegetables; Fruit including apples, pears, cherries

Eficacia y actividad: -

Availability status: Current

Introduction & key dates: 1996, first reported; 2000, first registered & marketed USA

CEE Regulación 1107/2009 ( 91/414):
Estado Approved
Dossier rapporteur/co-rapporteur France/Spain
Date inclusion expires 31/10/2020
UE Candidatas a sustitución No
Incluido en la base de datos de la UE

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia, Estados Unidos, Cameroon, India, Nueva Zelanda, África, Senegal

Estructura química: Click here for further information on the general chemical status information used on this site
Isomerism A chiral molecule, existing in the R- and S-forms but normally used as the S-stereosomer
Fórmula química C22H17ClF3N3O7
Canonical SMILES COC(=O)C12CC3=C(C1=NN(CO2)C(=O)N(C4=CC=C(C=C4)OC(F)(F)F)C(=O)OC)C=CC(=C3)Cl
Isomeric SMILES COC(=O)[C@]12CC3=C(C1=NN(CO2)C(=O)N(C4=CC=C(C=C4)OC(F)(F)F)C(=O)OC)C=CC(=C3)Cl
International Chemical Identifier Key (InChIKey) VBCVPMMZEGZULK-NRFANRHFSA-N
International Chemical Identifier (InChI) InChI=1S/C22H17ClF3N3O7/c1-33-18(30)21-10-12-9-13(23)3-8-16(12)17(21)27-28(11-35-21)19(31)29(20(32)34-2)14-4-6-15(7-5-14)36-22(24,25)26/h3-9H,10-11H2,1-2H3/t21-/m0/s1
¿Diagrama de estructura 2D / imagen disponible?

Click to access the Cambridge Crystallographic Data Centre (CCDC) website
Cambridge Crystallographic Data Centre diagrams:
Nombre Común Relación Vínculo
Indoxacarb - Click here for the CCDC structure diagram

Estado general: Click here for further information on the general chemical status information used on this site
Tipo de pesticida Insecticide
Grupo químico Oxadiazine
Minimum active substance purity 930 g/kg
Known relevant impurities EU 2017 dossier - 4,4'-methylenebis(N,N-diethylaniline < 0.0025 g/kg
Sustancias de origen Sintéticas
Modo de acción Contact and stomach action. Voltage-dependent sodium channel blocker.
CAS RN 173584-44-6
CEE número -
Número CIPAC 612
EPA américaine chimiques de code 118200
PubChem CID 107720
Masa molecular (g mol-1) 527.83
PIN (Preferred Identification Name) methyl (S)-N-[7-chloro-2,3,4a,5-tetrahydro-4a-(methoxycarbonyl)indeno[1,2-e][1,3,4]oxadiazin-2-ylcarbonyl]-4'-(trifluoromethoxy)carbanilate
Nombre IUPAC methyl (S)-N-[7-chloro-2,3,4a,5-tetrahydro-4a-(methoxycarbonyl)indeno[1,2-e][1,3,4]oxadiazin-2-ylcarbonyl]-4'-(trifluoromethoxy)carbanilate
Nombre CAS methyl (4aS)-7-chloro-2,5-dihydro-2-(((methoxycarbonyl)(4-(trifluoromethoxy)phenyl)amino])carbonyl)indeno(1,2-e)(1,3,4)oxadiazine-4a(3H)-carboxylate
Otra información de estado -
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) No aplicable
Herbicide Resistance Classification (WSSA) No aplicable
Insecticide Resistance Classification (IRAC) 22A
Fungicide Resistance Classification (FRAC) No aplicable
Examples of recorded resistance Earias vittella
Heliothis virescens
Musca domestica
Choristoneura rosaceana
Plutella xylostella
Spodoptera litura
Estado físico White powder
Related substances & organisms -

Formulaciones:
Propiedad Click here for information on the general product and branding information used on this site Valor
Example manufacturers & suppliers of products using this active now or historically
  • DuPont
Example products using this active
  • Provaunt
  • Steward
  • Avaunt
Estado de UK LERAP None
Formulation and application details Often supplied as wettable granules that are mixed with water and used as a spray.


DESTINO AMBIENTAL

for indoxacarb

Propiedad Click here for information on the parameters used to describe environmental fate on this site Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with fate data Interpretación Click here for information on the way in which we interpret environmental fate data
Solubilidad - En aqua en 20oC (mg l-1) 0.2 F4 Bajo
Solubilidad - en solventes organicos en 20oC (mg l-1) 160000 C4 - Acetato de etilo -
250000 C4 - Acetona -
1720 C4 - Heptano -
117000 C4 - Xileno -
Punto de fusión (oC) 88.1 A5 -
Punto de ebullición (oC) Decomposes before boiling A5 -
El punto de degradación (oC) 235 A5 -
Punto de inflamación (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-aqua coeficiente de particiónat en pH 7, 20oC P 4.47 X 1004 Calculado -
Log P 4.65 A5 - @ 25 degC Alto
Masa densidad (g ml-1)/Peso específico 1.44 A5 -
Disociación constante (pKa) at 25oC No aplicable A5 -
Nota: Ninguna disociación
Presión de vapor en 20oC (mPa) 9.8 X 10-06 A5 Baja volatilidad
Constante de Henry a 25oC (Pa m3 mol-1) 6.00 X 10-05 A5 No volátil
Indice de potencial de lixiviación GUS Click here for a note on the limitations of the GUS index 0.27 Calculado Bajo posibilidad de lixiviación
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Valor 5.07 X 10-03 Calculado -
Nota -
Potencial para transportar de 'particle bound' Click here for a note on the limitations of the potential for particle bound transport index - Calculado Alto
Maximum UV-vis absorption L mol-1 cm-1 pH 0.91: 203nm=18075, 230nm=14342, 285nm=17871, 311nm=21106
pH 7.05: 235nm=9272, 285nm=16345, 290nm=15290, 311nm=20502, pH 12.67: 235nm=17682, 285nm=16437, 290nm=15653, 311nm=20098
A5 -
Surface tension (mN m-1) 76.8 A5 at 20 degC -

Degradación:
Propiedad Click here for information on the parameters used to describe substance degradation Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with degradation data Interpretación Click here for information on the way in which we interpret substance degradation data
Biodegradabilidad general Not readily biodegradable
Degradación de suelo (días) (aerobic) DT50 (típico) 113.2 A5 Persistente
DT50 (laboratorio en 20oC) 113.2 A5 Persistente
DT50 (campo) 5.97 A5 No persistente
DT90 (laboratorio en 20oC) 119 A4 -
DT90 (campo) 25.7 A5 -
Endpoint de modelado DT50 - - -
Nota EU 2018 dossier lab studies DT50 range 65.3-231 days, DT90 range 15.7-404 days, Soils=5, Field studies DT50 range 4.9-7.5 days, DT90 range 23.5-31.2 days, Soils=4; EU 2005 dossier Lab studies DT50 range 2-11 days, Feld study DT50 range 10-27 days. Other sources: DT50 4.5-117 days aerobic, 12.8-402 days anaerobic
Dissipation rate RL50 on plant matrix Valor 3.4 R3 -
Nota Eggplant fruit, n=1
Dissipation rate RL50 on and in plant matrix Valor 1.6 R4 -
Nota Published literature RL50 range 0.8-2.4 days, 2 field crops, various matrices, n=2
Acuoso fotólisis DT50 (días) en pH 7 Valor 4.5 A5 Moderado rápido
Nota -
Acuoso hidrólisis DT50 (días) en 20oC y pH 7 Valor 17.6 A5 No persistente
Nota pH sensitive: stable at pH 4, 0.4 days at pH 9 at 20 degC
Aqua-Sedimento DT50 (días) 6 A5 Rápido
Fase de agua sola DT50 (días) 1.4 A5 Moderado rápido

De absorción del suelo y la movilidad:
Propiedad Click here for information on the parameters used to describe substance adsorption and mobility Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretación Click here for information on the way in which we interpret substance adsorption and mobility
Lineal Kd 46.3 A5 No Móvil
Koc 4483
Notas y rango EU 2018 dossier Kd range 26-95 mL/g, Koc range 2500-9600 mL/g, Soils=4; Literature values range 2200-8200 mL/g
Freundlich Kf - - -
Kfoc -
1/n -
Notas y rango -
pH senbsibilidad No

Key metabolites:
Metabolito Medio de formación Maximó Calculado de Fracción Ocurrencia 1107/2009 Importancia Click here for further information on 1107/2009 relevancy
methyl-7-chloro-2,5-dihydro-2-(((trifluoromethoxy)phenyl)amino)carbonyl(indeno(1,3,4)oxadiazine-4a(3H)-carboxylate (Ref: IN-JT333) This metabolite may cause environmental pollution, click here for further information Suelo   0.186   Major fraction, Not relevant
(E)-methyl 5-chloro-2,3-dihydro-2-hydroxy-1-((((methoxycarbonyl)(4-trifluoromethoxy)phenyl)amino)carbonyl)hydrazono)-1H-indene-2-carboxylate (Ref: IN-KG433) This metabolite may cause environmental pollution, click here for further information Suelo   0.400   Major fraction, Not relevant
(4-trifluoromethoxy)phenyl urea (Ref: IN-MK638) This metabolite may cause environmental pollution, click here for further information Suelo   0.280   Major fraction, Not relevant

Other known metabolites:
Metabolite name and reference Aliases Medio de formación / Rate Maximó Calculado de Fracción Ocurrencia Metabolising enzymes
methyl 5-chloro-2,3-dihydro-2-hydroxy-1-[[[[4-trifluoromethoxy)phenyl]amino]carbonyl]hydrazono]-1H-indene-2-carboxylate
(Ref: IN-JU873)
Nota: Soil DT50 = 38.1 days; Koc = 12816 mL/g
- Soil 0.129 -
methyl [4-(trifluoromethoxy)phenyl]carbamate
(Ref: IN-KB687)
- Soil 0.069 -
methyl (4aS)-7-chloro-2-{[4-(trifluoromethoxy) phenyl]carbamoyl}-2,5-dihydroindeno[1,2-e] [1,3,4]oxadiazine-4a(3H)-carboxylate
(Ref: IN-KN-125)
- - - -
sodium 7-cholor-2,5,-dihydro-2-[[methoxycarbonyl)[4(trifluoromethoxy)phenyl]amino]carbonyl]indeno[1,2-e][1,3,4]oxadiazine-4a(3H)-carboxylic acid
(Ref: IN-KT413)
Nota: Soil DT50 = 2.6 days; Koc = 422 mL/g
- a = Soil; b = Water (Hydrolysis) a=0.184 -
2-(carboxymethyl)-4-chlorobenzoic acid
(Ref: IN-MA573)
- Water (Photolysis) 0.199 -
methyl 2-[[[4(trifluoromethoxy)phenyl]amino]carbonyl]hydrazine carboxylate
(Ref: IN-MF014)
- Water (a = Hydrolysis, b = Photolysis) a=0.150; b=0.376 -
methyl 6-chloro-3,4-dihydro-1-oxo-1H-2-benzopyran-3-carboxylate
(Ref: IN-MH304)
- Water (Photolysis) 0.323 -
1,3-dihydro-5-(trifluoromethoxy)-2H-benzimidazol-2-one
(Ref: IN-MK643)
Nota: Soil DT50 = 235.2 days; Koc = 692 mL/g
- Soil 0.120 -
7-chloro-2,4-dihydro-4-[4(trifluoromethoxy)phenyl]3H-indeno[2,1-e]-1,2,4-triazin-3-one
(Ref: IN-ML438)
Nota: Soil DT50 = 43.4 days; Koc = 692 mL/g
- Soil 0.097 -


ECOTOXICOLOGÍA

for indoxacarb

Propiedad Click here for information on the parameters used to describe substance ecotoxicology Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretación Click here for information on the way in which we interpret substance ecotoxicology
Factor de la bio-concentración BCF (l kg-1) 77.3 A5 Bajo potencial
CT50 (días) No disponible -
Mamíferos - Agudos oral LD50 (mg kg-1) 179 A5 Rata Moderado
Mamíferos - a corto plazo NOEL (mg kg-1) - L2 Rata, 2 año -
(ppm dieta) 40 -
Pájaros/aves - Agudos LD50 (mg kg-1) 73.5 A5 Colinus virginianus Alto
Birds - Short term dietary (LC50/LD50) 340 mg kg-1 bw/día A5 Colinus virginianus -
Pez - agudo 96 hora LC50 (mg l-1) > 0.17 A5 Oncorhynchus mykiss Moderado
Pez - Crónico 21 días NOEC (mg l-1) 0.15 A4 Oncorhynchus mykiss, 90 día Moderado
Invertebrados acuáticos - Agudos 48 hora EC50 (mg l-1) 0.17 A5 Daphnia magna Moderado
Invertebrados acuáticos - Crónicos 21 días NOEC (mg l-1) 3.9 A5 Daphnia magna Moderado
Crustáceos acuáticos - Agudos 96 hora LC50 (mg l-1) 0.75 A5 Mysidopsis bahia Moderado
Sediment dwelling organisms - Agudos 96 hora LC50 (mg l-1) 31.0 A5 Chironomus riparius, 48hr Moderado
Sediment dwelling organisms - Crónicos 28 día NOEC, estático, agua (mg l-1) - - -
Sediment dwelling organisms - Crónicos 28 día NOEC, sedimento (mg kg-1) - - -
Plantas acuáticas - Agudos 7 día EC50, biomasa (mg l-1) 0.084 C4 Lemna gibba Moderado
Non-target plants - - -
- - -
Algas - Agudos 72 hora EC50, crecimiento (mg l-1) 0.079 A5 Pseudokirchneriella subcapitata Moderado
Algas - Crónicos 96 hora NOEC, crecimiento (mg l-1) - - -
Abejas mielíferas (Apis spp.) Contacto aguda LD50 (peor caso de 24 , 48 y 72 hora valores - μg abeja-1) 0.08 A5 Apis mellifera Alto
Oral aguda LD50 (peor caso de 24 , 48 y 72 hora valores - μg abeja-1) 0.232 A5 Apis mellifera Alto
Modo desconocido aguda LD50 (peor caso de 24 , 48 y 72 hora valores - μg abeja-1) - - -
Abejorros (Bombus spp.) Contacto aguda LD50 (peor caso de 24 , 48 y 72 hora valores - μg abeja-1) 0.25 A5 Bombus terrestris Alto
-
Oral aguda LD50 (peor caso de 24 , 48 y 72 hora valores - μg abeja-1) > 0.07 A5 Bombus terrestris Alto
-
Abejas albañiles (Osmia spp.) Contacto aguda LD50 (peor caso de 24 , 48 y 72 hora valores - μg abeja-1) 1.26 R4 Osmia bicornis Moderado
Oral aguda LD50 (peor caso de 24 , 48 y 72 hora valores - μg abeja-1) - - -
Otros polinizadores (1) Agudos LD50 (peor caso de 24 , 48 y 72 hora valores - μg insect-1) - - -
Modo de exposición -
Otros polinizadores (2) Agudos LD50 (peor caso de 24 , 48 y 72 hora valores - μg insect-1) - - -
Modo de exposición -
Lombrices - Agudos 14 día LC50 (mg kg-1) > 625 A5 Eisenia foetida, as isomer mix, corr Moderado
Lombrices - Crónicos NOEC, reproducción (mg kg-1) >= 29.2 A5 Eisenia foetida, 56 día Moderado
Other soil macro-organisms Agudos LC50 (mg kg-1) - - -
Crónicos NOEC (mg kg-1) 1.0 A5 Folsomia candida -
Otro arthropoda (1) LR50 g ha-1 6.5 >
A5 Aphidius colemani, adult 48hr
-
% Causalidad 95 Mortalidad
Dose: 0.135 kg ha-1
A5 Aphidius colemani, adult
-
Otro arthropoda (2) LR50 g ha-1 100 7 día
A5 Typhlodromus pyri, protonymph
-
% Causalidad - - -
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: 0.25 kg ha-1
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


LA SALUD HUMANA Y PROTECCIÓN

for indoxacarb

General:
Propiedad Click here for information on the parameters used to describe human health and protection issues Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with human health and protection data Interpretación Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mamíferos - Agudos oral LD50 (mg kg-1) 179 A5 Rata Moderado
Mammals - Dermal LD50 (mg kg-1 body weight) > 5000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) > 4.2 A5 Rat, 4 hr (nose only) -
Other Mammal toxicity endpoints - -
Consumo cada día aceptable (mg kg-1p.c. días-1) 0.005 A5 Rat, SF=100 -
ARfD - Acute Reference Dose (mg kg-1p.c. días-1) 0.005 A5 Rat, SF=100 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) 0.003 A5 Rat, SF=100 -
El nivel de exposición del operador (AOEL) sistemíco (mg kg-1p.c. días-1) 0.003 A5 Rat, SF=100 -
Estudios den la absorción cutánea (%) 1-18 A5 concentration dependent -
Directivo 76/464 Sustancias Peligrosas Lista II - -
Exposure Routes Public Minimal risk from dietary exposure
Risk assessment indicates ARfD would not normally be execeeded
Occupational -
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Genotóxico Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

A3; B0; C0; D0; E3

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

Cuestiones generales de la salud humana Moderately toxic
Possible kidney, liver, spleen and CNS toxicant
Clave: Genotoxicidad
A: Aberración cromosómica (base de datos EFSA)
B: Daño/reparación del ADN (base de datos EFSA)
C: Mutación genética (base de datos EFSA)
D: Mutación del genoma (base de datos EFSA)
E: Tipo de genotoxicidad no especificada (fuente de datos diversos)
0: Sin datos
1: Positivo
2: Resultados mixtos/ambiguos
3: Negativo
Clave: Otro
: Sí, se sabe que causa un problema
: No, sabe no causar un problema
: Posiblemente, estado no identificado
- : Datos no encontrados

Handling issues:
Propiedad Click here for information on the parameters used to describe substance handling issues Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with data on handling issues Interpretación Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive or oxidising
IMDG Transport Code is usually 9
CLP classification 2013 Health: H301, H317, H332, H372
Environment: H400, H410
CEE clasificación de riesgos Click here to view information omn the EU risk phrases Xn - Harmful: R22
N - Dangerous for the environment: R51/53
CEE clasificación sin riesgos Click here to view information omn the EU safety phrases S2, S13, S20/21, S35, S46, S57
Clasificación de OSM II - Peligroso mediano
Número de las NU Usually 3077
Waste disposal & packaging Click here for a description of UN packaging marks Packaging Group III (minor danger)


TRADUCCIONES

for indoxacarb

Idioma Nombre
Inglés indoxacarb
Francés indoxacarbe
Alemán Indoxacarb
Danés indoxacarb
Italiano indoxacarb
Español indoxacarb
Griego -
Esloveno indoksakarb
Polaco indoksakarb
Sueco indoxakarb
Húngaro indoxacarb
Holandés indoxacarb

Última actualización del registro: Wednesday 11 March 2020
Contacto: aeru@herts.ac.uk