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2,4-D (Ref: L 208)
** 2,4-D ** 2,4 PA ** 2,4-dichlorophenoxyacetic acid ** aqualin ** hedonal ** Traducciones

Destino ambiental - Ecotoxicología - La salud humana - A a Z Indice - Inicio

RESUMEN

2,4-D is a selective, systemic herbicide approved for use in the EU and used for the control of broad-leaved weeds. It is highly soluble in water, volatile and has a low potential to leach to groundwater based on its chemical properties. It is non-persistent in soil but may persist in aquatic systems under certain conditions. It is moderately toxic to mammals but should not bioaccumulate. It may have negeative effects on reproduction, development and is considered to be a neurotoxin and an irritant. It is moderately toxic to birds and most aquatic species as well as honeybees and earthworms.

INFORMACIÓN GENERAL Click here for an explantaion of the general chemical status information
for 2,4-D

Descripción: A translocated phenoxy herbicide for use in cereals, grass and amenity use. Can also be a pesticide transformation product

Ejemplos de plagas controladas: Broad-leaved weeds, Evasive weeds in aquatic situations

Ejemplos de aplicaciones: Turf grass & pastures; Non-cropping situations; Amenity sites; Orchards; Cereals including barley, wheat and oats; Lucerne

Eficacia y actividad: -

Availability status: Current

Introduction & key dates: circa 1950

CEE Regulación 1107/2009 ( 91/414):
Estado Approved
Dossier rapporteur/co-rapporteur Greece/Poland
Date inclusion expires 31/12/2030
UE Candidatas a sustitución No
Incluido en la base de datos de la UE

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia, Estados Unidos

Estructura química: Click here for further information on the general chemical status information used on this site
Isomerism None
Fórmula química C8H6Cl2O3
Canonical SMILES C1=CC(=C(C=C1Cl)Cl)OCC(=O)O
Isomeric SMILES No data
International Chemical Identifier Key (InChIKey) OVSKIKFHRZPJSS-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C8H6Cl2O3/c9-5-1-2-7(6(10)3-5)13-4-8(11)12/h1-3H,4H2,(H,11,12)
¿Diagrama de estructura 2D / imagen disponible?

Estado general: Click here for further information on the general chemical status information used on this site
Tipo de pesticida Herbicida, Plant growth regulator, Metabolite
Metabolite Type Suelo
Grupo químico Alkylchlorophenoxy
Minimum active substance purity 960 g/kg
Known relevant impurities EU dossier - dioxins & furans; 2,4-dichlorophenol
Sustancias de origen Sintéticas
Modo de acción Selective, systemic, absorbed through roots and increases biosynthesis and production of ethylene causing uncontrolled cell division and so damages vascular tissue. Synthetic auxin.
CAS RN 94-75-7
CEE número 202-361-1
Número CIPAC 1
EPA américaine chimiques de code 030001
PubChem CID 1486
Masa molecular (g mol-1) 221.04
PIN (Preferred Identification Name) (2,4-dichlorophenoxy)acetic acid
Nombre IUPAC (2,4-dichlorophenoxy)acetic acid
Nombre CAS (2,4-dichlorophenoxy)acetic acid
Otra información de estado Potential groundwater contaminant
Relevant Environmental Water Quality Standards UK statutory standard for protection of aquatic life for inland, coastal & territorial surface waters as annual average: 40 ug/L
Herbicide Resistance Classification (HRAC) O
Herbicide Resistance Classification (WSSA) 4
Insecticide Resistance Classification (IRAC) No aplicable
Fungicide Resistance Classification (FRAC) No aplicable
Examples of recorded resistance Limnocharis flava
Limnophila erecta
Papaver rhoeas
Sisymbrium orientale
Estado físico White powdery solid
Related substances & organisms

Puede ser un metabolito de
Padre/origen Medio de formación Maximó Calculado de Fracción Ocurrencia 1107/2009 Importancia Click here for further information on 1107/2009 relevancy
2,4-DB Soil   0.261   Major fraction, Relevancy unknown
2,4-D-dimethylammonium     -
2,4-DEP Soil     -

Formulaciones:
Propiedad Click here for information on the general product and branding information used on this site Valor
Example manufacturers & suppliers of products using this active now or historically
  • AgriChem
  • Dow AgroSciences
  • Headland
  • Nufarm
  • Vitax
Example products using this active
  • Depitox
  • Esteem
  • Weed B Gone
  • Killex
  • Junction
  • Tordon 101
  • Herboxone
  • Polo
  • Staff 500
  • DMA SL
Estado de UK LERAP None
Formulation and application details Often supplied as a soluble concentrate which is mixed with water and applied as a spray.


DESTINO AMBIENTAL

for 2,4-D

Propiedad Click here for information on the parameters used to describe environmental fate on this site Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with fate data Interpretación Click here for information on the way in which we interpret environmental fate data
Solubilidad - En aqua en 20oC (mg l-1) 24300 A5 Alto
Solubilidad - en solventes organicos en 20oC (mg l-1) 6400 A5 - Tolueno -
212000 A5 - Acetona -
810000 A5 - Metanol -
8000 A5 - Cloruro de metileno -
Punto de fusión (oC) 138.7 A5 -
Punto de ebullición (oC) 273.0 A5 -
El punto de degradación (oC) 200 A4 -
Punto de inflamación (oC) Not expected to self ignite; Not highly flammable] A5 -
Octanol-aqua coeficiente de particiónat en pH 7, 20oC P 1.51 X 10-01 Calculado -
Log P -0.82 A5 Bajo
Masa densidad (g ml-1)/Peso específico 1.57 B5 -
Disociación constante (pKa) at 25oC 3.40 A5 -
Nota: Ácido fuerte
Presión de vapor en 20oC (mPa) 0.009 A5 Baja volatilidad
Constante de Henry a 25oC (Pa m3 mol-1) 4.0 X 10-06 A4 No volátil
Indice de potencial de lixiviación GUS Click here for a note on the limitations of the GUS index 1.69 Calculado Bajo posibilidad de lixiviación
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Valor 3.88 X 10-03 Calculado -
Nota -
Potencial para transportar de 'particle bound' Click here for a note on the limitations of the potential for particle bound transport index - Calculado Bajo
Maximum UV-vis absorption L mol-1 cm-1 pH 1.16: 227nm=7344.4, 228nm=1448.9
pH 7.0: 228nm=8815.6, 283nm=1940
pH 11.3: 229nm=8984.5nm, 283nm=1977.5
A5 -
Surface tension (mN m-1) 70.5 A5 -

Degradación:
Propiedad Click here for information on the parameters used to describe substance degradation Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with degradation data Interpretación Click here for information on the way in which we interpret substance degradation data
Biodegradabilidad general -
Degradación de suelo (días) (aerobic) DT50 (típico) 4.4 A5 No persistente
DT50 (laboratorio en 20oC) 4.4 A5 No persistente
DT50 (campo) 28.8 A5 No persistente
DT90 (laboratorio en 20oC) 47.9 A5 -
DT90 (campo) 96.3 A5 -
Endpoint de modelado DT50 - - -
Nota EU dossier lab studies DT50 range 1.2-94.6 days, DT90 range 5.4-195.56 days; Field studies DT50 range 22-38 days, DT90 range 74-127 days; Other sources: 1.7-13.1 days (R3)
Dissipation rate RL50 on plant matrix Valor 2.2 R4 -
Nota Published literature RL50 range 1.1-3.0 days, 3 field crops, various matrices, n=3
Dissipation rate RL50 on and in plant matrix Valor 12.7 R4 -
Nota Published literature RL50 range 1.1-24.8 days, 3 field crops, various matrices, n=5
Acuoso fotólisis DT50 (días) en pH 7 Valor 38 A5 Estable
Nota -
Acuoso hidrólisis DT50 (días) en 20oC y pH 7 Valor Estable A5 -
Nota Stable between pH 5 to pH 9
Aqua-Sedimento DT50 (días) 18.2 A5 Rápido
Fase de agua sola DT50 (días) 7.7 A5 Moderado rápido

De absorción del suelo y la movilidad:
Propiedad Click here for information on the parameters used to describe substance adsorption and mobility Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretación Click here for information on the way in which we interpret substance adsorption and mobility
Lineal Kd 0.70 A5 Móvil
Koc 39.3
Notas y rango EU dossier Kd range 0.32-1.22 mL/g, Koc range 23-68 mL/g, Soils=7; Other literature multiple studies Kd range 1.59-1.88 mL/g, Koc range 31-275 mL/g (R4)
Freundlich Kf 0.45 A5 Móvil
Kfoc 24
1/n 0.83
Notas y rango EU dossier Kf range 0.19-0.83 mL/g, Kfoc range 12-42 mL/g, 1/n range 0.78-0.90, Soils=7; Other literature multiple studies Kf range 0.003-8.7 mL/g, Kfoc range 0.15-875 mL/g, 1/n range 0.35-1.59, Soils = 18
pH senbsibilidad No

Key metabolites:
Metabolito Medio de formación Maximó Calculado de Fracción Ocurrencia 1107/2009 Importancia Click here for further information on 1107/2009 relevancy
2,4-dichlorophenol This metabolite may cause environmental pollution, click here for further information Suelo   0.380   Relevant; Major fraction
2,4-dichloro-1-methoxybenzene This metabolite may cause environmental pollution, click here for further information Suelo   0.150   Relevant; Major fraction
4-chlorophenol This metabolite may cause environmental pollution, click here for further information Suelo   0.330   Relevant; Major fraction

Other known metabolites:
Metabolite name and reference Aliases Medio de formación / Rate Maximó Calculado de Fracción Ocurrencia Metabolising enzymes
1,2,4-benzenetriol - Water (photolysis) - -
2-ethylhexyl (2,4-dichlorophenoxy)acetate 2,4-D 2-EHE - - -
(2,5-dichloro-4-hydroxyphenoxy)acetic acid 4-OH-2,5-D Plant - -
(4-chlorophenoxy)acetic acid - - - -
(2,4-dichloro-5-hydroxyphenoxy)acetic acid 5-OH-2,4-D Plant - -
(2,3-dichloro-4-hydroxyphenoxy)acetic acid 4-OH-2,3-D Plant - -


ECOTOXICOLOGÍA

for 2,4-D

Propiedad Click here for information on the parameters used to describe substance ecotoxicology Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretación Click here for information on the way in which we interpret substance ecotoxicology
Factor de la bio-concentración BCF (l kg-1) 10 A5 (Whole fish) Bajo potencial
CT50 (días) No disponible -
Mamíferos - Agudos oral LD50 (mg kg-1) > 300 A5 Rata Moderado
Mamíferos - a corto plazo NOEL (mg kg-1) 60 A5 Rata Alto
(ppm dieta) - -
Pájaros/aves - Agudos LD50 (mg kg-1) > 500 A5 Colinus virginianus Moderado
Birds - Short term dietary (LC50/LD50) > 5620 mg kg-1 A4 Colinus virginianus -
Pez - agudo 96 hora LC50 (mg l-1) 100 A4 Pimephales promelas Moderado
Pez - Crónico 21 días NOEC (mg l-1) 27.2 J3 Oryzias latipes, 28 día Bajo
Invertebrados acuáticos - Agudos 48 hora EC50 (mg l-1) 134.2 A5 Daphnia magna Bajo
Invertebrados acuáticos - Crónicos 21 días NOEC (mg l-1) 46.2 A5 Daphnia magna Bajo
Crustáceos acuáticos - Agudos 96 hora LC50 (mg l-1) - - -
Sediment dwelling organisms - Agudos 96 hora LC50 (mg l-1) - - -
Sediment dwelling organisms - Crónicos 28 día NOEC, estático, agua (mg l-1) - - -
Sediment dwelling organisms - Crónicos 28 día NOEC, sedimento (mg kg-1) - - -
Plantas acuáticas - Agudos 7 día EC50, biomasa (mg l-1) 2.7 A5 Lemna gibba Moderado
Non-target plants 19 A5 Lettuce
Vegetative vigour, ER50
as g/ha
-
27 A5 Lettuce
Seedling emergence, ER50
as g/ha
-
Algas - Agudos 72 hora EC50, crecimiento (mg l-1) 24.2 A5 Raphidocelis subcapitata Bajo
Algas - Crónicos 96 hora NOEC, crecimiento (mg l-1) 100 J4 Chlorella vulgaris Bajo
Abejas mielíferas Contacto aguda 48 hora LD50 (μg abeja-1) > 100 A5 Bajo
Oral aguda 48 hora LD50 (μg abeja-1) 94 A5 Moderado
Modo desconocido aguda 48 hora LD50 (μg abeja-1) - - -
Lombrices - Agudos 14 día LC50 (mg kg-1) 350 A5 Eisenia foetida Moderado
Lombrices - Crónicos 14 día NOEC, reproducción (mg kg-1) - - -
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Causalidad - - -
Otro arthropoda (1) LR50 g ha-1 3000 >
A5 Typhlodromus pyri
-
% Causalidad 7.5
-13.2
Mortalidad
Beneficial capacity
Dose: 3.0 kg ha-1
A5 Aphidius rhopalosiphi
-
Otro arthropoda (2) LR50 g ha-1 3000 >
A5 Aphidius rhopalosiphi
-
% Causalidad 5.3
-6.2
Mortalidad
Beneficial capacity
Dose: 3.0 kg ha-1
A5 Typhlodromus pyri
-
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: 3 mg kg-1, 28 días
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


LA SALUD HUMANA Y PROTECCIÓN

for 2,4-D

General:
Propiedad Click here for information on the parameters used to describe human health and protection issues Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with human health and protection data Interpretación Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mamíferos - Agudos oral LD50 (mg kg-1) > 300 A5 Rata Moderado
Mammals - Dermal LD50 (mg kg-1 body weight) > 2000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) > 1.79 A5 Rat, 4hr (whole body) -
Other Mammal toxicity endpoints - -
Consumo cada día aceptable (mg kg-1p.c. días-1) 0.05 A5 Rat, SF=100 -
ARfD - Acute Reference Dose (mg kg-1p.c. días-1) Ningunos asignaron A5 Rat -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
El nivel de exposición del operador (AOEL) sistemíco (mg kg-1p.c. días-1) 0.15 A4 Rat, SF=100 -
Estudios den la absorción cutánea (%) 0.1-4.0 A5 concentration dependent -
Directivo 76/464 Sustancias Peligrosas - - -
Limites de exposiciones [UK LT TWA 8 hr: 10 mg/m3], [UK STEL 15 mins: 20 mg/m3] UK EA QS database, 2018 -
Exposure Routes Public Small risk of dermal exposure from contact with sprayed vegetation
No risk to consumers via acute residue
Occupational Moderate risk of inhalation and dermal exposure depending on personal protection clothing and equipment utilised
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards Non-statutory WHO drinking water guideline 0.03 mg/L UK EA QS database, 2018 -
Drinking Water MAC (μg l-1) 70.0 F4 (For USA - EPA drinking water regulations) -

Health issues:
Carcinogen Mutágeno Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

Cuestiones generales de la salud humana Excessive doses may affect digestive systems
Possible liver and kidney toxicant
Endocrine issues - Synergistic androgenic effects when combined with testosterone

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Propiedad Click here for information on the parameters used to describe substance handling issues Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with data on handling issues Interpretación Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Corrosive to metals
IMDG Transport Code is usually 9 or 6.1
Not explosive or oxidising
CLP classification 2013 Health: H302, H317, H318, H335
Environment: H412
CEE clasificación de riesgos Click here to view information omn the EU risk phrases Xn - Harmful: R22, R41, R43
Xi - Irritant: R37
N - Dangerous for the environment: R52, R53
CEE clasificación sin riesgos Click here to view information omn the EU safety phrases S2, S24/25, S26, S46, S61, S36/37/39
Clasificación de OSM II - Peligroso mediano
US EPA Classification (formulation) II - III - -
Número de las NU Usually 3082 or 3077
Waste disposal & packaging Click here for a description of UN packaging marks Dispose of in accordance with local regulations
Packaging Group III (minor danger)


TRADUCCIONES

for 2,4-D

Idioma Nombre
Inglés 2,4-D
Francés 2,4-D
Alemán 2,4-D
Danés 2,4-D
Italiano 2,4-D
Español 2,4-D
Griego -
Esloveno 2,4-D
Polaco 2,4-D
Sueco 2,4-D
Húngaro 2,4-D
Holandés 2,4-D

Última actualización del registro: Thursday 23 August 2018
Contacto: aeru@herts.ac.uk