Seleccione la Opción
Inicio
A a Z Indice
Búsqueda
Términos y Condiciones
Información de Asistencia
Compras y Servicios
GET ADDITIONAL DATA HERE!

malation (Ref: OMS 1)
** malathion ** carbophos ** maldison ** mercaptothion ** carbofos ** ENT 17034 ** Traducciones

Destino ambiental - Ecotoxicología - La salud humana - A a Z Indice - Inicio
Otros datos se pueden encontrar en el VSDB

RESUMEN

Malathion is an insecticide approved for use in the EU and in many other countries. It is moderately soluble in water and readily soluible in many organic solvents. It is quite volatile and has a low potential for leaching to groundwater. Malathion is not usually persistent in soil or water systems. It is moderately toxic to mammals, a cholineserase inhibitor and a neurotoxin. Malathion is highly toxic to honey bees and aquatic species with the exception of algae. It is moderately toxic to birds and earthworms.

INFORMACIÓN GENERAL Click here for an explantaion of the general chemical status information
for malathion

Descripción: An insecticide and acaricide used to control a wide range of pests

Ejemplos de plagas controladas: Coleoptera; Diptera; Hemiptera; Lepidoptera; Mosquitoes; Fruit flies; Aphids; Mealybugs; Leaf hoppers; Spidermites

Ejemplos de aplicaciones: Vegetables including turnips; Public health applications; Ornamental trees and shrubs; Stored produce

Eficacia y actividad: -

Availability status: Current

Introduction & key dates: 1952, first reported

CEE Regulación 1107/2009 ( 91/414):
Estado Approved
Dossier rapporteur/co-rapporteur Czech Republic/Bulgaria
Date inclusion expires 30/04/2022
UE Candidatas a sustitución No
Incluido en la base de datos de la UE

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Estados Unidos

Estructura química: Click here for further information on the general chemical status information used on this site
Isomerism A chiral molecule existing as two enantiomers
Fórmula química C10H19O6PS2
Canonical SMILES CCOC(=O)CC(C(=O)OCC)SP(=S)(OC)OC
Isomeric SMILES No data
International Chemical Identifier Key (InChIKey) JXSJBGJIGXNWCI-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C10H19O6PS2/c1-5-15-9(11)7-8(10(12)16-6-2)19-17(18,13-3)14-4/h8H,5-7H2,1-4H3
¿Diagrama de estructura 2D / imagen disponible?

Estado general: Click here for further information on the general chemical status information used on this site
Tipo de pesticida Insecticide, Acaricide, Veterinary substance
Grupo químico Organophosphate
Minimum active substance purity 950 g/kg (racemic mixture)
Known relevant impurities EU dossier - malaoxon <1g/kg, isomalathion <2g/kg, MeOOSPS-triester <15g/kg, MeOOOPS-triester 5g/kg
Sustancias de origen Sintéticas
Modo de acción Broad-spectrum, non-systemic with contact, stomach and respiratory action. Acetylcholinesterase (AChE) inhibitor.
CAS RN 121-75-5
CEE número 204-497-7
Número CIPAC 12
EPA américaine chimiques de code 057701
PubChem CID 4004
Masa molecular (g mol-1) 330.36
PIN (Preferred Identification Name) -
Nombre IUPAC diethyl (dimethoxyphosphinothioylthio)succinate
Nombre CAS diethyl ((dimethoxyphosphinothioyl)thio)butanedioate
Otra información de estado Marine Pollutant; Evidence of use in third world countries; Chemical subject to PIC regulations; Phytotoxic to some ornamentals including orchids, ferns and petunias
Relevant Environmental Water Quality Standards UK statutory standard for the protection of aquatic life in inland waters and for surface water quality: 0.01 ug/L as annual average conc.
UK statutory standard for the protection of aquatic life in coastal and territorial waters: 0.02 ug/L as annual average conc.
Herbicide Resistance Classification (HRAC) No aplicable
Herbicide Resistance Classification (WSSA) No aplicable
Insecticide Resistance Classification (IRAC) 1B
Fungicide Resistance Classification (FRAC) No aplicable
Examples of recorded resistance Aedes aegypti
Amblyseius fallacis
Aphis gossypii
Culex restuans
Aedes caspius
many more
Estado físico Clear to amber liquid
Related substances & organisms

Formulaciones:
Propiedad Click here for information on the general product and branding information used on this site Valor
Example manufacturers & suppliers of products using this active now or historically
  • Cheminova A/S
  • FMC Chemicals
  • Headland
  • Nickerson
  • American Cyanamid
  • Farmoplant
Example products using this active
  • Fyfanon 440
  • Karbofos
  • Cythion
  • Maltox
  • Malixol
  • Cekumal
Estado de UK LERAP None
Formulation and application details Often supplied as an emulsifiable concentrate, wettable powder or ULV.


DESTINO AMBIENTAL

for malathion

Propiedad Click here for information on the parameters used to describe environmental fate on this site Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with fate data Interpretación Click here for information on the way in which we interpret environmental fate data
Solubilidad - En aqua en 20oC (mg l-1) 148 A5 Moderado
Solubilidad - en solventes organicos en 20oC (mg l-1) 250000 A5 - Xileno -
62000 A5 - Heptano -
250000 A5 - Acetona -
250000 A5 - Metanol -
Punto de fusión (oC) -20 A5 -
Punto de ebullición (oC) Decomposes before boiling A5 -
El punto de degradación (oC) 174 A5 -
Punto de inflamación (oC) 173 A5 -
Octanol-aqua coeficiente de particiónat en pH 7, 20oC P 5.62 X 1002 Calculado -
Log P 2.75 A5 Moderado
Masa densidad (g ml-1)/Peso específico 1.23 B5 -
Disociación constante (pKa) at 25oC No aplicable B5 -
Nota: Ninguna disociación
Presión de vapor en 20oC (mPa) 3.1 A5 Baja volatilidad
Constante de Henry a 25oC (Pa m3 mol-1) 1.00 X 10-03 A5 No volátil
Indice de potencial de lixiviación GUS Click here for a note on the limitations of the GUS index -1.28 Calculado Bajo posibilidad de lixiviación
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Valor 3.12 X 10-05 Calculado -
Nota -
Potencial para transportar de 'particle bound' Click here for a note on the limitations of the potential for particle bound transport index - Calculado Bajo
Maximum UV-vis absorption L mol-1 cm-1 No absorbance above 290nm A5 -
Surface tension (mN m-1) 58.0 A5 at 20oC -

Degradación:
Propiedad Click here for information on the parameters used to describe substance degradation Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with degradation data Interpretación Click here for information on the way in which we interpret substance degradation data
Biodegradabilidad general -
Degradación de suelo (días) (aerobic) DT50 (típico) 0.17 Click here to see a warning relating to modelling and this active substance A5 No persistente
DT50 (laboratorio en 20oC) 0.17 A5 No persistente
DT50 (campo) 1 A5 No persistente
DT90 (laboratorio en 20oC) 0.63 A5 -
DT90 (campo) - - -
Endpoint de modelado DT50 - - -
Nota EU dossier lab studies range DT50 0.1-0.25 days, DT90 range 0.3-0.84 days; Other sources: DT50 1.0 days (DW4)
Dissipation rate RL50 on plant matrix Valor 2.4 R4 -
Nota Published literature RL50 range 0.4-4.5 days, 10 field & undercover grown crops, various matrices, n=11
Dissipation rate RL50 on and in plant matrix Valor 4.3 R4 -
Nota Published literature RL50 range 0.3-19.5 days, 26 field & undercover grown crops, various matrices, n=42; Stored corn RL50=112 days.
Acuoso fotólisis DT50 (días) en pH 7 Valor 98 B5 Estable
Nota DT50 156 days under test conditions - not natural light (A5)
Acuoso hidrólisis DT50 (días) en 20oC y pH 7 Valor 6.2 A5 No persistente
Nota pH sensitive: DT50 107 days at pH 5, 0.49 days at pH 9, all at 25 degC
Aqua-Sedimento DT50 (días) 0.4 A4 Rápido
Fase de agua sola DT50 (días) 0.4 A4 Rápido

De absorción del suelo y la movilidad:
Propiedad Click here for information on the parameters used to describe substance adsorption and mobility Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretación Click here for information on the way in which we interpret substance adsorption and mobility
Lineal Kd - DW2 Móvil un poco
Koc 1800
Notas y rango -
Freundlich Kf 1.58 A5 Móvil moderado
Kfoc 217
1/n 0.94
Notas y rango EU dossier kf range 0.83-2.47 mL/g, Kfoc range 151-308 mL/g, 1/n range 0.904-0.978, Soils=5
pH senbsibilidad No

Key metabolites:
Metabolito Medio de formación Maximó Calculado de Fracción Ocurrencia 1107/2009 Importancia Click here for further information on 1107/2009 relevancy
malathion monocarboxylic acid (Ref: MMCA) This metabolite may cause environmental pollution, click here for further information Suelo   0.25   Major fraction, Relevant
malathion dicarboxylic acid This metabolite may cause environmental pollution, click here for further information Suelo   0.62   Major fraction, Relevant
isomalathion On heating   -   Relevant

Other known metabolites:
Metabolite name and reference Aliases Medio de formación / Rate Maximó Calculado de Fracción Ocurrencia Metabolising enzymes
diethyl (2RS)-2-[(dimethoxyphosphoryl)sulfanyl]butanedioate
Nota: Considerably more toxic than malathion
Malaoxon Plant; Animal - -
desmethyl malathion DMM Plant - -
malathion dicarboxylic acid DCA Human (Liver) - -
malathion monocarboxylic acid DMA Human (Liver) - -


ECOTOXICOLOGÍA

for malathion

Propiedad Click here for information on the parameters used to describe substance ecotoxicology Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretación Click here for information on the way in which we interpret substance ecotoxicology
Factor de la bio-concentración BCF (l kg-1) 103 A5 (Other literature Log BCF range 0-3.7 (R3)) Umbral de importancia
CT50 (días) 0.69 -
Mamíferos - Agudos oral LD50 (mg kg-1) 1778 A5 Rata Moderado
Mamíferos - a corto plazo NOEL (mg kg-1) 34.4 A5 Rata Alto
(ppm dieta) - -
Pájaros/aves - Agudos LD50 (mg kg-1) 359 A5 Colinus virginianus Moderado
Birds - Short term dietary (LC50/LD50) 554 mg kg-1 bw/día A5 Colinus virginianus -
Pez - agudo 96 hora LC50 (mg l-1) 0.018 A5 Oncorhynchus mykiss Alto
Pez - Crónico 21 días NOEC (mg l-1) 0.091 A5 Oncorhynchus mykiss Moderado
Invertebrados acuáticos - Agudos 48 hora EC50 (mg l-1) 0.0007 A5 Daphnia magna Alto
Invertebrados acuáticos - Crónicos 21 días NOEC (mg l-1) 0.00006 A5 Daphnia magna Alto
Crustáceos acuáticos - Agudos 96 hora LC50 (mg l-1) 0.0015 F3 Americamysis bahia Alto
Sediment dwelling organisms - Agudos 96 hora LC50 (mg l-1) 0.0004 F2 Chironomus riparius, 1 día Alto
Sediment dwelling organisms - Crónicos 28 día NOEC, estático, agua (mg l-1) - - -
Sediment dwelling organisms - Crónicos 28 día NOEC, sedimento (mg kg-1) - - -
Plantas acuáticas - Agudos 7 día EC50, biomasa (mg l-1) - - -
Non-target plants > 1800 A5, six species
Vegetative vigour, ER50
as g/ha
-
- - -
Algas - Agudos 72 hora EC50, crecimiento (mg l-1) 13 B5 Raphidocelis subcapitata, EU dossier EC50 = 4.1 Unknown species Bajo
Algas - Crónicos 96 hora NOEC, crecimiento (mg l-1) - - -
Abejas mielíferas (Apis spp.) Contacto aguda LD50 (peor caso de 24 , 48 y 72 hora valores - μg abeja-1) 0.16 A5 Alto
Oral aguda LD50 (peor caso de 24 , 48 y 72 hora valores - μg abeja-1) 0.40 A5 Alto
Modo desconocido aguda LD50 (peor caso de 24 , 48 y 72 hora valores - μg abeja-1) - - -
Abejorros (Bombus spp.) Contacto aguda LD50 (peor caso de 24 , 48 y 72 hora valores - μg abeja-1) - - -
-
Oral aguda LD50 (peor caso de 24 , 48 y 72 hora valores - μg abeja-1) - - -
-
Abejas albañiles (Osmia spp.) Contacto aguda LD50 (peor caso de 24 , 48 y 72 hora valores - μg abeja-1) - - -
Oral aguda LD50 (peor caso de 24 , 48 y 72 hora valores - μg abeja-1) - - -
Otros polinizadores (1) Agudos LD50 (peor caso de 24 , 48 y 72 hora valores - μg insect-1) 0.0005 R4 Megachile rotundata Alto
Modo de exposición Contact
Otros polinizadores (2) Agudos LD50 (peor caso de 24 , 48 y 72 hora valores - μg insect-1) 0.265 R4 Trigona spinipes Alto
Modo de exposición Contact
Lombrices - Agudos 14 día LC50 (mg kg-1) 306 A5 Eisenia foetida, corr Moderado
Lombrices - Crónicos 14 día NOEC, reproducción (mg kg-1) - - -
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Causalidad - - -
Otro arthropoda (1) LR50 g ha-1 0.061 48 hora
A5 Aphidius rhopalosiphi
-
% Causalidad - - -
Otro arthropoda (2) LR50 g ha-1 85.4 A5 Typhlodromus pyri -
% Causalidad - - -
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: 6.3 kg ha-1
-
Mesocosm study data NOEAEC mg l-1 0.030 A5 Aquatic invertebrates -
NOEAEC mg l-1 - - -


LA SALUD HUMANA Y PROTECCIÓN

for malathion

General:
Propiedad Click here for information on the parameters used to describe human health and protection issues Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with human health and protection data Interpretación Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mamíferos - Agudos oral LD50 (mg kg-1) 1778 A5 Rata Moderado
Mammals - Dermal LD50 (mg kg-1 body weight) > 2000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) > 5.0 A5 Rat, 4 hr -
Other Mammal toxicity endpoints Intraperitoneal LD50 = 250 mg kg-1 V3 Rat -
Intravenosa LD50 = 50 mg kg-1 V3 Rata -
Consumo cada día aceptable (mg kg-1p.c. días-1) 0.03 A5 Rat, SF=1000 -
ARfD - Acute Reference Dose (mg kg-1p.c. días-1) 0.3 A5 Rat, SF=100 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
El nivel de exposición del operador (AOEL) sistemíco (mg kg-1p.c. días-1) 0.03 A2 Rat, SF=1000 -
Estudios den la absorción cutánea (%) 5.0-15.0 A5 concentration dependent -
Directivo 76/464 Sustancias Peligrosas List I; List II - -
Limites de exposiciones [UK LT TWA 8 hr: 10 mg/m3] UK EA QS database, 2018 -
Exposure Routes Public Possible concerns for bystanders especially children should they enter a sprayed area
Occupational Operators should use PPC/PPE at all times
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutágeno Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

Cuestiones generales de la salud humana Possible adrenal gland, thyroid and liver toxicant
Acetylcholinesterase inhibition
IARC group 2A carcinogen; USEPA - some evidence to suggest possible human carcinogen
Endocrine issues - Inhibition of catecholamine secretion

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Propiedad Click here for information on the parameters used to describe substance handling issues Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with data on handling issues Interpretación Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Prevent generation of mists
Store at low temperatures, do not heat
Not explosive or oxidising
IMDG Transport Code is usually 6.1
CLP classification 2013 -
CEE clasificación de riesgos Click here to view information omn the EU risk phrases Xn - Harmful: R22, R43
N - Dangerous for the environment: R50, R53
CEE clasificación sin riesgos Click here to view information omn the EU safety phrases S2, S24, S37, S46, S60, S61
Clasificación de OSM III - Peligroso un poco
US EPA Classification (formulation) III - Caution - Slightly toxic
Número de las NU Usually 2783
Waste disposal & packaging Click here for a description of UN packaging marks Packaging Group III (minor danger)


TRADUCCIONES

for malathion

Idioma Nombre
Inglés malathion
Francés malathion
Alemán Malathion
Danés malathion
Italiano malation
Español malation
Griego malathion
Esloveno malation
Polaco malation
Sueco -
Húngaro malathion
Holandés malathion

Última actualización del registro: Thursday 20 June 2019
Contacto: aeru@herts.ac.uk