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mandipropamida (Ref: NOA 446510)
** mandipropamid ** Traducciones

Destino ambiental - Ecotoxicología - La salud humana - A a Z Indice - Inicio

INFORMACIÓN GENERAL Click here for an explantaion of the general chemical status information
for mandipropamid

Descripción: A new fungicide used to control Oomycete pathogens on grapes, potatoes and other crops

Ejemplos de plagas controladas: Plasmopara viticola; Phytophthora infestans; Pseudoperonospora cubensis

Ejemplos de aplicaciones: Grapes; Potatoes; Tomatoes; Curcubits

Eficacia y actividad: -

Availability status: Current

Introduction & key dates: 1999, discovered

CEE Regulación 1107/2009 ( 91/414):
Estado Approved
Dossier rapporteur/co-rapporteur Austria
Date inclusion expires 31/07/2023
UE Candidatas a sustitución No
Incluido en la base de datos de la UE

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Estructura química: Click here for further information on the general chemical status information used on this site
Isomerism Mandipropamid is a chiral molecule with an asymmetrically substituted carbon atom and consists of a pair of enantiomers. The technical material is a racemate comprising equimolar amounts of (R)- and (S)-mandipropamid
Fórmula química C23H22ClNO4
Canonical SMILES COC1=C(C=CC(=C1)CCNC(=O)C(C2=CC=C(C=C2)Cl)OCC#C)OCC#C
Isomeric SMILES No data
International Chemical Identifier Key (InChIKey) KWLVWJPJKJMCSH-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C23H22ClNO4/c1-4-14-28-20-11-6-17(16-21(20)27-3)12-13-25-23(26)22(29-15-5-2)18-7-9-19(24)10-8-18/h1-2,6-11,16,22H,12-15H2,3H3,(H,25,26)
¿Diagrama de estructura 2D / imagen disponible?

Click to access the Cambridge Crystallographic Data Centre (CCDC) website
Cambridge Crystallographic Data Centre diagrams:
Nombre Común Relación Vínculo
Mandipropamid Unstated isomer Click here for the CCDC structure diagram

Estado general: Click here for further information on the general chemical status information used on this site
Tipo de pesticida Fungicide
Grupo químico Mandelamide
Minimum active substance purity 930 g/kg
Known relevant impurities EU dossier - SYN 5455038 < 0.1g/kg
Sustancias de origen Sintéticas
Modo de acción Inhibits spore germination with preventative action. Cellulose synthesis inhibitor.
CAS RN 374726-62-2
CEE número -
Número CIPAC 783
EPA américaine chimiques de code 036602
PubChem CID 11292824
Masa molecular (g mol-1) 411.9
PIN (Preferred Identification Name) -
Nombre IUPAC (RS)-2-(4-chlorophenyl)-N-[3-methoxy-4-(prop-2-ynyloxy)phenethyl]-2-(prop-2-ynyloxy)acetamide
Nombre CAS 4-chloro-N-(2-(3-methoxy-4-(2-propynyloxy)phenyl)ethyl)-a-(2-propynyloxy)benzeneacetamide
Otra información de estado -
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) No aplicable
Herbicide Resistance Classification (WSSA) No aplicable
Insecticide Resistance Classification (IRAC) No aplicable
Fungicide Resistance Classification (FRAC) 40
Examples of recorded resistance -
Estado físico Light beige powder
Related substances & organisms -

Formulaciones:
Propiedad Click here for information on the general product and branding information used on this site Valor
Example manufacturers & suppliers of products using this active now or historically
  • Syngenta
Example products using this active
  • Revus
Estado de UK LERAP None
Formulation and application details Often supplied as soluble concentrate that is mixed with water and used as a spray.


DESTINO AMBIENTAL

for mandipropamid

Propiedad Click here for information on the parameters used to describe environmental fate on this site Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with fate data Interpretación Click here for information on the way in which we interpret environmental fate data
Solubilidad - En aqua en 20oC (mg l-1) 4.2 A5 Bajo
Solubilidad - en solventes organicos en 20oC (mg l-1) 300000 A5 - Acetona -
120000 A5 - Acetato de etilo -
29000 A5 - Tolueno -
400000 A5 - Cloruro de metileno -
Punto de fusión (oC) 96 A5 -
Punto de ebullición (oC) Decomposes before boiling A5 -
El punto de degradación (oC) 200 A5 -
Punto de inflamación (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-aqua coeficiente de particiónat en pH 7, 20oC P 1.58 X 1003 Calculado -
Log P 3.2 A5 Alto
Masa densidad (g ml-1)/Peso específico - - -
Disociación constante (pKa) at 25oC No aplicable A5 -
Nota: Ninguna disociación
Presión de vapor en 20oC (mPa) 9.40 X 10-04 A5 Baja volatilidad
Constante de Henry a 25oC (Pa m3 mol-1) 9.2 X 10-05 A5 No volátil
Indice de potencial de lixiviación GUS Click here for a note on the limitations of the GUS index 1.81 Calculado Estado de transición
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Valor 6.06 X 10-02 Calculado -
Nota -
Potencial para transportar de 'particle bound' Click here for a note on the limitations of the potential for particle bound transport index - Calculado Mediano
Maximum UV-vis absorption L mol-1 cm-1 Neutral solution: 223nm = 20144, 276nm = 2724; [Acidic solution: 223nm = 20313, 276nm = 2845; [Basic solution: 223nm = 19414, 276nm = 2864 A5 -
Surface tension (mN m-1) 72.8 A5 at 20oC -

Degradación:
Propiedad Click here for information on the parameters used to describe substance degradation Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with degradation data Interpretación Click here for information on the way in which we interpret substance degradation data
Biodegradabilidad general -
Degradación de suelo (días) (aerobic) DT50 (típico) 49.1 A5 Persistente moderado
DT50 (laboratorio en 20oC) 49.1 A5 Persistente moderado
DT50 (campo) 13.6 A5 No persistente
DT90 (laboratorio en 20oC) 162 A5 -
DT90 (campo) 76.4 A5 -
Endpoint de modelado DT50 - - -
Nota EU dossier lab studies range DT50 23.4-83.9 days, DT90 range 102-285 days; field studies DT50 range 5.6-29.2 days, DT90 range 42.1-240 days
Dissipation rate RL50 on plant matrix Valor - - -
Nota -
Dissipation rate RL50 on and in plant matrix Valor 3.7 R4 -
Nota Published literature RL50 range 2.2-5.3 days, 2 field crops, various matrices, n=2
Acuoso fotólisis DT50 (días) en pH 7 Valor 4.0 A3 Moderado rápido
Nota DT50 1.4-6.7 days sterilised water pH 7, 4.8 days natural summer light 40 deg N, slightly faster at pH 7.4
Acuoso hidrólisis DT50 (días) en 20oC y pH 7 Valor Estable A5 -
Nota Stable pH 4 to pH 9
Aqua-Sedimento DT50 (días) 12.2 A5 Rápido
Fase de agua sola DT50 (días) Estable A5 -

De absorción del suelo y la movilidad:
Propiedad Click here for information on the parameters used to describe substance adsorption and mobility Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretación Click here for information on the way in which we interpret substance adsorption and mobility
Lineal Kd - - -
Koc -
Notas y rango -
Freundlich Kf 16.1 A5 Móvil un poco
Kfoc 847
1/n 0.845
Notas y rango EU dossier Kf range 2.88-53.2 mL/g, Kfoc range 405-1294 mL/g, 1/n range 0.780-0.916, Soils=7
pH senbsibilidad No

Key metabolites:
Metabolito Medio de formación Maximó Calculado de Fracción Ocurrencia 1107/2009 Importancia Click here for further information on 1107/2009 relevancy
2-(4-chlorophenyl)-2-hydroxy-N-(2-(3-methoxy-4-prop-2-ynyloxy-phenyl)-ethyl)-acetamide (Ref: CGA 380778) Suelo   0.060   Minor fraction, Relevant
(R/S)2-(4-chloro-phenyl)-2-hydroxy-N-(2-(4-hydroxy-3-methoxy-phenyl)-ethyl)-acetamide (Ref: CGA 380775) Suelo   -   Minor fraction, Not relevant
(R/S)(4-Chloro-phenyl)-prop-2-ynyloxy-acetic acid (Ref: SYN 500003) Suelo   -   Minor fraction, Not relevant
(R/S)allyloxy-(4-chloro-phenyl)-acetic acid (Ref: SYN 504851) Suelo   -   Minor fraction, Not relevant

Other known metabolites:
Metabolite name and reference Aliases Medio de formación / Rate Maximó Calculado de Fracción Ocurrencia Metabolising enzymes
4-(2-aminoethyl)-2-methoxyphenol
(Ref: CGA 353043)
- unknown - -
2-[3-methoxy-4-(prop-2-yn-1-yloxy)phenyl]ethanamine
(Ref: NOA 440567)
- unknown - -
2-(4-chlorophenyl)-N-[2-(4-hydroxy-3-methoxy-phenyl)-ethyl]-2-prop-2-ynyloxy-acetamide
(Ref: NOA 458422)
- Rat (Faeces); Plant; Animal; Soil - -
(4-chlorophenyl)-hydroxy acetic acid
(Ref: NOA 495119)
- unknown - -
allyloxy-(4-chlorophenyl)-actic acid
(Ref: SYN 504851)
- Water/sediment 0.100 -
2-(4-chlorophenyl)-N-[2-(3,4-dihydroxy-phenyl)-ethyl]-2-prop-2-ynyloxy-acetamide
(Ref: SYN 505503)
- unknown - -
2-(4-chlorophenyl)-N-[2-(3,4-dihydroxy-phenyl)-ethyl]-2-hydroxyacetamide
(Ref: SYN 505504)
- unknown - -
2-(4-chlorophenyl)-N-[2-(3-hydroxy-4-prop-2-ynyloxy-phenyl)-ethyl]-2-prop-2-ynyloxy-acetamide
(Ref: SYN 521195)
- Animal; Sediment - -
2-allyloxy-N-[2-(4-allyloxy-3-methoxy-phenyl)-ethyl]-2-(4-chloro-phenyl)-acetamide
(Ref: SYN 535839)
- unknown - -
N-[2-(4-allyloxy-3-methoxyphenyl)-ethyl]-2-(4-chloro-phenyl)-2-prop-2-ynyloxy-acetamide
(Ref: SYN 536638)
- Soil - -
N-[2-(4-allyloxy-3-hydroxy-phenyl)-ethyl]-2-(4-chloro-phenyl)-2-prop-2-ynyloxy-acetamide
(Ref: SYN 539678)
- Sediment - -
2-allyloxy-N-[2-(4-allyloxy-3-hydroxy-phenyl)-ethyl]-2-(4-chloro-phenyl)-acetamide
(Ref: SYN 539679)
- Water (Anaerobic); Water/sediment - -


ECOTOXICOLOGÍA

for mandipropamid

Propiedad Click here for information on the parameters used to describe substance ecotoxicology Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretación Click here for information on the way in which we interpret substance ecotoxicology
Factor de la bio-concentración BCF (l kg-1) 48 A5 Bajo potencial
CT50 (días) 1 -
Mamíferos - Agudos oral LD50 (mg kg-1) > 5000 A5 Rata Bajo
Mamíferos - a corto plazo NOEL (mg kg-1) - - -
(ppm dieta) - -
Pájaros/aves - Agudos LD50 (mg kg-1) > 1000 A5 Anas platyrhynchos Moderado
Birds - Short term dietary (LC50/LD50) > 2141 mg kg-1 bw/Day A5 Colinus virginianus -
Pez - agudo 96 hora LC50 (mg l-1) > 2.9 A5 Oncorhynchus mykiss Moderado
Pez - Crónico 21 días NOEC (mg l-1) 0.5 A5 Pimephales promelas Moderado
Invertebrados acuáticos - Agudos 48 hora EC50 (mg l-1) 7.1 A5 Daphnia magna Moderado
Invertebrados acuáticos - Crónicos 21 días NOEC (mg l-1) 0.87 A5 Daphnia magna Moderado
Crustáceos acuáticos - Agudos 96 hora LC50 (mg l-1) - - -
Sediment dwelling organisms - Agudos 96 hora LC50 (mg l-1) - - -
Sediment dwelling organisms - Crónicos 28 día NOEC, estático, agua (mg l-1) - - -
Sediment dwelling organisms - Crónicos 28 día NOEC, sedimento (mg kg-1) - - -
Plantas acuáticas - Agudos 7 día EC50, biomasa (mg l-1) > 4.4 A5 Lemna gibba Moderado
Non-target plants > 450 A4 Unknown species
Vegetative vigour, ER50
as g/ha
-
> 450 A4 Unknown species
Seedling emergence, ER50
as g/ha
-
Algas - Agudos 72 hora EC50, crecimiento (mg l-1) > 19.8 A5 Anabaena flos-aquae Bajo
Algas - Crónicos 96 hora NOEC, crecimiento (mg l-1) - - -
Abejas mielíferas Contacto aguda 48 hora LD50 (μg abeja-1) > 200 A5 Bajo
Oral aguda 48 hora LD50 (μg abeja-1) > 200 A5 Bajo
Modo desconocido aguda 48 hora LD50 (μg abeja-1) - - -
Lombrices - Agudos 14 día LC50 (mg kg-1) > 500 A5 Eisenia foetida, corr Moderado
Lombrices - Crónicos 14 día NOEC, reproducción (mg kg-1) > 16.0 A5 Eisenia foetida, corr Moderado
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Causalidad - - -
Otro arthropoda (1) LR50 g ha-1 827 A5 Aphidius rhopalosiphi -
% Causalidad - - -
Otro arthropoda (2) LR50 g ha-1 900 >
A5 Typhlodromus pyri
-
% Causalidad - - -
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: 4.5 kg ha-1, 28 días
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


LA SALUD HUMANA Y PROTECCIÓN

for mandipropamid

General:
Propiedad Click here for information on the parameters used to describe human health and protection issues Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with human health and protection data Interpretación Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mamíferos - Agudos oral LD50 (mg kg-1) > 5000 A5 Rata Bajo
Mammals - Dermal LD50 (mg kg-1 body weight) > 5050 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) > 5.19 A5 Rat, 4 hr (nose only) -
Other Mammal toxicity endpoints - -
Consumo cada día aceptable (mg kg-1p.c. días-1) 0.15 A3 Rat, SF=100 -
ARfD - Acute Reference Dose (mg kg-1p.c. días-1) Ningunos asignaron A5 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
El nivel de exposición del operador (AOEL) sistemíco (mg kg-1p.c. días-1) 0.17 A3 Dog, SF=100 -
Estudios den la absorción cutánea (%) 0.2-0.6 A5 concentration dependent -
Directivo 76/464 Sustancias Peligrosas - - -
Limites de exposiciones - - -
Exposure Routes Public Acceptable for proposed uses
Occupational Acceptable for proposed uses
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutágeno Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

Cuestiones generales de la salud humana Liver toxicant

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Propiedad Click here for information on the parameters used to describe substance handling issues Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with data on handling issues Interpretación Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive or oxidising
CLP classification 2013 Environment: H400, H411
CEE clasificación de riesgos Click here to view information omn the EU risk phrases N - Dangerous for the environment: R51, R53
CEE clasificación sin riesgos Click here to view information omn the EU safety phrases None
Clasificación de OSM U - Es poco probable que presente un riesgo agudo
US EPA Classification (formulation) No consensus across products or no products available - -
Número de las NU -
Waste disposal & packaging Click here for a description of UN packaging marks -


TRADUCCIONES

for mandipropamid

Idioma Nombre
Inglés mandipropamid
Francés mandipropamide
Alemán Mandipropamid
Danés mandipropamid
Italiano mandipropamid
Español mandipropamida
Griego -
Esloveno mandipropamid
Polaco mandipropamid
Sueco mandipropamid
Húngaro -
Holandés -

Última actualización del registro: Wednesday 31 October 2018
Contacto: aeru@herts.ac.uk