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metalaxil-M; mefenoxam (Ref: CGA 329351)
** metalaxyl-M ** mefenoxam ** R-metalaxyl ** Traducciones

Destino ambiental - Ecotoxicología - La salud humana - A a Z Indice - Inicio

INFORMACIÓN GENERAL Click here for an explantaion of the general chemical status information
for metalaxyl-M

Descripción: A fungicide used to control diseases caused by air- and soil-borne pathogens

Ejemplos de plagas controladas: Foliar and tuber blight; Downey mildews; Pseudoperonospora humuli; Phytophthora infestans ; Peronospora tabacina

Ejemplos de aplicaciones: Potatoes; Tomatoes; Hops; Lettuce; Vegetables; Tobacco

Eficacia y actividad: -

Availability status: Current

Introduction & key dates: 1996, first reported & introduced USA

CEE Regulación 1107/2009 ( 91/414):
Estado Approved
Dossier rapporteur/co-rapporteur Belgium/Greece
Date inclusion expires 30/06/2019
UE Candidatas a sustitución No
Incluido en la base de datos de la UE

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia, Estados Unidos

Estructura química: Click here for further information on the general chemical status information used on this site
Isomerism Metalaxyl-M is the biologically active enantiomer (R-form) of the isomeric compound metalaxyl
Fórmula química C15H21NO4
Canonical SMILES CC1=C(C(=CC=C1)C)N(C(C)C(=O)OC)C(=O)COC
Isomeric SMILES No data
International Chemical Identifier Key (InChIKey) ZQEIXNIJLIKNTD-GFCCVEGCSA-N
International Chemical Identifier (InChI) InChI=1S/C15H21NO4/c1-10-7-6-8-11(2)14(10)16(13(17)9-19-4)12(3)15(18)20-5/h6-8,12H,9H2,1-5H3/t12-/m1/s1
¿Diagrama de estructura 2D / imagen disponible?

Click to access the Cambridge Crystallographic Data Centre (CCDC) website
Cambridge Crystallographic Data Centre diagrams:
Nombre Común Relación Vínculo
Metalaxyl Unstated isomer Click here for the CCDC structure diagram

Estado general: Click here for further information on the general chemical status information used on this site
Tipo de pesticida Fungicide
Grupo químico Phenylamide
Minimum active substance purity 910 g/kg
Known relevant impurities EU dossier - 2,6-dimethyl-phenylamine; 4-methoxy-5-methyl-5H-(1,2)oxathiole 2,2-dioxide; 1-methoxy-1-oxopropan-2-yl N-(2,6-dimethylphenyl)-N-(methoxyacetyl)alaninate
Sustancias de origen Sintéticas
Modo de acción Systemic with curative and protective action. Disrupts fungal nucleic acid synthesis - RNA ploymerase 1.
CAS RN 70630-17-0
CEE número -
Número CIPAC 580
EPA américaine chimiques de code -
PubChem CID 11150163
Masa molecular (g mol-1) 279.33
PIN (Preferred Identification Name) -
Nombre IUPAC methyl N-(methoxyacetyl)-N-(2,6-xylyl)-D-alaninate
Nombre CAS methyl N-(2,6-dimethylphenyl)-N-(methoxyacetyl)-D-alaninate
Otra información de estado -
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) No aplicable
Herbicide Resistance Classification (WSSA) No aplicable
Insecticide Resistance Classification (IRAC) No aplicable
Fungicide Resistance Classification (FRAC) 4
Examples of recorded resistance -
Estado físico Clear to pale yellow viscous liquid with weak odour at 97.2% purity, darkens with reducing purity
Related substances & organisms

Formulaciones:
Propiedad Click here for information on the general product and branding information used on this site Valor
Example manufacturers & suppliers of products using this active now or historically
  • Fargro
  • Syngenta
  • Clayton
Example products using this active
  • Folio
  • Fubol Gold
  • SL567
  • Wakil XL
Estado de UK LERAP Buffer probably required in UK - see product label
Formulation and application details Often supplied as a soluble concentrate that is mixed with water and used as a spray.


DESTINO AMBIENTAL

for metalaxyl-M

Propiedad Click here for information on the parameters used to describe environmental fate on this site Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with fate data Interpretación Click here for information on the way in which we interpret environmental fate data
Solubilidad - En aqua en 20oC (mg l-1) 26000 A5 Alto
Solubilidad - en solventes organicos en 20oC (mg l-1) 59000 A5 - n-Hexano -
Miscible A5 - Tolueno -
Miscible A5 - Metanol -
Miscible A5 - Acetona -
Punto de fusión (oC) -38.7 A5 -
Punto de ebullición (oC) Decomposes before boiling A5 -
El punto de degradación (oC) 270 A5 -
Punto de inflamación (oC) 179 A5 -
Octanol-aqua coeficiente de particiónat en pH 7, 20oC P 5.13 X 1001 Calculado -
Log P 1.71 A5 Bajo
Masa densidad (g ml-1)/Peso específico 1.13 A5 -
Disociación constante (pKa) at 25oC No aplicable A5 -
Nota: Ninguna disociación
Presión de vapor en 20oC (mPa) 3.3 A5 Baja volatilidad
Constante de Henry a 25oC (Pa m3 mol-1) 3.50 X 10-05 A5 No volátil
Indice de potencial de lixiviación GUS Click here for a note on the limitations of the GUS index 1.71 Calculado Bajo posibilidad de lixiviación
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Valor 8.56 X 10-03 Calculado -
Nota -
Potencial para transportar de 'particle bound' Click here for a note on the limitations of the potential for particle bound transport index - Calculado Bajo
Maximum UV-vis absorption L mol-1 cm-1 266nm = 512, 274nm = 477, no absorption 290-750nm A5 -
Surface tension (mN m-1) 57.6 A5 -

Degradación:
Propiedad Click here for information on the parameters used to describe substance degradation Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with degradation data Interpretación Click here for information on the way in which we interpret substance degradation data
Biodegradabilidad general -
Degradación de suelo (días) (aerobic) DT50 (típico) 6.5 A5 No persistente
DT50 (laboratorio en 20oC) 6.5 A5 No persistente
DT50 (campo) 14.1 A5 No persistente
DT90 (laboratorio en 20oC) 48.7 A5 -
DT90 (campo) 46.7 A5 -
Endpoint de modelado DT50 - - -
Nota EU dossier 2015 lab studies DT50 range 1.38-73.1 days, DT90 range 12.7-87.6 days, field studies DT50 range 9.3-30.9 days DT90 range 30.7-102.6 days
Dissipation rate RL50 on plant matrix Valor - - -
Nota -
Dissipation rate RL50 on and in plant matrix Valor 10.8 R4 -
Nota Published literature RL50 range 1.6-19.8 days, 6 field crops, various matrices, n=8
Acuoso fotólisis DT50 (días) en pH 7 Valor Estable A5 -
Nota -
Acuoso hidrólisis DT50 (días) en 20oC y pH 7 Valor Estable A5 -
Nota Stable at all pH values
Aqua-Sedimento DT50 (días) 32.1 A5 Moderado rápido
Fase de agua sola DT50 (días) 24.8 A5 Lento

De absorción del suelo y la movilidad:
Propiedad Click here for information on the parameters used to describe substance adsorption and mobility Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretación Click here for information on the way in which we interpret substance adsorption and mobility
Lineal Kd - - -
Koc -
Notas y rango -
Freundlich Kf 1.63 A5 Móvil moderado
Kfoc 78.9
1/n 0.955
Notas y rango EU dossier (2015) Kf range 0.07-8.01 mL/g, Kfoc range 20-284 mL/g, 1/n range 0.77-1.12, Soils=20
pH senbsibilidad No

Key metabolites:
Metabolito Medio de formación Maximó Calculado de Fracción Ocurrencia 1107/2009 Importancia Click here for further information on 1107/2009 relevancy
N-(2,6-dimethylphenyl)-N-(methoxyacetyl)alanine (Ref: CGA 62826 (racemate)) This metabolite may cause environmental pollution, click here for further information Suelo   0.404   Major fraction, Not Relevant
(R)-2-((2,6-Dimethyl-phenyl)-(2-methoxy-acetyl)-amino)-propionic acid (Ref: NOA 409045) This metabolite may cause environmental pollution, click here for further information Suelo   0.720   Major fraction; Relevant
N-(2,6-Dimethyl-phenyl)-2-methoxy-acetamide (Ref: CGA 67868) Suelo   0.06   Minor fraction; Relevant
2-(((R)-1-Carboxy-ethyl)-(2-methoxy-acetyl)-amino)-3-methyl-benzoic acid (Ref: SYN 546520) Suelo   0.04   Minor fraction; Relevant

Other known metabolites:
Metabolite name and reference Aliases Medio de formación / Rate Maximó Calculado de Fracción Ocurrencia Metabolising enzymes
N-(2-hydroxymethyl-6-methylphenyl)-N-(methoxyacetyl)alanine
Nota: CAS 53823-88-4
- - - -
N-(2,6-dimethyl- 5-hydroxyphenyl)-N-(methoxyacetyl)alanine methyl ester
(Ref: CGA 100255)
Nota: CAS 96258-85-4
- - - -
N-(2,6-dimethylphenyl)-N-(hydroxyacetyl)alanine
(Ref: CGA 107955)
Nota: CAS 104390-55-8
- Rat - -
N-(2-carboxy-6-methylphenyl)-N-(methoxyacetyl)alanine methyl ester
(Ref: CGA 108905)
- - - -
N-(2-carboxy-6-methylphenyl)-N-(methoxyacetyl)alanine
(Ref: CGA 108906)
Nota: CAS: 104390-56-9; LC50(fish) = 100 mg l-1; LC50(Daphnia) = 100 mg l-1
- Plant; Soil - -
N-(3-hydroxy-2,6-dimethylphenyl)-N-(methoxyacetyl)alanine
(Ref: CGA 119857)
- - - -
N-hydroxyacetyl-2,6-dimethyl-aniline
(Ref: CGA 37734)
Nota: CAS 29183-14-0
- - - -
N-(2,6-dimethylphenyl) alanine
(Ref: CGA 67867)
- - - -
N-methoxyacetyl-2,6-dimethyl-aniline
(Ref: CGA 67868)
Nota: LC50(fish) = 98.9 mg l-1; LC50(Daphnia) = 158 mg l-1
- Water - -
N-(2,6-dimethylphenyl)-N-(hydroxyacetyl)alanine methyl ester
(Ref: CGA 67869)
Nota: CAS 66637-79-4
- - - -
2,6-dimethylanilinoxoacetic acid
(Ref: CGA 68124)
Nota: CAS 2903-48-2
- - - -
N-(carboxycarbonyl)-N-(2,6-dimethylphenyl)alanine
(Ref: CGA 78532)
- - - -
N-(carboxycarbonyl)-N-(2,6-dimethylphenyl)alanine methyl ester
(Ref: CGA 79353)
- - - -
N-(2-hydroxymethyl-6-methylphenyl)-N-(methoxyacetyl)alanine methyl ester
(Ref: CGA 94689)
Nota: CAS 85933-49-9
- - - -


ECOTOXICOLOGÍA

for metalaxyl-M

Propiedad Click here for information on the parameters used to describe substance ecotoxicology Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretación Click here for information on the way in which we interpret substance ecotoxicology
Factor de la bio-concentración BCF (l kg-1) 15 A5 Bajo potencial
CT50 (días) No disponible -
Mamíferos - Agudos oral LD50 (mg kg-1) 375 A5 Rata Moderado
Mamíferos - a corto plazo NOEL (mg kg-1) 2.5 L1 Rata Alto
(ppm dieta) - -
Pájaros/aves - Agudos LD50 (mg kg-1) 981 A5 Colinus virginianus Moderado
Birds - Short term dietary (LC50/LD50) > 5620 mg kg feed-1 A5 Colinus virginianus -
Pez - agudo 96 hora LC50 (mg l-1) > 100 A5 Oncorhynchus mykiss Bajo
Pez - Crónico 21 días NOEC (mg l-1) 9.1 A4 Pimephales promelas Moderado
Invertebrados acuáticos - Agudos 48 hora EC50 (mg l-1) > 100 A5 Daphnia magna Bajo
Invertebrados acuáticos - Crónicos 21 días NOEC (mg l-1) 1.2 A4 Daphnia magna, as metalaxyl Moderado
Crustáceos acuáticos - Agudos 96 hora LC50 (mg l-1) - - -
Sediment dwelling organisms - Agudos 96 hora LC50 (mg l-1) - - -
Sediment dwelling organisms - Crónicos 28 día NOEC, estático, agua (mg l-1) - - -
Sediment dwelling organisms - Crónicos 28 día NOEC, sedimento (mg kg-1) - - -
Plantas acuáticas - Agudos 7 día EC50, biomasa (mg l-1) 69.5 F3 Lemna gibba Bajo
Non-target plants - - -
- - -
Algas - Agudos 72 hora EC50, crecimiento (mg l-1) 36 A4 Unknown species Bajo
Algas - Crónicos 96 hora NOEC, crecimiento (mg l-1) - - -
Abejas mielíferas Contacto aguda 48 hora LD50 (μg abeja-1) > 100 A5 Bajo
Oral aguda 48 hora LD50 (μg abeja-1) > 97.3 A5 Moderado
Modo desconocido aguda 48 hora LD50 (μg abeja-1) - - -
Lombrices - Agudos 14 día LC50 (mg kg-1) 830 A5 Eisenia foetida Moderado
Lombrices - Crónicos 14 día NOEC, reproducción (mg kg-1) 35.63 A5 Eisenia foetida Moderado
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Causalidad - - -
Otro arthropoda (1) LR50 g ha-1 - - -
% Causalidad -14.5 Beneficial capacity
Dose: 3.5 kg ha-1
A5 Aphidius rhopalosiphi, adult
-
Otro arthropoda (2) LR50 g ha-1 - - -
% Causalidad 11.8 Beneficial capacity
Dose: 2.5 kg ha-1, 5 applications at 14 día interval, 7 día
A5 Typhlodromus pyri
-
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: 6.6 mg kg-1 soil, 100 días
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


LA SALUD HUMANA Y PROTECCIÓN

for metalaxyl-M

General:
Propiedad Click here for information on the parameters used to describe human health and protection issues Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with human health and protection data Interpretación Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mamíferos - Agudos oral LD50 (mg kg-1) 375 A5 Rata Moderado
Mammals - Dermal LD50 (mg kg-1 body weight) > 2000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) > 2.29 A5 Rat, 4 hr (nose only) -
Other Mammal toxicity endpoints - -
Consumo cada día aceptable (mg kg-1p.c. días-1) 0.08 A5 Dog, SF=100 -
ARfD - Acute Reference Dose (mg kg-1p.c. días-1) 0.5 A5 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
El nivel de exposición del operador (AOEL) sistemíco (mg kg-1p.c. días-1) 0.08 A5 Rat, 90 day, SF=100 -
Estudios den la absorción cutánea (%) 10 A5 -
Directivo 76/464 Sustancias Peligrosas - - -
Limites de exposiciones - - -
Exposure Routes Public No unacceptable risks to bystanders identified
Occupational No unacceptable risks to operators or other workers identified
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutágeno Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

-

Cuestiones generales de la salud humana Possible liver toxicant

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Propiedad Click here for information on the parameters used to describe substance handling issues Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with data on handling issues Interpretación Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive or oxidising
CLP classification 2013 Health: H302, H318
CEE clasificación de riesgos Click here to view information omn the EU risk phrases Xn - Harmful: R22, R41
CEE clasificación sin riesgos Click here to view information omn the EU safety phrases S2, S26, S39, S46
Clasificación de OSM NL - No inscripto en la lista
US EPA Classification (formulation) - -
Número de las NU -
Waste disposal & packaging Click here for a description of UN packaging marks -


TRADUCCIONES

for metalaxyl-M

Idioma Nombre
Inglés metalaxyl-M
Francés metalaxyl-M
Alemán Metalaxyl-M
Danés metalaxyl-M
Italiano metalaxil-M
Español metalaxil-M; mefenoxam
Griego metalaxyl-M
Esloveno metalaksil-M
Polaco metalaksyl-M
Sueco metalaxyl-M
Húngaro metalaxyl-M
Holandés methalaxyl-M

Última actualización del registro: Wednesday 31 October 2018
Contacto: aeru@herts.ac.uk