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napropamida (Ref: R 7465)
** napropamide ** Traducciones

Destino ambiental - Ecotoxicología - La salud humana - A a Z Indice - Inicio

RESUMEN

Napropamide is a widely used herbicide approved for use on the EU and many other countries. It has a low mammalian toxicity but is is a known skin and eye irritant. It is moderately soluble in water, and is quite volatile. It is moderately persistent in soil systems and data suggests that under certain conditions it may be persistent in water. It has a low toxicity to birds but is moderately toxic to most aquatic species, honeybees and earthworms.

INFORMACIÓN GENERAL Click here for an explantaion of the general chemical status information
for napropamide

Descripción: A soil applied herbicide for pre-emergence control of weeds in a range of crops including oilseed rape, fruit and woody ornamentals

Ejemplos de plagas controladas: Annual grasses; Broad-leaved weeds

Ejemplos de aplicaciones: Vegetables, Fruit tree and bushes; Vines; Tobacco; Olives; Sunflowers; Turf; Oilseed rape; Ornamentals

Eficacia y actividad: -

Availability status: Current

Introduction & key dates: circa 1970

CEE Regulación 1107/2009 ( 91/414):
Estado Approved
Dossier rapporteur/co-rapporteur Solvenia/Hungary
Date inclusion expires 31/12/2023
UE Candidatas a sustitución No
Incluido en la base de datos de la UE

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia

Estructura química: Click here for further information on the general chemical status information used on this site
Isomerism A ciral molecule. The technical material is a racemate composed of equimolar amounts of (S)- and (R)-napropamide.
Fórmula química C17H21NO2
Canonical SMILES CCN(CC)C(=O)C(C)OC1=CC=CC2=CC=CC=C21
Isomeric SMILES No data
International Chemical Identifier Key (InChIKey) WXZVAROIGSFCFJ-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C17H21NO2/c1-4-18(5-2)17(19)13(3)20-16-12-8-10-14-9-6-7-11-15(14)16/h6-13H,4-5H2,1-3H3
¿Diagrama de estructura 2D / imagen disponible?

Estado general: Click here for further information on the general chemical status information used on this site
Tipo de pesticida Herbicida
Grupo químico Alkanamide
Minimum active substance purity 930 g/kg
Known relevant impurities EU dossier - toluene <0.14%
Sustancias de origen Sintéticas
Modo de acción Selective, systemic, absorbed through roots and translocated. Acts by preventing root cell elongation and so disrupting growth. Inhibition of VLCFA (inhibition of cell division).
CAS RN 15299-99-7
CEE número 239-333-3
Número CIPAC 271
EPA américaine chimiques de code 103001
PubChem CID 27189
Masa molecular (g mol-1) 271.36
PIN (Preferred Identification Name) -
Nombre IUPAC (RS)-N,N-diethyl-2-(1-naphthyloxy)propionamide
Nombre CAS N,N-diethyl-2-(1-naphthalenyloxy)propanamide
Otra información de estado Potential groundwater contaminant; PAN listed Highly Hazardous Chemical
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) K3
Herbicide Resistance Classification (WSSA) 15
Insecticide Resistance Classification (IRAC) No aplicable
Fungicide Resistance Classification (FRAC) No aplicable
Examples of recorded resistance -
Estado físico Colourless crystals to light brown solid depending on purity
Related substances & organisms -

Formulaciones:
Propiedad Click here for information on the general product and branding information used on this site Valor
Example manufacturers & suppliers of products using this active now or historically
  • AgriGuard
  • United Phosphorus
  • Globalchem
  • Stauffer
Example products using this active
  • Devrinol 45F
  • Jouster
  • Naprop
Estado de UK LERAP None
Formulation and application details Usually supplied as a suspension concentrate, emulsifiable concentrate, wettable powder or ganules.


DESTINO AMBIENTAL

for napropamide

Propiedad Click here for information on the parameters used to describe environmental fate on this site Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with fate data Interpretación Click here for information on the way in which we interpret environmental fate data
Solubilidad - En aqua en 20oC (mg l-1) 74.0 A5 Moderado
Solubilidad - en solventes organicos en 20oC (mg l-1) 440000 A5 - Acetona -
11100 A5 - n-Heptano -
290000 A5 - Acetato de etilo -
692000 A5 - Cloruro de metileno -
Punto de fusión (oC) 74.8 A5 -
Punto de ebullición (oC) 316.7 A5 -
El punto de degradación (oC) - - -
Punto de inflamación (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-aqua coeficiente de particiónat en pH 7, 20oC P 2.00 X 1003 Calculado -
Log P 3.3 A5 Alto
Masa densidad (g ml-1)/Peso específico 1.18 A5 -
Disociación constante (pKa) at 25oC No aplicable A5 -
Nota: Ninguna disociación
Presión de vapor en 20oC (mPa) 2.2 X 10-02 A5 Baja volatilidad
Constante de Henry a 25oC (Pa m3 mol-1) 8.1 X 10-05 A5 No volátil
Indice de potencial de lixiviación GUS Click here for a note on the limitations of the GUS index 2.62 Calculado Estado de transición
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Valor 1.99 X 10-01 Calculado -
Nota -
Potencial para transportar de 'particle bound' Click here for a note on the limitations of the potential for particle bound transport index - Calculado Mediano
Maximum UV-vis absorption L mol-1 cm-1 Neutral solution 215nm = 58800, 282nm = 10500; [Acidic solution 215nm = 58600, 282nm = 10900 A5 -
Surface tension (mN m-1) 66.0 A5 at 20oC -

Degradación:
Propiedad Click here for information on the parameters used to describe substance degradation Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with degradation data Interpretación Click here for information on the way in which we interpret substance degradation data
Biodegradabilidad general -
Degradación de suelo (días) (aerobic) DT50 (típico) 70 G4 Persistente moderado
DT50 (laboratorio en 20oC) 308 A5 Persistente
DT50 (campo) 72 A5 Persistente moderado
DT90 (laboratorio en 20oC) 1000 A3 -
DT90 (campo) 290 A4 -
Endpoint de modelado DT50 - - -
Nota EU dossier lab studies DT50 range 120-400 days, DT90 >1000 days; field studies DT50 range 31-127 days, DT90 range 180-400 days; Other sources: 8-12 weeks (R3)
Dissipation rate RL50 on plant matrix Valor - - -
Nota -
Dissipation rate RL50 on and in plant matrix Valor - - -
Nota -
Acuoso fotólisis DT50 (días) en pH 7 Valor 1.5 A5 Moderado rápido
Nota Mid-European conditions
Acuoso hidrólisis DT50 (días) en 20oC y pH 7 Valor Estable A5 -
Nota Stable pH 5 to pH 7, 25 and 40 degC
Aqua-Sedimento DT50 (días) 316 A5 Lento
Fase de agua sola DT50 (días) 28 A5 Lento

De absorción del suelo y la movilidad:
Propiedad Click here for information on the parameters used to describe substance adsorption and mobility Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretación Click here for information on the way in which we interpret substance adsorption and mobility
Lineal Kd 21.5 A5 Móvil un poco
Koc 839
Notas y rango EU dossier Kd range 6.87-47.4 mL/g, Koc range 435-1609 mL/g, Soils=5
Freundlich Kf 21.6 A5 Móvil un poco
Kfoc 885
1/n 0.815
Notas y rango EU dossier Kf range 8.1-44.5 mL/g, EU dossier Kfoc range 409-1593 mL/g, 1/n range 0.720-0.815, Soils=5
pH senbsibilidad No

Key metabolites:
Metabolito Medio de formación Maximó Calculado de Fracción Ocurrencia 1107/2009 Importancia Click here for further information on 1107/2009 relevancy
alpha-naphthoxy propionic acid Suelo   0.01   Minor fraction, Not relevant

Other known metabolites:
Metabolite name and reference Aliases Medio de formación / Rate Maximó Calculado de Fracción Ocurrencia Metabolising enzymes
N,N-diethyl-2-(4-hydroxynaphthalen-1-yl)propanamide hydroxy napropamide isomer 1 a=Surface water (photolysis); b=Sediment a=0.20 -
N,N-diethyl-2-(1-hydroxynaphthalen-2-yl)propanamide hydroxy napropamide isomer 2 a=Surface water (photolysis); b=Sediment a=0.27 -
N-ethylethanamine diethylamine a=Surface water (photolysis); b=Sediment a=0.26 -
2-methylnaphtho[1,2-b]furan-3(2H)-one MNF a=Surface water (photolysis); b=Sediment a=0.15 -
[4-glucuronyl-(N-ethyl-2-(1-naphthoxy)) propionamide] 4-OGlu-DE-NPAM Rat (urine, faeces) - -
N-({4-[(1-amino-1-oxopropan-2-yl)oxy]naphthalen-1-yl}oxy)glutamic acid 4-OGlu-NOPAM Rat (urine, faeces) - -
N-{[4-(1-carboxyethoxy)naphthalen-1-yl]oxy}glutamic acid 4-OGlu-NOPA Rat (urine, faeces) - -
naphthalene-1,4-dione NQ Plant - -
2-hydroxynaphthalene-1,4-dione HNQ Plant - -
benzene-1,2-dicarboxylic acid PA Plant - -
1-naphthol
(Ref: )
Nota: Minor fraction, Not relevant
1-naphthol Plant - -
[4-glucuronyl-(N,N-diethyl-2-(1-naphthoxy)) propionamide] 4-OGlu-NPAM Rat (urine, faeces) - -
2,2'-(4,4'-dihydroxy-1,1'-binaphthalene-3,3'-diyl)bis(N,N-diethylpropanamide) dimer a=Surface water (photolysis); b=Sediment a=0.09 -


ECOTOXICOLOGÍA

for napropamide

Propiedad Click here for information on the parameters used to describe substance ecotoxicology Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretación Click here for information on the way in which we interpret substance ecotoxicology
Factor de la bio-concentración BCF (l kg-1) 98 A5 Bajo potencial
CT50 (días) No disponible -
Mamíferos - Agudos oral LD50 (mg kg-1) > 4680 A5 Rata Bajo
Mamíferos - a corto plazo NOEL (mg kg-1) 30 L3 Rata Alto
(ppm dieta) - -
Pájaros/aves - Agudos LD50 (mg kg-1) > 2250 A5 Colinus virginianus Bajo
Birds - Short term dietary (LC50/LD50) > 7200 mg kg feed-1 A5 Anas platyrhynchos -
Pez - agudo 96 hora LC50 (mg l-1) 6.6 A5 Salmo gairdneri Moderado
Pez - Crónico 21 días NOEC (mg l-1) 1.1 A5 Salmo gairdneri Moderado
Invertebrados acuáticos - Agudos 48 hora EC50 (mg l-1) 14.3 A5 Daphnia magna Moderado
Invertebrados acuáticos - Crónicos 21 días NOEC (mg l-1) 4.3 A5 Daphnia magna Moderado
Crustáceos acuáticos - Agudos 96 hora LC50 (mg l-1) 3.1 F3 Americamysis bahia Moderado
Sediment dwelling organisms - Agudos 96 hora LC50 (mg l-1) - - -
Sediment dwelling organisms - Crónicos 28 día NOEC, estático, agua (mg l-1) - - -
Sediment dwelling organisms - Crónicos 28 día NOEC, sedimento (mg kg-1) - - -
Plantas acuáticas - Agudos 7 día EC50, biomasa (mg l-1) 0.24 A5 Lemna gibba Moderado
Non-target plants 310 A5 Avena fatua
Vegetative vigour, ER50
as g/ha
-
> 4500 A5 Avena fatua
Seedling emergence, ER50
as g/ha
-
Algas - Agudos 72 hora EC50, crecimiento (mg l-1) 3.4 F4 Pseudokirchneriella subcapitata Moderado
Algas - Crónicos 96 hora NOEC, crecimiento (mg l-1) - - -
Abejas mielíferas Contacto aguda 48 hora LD50 (μg abeja-1) > 100 A4 Bajo
Oral aguda 48 hora LD50 (μg abeja-1) > 100 A4 Bajo
Modo desconocido aguda 48 hora LD50 (μg abeja-1) - - -
Lombrices - Agudos 14 día LC50 (mg kg-1) 282 A5 Eisenia foetida, corr Moderado
Lombrices - Crónicos 14 día NOEC, reproducción (mg kg-1) 30 A5 Eisenia foetida, corr Moderado
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Causalidad - - -
Otro arthropoda (1) LR50 g ha-1 - - -
% Causalidad 0.0 Mortalidad
Dose: 4.5 kg ha-1
A5 Typhlodromus pyri
-
Otro arthropoda (2) LR50 g ha-1 - - -
% Causalidad 6.0 Mortalidad
Dose: 4.5 kg ha-1
A5 Aphidius rhopalosiphi
-
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: 2.25 g ha-1
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


LA SALUD HUMANA Y PROTECCIÓN

for napropamide

General:
Propiedad Click here for information on the parameters used to describe human health and protection issues Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with human health and protection data Interpretación Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mamíferos - Agudos oral LD50 (mg kg-1) > 4680 A5 Rata Bajo
Mammals - Dermal LD50 (mg kg-1 body weight) > 2000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) > 4.8 A5 Rat, 4 hr -
Other Mammal toxicity endpoints - -
Consumo cada día aceptable (mg kg-1p.c. días-1) 0.3 A5 Rat, SF=100 -
ARfD - Acute Reference Dose (mg kg-1p.c. días-1) Ningunos asignaron A5 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
El nivel de exposición del operador (AOEL) sistemíco (mg kg-1p.c. días-1) 0.5 A4 Dog, SF=100 -
Estudios den la absorción cutánea (%) 0.7-13.4 A5 concentration dependent -
Directivo 76/464 Sustancias Peligrosas - - -
Limites de exposiciones - - -
Exposure Routes Public Risk to bystanders acceptable for proposed uses
Occupational Risks identified for operators - PPE/PPC advised
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutágeno Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

Cuestiones generales de la salud humana Possible liver and kidney toxicant

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Propiedad Click here for information on the parameters used to describe substance handling issues Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with data on handling issues Interpretación Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive or oxidising
IMDG Transport Code is usually 9
CLP classification 2013 Environment: H410
CEE clasificación de riesgos Click here to view information omn the EU risk phrases N - Dangerous for the environment: R50, R53
CEE clasificación sin riesgos Click here to view information omn the EU safety phrases -
Clasificación de OSM U - Es poco probable que presente un riesgo agudo
US EPA Classification (formulation) III - Caution - Slightly toxic
Número de las NU Usually 3082
Waste disposal & packaging Click here for a description of UN packaging marks Packaging Group III (minor danger)


TRADUCCIONES

for napropamide

Idioma Nombre
Inglés napropamide
Francés napropamide
Alemán Napropamid
Danés napropamid
Italiano napropamide
Español napropamida
Griego -
Esloveno napropamid
Polaco napropamid
Sueco napropamid
Húngaro napropamid
Holandés -

Última actualización del registro: Thursday 13 September 2018
Contacto: aeru@herts.ac.uk