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azoxiestrobina (Ref: ICI 5504)
** azoxystrobin ** azoxystrobine ** ICI-A 5504 ** Icia 5504 ** Traducciones

Destino ambiental - Ecotoxicología - La salud humana - A a Z Indice - Inicio

RESUMEN

Azoxystrobin is a broad-spectrum QoL fungicide that is approved for use at EU level. It has a low aqueous solubility, is non-volatile and imay leach to groundwater under certain conditions. It may be persistent in soil and can also be persistent in water systems if conditions are right. It has a low mammalian toxicity but may bioaccumulate. It is a skin and eye irritant. It is moderately toxic to birds, most aquatic life, honeybees and earthworms.

INFORMACIÓN GENERAL Click here for an explantaion of the general chemical status information
for azoxystrobin

Descripción: A post-emergence broad spectrum strobilurin fungicide used mainly for cereals

Ejemplos de plagas controladas: Rusts; Powdery mildew; Black rot; Scab; Anthracnose; White mould; Peg rot; Early & late blight; Leaf spot; Rice blast; Botrytis

Ejemplos de aplicaciones: Wheat; Fruit including grapes, citrus, strawberries, peaches; Sunflowers; Vegetables including onions, brassicas and curcubits; Potatoes; Cotton; pecans; Canola; Soybeans; Peanuts; Turf; Ornamentals

Eficacia y actividad: Wheat/Midlew=Low; Wheat/Septoria=Low; Wheat/Rust=Moderate-High; Barley/Rhynchosporium=Low; Barley/Rust=Moderate; Barley/Net blotch=Low; Corn/Leaf blight=High; Corn/Rust=High; Corn/Eyespot=High; Soybean/Blight=High; Soybean/Anthracnose=High; Soybean/Brown spot=Moderate; Soybean/Leaf blight=Moderate; Soybean/Rust=High; Soybean/White mould=Low

Availability status: Current

Introduction & key dates: 1992

CEE Regulación 1107/2009 ( 91/414):
Estado Approved
Dossier rapporteur/co-rapporteur UK/Norway
Date inclusion expires 31/12/2021
UE Candidatas a sustitución No
Incluido en la base de datos de la UE

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia, Estados Unidos

Estructura química: Click here for further information on the general chemical status information used on this site
Isomerism Isomeric - E-form
Fórmula química C22H17N3O5
Canonical SMILES COC=C(C1=CC=CC=C1OC2=NC=NC(=C2)OC3=CC=CC=C3C#N)C(=O)OC
Isomeric SMILES CO/C=C(\C1=CC=CC=C1OC2=NC=NC(=C2)OC3=CC=CC=C3C#N)/C(=O)OC
International Chemical Identifier Key (InChIKey) WFDXOXNFNRHQEC-GHRIWEEISA-N
International Chemical Identifier (InChI) InChI=1S/C22H17N3O5/c1-27-13-17(22(26)28-2)16-8-4-6-10-19(16)30-21-11-20(24-14-25-21)29-18-9-5-3-7-15(18)12-23/h3-11,13-14H,1-2H3/b17-13+
¿Diagrama de estructura 2D / imagen disponible?

Click to access the Cambridge Crystallographic Data Centre (CCDC) website
Cambridge Crystallographic Data Centre diagrams:
Nombre Común Relación Vínculo
Azoxystrobin - Click here for the CCDC structure diagram

Estado general: Click here for further information on the general chemical status information used on this site
Tipo de pesticida Fungicide
Grupo químico Strobilurin
Minimum active substance purity 965 g/kg
Known relevant impurities EU dossier: Toluene
Sustancias de origen Sintéticas
Modo de acción Systemic translaminar and protectant action having additional curative and eradicant properties. Respiration inhibitor (QoL fungicide).
CAS RN 131860-33-8
CEE número -
Número CIPAC 571
EPA américaine chimiques de code 128810
PubChem CID 3034285
Masa molecular (g mol-1) 403.4
PIN (Preferred Identification Name) methyl (2E)-2-(2-{[6-(2-cyanophenoxy)pyrimidin-4-yl]oxy}phenyl)-3-methoxyprop-2-enoate
Nombre IUPAC methyl (E)-2-{2-[6-(2-cyanophenoxy)pyrimidin-4-yloxy]phenyl}-3-methoxyacrylate
Nombre CAS methyl (αE)-2-[[6-(2-cyanophenoxy)-4-pyrimidinyl]oxy]-α-(methoxymethylene)benzeneacetate
Otra información de estado -
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) No aplicable
Herbicide Resistance Classification (WSSA) No aplicable
Insecticide Resistance Classification (IRAC) No aplicable
Fungicide Resistance Classification (FRAC) 11
Examples of recorded resistance -
Estado físico White crystalline solid
Related substances & organisms

Formulaciones:
Propiedad Click here for information on the general product and branding information used on this site Valor
Example manufacturers & suppliers of products using this active now or historically
  • AgriGuard
  • Clayton
  • Syngenta
Example products using this active
  • Amistar
  • Amistar Opti
  • Amistar Pro
  • Olympus
  • Priori Xtra
  • Quadris
  • Abound
  • Ortiva
Estado de UK LERAP Buffer may be required in UK - see product label
Formulation and application details Often supplied as a suspension concentrated diluted for spray application.


DESTINO AMBIENTAL

for azoxystrobin

Propiedad Click here for information on the parameters used to describe environmental fate on this site Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with fate data Interpretación Click here for information on the way in which we interpret environmental fate data
Solubilidad - En aqua en 20oC (mg l-1) 6.7 A5 Bajo
Solubilidad - en solventes organicos en 20oC (mg l-1) 57 A5 - Hexano -
20000 A5 - Metanol -
55000 A5 - Tolueno -
86000 A5 - Acetona -
Punto de fusión (oC) 116 A5 -
Punto de ebullición (oC) 360 A5 -
El punto de degradación (oC) 345 A5 -
Punto de inflamación (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-aqua coeficiente de particiónat en pH 7, 20oC P 3.16 X 1002 Calculado -
Log P 2.5 A5 Bajo
Masa densidad (g ml-1)/Peso específico 1.34 A5 -
Disociación constante (pKa) at 25oC No aplicable A5 -
Nota: Ninguna disociación
Presión de vapor en 20oC (mPa) 1.10 X 10-07 A5 Baja volatilidad
Constante de Henry a 25oC (Pa m3 mol-1) 7.40 X 10-09 A5 No volátil
Indice de potencial de lixiviación GUS Click here for a note on the limitations of the GUS index 2.65 Calculado Estado de transición
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Valor 1.98 X 10-01 Calculado -
Nota -
Potencial para transportar de 'particle bound' Click here for a note on the limitations of the potential for particle bound transport index - Calculado Mediano
Maximum UV-vis absorption L mol-1 cm-1 202.6nm = 60700, 242.7nm = 17800, 295nm = 302 A5 -
Surface tension (mN m-1) - - -

Degradación:
Propiedad Click here for information on the parameters used to describe substance degradation Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with degradation data Interpretación Click here for information on the way in which we interpret substance degradation data
Biodegradabilidad general -
Degradación de suelo (días) (aerobic) DT50 (típico) 78 A5 Persistente moderado
DT50 (laboratorio en 20oC) 84.5 A5 Persistente moderado
DT50 (campo) 180.7 A5 Persistente
DT90 (laboratorio en 20oC) 363.3 A5 -
DT90 (campo) 600.4 A5 -
Endpoint de modelado DT50 - - -
Nota EU Dossier lab studies DT50 range 35.2-248 days, DT90 range 187-824 days; Field studies DT50 range 120.9-261.9 days (actual), DT90 range 401.7-869.9 days; Other sources: 72-164 days
Dissipation rate RL50 on plant matrix Valor 8.4 R4 -
Nota Published literature RL50 range 1.6-15.2 days, 2 field & undercover grown crops, various matrices, n=2
Dissipation rate RL50 on and in plant matrix Valor 7.0 R4 -
Nota Published literature RL50 range 0.4-15.6 days, 14 field & undercover grown crops, various matrices, n=22
Acuoso fotólisis DT50 (días) en pH 7 Valor 8.7 A5 Moderado rápido
Nota -
Acuoso hidrólisis DT50 (días) en 20oC y pH 7 Valor Estable A5 -
Nota Not pH senstive, hydrolytically stable
Aqua-Sedimento DT50 (días) 205 A5 Lento
Fase de agua sola DT50 (días) 6.1 A5 Moderado rápido

De absorción del suelo y la movilidad:
Propiedad Click here for information on the parameters used to describe substance adsorption and mobility Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretación Click here for information on the way in which we interpret substance adsorption and mobility
Lineal Kd 8.93 A5 Móvil un poco
Koc 589
Notas y rango EU dossier Kd range 2.1-15.0 mL/g; Koc range 304-739 mL/g, Soils=6; Other data sources: Koc = 1590 mL/g (DW3)
Freundlich Kf 7.35 A5 Móvil moderado
Kfoc 423
1/n 0.85
Notas y rango EU dossier Kf range 1.5-15.0 mL/g, Kfoc range 207-594 mL/g, 1/n range 0.82-0.90, Soils=6
pH senbsibilidad No

Key metabolites:
Metabolito Medio de formación Maximó Calculado de Fracción Ocurrencia 1107/2009 Importancia Click here for further information on 1107/2009 relevancy
(E)-2-(2-(6-(2-cyanophenoxy)pyrimidin-4-yloxy)phenyl)-3-methoxyacrylic acid (Ref: R234886) This metabolite may cause environmental pollution, click here for further information Suelo   0.288   Major fraction, Relevant
4-(2-cyanophenoxy)-6-hydroxypyrimidine (Ref: R401553) Suelo   0.057   Minor fraction, Relevant
2-(6-(2-cyanophenoxy)pyrimidin-4-yloxy)benzoic acid (Ref: R402173) Suelo   0.076   Minor fraction, Relevant

Other known metabolites:
Metabolite name and reference Aliases Medio de formación / Rate Maximó Calculado de Fracción Ocurrencia Metabolising enzymes
2-(2-{[6-(2-cyanophenoxy)pyrimidin-4-yl]oxy}phenyl)-3-methoxypropanoic acid Metabolite U5 unknown - -
glucosylmalonyl 2-{2-[6-(2-cyanophenoxy)pyrimidin-4-yloxy]phenyl}-3-methoxypropionate Metabolite O2 Plant - -
glucosylmalonyl (2E)-2-{2-[6-(2-cyanophenoxy)pyrimidin-4-yloxy]phenyl}-3-methoxyacrylate Metabolite O3 Plant - -
S-(2-cyano-x-hydroxyphenyl)cysteine Metabolite L4 Animal - -
glucosyl (E)-2-{2-[6-(2-cyanophenoxy)pyrimidin-4-yloxy]phenyl}-3-methoxypropionate Metabolite N1 Plant - -
glucosyl (2E)-2-{2-[6-(2-cyanophenoxy)pyrimidin-4-yloxy]phenyl}-3-methoxyacrylate Metabolite N2 Plant - -
(2-{[6-(2-cyanophenoxy)pyrimidin-4-yl]oxy}phenyl)acetic acid Metabolite M20 Animal - -
2-hydroxybenzonitrile Metabolite M13 unknown - -
4-{[6-(2-cyanophenoxy)pyrimidin-4-yl]oxy}-3-[(1E)-1,3-dimethoxy-3-oxoprop-1-en-2-yl]phenyl glucopyranuronic acid Metabolite K1 unknown - -
2-{[6-(2-cyanophenoxy)pyrimidin-4-yl]oxy}-x-hydroxybenzoic acid Metabolite L9 Animal - -
methyl (2E)-2-(2-{[6-(2-cyanophenoxy)pyrimidin-4-yl]oxy}-x-hydroxyphenyl)-3-methoxyprop-2-enoate Metabolite L1 Animal - -
methyl (Z)-2-{2-[6-(2-cyanophenoxy)pyrimidin-4-yloxy]phenyl}-3-methoxyacrylate
(Ref: R230310)
Metabolite M09; Z-isomer of azoxystrobin Plant - -
6-(2-cyanophenoxy)-3-glucosylpyrimidin-4-one
(Ref: R405287)
Metabolite M42 Plant - -


ECOTOXICOLOGÍA

for azoxystrobin

Propiedad Click here for information on the parameters used to describe substance ecotoxicology Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretación Click here for information on the way in which we interpret substance ecotoxicology
Factor de la bio-concentración BCF (l kg-1) Low risk A5 Based on LogP < 3 Bajo potencial
CT50 (días) - -
Mamíferos - Agudos oral LD50 (mg kg-1) > 5000 A5 Rata Bajo
Mamíferos - a corto plazo NOEL (mg kg-1) 10 A5 Rata Alto
(ppm dieta) - -
Pájaros/aves - Agudos LD50 (mg kg-1) > 2000 A5 Colinus virginianus Bajo
Birds - Short term dietary (LC50/LD50) > 1179 mg kg-1 A5 Colinus virginianus -
Pez - agudo 96 hora LC50 (mg l-1) 0.47 A5 Oncorhynchus mykiss Moderado
Pez - Crónico 21 días NOEC (mg l-1) 0.147 A5 Pimephales promelas Moderado
Invertebrados acuáticos - Agudos 48 hora EC50 (mg l-1) 0.23 A5 Daphnia magna Moderado
Invertebrados acuáticos - Crónicos 21 días NOEC (mg l-1) 0.044 A5 Daphnia magna Moderado
Crustáceos acuáticos - Agudos 96 hora LC50 (mg l-1) 0.055 A5 Americamysis bahia Alto
Sediment dwelling organisms - Agudos 96 hora LC50 (mg l-1) - - -
Sediment dwelling organisms - Crónicos 28 día NOEC, estático, agua (mg l-1) 0.8 A5 Chironomus riparius Moderado
Sediment dwelling organisms - Crónicos 28 día NOEC, sedimento (mg kg-1) - - -
Plantas acuáticas - Agudos 7 día EC50, biomasa (mg l-1) 3.2 A5 Lemna gibba, fronds Moderado
Non-target plants > 20 A5 Lettuce, Radish, Wheat
Seedling emergence, ER50
as mg/kg soil
-
- - -
Algas - Agudos 72 hora EC50, crecimiento (mg l-1) 0.36 A5 Pseudokirchneriella subcapitata Moderado
Algas - Crónicos 96 hora NOEC, crecimiento (mg l-1) 0.8 Q2 Unknown species Moderado
Abejas mielíferas (Apis spp.) Contacto aguda LD50 (peor caso de 24 , 48 y 72 hora valores - μg abeja-1) > 200 A5 Bajo
Oral aguda LD50 (peor caso de 24 , 48 y 72 hora valores - μg abeja-1) > 25 A5 Moderado
Modo desconocido aguda LD50 (peor caso de 24 , 48 y 72 hora valores - μg abeja-1) - - -
Abejorros (Bombus spp.) Contacto aguda LD50 (peor caso de 24 , 48 y 72 hora valores - μg abeja-1) - - -
-
Oral aguda LD50 (peor caso de 24 , 48 y 72 hora valores - μg abeja-1) - - -
-
Abejas albañiles (Osmia spp.) Contacto aguda LD50 (peor caso de 24 , 48 y 72 hora valores - μg abeja-1) - - -
Oral aguda LD50 (peor caso de 24 , 48 y 72 hora valores - μg abeja-1) - - -
Otros polinizadores (1) Agudos LD50 (peor caso de 24 , 48 y 72 hora valores - μg insect-1) - - -
Modo de exposición -
Otros polinizadores (2) Agudos LD50 (peor caso de 24 , 48 y 72 hora valores - μg insect-1) - - -
Modo de exposición -
Lombrices - Agudos 14 día LC50 (mg kg-1) 283 A5 Eisenia foetida Moderado
Lombrices - Crónicos 14 día NOEC, reproducción (mg kg-1) 20.0 A5 Eisenia foetida Moderado
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Causalidad - - -
Otro arthropoda (1) LR50 g ha-1 1000 > Mortality
A5 Aphidius rhopalosiphi
-
% Causalidad 23.0 Subletales efecto
Dose: 0.25 kg ha-1
A5 Aphidius rhopalosiphi
-
Otro arthropoda (2) LR50 g ha-1 1500 > Mortality
A5 Typhlodromus pyri
-
% Causalidad 3.9 Mortalidad
Dose: 0.188 kg ha-1
A5 Typhlodromus pyri
-
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: 2.5 kg ha-1
-
Mesocosm study data NOEAEC mg l-1 10 A5 Daphna, Cladocera, Copepoda -
NOEAEC mg l-1 - - -


LA SALUD HUMANA Y PROTECCIÓN

for azoxystrobin

General:
Propiedad Click here for information on the parameters used to describe human health and protection issues Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with human health and protection data Interpretación Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mamíferos - Agudos oral LD50 (mg kg-1) > 5000 A5 Rata Bajo
Mammals - Dermal LD50 (mg kg-1 body weight) > 2000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) 0.69 A5 Rat (particle size <2/0 um) -
Other Mammal toxicity endpoints - -
Consumo cada día aceptable (mg kg-1p.c. días-1) 0.2 A5 Rat, SF=100 -
ARfD - Acute Reference Dose (mg kg-1p.c. días-1) Ningunos asignaron A5 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
El nivel de exposición del operador (AOEL) sistemíco (mg kg-1p.c. días-1) 0.2 A5 Rat, SF=100 -
Estudios den la absorción cutánea (%) 0.3-0.5 A5 -
Directivo 76/464 Sustancias Peligrosas - - -
Exposure Routes Public No unacceptable risks identified
Occupational No unacceptable risks identified
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Genotóxico Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

A2; B0; C3; D0; E2

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

-

Cuestiones generales de la salud humana Minor effects on reproduction / development observed
Liver toxicant
Clave: Genotoxicidad
A: Aberración cromosómica (base de datos EFSA)
B: Daño/reparación del ADN (base de datos EFSA)
C: Mutación genética (base de datos EFSA)
D: Mutación del genoma (base de datos EFSA)
E: Tipo de genotoxicidad no especificada (fuente de datos diversos)
0: Sin datos
1: Positivo
2: Resultados mixtos/ambiguos
3: Negativo
Clave: Otro
: Sí, se sabe que causa un problema
: No, sabe no causar un problema
: Posiblemente, estado no identificado
- : Datos no encontrados

Handling issues:
Propiedad Click here for information on the parameters used to describe substance handling issues Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with data on handling issues Interpretación Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive or oxidising
IMDG Transport Code is usually 9
CLP classification 2013 Health: H331
Environment: H400, H410
CEE clasificación de riesgos Click here to view information omn the EU risk phrases T - Toxic: R23
N - Dangerous for the environment: R50, R53
CEE clasificación sin riesgos Click here to view information omn the EU safety phrases S1/2, S22, S45, S60, S61
Clasificación de OSM U - Es poco probable que presente un riesgo agudo
Número de las NU Variable with product, usually 2811, 3077 or 3082
Waste disposal & packaging Click here for a description of UN packaging marks Packaging Group III (minor danger)


TRADUCCIONES

for azoxystrobin

Idioma Nombre
Inglés azoxystrobin
Francés azoxystrobine
Alemán Azoxystrobin
Danés azoxystrobin
Italiano azoxystrobin
Español azoxiestrobina
Griego azoxystrobin
Esloveno azoksistrobin
Polaco azoksystrobina
Sueco azoxystrobin
Húngaro azoxistrobin
Holandés azoxystrobin

Última actualización del registro: Tuesday 25 June 2019
Contacto: aeru@herts.ac.uk