| tribenuron-metil (Ref: DPX L5300) |
 |
Destino ambiental - Ecotoxicología - La salud humana - A a Z Indice - Inicio
INFORMACIÓN GENERAL 
for tribenuron-methyl
Descripción: A foliar acting, post-emergence herbicide used to control broad-leaved weeds in cereals and other crops
Ejemplos de plagas controladas: Charlock; Chickweed; Red deadnettle; Fat hen; Forget-me-not; Hemp nettle; Mayweed; Common poppy; Redshank; Shepherd's purse
Ejemplos de aplicaciones: Cereals including wheat, barley, triticale, oats; Olives; Sunflower; Grass seed crops; Cotton; Pre-harvest burndown
Eficacia y actividad: Efficacy established via field trials and long-term use in the EU.
Availability status: Current
Introduction & key dates: 1987, first approvals
CEE Regulación 1107/2009 ( 91/414):
| Estado | Approved |
| Dossier rapporteur/co-rapporteur | Sweden/Latvia |
| Date inclusion expires | 31/10/2019 |
| UE Candidatas a sustitución | No |
| Incluido en la base de datos de la UE | Sí |
Approved for use (
) or known to be used (
) in the following European countries: 
AT |
BE |
BG |
CY |
CZ |
DE |
DK |
EE |
EL |
ES |
FI |
FR |
HR |
HU |
IE |
IT |
LT |
LU |
LV |
MT |
NL |
PL |
PT |
RO |
SE |
SI |
SK |
UK |
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Also used in: Australia
Estructura química:
| Isomerism | - |
| Fórmula química | C15H17N5O6S |
| Canonical SMILES | CC1=NC(=NC(=N1)OC)N(C)C(=O)NS(=O)(=O)C2=CC=CC=C2C(=O)OC |
| Isomeric SMILES | No data |
| International Chemical Identifier Key (InChIKey) | VLCQZHSMCYCDJL-UHFFFAOYSA-N |
| International Chemical Identifier (InChI) | InChI=1S/C15H17N5O6S/c1-9-16-13(18-14(17-9)26-4)20(2)15(22)19-27(23,24)11-8-6-5-7-10(11)12(21)25-3/h5-8H,1-4H3,(H,19,22) |
| ¿Diagrama de estructura 2D / imagen disponible? | Sí |
Estado general:
| Tipo de pesticida | Herbicida | |
| Grupo químico | Sulfonylurea | |
| Minimum active substance purity | 950 g/kg | |
| Known relevant impurities | EU dossier - None declared | |
| Sustancias de origen | Sintéticas | |
| Modo de acción | Selective, absorbed through foliage. Inhibits plant amino acid synthesis - acetohydroxyacid synthase AHAS | |
| CAS RN | 101200-48-0 | |
| CEE número | 401-190-1 | |
| Número CIPAC | 546 | |
| EPA américaine chimiques de code | 128887 | |
| PubChem CID | 153909 | |
| Masa molecular (g mol-1) | 395.4 | |
| PIN (Preferred Identification Name) | 2-{[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)methylcarbamoyl]sulfamoyl}benzoic acid | |
| Nombre IUPAC | methyl 2-[4-methoxy-6-methyl-1,3,5-triazin-2-yl(methyl)carbamoylsulfamoyl]benzoate | |
| Nombre CAS | methyl 2-[[[[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)methylamino]carbonyl]amino]sulfonyl]benzoate | |
| Otra información de estado | - | |
| Relevant Environmental Water Quality Standards | - | |
| Herbicide Resistance Classification (HRAC) | B | |
| Herbicide Resistance Classification (WSSA) | 2 | |
| Insecticide Resistance Classification (IRAC) | No aplicable | |
| Fungicide Resistance Classification (FRAC) | No aplicable | |
| Examples of recorded resistance | Many recorded cases Capsella bursa-pastoris Chrysanthemum coronarium Descurainia sophia Galium spurium |
|
| Estado físico | White to off-white solid | |
| Related substances & organisms | ||
Formulaciones:
| Propiedad |
Valor | |||
| Example manufacturers & suppliers of products using this active now or historically |
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| Example products using this active |
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| Estado de UK LERAP | None (may vary with mixtures) | |||
| Formulation and application details | Often supplied as water dispersible or water soluble granules that are mixed with water and used as a spray. | |||
DESTINO AMBIENTAL
for tribenuron-methyl
| Propiedad |
Valor | Fuente/Cuenta de Cualidad/Otra Información |
Interpretación |
|
| Solubilidad - En aqua en 20oC (mg l-1) | 2483 | A5 | Alto | |
| Solubilidad - en solventes organicos en 20oC (mg l-1) | 20800 | A5 - n-Heptano | - | |
| 250000 | A5 - Cloruro de metileno | - | ||
| 39100 | L3 - Acetona | - | ||
| 16300 | L3 - Acetato de etilo | - | ||
| Punto de fusión (oC) | 142 | A5 | - | |
| Punto de ebullición (oC) | Decomposes before boiling | A5 | - | |
| El punto de degradación (oC) | 175 | A4 | - | |
| Punto de inflamación (oC) | Not expected to self ignite; Not highly flammable | A5 | - | |
| Octanol-aqua coeficiente de particiónat en pH 7, 20oC | P | 2.40 X 1000 | Calculado | - |
| Log P | 0.38 | A5 | Bajo | |
| Masa densidad (g ml-1)/Peso específico | 1.46 | A5 | - | |
| Disociación constante (pKa) at 25oC | 4.65 | A5 | - | |
| Nota: Ácido débil | ||||
| Presión de vapor en 20oC (mPa) | 5.99 X 10-06 | A5 | Baja volatilidad | |
| Constante de Henry a 25oC (Pa m3 mol-1) | 1.00 X 10-08 | A5 | No volátil | |
Indice de potencial de lixiviación GUS  |
2.40 | Calculado | Estado de transición | |
| SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate |
Valor | 4.17 X 10-02 | Calculado | - |
| Nota | - | |||
| Potencial para transportar de 'particle bound' |
- | Calculado | Bajo | |
| Maximum UV-vis absorption L mol-1 cm-1 | pH 1.66: 200nm=41720, 231nm=20730, 290nm=396.2 pH 7.0: 201nm=37320, 256nm=18040, 290nm=342.4 pH 11.72: 208nm=23760, 256nm=17200, 290nm=334.4 |
A5 | - | |
| Surface tension (mN m-1) | 73.0 | A5 at 20 degC | - | |
Degradación:
| Propiedad |
Valor | Fuente/Cuenta de Cualidad/Otra Información |
Interpretación |
Biodegradabilidad general | Not readily biodegradable |
| Degradación de suelo (días) (aerobic) | DT50 (típico) | 9.1 | A5 | No persistente |
| DT50 (laboratorio en 20oC) | 9.1 | A5 | No persistente | |
| DT50 (campo) | 3.6 | A5 | No persistente | |
| DT90 (laboratorio en 20oC) | 46.0 | A5 | - | |
| DT90 (campo) | 26.1 | A5 | - | |
| Endpoint de modelado DT50 | - | - | - | |
| Nota | EU 2018 dossier lab studies DT50 range 2.9-23.1 days, DT90 range 9.7-158 days, Soils=16; field studies DT50 range 1.7-10.4 days, DT90 range 5.8-115 days, Soils=9 | |||
| Dissipation rate RL50 on plant matrix | Valor | - | - | - |
| Nota | - | |||
| Dissipation rate RL50 on and in plant matrix | Valor | - | - | - |
| Nota | - | |||
| Acuoso fotólisis DT50 (días) en pH 7 | Valor | Estable | A5 | - |
| Nota | - | |||
| Acuoso hidrólisis DT50 (días) en 20oC y pH 7 | Valor | 31.0 | A5 | Persistente moderado |
| Nota | pH sensitive: DT50 0.1 days at pH 4@ 20 degC, stable at pH 9 @ 25 degC | |||
| Aqua-Sedimento DT50 (días) | 139 | A5 | Lento | |
| Fase de agua sola DT50 (días) | 86.2 | A5 | Estable | |
De absorción del suelo y la movilidad:
| Propiedad |
Valor | Fuente/Cuenta de Cualidad/Otra Información |
Interpretación |
|
| Lineal | Kd | 1.1 | A5 | Móvil |
| Koc | 35 | |||
| Notas y rango | EU 2004 dossier Kd range 0.1-2.1 mL/g, Koc range 8.3-91.0 mL/g, Soils=5 | |||
| Freundlich | Kf | 0.59 | A5 | Móvil |
| Kfoc | 31.6 | |||
| 1/n | 0.98 | |||
| Notas y rango | EU 2018 dossier kf range 0.05-1.7, Kfoc range 4.55-74.0 mL/g, 1/n range 0.90-1.11, Soils=10 | |||
| pH senbsibilidad | Lower sorption at high pH | |||
Key metabolites:
| Metabolito | Medio de formación | Maximó Calculado de Fracción Ocurrencia | 1107/2009 Importancia |
|
| N-methyl triazine amine (Ref: IN-L5296) |
Suelo | 0.857 | Major fraction, Relevant | |
| 2-amino-4-methoxy-6-methyl-1,3,5-triazine (Ref: IN-A4098) |
Suelo | 0.126 | Major fraction, Relevant | |
| 1,2-benzisothiazol-3(2H)-one,1,1-dioxide (Ref: IN-00581) |
Suelo | 0.339 | Major fraction, Relevant | |
| tribenuron (Ref: IN-R9803) | Suelo | 0.076 | Minor fraction, Relevant | |
| 1-(4-methoxy-6-methyl-1,3,5-triazin-2-yl)-1-methylurea (Ref: ) |
Suelo | 0.162 | Major fraction, Relevant | |
Other known metabolites:
| Metabolite name and reference | Aliases | Medio de formación / Rate | Maximó Calculado de Fracción Ocurrencia | Metabolising enzymes |
| metsulfuron-methyl (Ref: DPX T6376) Nota: Major fraction, Relevant |
- | Crops; Livestock; Poultry | - | - |
| (((aminocarbonyl)amino)sulfonyl)benzoate (Ref: IN-B5685) |
sulfonamide urea | Crops; Livestock; Poultry | - | - |
| methyl 2-(((((4-methoxy-6-methyl-1,2,5-triazin-2-yl)amino)carbonyl)amino)sulfonyl)4-(beta-D-glucopyranpsyl)benzoate (Ref: IN-B9700) |
- | Crops | - | - |
| 2-(aminosulfonyl)benzoic acid (Ref: IN-D5119) |
- | Crops; Livestock; Poultry | - | - |
| methyl-2-(amonosulfonyl)benzoate (Ref: IN-D5803) |
- | Crops; Livestock; Poultry | - | - |
| methyl 2-(((((4-methoxy-6-methyl-1,2,5-triazin-2-yl)amino)carbonyl)amino)sulfonyl)4-hydroxybenzoate (Ref: IN-G7460) |
- | Crops, Livestock | - | - |
| methyl-2(((((4-hydroxy-6-methyl-1,3,5-triazin-2-yl)methylamino)carbonyl)amino)solfonyl)benzoate (Ref: IN-GK521) |
- | Crops; Livestock; Poultry | - | - |
| methyl 2-(((((4-methoxy-6-methyl-1,2,5-triazin-2-yl)methylamino)carbonyl)amino)sulfonyl)benzoate (Ref: IN-GN815) |
- | Crops; Poultry | - | - |
| methyl 2-(((((4-(hyroxymethyl)-6-methoxy-13,5-triazin-2-yl)methylamino)carbonyl)amino)sulfonyl)benzoate (Ref: IN-QKK48) |
- | Crops; Livestock; Poultry | - | - |
ECOTOXICOLOGÍA
for tribenuron-methyl
| Propiedad |
Valor | Fuente/Cuenta de Cualidad/Otra Información |
Interpretación |
|
| Factor de la bio-concentración | BCF (l kg-1) | 0.08 | Q2 Estimado | Bajo potencial |
| CT50 (días) | No disponible | - | ||
| Mamíferos - Agudos oral LD50 (mg kg-1) | > 5000 | A5 Rata | Bajo | |
| Mamíferos - a corto plazo NOEL | (mg kg-1) | > 12 | B5 Rata | Alto |
| (ppm dieta) | > 100 | - | ||
| Pájaros/aves - Agudos LD50 (mg kg-1) | > 2250 | A5 Colinus virginianus | Bajo | |
| Birds - Short term dietary (LC50/LD50) | > 974 mg kg-1 bw/día | A5 Anas platyrhynchos | - | |
| Pez - agudo 96 hora LC50 (mg l-1) | 738 | A5 Oncorhynchus mykiss | Bajo | |
| Pez - Crónico 21 días NOEC (mg l-1) | 560 | A5 Oncorhynchus mykiss | Bajo | |
| Invertebrados acuáticos - Agudos 48 hora EC50 (mg l-1) | 894 | A5 Daphnia magna | Bajo | |
| Invertebrados acuáticos - Crónicos 21 días NOEC (mg l-1) | 120 | A5 Daphnia magna | Bajo | |
| Crustáceos acuáticos - Agudos 96 hora LC50 (mg l-1) | - | - | - | |
| Sediment dwelling organisms - Agudos 96 hora LC50 (mg l-1) | - | - | - | |
| Sediment dwelling organisms - Crónicos 28 día NOEC, estático, agua (mg l-1) | - | - | - | |
| Sediment dwelling organisms - Crónicos 28 día NOEC, sedimento (mg kg-1) | - | - | - | |
| Plantas acuáticas - Agudos 7 día EC50, biomasa (mg l-1) | 0.0099 | B5 Lemna minor | Alto | |
| Non-target plants | - | - | - | |
| - | - | - | ||
| Algas - Agudos 72 hora EC50, crecimiento (mg l-1) | 0.11 | A5 Raphidocelis subcapitata, 120 hora | Moderado | |
| Algas - Crónicos 96 hora NOEC, crecimiento (mg l-1) | 0.25 | Q2 Unknown species | Moderado | |
| Abejas mielíferas | Contacto aguda 48 hora LD50 (μg abeja-1) | - | - | - |
| Oral aguda 48 hora LD50 (μg abeja-1) | > 9.1 | A5 | Moderado | |
| Modo desconocido aguda 48 hora LD50 (μg abeja-1) | > 98.4 | A5 | Moderado | |
| Lombrices - Agudos 14 día LC50 (mg kg-1) | > 1000 | A5 Eisenia foetida | Bajo | |
| Lombrices - Crónicos 14 día NOEC, reproducción (mg kg-1) | - | - | - | |
| Other soil macro-organisms - e.g. Collembola | LR50 / EC50 / NOEC / % Causalidad | - | - | - |
| Otro arthropoda (1) | LR50 g ha-1 | - | - | - |
| % Causalidad | 14 10 |
Mortalidad Reproducción Dose: 0.03 kg ha-1 A5 Aphidius rhopalosiphi |
- | |
| Otro arthropoda (2) | LR50 g ha-1 | - | - | - |
| % Causalidad | -3.2 -7 |
Mortalidad Reproducción Dose: 0.03 kg ha-1 A5 Typhlodromus pyri |
- | |
| Soil micro-organisms | Nitrogen mineralisation: No significant adverse effect Carbon mineralisation: No significant adverse effect |
A3 Dose: Not stated |
- | |
| Mesocosm study data | NOEAEC mg l-1 | - | - | - |
| NOEAEC mg l-1 | - | - | - | |
LA SALUD HUMANA Y PROTECCIÓN
for tribenuron-methyl
General:
| Propiedad |
Valor | Fuente/Cuenta de Cualidad/Otra Información |
Interpretación |
|
| Threshold of Toxicological Concern (Cramer Class) |
High (class III) | - | - | |
| Mamíferos - Agudos oral LD50 (mg kg-1) | > 5000 | A5 Rata | Bajo | |
| Mammals - Dermal LD50 (mg kg-1 body weight) | > 5000 | A5 Rat | - | |
| Mammals - Inhalation LC50 (mg l-1) | > 6.0 | A5 Rat, 4 hr (nose only) | - | |
| Other Mammal toxicity endpoints | - | - | ||
| Consumo cada día aceptable (mg kg-1p.c. días-1) | 0.01 | A5 Rat, 2 year, SF=100 | - | |
| ARfD - Acute Reference Dose (mg kg-1p.c. días-1) | 0.2 | A5 Rat, SF=100 | - | |
| AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) | 0.13 | A5 Rat, SF=167 | - | |
| El nivel de exposición del operador (AOEL) sistemíco (mg kg-1p.c. días-1) | 0.05 | A5 Rat, SF=167 | - | |
| Estudios den la absorción cutánea (%) | 25-75 | A5 concentration dependent | - | |
| Directivo 76/464 Sustancias Peligrosas | - | - | - | |
| Limites de exposiciones | - | - | - | |
| Exposure Routes | Public | No unacceptable risks to bystanders identified | ||
| Occupational | No unacceptable risks to operators or other workers identified | |||
| European MRLs | Click here for the EU MRL pesticide database | |||
| Drinking Water Standards | - | - | - | |
| Drinking Water MAC (μg l-1) | - | - | - | |
Health issues:
| Carcinogen | Mutágeno | Endocrine disrupter | Reproduction / development effects | Cholinesterase inhibitor | Neurotoxicant | |||
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| Respiratory tract irritant | Skin irritant | Skin sensitiser | Eye irritant | Phototoxicant | ||||
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| Cuestiones generales de la salud humana | USEPA - possible human carcinogen Possible liver & spleen toxicant Endocrine issues - Weak estrogenic effect |
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: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found
Handling issues:
| Propiedad |
Valor | Fuente/Cuenta de Cualidad/Otra Información |
Interpretación |
|
| General |
Not explosive or oxidising IMDG Transport Code is usually 9 |
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| CLP classification 2013 | Health: H317, H373 Human: H400, H410 |
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| CEE clasificación de riesgos |
Xn - Harmful: R43 | |||
| CEE clasificación sin riesgos |
S2, S22, S24, S37 | |||
| Clasificación de OSM | U | - | Es poco probable que presente un riesgo agudo | |
| US EPA Classification (formulation) | III | - | Caution - Slightly toxic | |
| Número de las NU | Usually 3077 | |||
| Waste disposal & packaging |
Packaging Group III (minor danger) | |||
TRADUCCIONES
for tribenuron-methyl
| Idioma | Nombre |
| Inglés | tribenuron-methyl |
| Francés | tribenuron-methyle |
| Alemán | Tribenuron |
| Danés | tribenuron-methyl |
| Italiano | tribenuron-metile |
| Español | tribenuron-metil |
| Griego | - |
| Esloveno | tribenuron-metil |
| Polaco | tribenuron metylu |
| Sueco | tribenuronmetyl |
| Húngaro | tribenuron-metil |
| Holandés | - |
Última actualización del registro: Monday 05 November 2018
Contacto: aeru@herts.ac.uk