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zoxamida (Ref: RH 7281)
** zoxamide ** benzamide ** RH 117281 ** zoxium ** HSDB 7278 ** Traducciones

Destino ambiental - Ecotoxicología - La salud humana - A a Z Indice - Inicio

RESUMEN

A fungicide with approval for use in the EU and many other countries. It has a low aqueous solubility, is volatile and has a low potential for leaching to groundwater. It is not usually persistent in soil or water systems. Zoxamide has a low mammalian toxicity but is a probably skin sensitiser and a recognised eye irritant. It is moderately toxic to most fauna and flora.

INFORMACIÓN GENERAL Click here for an explantaion of the general chemical status information
for zoxamide

Descripción: A fungicide used for the control of various fungal inflections including blight in potatoes and tomatoes

Ejemplos de plagas controladas: Early and late blight; Leaf blight; Anthracnose; Downy mildew; Bunch rot; Dead arm

Ejemplos de aplicaciones: Potatoes; Grapes; Tomatoes; Curcubits including gourd, melons, squash; Onions and garlic

Eficacia y actividad: Efficacy demonstrated via field trials and extensive use.

Availability status: Current

Introduction & key dates: 2001, Europe

CEE Regulación 1107/2009 ( 91/414):
Estado Approved
Dossier rapporteur/co-rapporteur Latvia/France
Date inclusion expires 30/06/2033
UE Candidatas a sustitución No
Incluido en la base de datos de la UE

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Estados Unidos

Estructura química: Click here for further information on the general chemical status information used on this site
Isomerism Chiral, a specific isomer or a derivative of a chiral molecule
Fórmula química C14H16Cl3NO2
Canonical SMILES CCC(C)(C(=O)CCl)NC(=O)C1=CC(=C(C(=C1)Cl)C)Cl
Isomeric SMILES No data
International Chemical Identifier Key (InChIKey) SOUGWDPPRBKJEX-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C14H16Cl3NO2/c1-4-14(3,12(19)7-15)18-13(20)9-5-10(16)8(2)11(17)6-9/h5-6H,4,7H2,1-3H3,(H,18,20)
¿Diagrama de estructura 2D / imagen disponible?

Click to access the Cambridge Crystallographic Data Centre (CCDC) website
Cambridge Crystallographic Data Centre diagrams:
Nombre Común Relación Vínculo
Zoxamide Unstated isomer Click here for the CCDC structure diagram

Estado general: Click here for further information on the general chemical status information used on this site
Tipo de pesticida Fungicide
Grupo químico Benzamide
Minimum active substance purity 953 g/kg
Known relevant impurities EU dossier - None declared
Sustancias de origen Sintéticas
Modo de acción Contact with additional vapour activity. Rainfast preventative action with residual properties. Inhibition of mitosis and cell division (Beta-tubulin assembly in mitosis).
CAS RN 156052-68-5
CEE número -
Número CIPAC 640
EPA américaine chimiques de code 101702
PubChem CID 122087
Masa molecular (g mol-1) 336.64
PIN (Preferred Identification Name) rac-3,5-dichloro-N-[(3R)-1-chloro-3-methyl-2-oxopentan-3-yl]-4-methylbenzamide
Nombre IUPAC (RS)-3,5-dichloro-N-(3-chloro-1-ethyl-1-methyl-2-oxopropyl)-p-toluamide
Nombre CAS 3,5-dichloro-N-(3-chloro-1-ethyl-1-methyl-2-oxopropyl)-4-methylbenzamide
Otra información de estado -
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) No aplicable
Herbicide Resistance Classification (WSSA) No aplicable
Insecticide Resistance Classification (IRAC) No aplicable
Fungicide Resistance Classification (FRAC) 22
Examples of recorded resistance -
Estado físico White powder
Related substances & organisms

Formulaciones:
Propiedad Click here for information on the general product and branding information used on this site Valor
Example manufacturers & suppliers of products using this active now or historically
  • Dow AgroSciences
  • Rohm and Haas
Example products using this active
  • Gavel
  • Electis
  • Zoxium 80 WP
  • Tirms
Estado de UK LERAP Buffer probably required in UK - see product label
Formulation and application details Usually supplied as aqueous flowable concentrates and wettable powders.


DESTINO AMBIENTAL

for zoxamide

Propiedad Click here for information on the parameters used to describe environmental fate on this site Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with fate data Interpretación Click here for information on the way in which we interpret environmental fate data
Solubilidad - En aqua en 20oC (mg l-1) 0.681 A5 Bajo
Solubilidad - en solventes organicos en 20oC (mg l-1) 20000 A5 - Acetato de etilo -
55700 A5 - Acetona -
1560 A5 - Xileno -
38 A5 - n-Heptano -
Punto de fusión (oC) 159.5 A5 -
Punto de ebullición (oC) Decomposes before boiling A5 -
El punto de degradación (oC) 160 A5 -
Punto de inflamación (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-aqua coeficiente de particiónat en pH 7, 20oC P 5.75 X 1003 Calculado -
Log P 3.76 A5 Alto
Masa densidad (g ml-1)/Peso específico 1.38 A5 -
Disociación constante (pKa) at 25oC No aplicable A5 -
Nota: Ninguna disociación
Presión de vapor en 20oC (mPa) 0.013 A5 Baja volatilidad
Constante de Henry a 25oC (Pa m3 mol-1) 6.59 X 10-03 A5 No volátil
Indice de potencial de lixiviación GUS Click here for a note on the limitations of the GUS index 0.71 Calculado Bajo posibilidad de lixiviación
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Valor 5.12 X 10-03 Calculado -
Nota -
Potencial para transportar de 'particle bound' Click here for a note on the limitations of the potential for particle bound transport index - Calculado Mediano
Maximum UV-vis absorption L mol-1 cm-1 Neutral soln: 241.2nm=10034, 212nm=46330
Acidic soln: 241.4=11549, 212.4nm=49596
Alkaline soln: 244.8nm=13300, 218.2nm=29899
A5 -
Surface tension (mN m-1) - - -

Degradación:
Propiedad Click here for information on the parameters used to describe substance degradation Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with degradation data Interpretación Click here for information on the way in which we interpret substance degradation data
Biodegradabilidad general -
Degradación de suelo (días) (aerobic) DT50 (típico) 5.5 A5 No persistente
DT50 (laboratorio en 20oC) 5.5 A5 No persistente
DT50 (campo) 6 E4 No persistente
DT90 (laboratorio en 20oC) 35.2 A5 -
DT90 (campo) - - -
Endpoint de modelado DT50 - - -
Nota EU 2018 dossier DT50 lab studies range 1.87-34.27 days, DT90 range 6.62-115 days, Soils=8; Manufacturers published data field DT50 2-10 days; Other sources: DT50 15 days (DW4)
Dissipation rate RL50 on plant matrix Valor - - -
Nota -
Dissipation rate RL50 on and in plant matrix Valor - - -
Nota -
Acuoso fotólisis DT50 (días) en pH 7 Valor 8 A5 Moderado rápido
Nota Test conditions equivalent to summer sunlight in New Jersey USA, 42 deg N
Acuoso hidrólisis DT50 (días) en 20oC y pH 7 Valor 15.7 A5 No persistente
Nota pH sensitive: DT50 16 days at pH 4, 8 days at pH 9, all at 25 degC
Aqua-Sedimento DT50 (días) 6.4 A5 Rápido
Fase de agua sola DT50 (días) 3 A5 Moderado rápido

De absorción del suelo y la movilidad:
Propiedad Click here for information on the parameters used to describe substance adsorption and mobility Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretación Click here for information on the way in which we interpret substance adsorption and mobility
Lineal Kd - A4 Móvil un poco
Koc 1224
Notas y rango Manufacturers published data Koc circa 1000 mL/g (E3)
Freundlich Kf 13.3 A5 Móvil un poco
Kfoc 1224.2
1/n 0.973
Notas y rango EU 2016 dossier kf range 3.36-25.33 mL/g, Kfoc range 815-1431 mL/g, 1/n range 0.973-1.067, Soils=6
pH senbsibilidad No

Key metabolites:
Metabolito Medio de formación Maximó Calculado de Fracción Ocurrencia 1107/2009 Importancia Click here for further information on 1107/2009 relevancy
3,5-dichloro-N-(2-carboxy-1-ethyl-1-methyl-2-oxoethyl)-4-methylbenzamide (Ref: RH-163353) This metabolite may cause environmental pollution, click here for further information Suelo   0.150   Major fraction, Relevant
3,5-dichloro-N-(1-ethyl-1-methyl-2-oxopropyl)-4-methylbenzamide (Ref: RH-127450) This metabolite may cause environmental pollution, click here for further information Suelo   0.151   Major fraction, Relevant
3,5-dichloro-4-methylbenzoic acid (Ref: RH-24549) This metabolite may cause environmental pollution, click here for further information Suelo   0.338   Major fraction, Relevant

Other known metabolites:
Metabolite name and reference Aliases Medio de formación / Rate Maximó Calculado de Fracción Ocurrencia Metabolising enzymes
3,5-dichloro-N-(3-hydroxy-1-ethyl-1-methyl-2-oxopropyl)-4-methylbenzamide
(Ref: RH 141288)
RH-1288 Water (Hydrolysis) - -
2-(3,5-dichloro-4-methylphenyl)-4-ethyl-4-methyl-4H-1,3-oxazin-5(6H)-one
(Ref: RH-129151)
RH-9151 Water (Hydrolysis) 0.164 -
3,5-dichloro-4-methylbenzamide
(Ref: RH-139432)
RH-9432 - - -
3,5-dichloro-4-hydroxymethylbenzoic acid
(Ref: RH-141452)
RH-1452 - - -
3,5-dichloro-N-(1-ethyl-1-methyl-2-oxopropyl)-4-hydroxymethylbenzamide
(Ref: RH-141454)
RH-1454 - - -
3,5-dichloro-1,4-benzenedicarboxylic acid3,5-dichloro-terephthalic acid
(Ref: RH-141455)
RH-1455 Soil 0.08 -
3,5-dichloro-N-(2-carboxy-1-ethyl-1-methyl)-4-methylbenzamide
(Ref: RH-141643)
RH-1643 - - -
3,5-dichloro-4-hydroxymethylbenzamide
(Ref: RH-149736)
RH-9736 - - -
4-carboxy-3,5-dichlorobenzamide
(Ref: RH-149737)
RH-9737 - - -
(3-amino-3-methyl-2-oxo)pentyl-(3,5-dichloro-4-methyl)benzoate
(Ref: RH-150721)
RH-0721 Water (a = Hydrolysis, b = Photolysis) - -
3,5-dichloro-4-methylbenzoic acid
(Ref: RH-24549)
RH-4549 Soil (a = Aerobic, b = Anaerobic, c = Photolysis); Water (d = Hydrolysis, e = Pholtolysis) a=0.338; b=0.237; c=0.222 -


ECOTOXICOLOGÍA

for zoxamide

Propiedad Click here for information on the parameters used to describe substance ecotoxicology Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretación Click here for information on the way in which we interpret substance ecotoxicology
Factor de la bio-concentración BCF (l kg-1) 115 A5 Umbral de importancia
CT50 (días) 0.4 -
Mamíferos - Agudos oral LD50 (mg kg-1) > 5000 A5 Rata Bajo
Mamíferos - a corto plazo NOEL (mg kg-1) > 50 A4 Perro Alto
(ppm dieta) - -
Pájaros/aves - Agudos LD50 (mg kg-1) > 2000 A5 Colinus virginianus Bajo
Birds - Short term dietary (LC50/LD50) > 5250 mg kg feed-1 A5 Colinus virginianus -
Pez - agudo 96 hora LC50 (mg l-1) 0.16 A5 Oncorhynchus mykiss Moderado
Pez - Crónico 21 días NOEC (mg l-1) 0.004 A5 Oncorhynchus mykiss Alto
Invertebrados acuáticos - Agudos 48 hora EC50 (mg l-1) > 0.78 A5 Daphnia magna Moderado
Invertebrados acuáticos - Crónicos 21 días NOEC (mg l-1) 0.039 A5 Daphnia magna Moderado
Crustáceos acuáticos - Agudos 96 hora LC50 (mg l-1) - - -
Sediment dwelling organisms - Agudos 96 hora LC50 (mg l-1) - - -
Sediment dwelling organisms - Crónicos 28 día NOEC, estático, agua (mg l-1) 0.45 A5 Chironomus riparius Moderado
Sediment dwelling organisms - Crónicos 28 día NOEC, sedimento (mg kg-1) - - -
Plantas acuáticas - Agudos 7 día EC50, biomasa (mg l-1) 0.017 A5 Lemna gibba Moderado
Non-target plants - - -
- - -
Algas - Agudos 72 hora EC50, crecimiento (mg l-1) 0.011 A5 Scenedemus subspicatus Moderado
Algas - Crónicos 96 hora NOEC, crecimiento (mg l-1) - - -
Abejas mielíferas (Apis spp.) Contacto aguda LD50 (peor caso de 24 , 48 y 72 hora valores - μg abeja-1) > 100 A5 Apis mellifera Bajo
Oral aguda LD50 (peor caso de 24 , 48 y 72 hora valores - μg abeja-1) > 147 A5 Apis mellifera Bajo
Modo desconocido aguda LD50 (peor caso de 24 , 48 y 72 hora valores - μg abeja-1) - - -
Abejorros (Bombus spp.) Contacto aguda LD50 (peor caso de 24 , 48 y 72 hora valores - μg abeja-1) - - -
-
Oral aguda LD50 (peor caso de 24 , 48 y 72 hora valores - μg abeja-1) - - -
-
Abejas albañiles (Osmia spp.) Contacto aguda LD50 (peor caso de 24 , 48 y 72 hora valores - μg abeja-1) - - -
Oral aguda LD50 (peor caso de 24 , 48 y 72 hora valores - μg abeja-1) - - -
Otros polinizadores (1) Agudos LD50 (peor caso de 24 , 48 y 72 hora valores - μg insect-1) - - -
Modo de exposición -
Otros polinizadores (2) Agudos LD50 (peor caso de 24 , 48 y 72 hora valores - μg insect-1) - - -
Modo de exposición -
Lombrices - Agudos 14 día LC50 (mg kg-1) > 1070 A5 Eisenia foetida Bajo
Lombrices - Crónicos NOEC, reproducción (mg kg-1) 66.7 A5 Eisenia foetida Moderado
Other soil macro-organisms Agudos LC50 (mg kg-1) - - -
Crónicos NOEC (mg kg-1) - - -
Otro arthropoda (1) LR50 g ha-1 Inofensivo Dose: 150 g ha-1
L3 Aphidius rhopalosiphi
-
% Causalidad 0 Mortalidad
Dose: 0.3 kg ha-1
A5 Aphidius rhopalosiphi, adult
-
Otro arthropoda (2) LR50 g ha-1 Inofensivo Dose: 150 g ha-1
L3 Typhlodromus pyri
-
% Causalidad 29 Mortalidad
Dose: 0.3 kg ha-1
A5 Typhlodromus pyri, adult
-
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: 2 mg kg-1 soil
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


LA SALUD HUMANA Y PROTECCIÓN

for zoxamide

General:
Propiedad Click here for information on the parameters used to describe human health and protection issues Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with human health and protection data Interpretación Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mamíferos - Agudos oral LD50 (mg kg-1) > 5000 A5 Rata Bajo
Mammals - Dermal LD50 (mg kg-1 body weight) > 2000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) > 5.3 A5 Rat, 4 hr (nose only) -
Other Mammal toxicity endpoints - -
Consumo cada día aceptable (mg kg-1p.c. días-1) 0.5 A5 Dog, SF=100 -
ARfD - Acute Reference Dose (mg kg-1p.c. días-1) Ningunos asignaron A5 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) Ningunos asignaron A5 -
El nivel de exposición del operador (AOEL) sistemíco (mg kg-1p.c. días-1) 0.3 A5 Rat, 90 day, SF=100 -
Estudios den la absorción cutánea (%) 4.0-10.0 A5 concentration dependent -
Directivo 76/464 Sustancias Peligrosas - - -
Exposure Routes Public No unacceptable risks to bystanders identified
Occupational No unacceptable risks to operators or other workers identified
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Genotóxico Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

A0; B0; C0; D0; E3

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

Cuestiones generales de la salud humana Liver and thyroid toxicant
Clave: Genotoxicidad
A: Aberración cromosómica (base de datos EFSA)
B: Daño/reparación del ADN (base de datos EFSA)
C: Mutación genética (base de datos EFSA)
D: Mutación del genoma (base de datos EFSA)
E: Tipo de genotoxicidad no especificada (fuente de datos diversos)
0: Sin datos
1: Positivo
2: Resultados mixtos/ambiguos
3: Negativo
Clave: Otro
: Sí, se sabe que causa un problema
: No, sabe no causar un problema
: Posiblemente, estado no identificado
- : Datos no encontrados

Handling issues:
Propiedad Click here for information on the parameters used to describe substance handling issues Valor Fuente/Cuenta de Cualidad/Otra Información Click here for information on the primary data sources used to populate this database with data on handling issues Interpretación Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive or oxidising
CLP classification 2013 Health: H317
Environment: H400, H410
CEE clasificación de riesgos Click here to view information omn the EU risk phrases Xn - Harmful: R43
N - Dangerous for the environment: R50/53
CEE clasificación sin riesgos Click here to view information omn the EU safety phrases S2, S24, S37, S46, S60, S61
Clasificación de OSM U - Es poco probable que presente un riesgo agudo
Número de las NU -
Waste disposal & packaging Click here for a description of UN packaging marks -


TRADUCCIONES

for zoxamide

Idioma Nombre
Inglés zoxamide
Francés zoxamide
Alemán Zoxamide
Danés zoxamid
Italiano zoxamide
Español zoxamida
Griego -
Esloveno zoksamid
Polaco zoksamid
Sueco zoxamid
Húngaro zoxamid
Holandés -

Última actualización del registro: Wednesday 04 March 2020
Contacto: aeru@herts.ac.uk