| tolfenpyrad (Ref: OMI 88) |
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Devenir environnemental - Ecotoxicologie - Santé humaine - Liste alphabétique - Page d'accueil
IDENTITÉ 
Description: Novel insecticide for use use in vegetables, particularly cruciferous leafy vegetables, fruits and other high-value markets. Also shows some fungidal activity against powdery mildew.
Introduction: 2002, Japon
Directive EEC 1107/2009 (abrogeant 91/414):
| Status | Not listed |
| Dossier rapporteur/co-rapporteur | Non applicable |
| Date inclusion expires | Non applicable |
Approved for use (
) or known to be used (
) in the following European countries: 
AT |
BE |
BG |
CY |
CZ |
DE |
DK |
EE |
EL |
ES |
FI |
FR |
HU |
IE |
IT |
LT |
LU |
LV |
MT |
NL |
PL |
PT |
RO |
SE |
SI |
SK |
UK |
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Également enregistré dedans: Japan; Dominican Republic; Thailand; Taiwan
Généralités:
| Type de pesticide | Insecticide, Fongicide | |||
| Groupe de substances | Pyrazole | |||
| L'origine des substances | Synthétique | |||
| Mode d'action | Broad spectrum, contact activity, exhibits antifeedant activity especially against Lepidoptera. | |||
| Dénomination CAS | 129558-76-5 | |||
| Dénomination UE | - | |||
| Nombre CIPAC | - | |||
| EPA américaine chimiques de code | 090111 | |||
| Formule brute | C21H22ClN3O2 | |||
| SMILES | c1(nn(c(c1Cl)C(=O)NCc1ccc(cc1)Oc1ccc(cc1)C)C)CC | |||
| International Chemical Identifier (InChI) | - | |||
| Formule plane/l'image | Oui | |||
| Poids moléculaire (g mol-1) | 383.88 | |||
| Nom IUPAC | 4-chloro-3-ethyl-1-methyl-N-[4-(p-tolyloxy)benzyl]pyrazole-5-carboxamide | |||
| Nom CAS | 4-chloro-3-ethyl-1-methyl-N-[[4-(4-methylphenoxy)phenyl]methyl]-1H-pyrazole-5-carboxamide | |||
| Autres informations sur l'état | - | |||
| Herbicide Resistance Classification (HRAC) | Non applicable | |||
| Insecticide Resistance Classification (IRAC) | 21 | |||
| Fungicide Resistance Classification (FRAC) | Non applicable | |||
| État physique | White powder | |||
| Related substances & organisms | - | |||
Formulations:
| Propriété |
Valeur | |||
| Example manufacturers of products using this active |
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| Example products using this active |
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| Statut LERAP britannique | No UK approval for use or outside scope | |||
| Formulation and application details | - | |||
| Propriété |
Valeur | Origine/Qualité de la donnée/informations complémentaires |
Interprétation |
|
| Solubilité - dans l'eau à 20oC (mg l-1) | 0.087 | E3 - at 25 DegC | Faible | |
| Solubilité - dans les solvants organiques à 20oC (mg l-1) | 7410 | E3 - n-Hexane at 25 DegC | - | |
| 366000 | E3 - Toluene at 25 DegC | - | ||
| 59600 | E3 - Methanol at 25 DegC | - | ||
| Point de fusion (oC) | 87.8 | E4 | - | |
| Point d’ébullition (oC) | - | - | - | |
| Degradation point (oC) | - | - | - | |
| Point d’éclair (oC) | - | - | - | |
| Coefficient de Partage octanol / eau à pH 7, 20oC | P | 4.07 X 1005 | Calculé | - |
| Log P | 5.61 | E4 - @ 25 degC | Elevé | |
| Densité (g ml-1) | 1.18 | E4 - at 25 DegC | - | |
| Constante de dissociation (pKa) à 25oC | - | - | - | |
| Remarque: | ||||
| Pression de vapeur à 25oC (mPa) | 5.0 X 10-04 | E4 - @ 25 degC | Non-volatil | |
| Constante de Henry à 25oC (Pa m3 mol-1) | - | - | - | |
| Constante de Henry à 20oC (dimensionless) | 9.06 X 10-07 | Calculé | Volatilité modérée | |
Index GUS  |
-0.48 | Calculé | Potentiel de lixiviation faible | |
| SCI-GROW groundwater index (µg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate |
Valeur | 5.35 X 10-03 | Calculé | - |
| Remarque | Estimated concentrations of chemicals with Koc values greater than 9995 ml g-1 are beyond the scope of the regression data used in SCI-GROW development. If there are concerns for such chemicals, a higher tier groundwater exposure assessment should be considered, regardless of the concentration returned by SCI-GROW | |||
| Potentiel de transport colloïdal |
- | Calculé | Moyen | |
| Maximum UV-vis absorption L mol-1 cm-1 | - | - | - | |
| Surface tension (mN m-1) | - | - | - | |
Dégradation:
| Propriété |
Valeur | Origine/Qualité de la donnée/informations complémentaires |
Interprétation |
|
| Soil degradation (jours) (aerobic) | DT50 (typique) | 4 | P4 | Non persistant |
| DT50 (au laboratoire à 20oC) | - | - | - | |
| DT50 (au champ) | - | - | - | |
| DT90 (au laboratoire à 20oC) | - | - | - | |
| DT90 (au champ) | - | - | - | |
| Remarque | Literature states DT50 3-5 days aerobic and 127-179 days anaerobic | |||
| DT50 par photolyse dans l’eau (jours) à pH 7 | Valeur | - | - | - |
| Remarque | - | |||
| DT50 par hydrolyse dans l’eau (jours) à 20oC et pH 7 | Valeur | Stable | P4 | Très persistant |
| Remarque | - | |||
| DT50 sédiment dans études eau-sédiment (jours) | - | - | - | |
| DT50 phase liquide dans études eau-sédiment (jours) | - | - | - | |
Adsorption au sol et à la mobilité:
| Propriété |
Valeur | Origine/Qualité de la donnée/informations complémentaires |
Interprétation |
|
| Linéaire | Kd | - | P4 | Non mobile |
| Koc | 63300 | |||
| Notes et large | Koc range 15100-149000 mL/g | |||
| Freundlich | Kf | - | - | - |
| Kfoc | - | |||
| 1/n | - | |||
| Notes et large | - | |||
| pH sensibilité | - | |||
Other known metabolites:
| Metabolite name and reference | Aliases | Milieu de Formation / Rate | Estimation du Pourcentage Maximum de Occurrence | Metabolising Enzymes |
| 4-chloro-3-(1-hydroxyethyl)-1-methylpyrazole-5-carboxamide | OH-PAM | Plant | - | - |
| 4-[4-[[4-chloro-3-(1-hydroxyethyl)-1-methylpyrazol-5-yl]carbonylaminomehtyl]phenoxy] benzoic acid | OH-PT-CA | Rat | - | - |
| 4-chloro-3-(1-hydroxyethyl)-N-[4-[4-(hydroxymethyl)phenoxy]benzyl]-1-methylpyrazole-5-carboxamide | OH-PT-OH | Plant | - | - |
| 4-[4-(hydroxymethyl)phenoxy]benzoic acid | OH-T-CA | Plant | - | - |
| bis[4-(hydroxymethyl)phenyl]ether | OH-T-OH | Plant | - | - |
| 4-chloro-3-ethyl-1-methylpyrazole-5-carboxylic acid | PCA | a=Plant; b=Soil | b=0.158 | - |
| 4-[4-[(4-chloro-3-ethyl-1-methylpyrazol-5-yl)carbonylaminomethyl]phenoxy]benzoic acid | PT-CA | Rat | - | - |
| Glucuronic acid conjugate of PT-CA | PT-CA-GA | Rat | - | - |
| 4-[4-[(4-chloro-3-ethyl-1-methylpyrazol-5-yl)carbonylaminomethyl]phenoxy]benzoic methyl ester | PT-CA-Me | Animal (Milk) | - | - |
| 2-[4-[(4-chloro-3-ethyl-1-methylpyrazol-5-yl)carbonylaminomethyl]phenoxy]phenylcarbonylamino]ethane-1-sulfonic acid | PT-CA-TA | Rat | - | - |
| 4-chloro-3-ethyl-N-[4-(4-formylphenoxy)benzyl]-1-methylpyrazole-5-carboxamide | PT-CHO | Water | - | - |
| 4-chloro-3-ethyl-N-[4-[4-(hydroxymethyl)phenoxy]benzyl]-1-methylpyrazole-5-carboxamide | PT-OH | Plant; Soil | - | - |
| 4-chloro-3-ethyl-N-(4-hydroxybenzyl-1-methylpyrazole-5-carboxamide | PT(A)-4OH | Soil | 0.046 | - |
| 4-(p-tolyloxy)benzamide | T-AM | Plant | - | - |
| 4-(p-tolyloxy)benzoic acid | T-CA | Rat | - | - |
| 4-[4-[[4-chloro-1-methyl-3-(1-sulfoxyethyl)pyrazole-5-yl]]]carbonylaminomethyl]phenoxy]benzoic acid | Sul-OH-PT-CA | Rat | - | - |
| 4-[4-[(3-acetyl-4-chloro-1-methylpyrazol-5-yl)carbonylaminomethyl]phenoxy]benzoic acid | CO-PT-CA | Rat | - | - |
| 3-acetyl-4-chloro-1-methyl-???? | CO-PT | Plant; Rat | - | - |
| 4-chloro-3-ethyl-N-[4-(p-tolyloxy)benzyl]pyrazole-5-carboxamide | DM-PT | Plant | - | - |
| 4-chloro-(1-hydroxyethyl)-1-methyl-N-[4-(p-tolyloxy)benzyl]pyrazole-5-carboxamide | OH-PT | Plant | - | - |
| 4-(4-carbamoylphenoxy)benzoic acid | CA-T-AM | Plant | - | - |
| 4,4’-oxydibenzoic acid | CA-T-CA | Plant | - | - |
| 4-[4-(aminomethyl)phenoxy]benzoic acid | CA-T-NH2 | Water | - | - |
| Propriété |
Valeur | Origine/Qualité de la donnée/informations complémentaires |
Interprétation |
|
| Facteur de bio-concentration | BCF | - | - | - |
| CT50 (jours) | - | - | ||
| Potentiel de bioaccumulation | - | - | - | |
| Mammifères - Toxicité aiguë par voie orale LD50 (mg kg-1) | 386 | E4 Rat | Modéré | |
| Mammifères - Toxicité à court terme NOEL | (mg kg-1) | - | - | - |
| (ppm diète) | - | - | ||
| Oiseaux - Toxicité aiguë par voie orale LD50 (mg kg-1) | 83.0 | E4 Colinus virginianus | Elevé | |
| Birds - Short term dietary (LC50/LD50) | - | - | - | |
| Poissons - Toxicité aiguë 96 heure LC50 (mg l-1) | 0.049 | E4 Cyprinus carpio | Elevé | |
| Poissons - Toxicité chronique NOEC 21 jours (mg l-1) | - | - | - | |
| Invertébrés aquatiques - Toxicité aiguë 48 heure EC50 (mg l-1) | 0.008 | E4 Daphnia magna | Elevé | |
| Invertébrés aquatiques - Toxicité chronique NOEC 21 jours (mg l-1) | - | - | - | |
| Crustacés aquaticues - Toxicité aiguë 96 heure LC50 (mg l-1) | - | - | - | |
| Sediment dwelling organisms - Toxicité aiguë 96 heure LC50 (mg l-1) | - | - | - | |
| Sediment dwelling organisms - Toxicité chronique 28 jour NOEC, statique, eau (mg l-1) | - | - | - | |
| Sediment dwelling organisms - Toxicité chronique 28 jour NOEC, sédiment (mg kg-1) | - | - | - | |
| Plantes aquatiques - Toxicité aiguë 7 jour EC50, biomasse (mg l-1) | - | - | - | |
| Algues - Toxicité aiguë 72 heure EC50, croissance (mg l-1) | 1.36 | E3 Unknown species | Modéré | |
| Algues - Toxicité chronique 96 heure NOEC, croissance (mg l-1) | - | - | - | |
| Abeilles - Toxicité aiguë 48 heure LD50 (µg abeille-1) | - | - | - | |
| Lombrics - Toxicité aiguë 14 jour LC50 (mg kg-1) | - | - | - | |
| Lombrics - Toxicité chronique 14 jour NOEC, reproduction (mg kg-1) | - | - | - | |
| Other soil macro-organisms - e.g. Collembola | LR50product ha EC50product ha NOECproduct ha % Causalité |
- | - | - |
| Autre arthropode (1) | LR50 g ha-1 | - | - | - |
| % Causalité | Nocif | E3 Aphidius colemani | Inoffensif | |
| Autre arthropode (2) | LR50 g ha-1 | - | - | - |
| % Causalité | - | - | - | |
| Soil micro-organisms | - | - | - | |
| Mesocosm study data | NOEAEC mg l-1 | - | - | - |
| NOEAEC mg l-1 | - | - | - | |
General:
| Propriété |
Valeur | Origine/Qualité de la donnée/informations complémentaires |
Interprétation |
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| Mammifères - Toxicité aiguë par voie orale LD50 (mg kg-1) | 386 | E4 Rat | Modéré | |
| Mammals - Dermal LD50 (mg kg-1 body weight) | 2000 | E4 Rat | - | |
| Mammals - Inhalation LC50 (mg l-1) | > 2.21 | E4 Rat | - | |
| Other Mammal toxicity endpoints | - | - | ||
| DJA - Dose journalière admissible (mg kg-1 de poids corporel jours-1) | - | - | - | |
| ARfD - Acute Reference Dose (mg kg-1 de poids corporel jours-1) | - | - | - | |
| NEAO- Niveau d'exposition Acceptable pour l'Opérateur (mg kg-1 de poids corporel jours-1) | - | - | - | |
| Dermique études (%) | - | - | - | |
| Directive 76/464 relative aux substances dangereuses | - | - | - | |
| Limites d'exposition | - | - | - | |
| Exposure Routes | Public | - | ||
| Occupational | - | |||
| Examples of European MRLs (mg kg-1) | Valeur | - | ||
| Remarque | For the EU pesticides database click here | |||
| Drinking Water MAC (µg l-1) | - | - | - | |
Health issues:
| Carcinogen | Mutagène | Endocrine disrupter | Reproduction / development effects | Acetyl cholinesterase inhibitor | Neurotoxicant | Respiratory tract irritant | Skin irritant | Eye irritant |
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| Risque suspecté pour la santé humaine | [Possible liver toxicant] | |||||||
: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data
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| Propriété |
Valeur | Origine/Qualité de la donnée/informations complémentaires |
Interprétation |
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| General |
[No information available] | ||||||
| Classement toxicologique selon l'UE |
- | ||||||
| Précautions selon l'UE |
- | ||||||
| Classement toxicologique selon l'OMS | NL | - | Non listé | ||||
| US EPA Classification (formulation) | - | - | - | ||||
| Nombre des NU | - | ||||||
| Waste disposal & packaging |
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| Langue | Nom |
| Anglais | tolfenpyrad |
| Français | - |
| Allemand | - |
| Danois | - |
| Italien | - |
| Espagnol | - |
| Grec | - |
| Slovène | - |
| Polonais | - |
| Suédois | - |
| Hongrois | - |
| Hollandais | - |
| Record dernière mise à jour: Tuesday 01 May 2012 Contact: aeru@herts.ac.uk |
