| bispyribac sodium (Ref: KIH-2023) |
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Devenir environnemental - Ecotoxicologie - Santé humaine - Liste alphabétique - Page d'accueil
IDENTITÉ 
Description: A post-emergence herbicide for the control of grasses, sedges and broad-leaved weeds in rice and other crops
Introduction: 1998, discovered; 1997, first introduced
Directive EEC 1107/2009 (abrogeant 91/414):
| Status | Pending |
| Dossier rapporteur/co-rapporteur | Italy |
| Date inclusion expires | - |
Approved for use (
) or known to be used (
) in the following European countries: 
AT |
BE |
BG |
CY |
CZ |
DE |
DK |
EE |
EL |
ES |
FI |
FR |
HU |
IE |
IT |
LT |
LU |
LV |
MT |
NL |
PL |
PT |
RO |
SE |
SI |
SK |
UK |
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Généralités:
| Type de pesticide | Herbicide | |||
| Groupe de substances | Pyrimidinyl carboxy compound | |||
| L'origine des substances | Synthétique | |||
| Mode d'action | Selective, systemic action absorbed by foliage and roots. Inhibits enzyme acetolactate synthase (ALS). | |||
| Dénomination CAS | 125401-92-5 | |||
| Dénomination UE | - | |||
| Nombre CIPAC | 748.011 | |||
| EPA américaine chimiques de code | 078906 | |||
| Formule brute | C19H17N4NaO8 | |||
| SMILES | [Na+].COc1nc(nc(OC)c1)Oc3cccc(Oc2nc(cc(OC)n2)OC)c3C([O-])=O | |||
| International Chemical Identifier (InChI) | InChI=1/C19H18N4O8.Na/c1-26-12-8-13(27-2)21-18(20-12)30-10-6-5-7-11(16(10)17(24)25)31-19-22-14(28-3)9-15(23-19)29-4;/h5-9H,1-4H3,(H,24,25);/q;+1/p-1/fC19H17N4O8.Na/q-1;m | |||
| Formule plane/l'image | Oui | |||
| Poids moléculaire (g mol-1) | 452.36 | |||
| Nom IUPAC | sodium 2,6-bis(4,6-dimethoxypyrimidin-2-yloxy)benzoate | |||
| Nom CAS | sodium 2,6-bis[(4,6-dimethoxy-2-pyrimidinyl)oxy]benzoate | |||
| Autres informations sur l'état | - | |||
| Herbicide Resistance Classification (HRAC) | B | |||
| Insecticide Resistance Classification (IRAC) | Non applicable | |||
| Fungicide Resistance Classification (FRAC) | Non applicable | |||
| État physique | White powder | |||
| Related substances & organisms | - | |||
Formulations:
| Propriété |
Valeur | |||
| Example manufacturers of products using this active |
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| Example products using this active |
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| Statut LERAP britannique | No UK approval for use or outside scope | |||
| Formulation and application details | Usually supplied as a suspension concentrate that is mixed with water and applied as a spray. | |||
| Propriété |
Valeur | Origine/Qualité de la donnée/informations complémentaires |
Interprétation |
|
| Solubilité - dans l'eau à 20oC (mg l-1) | 64000 | A5 | Elevé | |
| Solubilité - dans les solvants organiques à 20oC (mg l-1) | 25000 | A5 - Méthanol | - | |
| 0.061 | A5 - Acétate d'éthyle | - | ||
| 0.0083 | A5 - n-Hexane | - | ||
| 1.4 | A5 - Acétone | - | ||
| Point de fusion (oC) | 223 | A5 | - | |
| Point d’ébullition (oC) | Decomposes before boiling | A5 | - | |
| Degradation point (oC) | 223 | A5 | - | |
| Point d’éclair (oC) | Not highly flammable | A5 | - | |
| Coefficient de Partage octanol / eau à pH 7, 20oC | P | 9.33 X 10-02 | Calculé | - |
| Log P | -1.03 | A5 | Faible | |
| Densité (g ml-1) | 1.47 | A5 | - | |
| Constante de dissociation (pKa) à 25oC | 3.35 | A5 | - | |
| Note: Acide faible | ||||
| Pression de vapeur à 25oC (mPa) | 5.50 X 10-06 | A5 | Non-volatil | |
| Constante de Henry à 25oC (Pa m3 mol-1) | 3.12 X 10-11 | A5 | Non-volatil | |
| Constante de Henry à 20oC (dimensionless) | 1.60 X 10-14 | Calculé | Non-volatil | |
Index GUS  |
1.69 | Calculé | Potentiel de lixiviation faible | |
| SCI-GROW groundwater index (µg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate |
Valeur | 3.49 X 10-02 | Calculé | - |
| Remarque | - | |||
| Potentiel de transport colloïdal |
- | Calculé | Faible | |
| Maximum UV-vis absorption L mol-1 cm-1 | Maxima is below 290nm | A3 | - | |
| Surface tension (mN m-1) | 69.79 | A5 at 20oC | - | |
Dégradation:
| Propriété |
Valeur | Origine/Qualité de la donnée/informations complémentaires |
Interprétation |
|
| Soil degradation (jours) (aerobic) | DT50 (typique) | 13 | V4 | Non persistant |
| DT50 (au laboratoire à 20oC) | 12.8 | A5 | Non persistant | |
| DT50 (au champ) | 6.3 | A5 | Non persistant | |
| DT90 (au laboratoire à 20oC) | 42.6 | A5 | - | |
| DT90 (au champ) | 20.7 | A5 | - | |
| Remarque | EU dossier lab studies DT50 range 6-19.6 days (soil) & 19.2 days (paddy field soil), DT90 range 19.9-65.3 days (soil) & 62.7-64.7 days (paddy field soil); Field studies DT50 range 2.1-7.6 days (Southern Europe), DT90 range 6.9-30.2 days | |||
| DT50 par photolyse dans l’eau (jours) à pH 7 | Valeur | 42 | L3 | Stable |
| Remarque | DT50: 42 days in natural waters, 500 days in pure water | |||
| DT50 par hydrolyse dans l’eau (jours) à 20oC et pH 7 | Valeur | Stable | A5 | Très persistant |
| Remarque | Stable pH 7 to pH 9; DT50: 18.7 days pH 4, 20 degC | |||
| DT50 sédiment dans études eau-sédiment (jours) | 35.3 | A5 | Vitesse modérée | |
| DT50 phase liquide dans études eau-sédiment (jours) | 32.1 | A5 | Stable | |
Adsorption au sol et à la mobilité:
| Propriété |
Valeur | Origine/Qualité de la donnée/informations complémentaires |
Interprétation |
|
| Linéaire | Kd | - | - | - |
| Koc | - | |||
| Notes et large | - | |||
| Freundlich | Kf | 1.16 | A5 | Mobilité modérée |
| Kfoc | 302 | |||
| 1/n | 0.958 | |||
| Notes et large | EU dossier Kf range 0.60-2.01 mL/g, Kfoc range 143-604 mL/g, 1/n range 0.935-0.990, Soils=5 | |||
| pH sensibilité | - | |||
Key metabolites:
| Métabolite | Milieu de Formation | Estimation du Pourcentage Maximum de Occurrence | 91/414 Pertinence |
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| benzoic acid, 2-[(4,6-dimethoxy-2-pyrimidinyl)oxy]6-hydroxy, sodium salt |
Sol | 0.15 | Major fraction, Relevant | |
| benzoic acid, 2-[4,6-dimethoxy-2-pyrimidinyl)oxy]-6-[(4-hydroxy-6-methoxy-2-pyrimidinyl)oxy], sodium salt (Ref: KIB 8651) |
Sol | 0.144 | Major fraction, Relevant | |
| 2,4-dihydroxy-6-methoxypyrimidine | Sol | 0.058 | Minor fraction, Relevant | |
Other known metabolites:
| Metabolite name and reference | Aliases | Milieu de Formation / Rate | Estimation du Pourcentage Maximum de Occurrence | Metabolising Enzymes |
| 2-(4,6-dimethoxypyrimidin-2-yl)oxy-6-(4-hydroxy-6-methoxypyrimidin-2-yl)oxybenzenzoic acid | DesMe-5750 (MO1); KIH-2023-M1 | Soil; Paddy soil; Water | - | - |
| 2-(4,6-dimethoxypyrimidin-2-yl)oxy-6-hydroxy benzoic acid | BX-180 (MO2); KIH-2023-M2; PHU120 | Animal; Rat; Plant; Soil; Water | - | - |
| 2-hydroxy-4-6-dimethoxypyrimidine | Me2BA (MO3); KIH-2023-M3; M15876; PHU1305 | Animal; Rat; Plant; Soil; Water | - | - |
| 2,4,6-trimethoxypyrimidine | Me3BA (MO7); FHW0112A; KIH-2023-M7 | Unknown | - | - |
| 2-(4,6-dimethoxy-5-hydroxypyrimidin-2-yl)oxy-6-(4,6-dimethoxypyrimidin-2-yl)oxybenzoic acid | 5-OH-5750 (MO8); KIH-2023-M8 | Animal; Plant; Rat | - | - |
| sodium 2-hydroxy-6-(4-hydroxy-6-methoxypyrimidin-2-yl)oxybenzoate | Na-DesMe-180 (M10); KIH-2023-M10; M9-Na | Plant; Soil; Paddy soil; Water | - | - |
| sodium 2-(4,6-dimethoxy-5-hydroxypyrimidin-2-yl)oxy-6-(4,6-dimethoxypyrimidin-2-yl)oxybenzoate | 5-OH-2023 (M11); M8-Na | Plant | - | - |
| benzoic acid, 2,6-bis[(4,6-dimethoxypyrimidin-2-yl)oxy] | KIA-5750 (M12); M12433 | Unknown | - | - |
| 2,6-dihydroxybenzoic acid | 2,6-DBA (M13) | Animal | - | - |
| 9-(4,6-dimethoxypyrimidin-2-yl)oxy-3-methoxy-1H, 10H-pyrimido[2,1-b]-[1,3]benzoxazine-1, 10dione | Cyc-DesMe-2023 (M14) | Unknown | - | - |
| methyl 1-O--[2,6-bis[(4,6-dimethoxypyrimidin-2-yl)oxy]-benzoyl-beta-D-glucuronate | Me-glucuro-2023 (M15) | Rat | - | - |
| - | DRS0571 (M16) | Unknown | - | - |
| - | Glu-DesMe-5750; KIH-2023-M17 | Plant | - | - |
| - | Me2BA-GA (M18); Metabolite F | Animal | - | - |
| - | KIB-4662 (M19) | Unknown | - | - |
| - | 2,6-MDB (M20) | Unknown | - | - |
| - | 2023-glucuronic acid (M21) | Animal; Hen | - | - |
| - | PHU0979 (M22) | Unknown | - | - |
| - | PHU0720 (M23) | Unknown | - | - |
| - | PHU1487 (M24) | Unknown | - | - |
| - | AND2338 (M25) | Unknown | - | - |
| 2-hydoxy-6-[(4-hydroxy-6-methoxypyrimidin-2-yl)oxy]benzoic acid Remarque: CAS no: 172838-16-3 |
DesMe-180 (MO9); KIH-2023-M9; FHW0122B;M18537 | Animal; Plant; Soil; Paddy soil; Water | - | - |
| Propriété |
Valeur | Origine/Qualité de la donnée/informations complémentaires |
Interprétation |
|
| Facteur de bio-concentration | BCF | - | - | - |
| CT50 (jours) | - | - | ||
| Potentiel de bioaccumulation | - | Calculé | Faible | |
| Mammifères - Toxicité aiguë par voie orale LD50 (mg kg-1) | 2635 | A5 Rat | Faible | |
| Mammifères - Toxicité à court terme NOEL | (mg kg-1) | 1.1 | V2 Rat | Elevé |
| (ppm diète) | 20 | - | ||
| Oiseaux - Toxicité aiguë par voie orale LD50 (mg kg-1) | > 2250 | A5 Colinus virginianus | Faible | |
| Birds - Short term dietary (LC50/LD50) | > 2081 mg kg-1 bw/jour | A5 Colinus virginianus | - | |
| Poissons - Toxicité aiguë 96 heure LC50 (mg l-1) | > 95 | A5 Oncorhynchus mykiss | Modéré | |
| Poissons - Toxicité chronique NOEC 21 jours (mg l-1) | 10 | A4 Pimephales promelas, 32 jour | - | |
| Invertébrés aquatiques - Toxicité aiguë 48 heure EC50 (mg l-1) | > 95 | A5 Daphnia magna | Modéré | |
| Invertébrés aquatiques - Toxicité chronique NOEC 21 jours (mg l-1) | 110 | A5 Daphnia magna | - | |
| Crustacés aquaticues - Toxicité aiguë 96 heure LC50 (mg l-1) | - | - | - | |
| Sediment dwelling organisms - Toxicité aiguë 96 heure LC50 (mg l-1) | - | - | - | |
| Sediment dwelling organisms - Toxicité chronique 28 jour NOEC, statique, eau (mg l-1) | 105 | A4 Chironomus riparius | Faible | |
| Sediment dwelling organisms - Toxicité chronique 28 jour NOEC, sédiment (mg kg-1) | - | - | - | |
| Plantes aquatiques - Toxicité aiguë 7 jour EC50, biomasse (mg l-1) | 0.0127 | A5 Lemna gibba | Modéré | |
| Algues - Toxicité aiguë 72 heure EC50, croissance (mg l-1) | 3.2 | V2 Raphidocelis subcapitata | Modéré | |
| Algues - Toxicité chronique 96 heure NOEC, croissance (mg l-1) | - | - | - | |
| Abeilles - Toxicité aiguë 48 heure LD50 (µg abeille-1) | > 141 | A5 Oral | Faible | |
| Lombrics - Toxicité aiguë 14 jour LC50 (mg kg-1) | > 957 | A5 Eisenia foetida | Modéré | |
| Lombrics - Toxicité chronique 14 jour NOEC, reproduction (mg kg-1) | - | - | - | |
| Other soil macro-organisms - e.g. Collembola | LR50product ha EC50product ha NOECproduct ha % Causalité |
- | - | - |
| Autre arthropode (1) | LR50 g ha-1 | - | - | - |
| % Causalité | 23.3 | Reduction in Beneficial capacity A5 Typhlodromus pyri |
Inoffensif | |
| Autre arthropode (2) | LR50 g ha-1 | - | - | - |
| % Causalité | 33.1 | Reduction in beneficial effect A5 Aphidius rhopalosiphi |
Moderately harmful | |
| Soil micro-organisms | Nitrogen mineralisation: No significant effect Carbon mineralisation: No significant effect |
A5 Dose: 5x field rate |
- | |
| Mesocosm study data | NOEAEC mg l-1 | - | - | - |
| NOEAEC mg l-1 | - | - | - | |
General:
| Propriété |
Valeur | Origine/Qualité de la donnée/informations complémentaires |
Interprétation |
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| Mammifères - Toxicité aiguë par voie orale LD50 (mg kg-1) | 2635 | A5 Rat | Faible | |
| Mammals - Dermal LD50 (mg kg-1 body weight) | > 2000 | A5 Rat | - | |
| Mammals - Inhalation LC50 (mg l-1) | 4.48 | A5 Rat | - | |
| Other Mammal toxicity endpoints | - | - | ||
| DJA - Dose journalière admissible (mg kg-1 de poids corporel jours-1) | 0.01 | A3 Rat, SF=100 | - | |
| ARfD - Acute Reference Dose (mg kg-1 de poids corporel jours-1) | Aucun assigné | A5 | - | |
| NEAO- Niveau d'exposition Acceptable pour l'Opérateur (mg kg-1 de poids corporel jours-1) | 0.072 | A3 Rat, SF=100 | - | |
| Dermique études (%) | - | - | - | |
| Directive 76/464 relative aux substances dangereuses | - | - | - | |
| Limites d'exposition | - | - | - | |
| Exposure Routes | Public | [Risks acceptable for proposed uses] | ||
| Occupational | [Risks acceptable for proposed uses] | |||
| Examples of European MRLs (mg kg-1) | Valeur | - | ||
| Remarque | For the EU pesticides database click here | |||
| Drinking Water MAC (µg l-1) | 0.03 | A5 | - | |
Health issues:
| Carcinogen | Mutagène | Endocrine disrupter | Reproduction / development effects | Acetyl cholinesterase inhibitor | Neurotoxicant | Respiratory tract irritant | Skin irritant | Eye irritant |
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| Risque suspecté pour la santé humaine | [Possible liver toxicant] | |||||||
: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data
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| Propriété |
Valeur | Origine/Qualité de la donnée/informations complémentaires |
Interprétation |
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| General |
[Not explosive] | ||||||
| Classement toxicologique selon l'UE |
[Xi - Irritant: R43], [N - Dangerous for the environment: R51/53] | ||||||
| Précautions selon l'UE |
- | ||||||
| Classement toxicologique selon l'OMS | III | - | Légèrement dangereux | ||||
| US EPA Classification (formulation) | No consensus across products or no products available | - | - | ||||
| Nombre des NU | - | ||||||
| Waste disposal & packaging |
- | ||||||
| Langue | Nom |
| Anglais | bispyribac-sodium |
| Français | bispyribac sodium |
| Allemand | Bispyribac-Natrium |
| Danois | bispyribac-natrium |
| Italien | bispyribac-sodium |
| Espagnol | bispiribac-sodio |
| Grec | - |
| Slovène | bispiribak-natrij |
| Polonais | bispirybak sodowy |
| Suédois | - |
| Hongrois | - |
| Hollandais | - |
| Record dernière mise à jour: Friday 26 October 2012 Contact: aeru@herts.ac.uk |
