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profoxydim (Ref: BAS 625H)
** clefoxydim ** clefoxidim ** Translations

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SUMMARY

Profoxydim is an EU approved, post-emergence rice herbicide. It has a low aqueous solubility, is volatile and does not present a risk of leaching to groundwater. It is non-persistent in soil but can be persistent in water. It has a low mammalian toxicity and the risk of bioaccumulation is low. No other serious human health risks have been identified. It shows a low to moderate toxicity to birds, aquatic organisms, honeybees and earthworms.

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for profoxydim

Description: Used for the post-emergence control of grass weeds in rice

Example pests controlled: Barnyard grass; Silvertop grass; Giant reed (Arundo donax); Crab grass; Yellow bristlegrass

Example applications: Rice

Efficacy & activity: -

Availability status: Current

Introduction & key dates: 1998

EC Regulation 1107/2009 (repealing 91/414):
Status Approved
Dossier rapporteur/co-rapporteur Spain/Greece
Date inclusion expires 31/07/2021
EU Candidate for substitution (CfS) Yes - endocrine disrupting properties
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism A chiral molecule existing in both the E- and Z-forms
Chemical formula C24H32ClNO4S
Canonical SMILES CCCC(=C1C(=O)CC(CC1=O)C2CCCSC2)NOCC(C)OC3=CC=C(C=C3)Cl
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) NZYQPWCHQXECMD-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C24H32ClNO4S/c1-3-5-21(26-29-14-16(2)30-20-9-7-19(25)8-10-20)24-22(27)12-18(13-23(24)28)17-6-4-11-31-15-17/h7-10,16-18,26H,3-6,11-15H2,1-2H3
2D structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Herbicide
Substance group Cyclohexadione
Minimum active substance purity >940 g/kg
Known relevant impurities -
Substance origin Synthetic
Mode of action Selective in rice, inhibiting weed growth, ACCase inhibitor.
CAS RN 139001-49-3
EC number -
CIPAC number 621
US EPA chemical code 121007
PubChem CID 197395
Molecular mass (g mol-1) 466.03
PIN (Preferred Identification Name) (5E)-2-{(1E)-N-[(2E)-2-(4-chlorophenoxy)propoxy]butanimidoyl}-3-hydroxy-5-[(3?)-thian-3-yl]cyclohex-2-en-1-one
IUPAC name (5RS)-2-{(EZ)-1-[(2RS)-2-(4-chlorophenoxy)propoxyimino]butyl}-3-hydroxy-5-[(3RS)-thian-3-yl]cyclohex-2-en-1-one
CAS name 2-[1-[[2-(4-chlorophenoxy)propoxy]imino]butyl]-3-hydroxy-5-(tetrahydro-2H-thiopyran-3-yl)-2-cyclohexen-1-one
Other status information -
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) A
Herbicide Resistance Classification (WSSA) 1
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance Leptochloa chinensis
Physical state Colourless liquid
Related substances & organisms -

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • BASF
Example products using this active
  • Aura
UK LERAP status No UK approval for use as a pesticide under EC Regulation 1107/2009
Formulation and application details -


ENVIRONMENTAL FATE

for profoxydim

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 27.8 A5 Low
Solubility - In organic solvents at 20oC (mg l-1) 1900000 A5 - Acetone -
1700000 A5 - Ethyl acetate -
480000 A5 - Methanol -
1300000 A5 - Toluene -
Melting point (oC) - - -
Boiling point (oC) Decomposes before boiling A5 -
Degradation point (oC) 150 A5 -
Flashpoint (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 7.94 X 1003 Calculated -
Log P 3.9 L3 High
Bulk density (g ml-1)/Specific gravity 1.198 A5 -
Dissociation constant (pKa) at 25oC 5.91 A5 -
Note: Weak acid
Vapour pressure at 20oC (mPa) 0.17 A5 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 0.0176 A5 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 0.47 Calculated Low leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 7.25 X 10-03 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Medium
Maximum UV-vis absorption L mol-1 cm-1 ax @ 300nm - -
Surface tension (mN m-1) - - -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 8 A5 Non-persistent
DT50 (lab at 20oC) 8 A5 Non-persistent
DT50 (field) - - -
DT90 (lab at 20oC) 21.5 A5 -
DT90 (field) - - -
DT50 modelling endpoint - - -
Note EU dosiser Lab DT50 range 3-13 days, DT90 2-41days
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value - - -
Note -
Aqueous photolysis DT50 (days) at pH 7 Value - - -
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value 140 L3 Persistent
Note -
Water-sediment DT50 (days) 53 A5 Moderately fast
Water phase only DT50 (days) 16 A5 Slow

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - - -
Koc -
Notes and range -
Freundlich Kf 11.49 A5 Slightly mobile
Kfoc 3032
1/n 1.01
Notes and range EU dossier Kf range 2.04-20.94 mL/g; Kfoc range 81-5983 mL/g, 1/n range 0.92-1.1, soils-6
pH sensitivity Yes, higher Koc values for lower pH values.

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
(Ref: BH 625-1)
Note: DT50 soil= 185-374 days; Koc= 24-1749 mL/g
- Soil 0.731 -
(Ref: BH 625-10)
Note: DT50 soil= 239-318 days; Koc= 89-6585 mL/g
- Soil 0.155 -


ECOTOXICOLOGY

for profoxydim

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 50 A5 Low potential
CT50 (days) 1.85 -
Mammals - Acute oral LD50 (mg kg-1) > 5000 A5 Rat Low
Mammals - Short term dietary NOEL (mg kg-1) 5 L3 Rat High
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) > 2000 A5 Colinus virginianus Low
Birds - Short term dietary (LC50/LD50) - - -
Fish - Acute 96 hour LC50 (mg l-1) 15 A5 Oncorhynchus mykiss Moderate
Fish - Chronic 21 day NOEC (mg l-1) 3.13 A5 Oncorhynchus mykiss 28d Moderate
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 18.1 L3 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 10.9 E3 Daphnia magna Low
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) > 29.4 A5 Lemna gibba Low
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) 33 L3 Anabaena flos-aquae Low
Algae - Chronic 96 hour NOEC, growth (mg l-1) 18.1 E3 Unknown species Low
Honeybees Contact acute 48 hour LD50 (μg bee-1) > 200 A5 Low
Oral acute 48 hour LD50 (μg bee-1) > 200 A5 Low
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) > 1000 A5 Eisenia foetida Low
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect 70.53 Mortality
A5 Aphidius rhopalosiphi
-
Other arthropod (2) LR50 g ha-1 - - -
% Effect 50.6 Mortality
A5 Typhlodromus pyri
-
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: 5x field rate
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for profoxydim

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) > 5000 A5 Rat Low
Mammals - Dermal LD50 (mg kg-1 body weight) > 4000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) > 5.2 A5 Rat -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.005 A5 Rat, SF=1000 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) 0.05 A5 Rat, SF=100 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.025 A5 Dog, SF=100 -
Dermal penetration studies (%) 1.5 A5 -
Dangerous Substances Directive 76/464 - - -
Exposure Limits - - -
Exposure Routes Public -
Occupational -
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

General human health issues Liver toxicant

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive or oxidising
CLP classification 2013 Health: H317, H351, H361d
EC Risk Classification Click here to view information omn the EU risk phrases Carcinogen category 3: R40
Reproduction risk category 3: R63
Xn - Harmful: R43
EC Safety Classification Click here to view information omn the EU safety phrases S2, S36/37, S46
WHO Classification NL - Not listed
US EPA Classification (formulation) No consensus across products or no products avalable - -
UN Number -
Waste disposal & packaging Click here for a description of UN packaging marks -


TRANSLATIONS

for profoxydim

Language Name
English profoxydim
French -
German -
Danish -
Italian -
Spanish -
Greek -
Slovenian profoksidim
Polish profoksydim
Swedish -
Hungarian -
Dutch -

Record last updated: Wednesday 30 May 2018
Contact: aeru@herts.ac.uk
© University of Hertfordshire