isoprocarb (Ref: OMS 32) ** MIPC ** ENT 25670 ** Translations

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GENERAL INFORMATION
for isoprocarb

Description: Used to control a variety of sucking and chewing insects including on rice, vegetables and other crops

Example pests controlled: Leaf hoppers; Aphids; Capsids; Plant hoppers

Example applications: Rice; Cocoa; Sugarcane; Vegetables; Cotton

Efficacy & activity: -

Availability status: Unknown

Introduction & key dates: 1967, Japan

EC Regulation 1107/2009 (repealing 91/414):

Status	Not approved
Dossier rapporteur/co-rapporteur	Not applicable
Date inclusion expires	Not applicable
EU Candidate for substitution (CfS)	Not applicable
Listed in EU database	Yes

Approved for use () or known to be used () in the following European countries:

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Chemical structure:

Isomerism	-
Chemical formula	C11H15NO2
Canonical SMILES	CC(C)C1=CC=CC=C1OC(=O)NC
Isomeric SMILES	No data
International Chemical Identifier key (InChIKey)	QBSJMKIUCUGGNG-UHFFFAOYSA-N
International Chemical Identifier (InChI)	InChI=1S/C11H15NO2/c1-8(2)9-6-4-5-7-10(9)14-11(13)12-3/h4-8H,1-3H3,(H,12,13)
2D structure diagram/image available?	Yes

General status:

Pesticide type	Insecticide
Substance group	Carbamate
Minimum active substance purity	-
Known relevant impurities	-
Substance origin	Synthetic
Mode of action	Contact and stomach action. Acetylcholinesterase (AChE) inhibitor.
CAS RN	2631-40-5
EC number	220-114-6
CIPAC number	392
US EPA chemical code	512300
PubChem CID	17517
Molecular mass (g mol-1)	193.24
PIN (Preferred Identification Name)	2-(propan-2-yl)phenyl methylcarbamate
IUPAC name	o-cumenyl methylcarbamate
CAS name	2-(1-methylethyl)phenyl methylcarbamate
Other status information	Marine Pollutant
Relevant Environmental Water Quality Standards	-
Herbicide Resistance Classification (HRAC)	Not applicable
Herbicide Resistance Classification (WSSA)	Not applicable
Insecticide Resistance Classification (IRAC)	1A
Fungicide Resistance Classification (FRAC)	Not applicable
Examples of recorded resistance	Nilaparvata lugens Plutella xylostella
Physical state	Colourless crystals
Related substances & organisms	-

Formulations:

Property	Value
Example manufacturers & suppliers of products using this active now or historically	-
Example products using this active	-
UK LERAP status	No UK approval for use as a pesticide under EC Regulation 1107/2009
Formulation and application details	-

ENVIRONMENTAL FATE
for isoprocarb

Property		Value	Source/Quality Score/Other Information	Interpretation
Solubility - In water at 20oC (mg l-1)		270	L3	Moderate
Solubility - In organic solvents at 20oC (mg l-1)		1500	L3 - n-Hexane	-
		65000	L3 - Toluene	-
		290000	L3 - Acetone	-
		180000	L3 - Ethyl acetate	-
Melting point (oC)		92.2	L3	-
Boiling point (oC)		-	-	-
Degradation point (oC)		-	-	-
Flashpoint (oC)		-	-	-
Octanol-water partition coefficient at pH 7, 20oC	P	2.09 X 1002	Calculated	-
	Log P	2.32	L3	Low
Bulk density (g ml-1)/Specific gravity		1.04	Q2	-
Dissociation constant (pKa) at 25oC		-	-	-
		Note:
Vapour pressure at 20oC (mPa)		2.8	L3	Low volatility
Henry's law constant at 25oC (Pa m3 mol-1)		0.002	L3	Non-volatile
GUS leaching potential index		-	-	-
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate	Value	-	-	-
	Note	-
Potential for particle bound transport index		-	-	-
Maximum UV-vis absorption L mol-1 cm-1		-	-	-
Surface tension (mN m-1)		-	-	-

Degradation:

Property		Value	Source/Quality Score/Other Information	Interpretation
General biodegradability		-
Soil degradation (days) (aerobic)	DT50 (typical)	11.5	L3	Non-persistent
	DT50 (lab at 20oC)	-	-	-
	DT50 (field)	-	-	-
	DT90 (lab at 20oC)	-	-	-
	DT90 (field)	-	-	-
	DT50 modelling endpoint	-	-	-
	Note	General literature gives DT50 3-20 days for paddy fields
Dissipation rate RL50 on plant matrix	Value	-	-	-
	Note	-
Dissipation rate RL50 on and in plant matrix	Value	0.9	R4	-
	Note	Published literature RL50 range 0.7-1.1 days, perilla leaves grown undercover & field, n=2
Aqueous photolysis DT50 (days) at pH 7	Value	-	-	-
	Note	-
Aqueous hydrolysis DT50 (days) at 20oC and pH 7	Value	-	-	-
	Note	-
Water-sediment DT50 (days)		-	-	-
Water phase only DT50 (days)		-	-	-

Soil adsorption and mobility:

Property		Value	Source/Quality Score/Other Information	Interpretation
Linear	Kd	-	Q2	-
	Koc	-
	Notes and range	Low mobility
Freundlich	Kf	-	-	-
	Kfoc	-
	1/n	-
	Notes and range	-
pH sensitivity		-

ECOTOXICOLOGY
for isoprocarb

Property		Value	Source/Quality Score/Other Information	Interpretation
Bio-concentration factor	BCF (l kg-1)	Low risk	Q3 Based on LogP < 3	Low potential
	CT50 (days)	-		-
Mammals - Acute oral LD50 (mg kg-1)		403	F4 Rat	Moderate
Mammals - Short term dietary NOEL	(mg kg-1)	-	L3 Rat	-
	(ppm diet)	> 300		-
Birds - Acute LD50 (mg kg-1)		-	-	-
Birds - Short term dietary (LC50/LD50)		-	-	-
Fish - Acute 96 hour LC50 (mg l-1)		22.0	L3 Cyprinus carpio	Moderate
Fish - Chronic 21 day NOEC (mg l-1)		-	-	-
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1)		0.024	L3 Daphnia magna	High
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1)		-	-	-
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1)		-	-	-
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1)		-	-	-
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1)		-	-	-
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1)		-	-	-
Aquatic plants - Acute 7 day EC50, biomass (mg l-1)		-	-	-
Non-target plants		-	-	-
		-	-	-
Algae - Acute 72 hour EC50, growth (mg l-1)		21.0	L3 Pseudokirchneriella subcapitata	Low
Algae - Chronic 96 hour NOEC, growth (mg l-1)		-	-	-
Honeybees (Apis spp.)	Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1)	> 2.0	Q2	Moderate
	Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1)	-	-	-
	Unknown mode acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1)	-	-	-
Bumblebees (Bombus spp.)	Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1)	-	-	-
		-
	Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1)	-	-	-
		-
Mason bees (Osmia spp.)	Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1)	-	-	-
	Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1)	-	-	-
Other pollinators (1)	Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1)	-	-	-
	Mode of exposure	-
Other pollinators (2)	Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1)	-	-	-
	Mode of exposure	-
Earthworms - Acute 14 day LC50 (mg kg-1)		> 2.82	R4 Eisenia foetida	High
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1)		-	-	-
Other soil macro-organisms - e.g. Collembola	LR50 / EC50 / NOEC / % Effect	-	-	-
Other arthropod (1)	LR50 g ha-1	-	-	-
	% Effect	-	-	-
Other arthropod (2)	LR50 g ha-1	-	-	-
	% Effect	-	-	-
Soil micro-organisms		-	-	-
Mesocosm study data	NOEAEC mg l-1	-	-	-
	NOEAEC mg l-1	-	-	-

HUMAN HEALTH AND PROTECTION
for isoprocarb

General:

Property		Value	Source/Quality Score/Other Information	Interpretation
Threshold of Toxicological Concern (Cramer Class)		Low (class I)	-	-
Mammals - Acute oral LD50 (mg kg-1)		403	F4 Rat	Moderate
Mammals - Dermal LD50 (mg kg-1 body weight)		> 2000	L3 Rat	-
Mammals - Inhalation LC50 (mg l-1)		2.09	L3 Rat (aerosol)	-
Other Mammal toxicity endpoints		-		-
ADI - Acceptable Daily Intake (mg kg-1bw day-1)		-	-	-
ARfD - Acute Reference Dose (mg kg-1bw day-1)		-	-	-
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1)		-	-	-
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1)		-	-	-
Dermal penetration studies (%)		-	-	-
Dangerous Substances Directive 76/464		-	-	-
Exposure Routes	Public	-
	Occupational	-
European MRLs		Click here for the EU MRL pesticide database
Drinking Water Standards		-	-	-
Drinking Water MAC (μg l-1)		-	-	-

Health issues:

Carcinogen	Genotoxic	Endocrine disrupter	Reproduction / development effects	Cholinesterase inhibitor	Neurotoxicant
	A0; B0; C0; D0; E0	-	-
Respiratory tract irritant	Skin irritant	Skin sensitiser	Eye irritant	Phototoxicant
-		-		-
General human health issues		Harmful if swallowed
Key: Genotoxicity A: Chromosome aberration (EFSA database) B: DNA damage/repair (EFSA database) C: Gene mutation (EFSA database) D: Genome mutation (EFSA database) E: Unspecified genotoxicity type (miscellaneous data source) 0: No data 1: Positive 2: Mixed/ambiguous results 3: Negative			Key: Other : Yes, known to cause a problem : No, known not to cause a problem : Possibly, status not identified - : No data found

Handling issues:

Property		Value	Source/Quality Score/Other Information	Interpretation
General		No information available
CLP classification 2013		Health: H302 Environment: H400, H410
EC Risk Classification		Xn - Harmful: R22 N - Dangerous for the environment: R50, R53
EC Safety Classification		S2, S60, S61
WHO Classification		II	-	Moderately hazardous
UN Number		2757
Waste disposal & packaging		-

TRANSLATIONS
for isoprocarb

Language	Name
English	isoprocarb
French	isoprocarbe
German	Isoprocarb
Danish	-
Italian	-
Spanish	isoprocarb
Greek	-
Slovenian	-
Polish	izoprokarb
Swedish	-
Hungarian	-
Dutch	-

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Record last updated: Friday 25 May 2018
Contact: aeru@herts.ac.uk
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