INTERNATIONAL UNION
   OF PURE AND APPLIED
   CHEMISTRY
contact
endrin
** nendrin ** OMS 197 ** aldrin epoxide ** Experimental Insecticide 269 ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

SUMMARY

Endrin is an obsolete, multi-use organochlorine insecticide that is not approved for use in the EU. It has a low aqueous solubility and is non-volatile. Based on its chemical properties it is not expected to leach to groundwater. Endrin tends to be persistent in soil systems. It is highly toxic to mammals and is a neurotoxin. It is also highly toxic to birds, honeybees and most aquatic organisms but slightly less so to earthworms.

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for endrin

Description: A multi-use but now obsolete pesticide used to control insects, rodents, and birds.

Example pests controlled: Aphids; Lygus bugs; Grasshoppers; Small mammals including mice, voles;

Example applications: Field crops; Cotton; Grains; Rice; Sugarcane

Availability status: Obsolete, Banned

Introduction & key dates: -

EC Regulation 1107/2009 (repealing 91/414):
Status Not approved
Dossier rapporteur/co-rapporteur -
Date inclusion expires Expired

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Insecticide, Avicide, Rodenticide
Substance group Organochlorine
Minimum active substance purity -
Known relevant impurities -
Substance origin Synthetic
Mode of action Broad-spectrum, with contact and stomach action. Is a chloride channel-blocking agent.
CAS RN 72-20-8
EC number 200-775-7
CIPAC number 28
US EPA chemical code 041601
Chiral molecule No
Chemical formula C12H8Cl6O
SMILES Cl\C1=C(/Cl)C2(Cl)C3C4CC(C3C1(Cl)C2(Cl)Cl)C5OC45
International Chemical Identifier key (InChIKey) DFBKLUNHFCTMDC-GKRDHZSOSA-N
International Chemical Identifier (InChI) InChI=1S/C12H8Cl6O/c13-8-9(14)11(16)5-3-1-2(6-7(3)19-6)4(5)10(8,15)12(11,17)18/h2-7H,1H2/t2-,3-,4?,5?,6?,7?,10-,11-/m0/s1
Structure diagram/image available? Yes
Molecular mass (g mol-1) 380.91
PIN (Preferred Identification Name) (1aR,2R,2aR,3R,6S,6aS,7S,7aS)-3,4,5,6,9,9-hexachloro-1a,2,2a,3,6,6a,7,7a-octahydro-2,7:3,6-dimethanonaphth[2,3-b]oxirene
IUPAC name 1,2,3,4,10,10-hexachloro-6,7-epoxy-1,4,4a,5,6,7,8,8a-octahydro-exo-1,4-exo-5,8-dimethanonaphthalene
CAS name (1aR,2R,2aR,3R,6S,6aS,7S,7aS)-rel-3,4,5,6,9,9-hexachloro-1a,2,2a,3,6,6a,7,7a-octahydro-2,7:3,6-dimethanonaphth(2,3-b)oxirene
Other status information POP; LRTAP Annex I; PAN Dirty Dozen; OSPAR soc; Severe Marine Pollutant
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) Not known
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance Many recorded cases
Aphis gossypii
Culex pipiens pipiens
Empoasca biguttula
Leptocorisa oratorius
Spodoptera littoralis
many others
Physical state White crystals
Related substances & organisms -

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • Shell Chemical Company
  • Velsicol
Example products using this active
  • Endrex
  • Mendrin
  • Nendrin
  • Hexadrin
UK LERAP status No UK approval for use or outside scope
Formulation and application details Available in a variety of formulations including wettable powders and emulsifiable concentrates.


ENVIRONMENTAL FATE

for endrin

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 0.24 H4 Low
Solubility - In organic solvents at 20oC (mg l-1) - - -
Melting point (oC) 200 V3 -
Boiling point (oC) - - -
Degradation point (oC) - - -
Flashpoint (oC) - - -
Octanol-water partition coefficient at pH 7, 20oC P 1.58 X 1003 Calculated -
Log P 3.2 H4 High
Bulk density (g ml-1)/Specific gravity 1.84 Q2 -
Dissociation constant (pKa) at 25oC - - -
Note:
Vapour pressure at 25oC (mPa) 2.0 X 10-07 F4 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 1.48 X 10-01 H4 Moderately volatile
Henry's law constant at 20oC (dimensionless) 3.08 X 10-04 Q2 Volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 0.00 Calculated Low leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 5.35 X 10-03 Calculated -
Note Estimated concentrations of chemicals with Koc values greater than 9995 ml g-1 are beyond the scope of the regression data used in SCI-GROW development. If there are concerns for such chemicals, a higher tier groundwater exposure assessment should be considered, regardless of the concentration returned by SCI-GROW
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated High
Maximum UV-vis absorption L mol-1 cm-1 - - -
Surface tension (mN m-1) - - -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
Soil degradation (days) (aerobic) DT50 (typical) 4300 M4 Very persistent
DT50 (lab at 20oC) - - -
DT50 (field) - - -
DT90 (lab at 20oC) - - -
DT90 (field) - - -
Note Other sources: DT50 up to 12 years (R3); FAO state DT50 4-14 days
Plant matrix DT50 (days) Value 3.8 R4 -
Note DT50 range 1.0 - 7.0 days, 3 crops/plants, leaf matrix
Aqueous photolysis DT50 (days) at pH 7 Value - - -
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value - - -
Note -
Water-sediment DT50 (days) - - -
Water phase only DT50 (days) - - -

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - H3 Non-mobile
Koc 10000
Notes and range Other sources: 31623 mL/g (R3)
Freundlich Kf - - -
Kfoc -
1/n -
Notes and range -
pH sensitivity -

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
endrin aldehyde
Note: Persistent
- Soil - -


ECOTOXICOLOGY

for endrin

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 3970 R3 (whole body, Literature values log BCF range 2.2-3.4 (R3)) Threshold for concern
CT50 (days) Not available -
Mammals - Acute oral LD50 (mg kg-1) > 7.5 R3 Rat High
Mammals - Short term dietary NOEL (mg kg-1) - - -
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) 5.6 R3 Anas platyrhynchos High
Birds - Short term dietary (LC50/LD50) - - -
Fish - Acute 96 hour LC50 (mg l-1) 0.00073 F4 Oncorhynchus mykiss High
Fish - Chronic 21 day NOEC (mg l-1) - - -
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 0.0042 F4 Daphnia magna High
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) - - -
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) - - -
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) - - -
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees Contact acute 48 hour LD50 (μg bee-1) > 0.46 F4 High
Oral acute 48 hour LD50 (μg bee-1) - - -
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) > 66 F4 Lumbricus terrestris Moderate
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect - - -
Other arthropod (2) LR50 g ha-1 - - -
% Effect - - -
Soil micro-organisms - - -
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for endrin

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) > 7.5 R3 Rat High
Mammals - Dermal LD50 (mg kg-1 body weight) 5.0 R3 Rat -
Mammals - Inhalation LC50 (mg l-1) - - -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.0002 A5 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) - - -
Dermal penetration studies (%) - - -
Dangerous Substances Directive 76/464 List I; List II - -
Exposure Limits [LT TWA 8hr: 380 mg/m3] Occupation Exposure -
Exposure Routes Public -
Occupational -
European MRLs Click here for the EU MRL pesticide database
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

General human health issues Highly toxic
Endocrine issues - Competitive binding to androgen receptors

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes No information available
CLP classification 2013 Health: H300, H311
Environment: H400, H410
EC Risk Classification Click here to view information omn the EU risk phrases T+ - Very toxic: R28
T - Toxic: R24
N - Dangerous for the environment: R50, R53
EC Safety Classification Click here to view information omn the EU safety phrases S1/2, S22, S36/37, S45, S60, S61
WHO Classification O - Obsolete substance
US EPA Classification (formulation) I - Danger - Highly toxic
UN Number 2761
Waste disposal & packaging Click here for a description of UN packaging marks -


TRANSLATIONS

for endrin

Language Name
English endrin
French endrine
German Endrin
Danish endrin
Italian endrin
Spanish endrin
Greek endrin
Slovenian endrin
Polish endryna
Swedish -
Hungarian -
Dutch endrine

Record last updated: Thursday 20 April 2017
Contact: aeru@herts.ac.uk
© University of Hertfordshire