Inpyrfluxam (Ref: S-2399)

Inpyrfluxam (Ref: S-2399)	Last updated: 09/01/2025
(Also known as: inpyrfluxame)

SUMMARY

Data alerts

The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.

Environmental fate	Ecotoxicity	Human health
Environmental fate High alert: Persistent	Ecotoxicity High alert: Fish acute ecotoxicity: High	Human health Moderate alert: Mammals acute toxicity: Moderate; Reproduction/development effects; Neurotoxicant

GENERAL INFORMATION

Description

A carboxiamide fungicide with high efficacy against a broad range of plant diseases

Example pests controlled

Blight; Rhizoctonia species, Rust; Net blotch; Black scurf; Puccinia spp.

Example applications

Cereals including wheat, triticale, rye, oats, barley; Soybean; Apple; Peanut; Rice; Sorghum; Sugar bee; Potatoes and many legume vegetables

Efficacy & activity

High efficacy against major plant diseases, especially rust, in Europe demonstrated

Availability status

Current

Introduction & key dates

2019, first introduced; 2020 first registered USA

GB regulatory status

GB COPR regulatory status

Pending

Date COPR inclusion expires

GB LERAP status

No UK approval for use as a pesticide - Buffer proposed

EC Regulation 1107/2009 (repealing 91/414)

EC Regulation 1107/2009 status

Pending

Dossier rapporteur/co-rapporteur

Netherlands/France

Date EC 1107/2009 inclusion expires

EU Candidate for substitution (CfS)

Listed in EU database

Yes

Approved for use (✓) under EC 1107/2009 in the following EU Member States

ATAustria	BEBelgium	BGBulgaria	CYCyprus	CZCzech Republic	DEGermany	DKDenmark	EEEstonia	ELGreece

ESSpain	FIFinland	FRFrance	HRCroatia	HUHungary	IEIreland	ITItaly	LTLithuania	LULuxembourg

LVLatvia	MTMalta	NLNetherlands	PLPoland	PTPortugal	RORomania	SESweden	SISlovenia	SKSlovakia

Approved for use (✓) under EC 1107/2009 by Mutual Recognition of Authorisation and/or national regulations in the following EEA countries

ISIceland	NONorway

Additional information

Also used in

USA, Japan

Chemical structure

Isomerism

None

Chemical formula

C₁₈H₂₁F₂N₃O

Canonical SMILES

CC1CC(C2=C1C(=CC=C2)NC(=O)C3=CN(N=C3C(F)F)C)(C)C

Isomeric SMILES

C[C@@H]1CC(C2=C1C(=CC=C2)NC(=O)C3=CN(N=C3C(F)F)C)(C)C

International Chemical Identifier key (InChIKey)

YTCIYOXHHQLDEI-SNVBAGLBSA-N

International Chemical Identifier (InChI)

InChI=1S/C18H21F2N3O/c1-10-8-18(2,3)12-6-5-7-13(14(10)12)21-17(24)11-9-23(4)22-15(11)16(19)20/h5-7,9-10,16H,8H2,1-4H3,(H,21,24)/t10-/m1/s1

2D structure diagram/image available?

Yes

General status

Pesticide type

Fungicide

Substance groups

Pyrazolecarboxamide fungicide; Pyrazole fungicide; Carboximide fungicide

Minimum active substance purity

940 g kg⁻¹

Known relevant impurities

GB HSE 2023: None declared

Substance origin

Synthetic

Mode of action

Succinate Dehydrogenase Inhibitor (SDHI) acting at complex II in the mitochondrial respiration chain and involving the inhibition of mitochondrial respiration.

CAS RN

1352994-67-2

EC number

875-886-2

CIPAC number

1005

US EPA chemical code

PubChem CID

70652048

CLP index number

No data found

Molecular mass

333.4

PIN (Preferred Identification Name)

3-(difluoromethyl)-1-methyl-N-[(3R)-1,1,3-trimethyl-2,3-dihydro-1H-inden-4-yl]-1H-pyrazole-4-carboxamide

IUPAC name

3-(difluoromethyl)-N-[(R)-2,3-dihydro-1,1,3-trimethyl-1H-inden-4-yl]-1-methyl-1H-pyrazole-4-carboxamide

CAS name

3-(difluoromethyl)-N-[(3R)-2,3-dihydro-1,1,3-trimethyl-1H-inden-4-yl]-1-methyl-1H-pyrazole-4-carboxamide

Other status information

Relevant Environmental Water Quality Standards

Herbicide Resistance Class (HRAC MoA class)

Not applicable

Herbicide Resistance Class (WSSA MoA class)

Not applicable

Insecticide Resistance Class (IRAC MoA class)

No applicable

Fungicide Resistance Class (FRAC MOA class)

Examples of recorded resistance

Physical state

Beige granular solid

Formulations

Property

Value

Example manufacturers & suppliers of products using this active now or historically

Sumitomo Chemicals

Example products using this active

Indiflin

Formulation and application details

Usually formulated as an emulsifiable concentrate and used as a foliar spray

ENVIRONMENTAL FATE

Property

Value

Source; quality score; and other information

Interpretation

Solubility - In water at 20 °C (mg l⁻¹)

1.64

Low

Solubility - In organic solvents at 20 °C (mg l⁻¹)

621000

Acetobe

353000

Dichloromethane

84600

n-Octanol

368000

Methanol

Melting point (°C)

104

Boiling point (°C)

Decomposes before boiling

Degradation point (°C)

Flashpoint (°C)

Octanol-water partition coefficient at pH 7, 20 °C

4.47 X 10⁰³

Calculated

Log P

3.65

High

Fat solubility of residues

Solubility

Insoluble

Data type

Regulatory data

Density (g ml⁻¹)

Dissociation constant pKa) at 25 °C

Vapour pressure at 20 °C (mPa)

3.8 X 10^-05

Low volatility

Henry's law constant at 25 °C (Pa m³ mol⁻¹)

7.74 X 10^-07

Non-volatile

Volatilisation as max % of applied dose lost

From plant surface

From soil surface

Maximum UV-vis absorption L mol⁻¹ cm⁻¹

Acidic soln: 242nm=10505, 290nm=1310
Neutral soln: 242nm=10404, 290nm=1330
Alkaline soln: 242nm=10600, 290nm=1330

Surface tension (mN m⁻¹)

60.4

at 21.3 °C 99.9%

Degradation

Property

Value

Source; quality score; and other information

Interpretation

General biodegradability

Not readily biodegradable

Soil degradation (days) (aerobic)

DT₅₀ (typical)

314

Persistent

DT₅₀ (lab at 20 °C)

314

Persistent

DT₅₀ (field)

127

Persistent

DT₉₀ (lab at 20 °C)

1378

Very persistent

DT₉₀ (field)

409

DT₅₀ modelling endpoint

Note

GB HSE 2023 dossier Lab studies: DT₅₀ (normalised) range 121-1720 days, DT₉₀ (measured) range 402-3600 days, Soils=4; Field studies DT₅₀ (normalised) range 41.6-421 days, Soils =8; DT₉₀ (measured) range 132-699 days, Soils-4

Dissipation rate RL₅₀ (days) on plant matrix

Value

Note

Dissipation rate RL₅₀ (days) on and in plant matrix

Value

Note

Aqueous photolysis DT₅₀ (days) at pH 7

Value

Stable

Note

Stable at all relevant pH values

Aqueous hydrolysis DT₅₀ (days) at 20 °C and pH 7

Value

Stable

Note

Stable at all relevant pH values

Water-sediment DT₅₀ (days)

372

Stable

Water phase only DT₅₀ (days)

Sediment phase only DT₅₀ (days)

Air degradation

As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below.

Decay in stored produce DT₅₀

Soil adsorption and mobility

Property

Value

Source; quality score; and other information

Interpretation

Linear

K_d (mL g⁻¹)

K_oc (mL g⁻¹)

Notes and range

Freundlich

K_f (mL g⁻¹)

11.88

Slightly mobile

K_foc (mL g⁻¹)

651

¹/_n

0.96

Notes and range

GB HSE 2023 dossier K_f range 1.59-19.02 mL g⁻¹, K_foc range 500-891 mL g⁻¹, ¹/_n range 0.932-0.995, Soils=7

pH sensitivity

None

Fate indices

Property

Value

Source; quality score; and other information

Interpretation

GUS leaching potential index

2.50

Calculated

Transition state

SCI-GROW groundwater index (μg l⁻¹) for a 1 kg ha⁻¹ or 1 l ha⁻¹ application rate

Value

1.64 X 10^-01

Calculated

Note

Potential for particle bound transport index

Medium

Calculated

Potential for loss via drain flow

Slightly mobile

Calculated

Photochemical oxidative DT₅₀ (hrs) as indicator of long-range air transport risk

2.8

Calculated using the Atkinson method

Below the level of concern for long-range air transport

Bio-concentration factor

BCF (l kg⁻¹)

Low potential

CT₅₀ (days)

0.33

Known soil metabolites

Metabolite

Major/Minor fraction

$Click here for further information on Major/Minor fraction$

Estimated maximum occurrence fraction

Notes

4-(3-(difluoromethyl)-1-methyl1H-pyrazole-4-carboxamido)-1,3-dimethyl2,3-dihydro-1H-indene-1-carboxylic acid

Major fraction

0.301

Sum of all isomers

3-(difluoromethyl)-N-(3-hydroxy-1,1,3-trimethyl-2,3-dihydro-1H-inden-4-yl)-1-methyl-1H-pyrazole-4-carboxamide

Major fraction

0.207

3-(difluoromethyl)-N-(1,1,3-trimethyl-2,3-dihydro-1H-inden-4-yl)-1H-pyrazole-4-carboxamide

Minor fraction

0.033

3-(difluoromethyl)-1-methyl1H-pyrazole-4-carboxylic acid

Minor fraction

0.0024

3-(difluoromethyl)-1Hpyrazole-4-carboxylic acid

Minor fraction

0.002

3-(difluoromethyl)-1-methyl1H-pyrazole-4-carboxamide

Minor fraction

0.0008

3-(difluoromethyl)-N-(1-(hydroxymethyl)-1,3-dimethyl-2,3-dihydro-1H-inden-4-yl)-1-methyl-1H-pyrazole-4-carboxamide

Minor fraction

0.0007

Sum of all isomers

Known groundwater metabolites

Metabolite

EC SANCO/221/2000 relevancy

ADI (mg kg⁻¹ bodyweight day⁻¹)

WHO drinking water guidance value (μg L⁻¹ day⁻¹)

3-(difluoromethyl)-N-(3-hydroxy-1,1,3-trimethyl-2,3-dihydro-1H-inden-4-yl)-1-methyl-1H-pyrazole-4-carboxamide

Not relevant

4-(3-(difluoromethyl)-1-methyl1H-pyrazole-4-carboxamido)-1,3-dimethyl2,3-dihydro-1H-indene-1-carboxylic acid

Not relevant

Other known metabolites

Metabolite name and reference

Aliases

Formation medium / Rate

Estimated maximum occurrence fraction

3-(difluoromethyl)-N-(1,1,3-trimethyl-2,3-dihydro-1H-inden-4-yl)-1H-pyrazole-4-carboxamide
Note: GB HSE 2023

N-des-Me-S-2840

Sediment; Rat; Plant; Hen

3-(difluoromethyl)-N-((1R,3S)-1-(hydroxymethyl)-1,3-dimethyl-2,3-dihydro-1H-inden-4-yl)-1-methyl-1H-pyrazole-4-carboxamide
Note: GB HSE 2023

1'-CH2OH-S-2840A

Rat; Plant; Hen

3-(difluoromethyl)-N-((1R,3R)-1-(hydroxymethyl)-1,3-dimethyl-2,3-dihydr-1H-inden-4-yl)-1-methyl-1H-pyrazole-4-carboxamide
Note: GB HSE 2023

1'-CH2OH-S-2840B

Rat; Plant; Hen; Animal

(R)-3-(difluoromethyl)-N-(7-hydroxy-1,1,3-trimethyl-2,3-dihydro-1H-inden-4-yl)-1-methyl-1H-pyrazole-4-carboxamide
Note: GB HSE 2023

7'-OH-S-2399

Rat

3-(difluoromethyl)-N-((1R,3R)-1-(hydroxymethyl)-1,3-dimethyl-2,3-dihydro-1H-inden-4-yl)-1H-pyrazole-4-carboxamide
Note: GB HSE 2023

N-des-Me-1'-CH2OH-S-2840B

Rat; Plant

glucuronide of N-[(1RS,3RS;1RS,3SR)-2,3-dihydro-1,3-dimethyl-1-(hydroxymethyl)-1H-inden4-yl)]-3-(difluoromethyl)-1H-pyrazole-4-carboxamide
Note: GB HSE 2023

glucuronide of N-des-Me-1'-CH2OH-S-2840

Rat

3-(difluoromethyl)-N-(3-hydroxy-1,1,3-trimethyl-2,3-dihydro-1H-inden-4-yl)-1-methyl-1H-pyrazole-4-carboxamide (Ref: 3911)
Note: GB HSE 2023

3’-OH-S-2840

Surface water; Sediment; Rat; Plant; Animal

N-[(1RS,3RS;1RS,3SR)-2,3-dihydro-1,3-dimethyl-3-hydroxy-1-(hydroxymethyl)-1H-inden-4-yl)]-1-methyl-3-(difluoromethyl)-1Hpyrazole-4-carboxamide
Note: GB HSE 2023

1'-CH2OH-3'-OH-S-2840

Rat

glucuronide of N-[(1RS,3RS;1RS,3SR)-2,3-dihydro-1,3-dimethyl-3-hydroxy-1-(hydroxymethyl)-1H-inden-4-yl)]-1-methyl-3-(difluoromethyl)-1Hpyrazole-4-carboxamide
Note: GB HSE 2023

glucuronide of 1'-CH2OH-3'-OH-S-2840

Rat

4-(3-(difluoromethyl)-1-methyl1H-pyrazole-4-carboxamido)-1,3-dimethyl2,3-dihydro-1H-indene-1-carboxylic acid (Ref: 3910)
Note: GB HSE 2023

1'-COOH-S-2840

Surface water; Sediment; Plant; Animal

N-(1,1-bis(hydroxymethyl)-3-methyl-2,3-dihydro-1Hinden-4-yl)-3-(difluoromethyl)-1-methyl1H-pyrazole-4-carboxamide
Note: GB HSE 2023

1',1'-bis(CH2OH)-S-2840

Rat; Animal

N-(1,1-bis(hydroxymethyl)-3-methyl-2,3-dihydro-1Hinden-4-yl)-3-(difluoromethyl)-1Hpyrazole-4-carboxamide
Note: GB HSE 2023

N-des-Me-1',1'-bis(CH2OH)-S2840

Rat

3-(difluoromethyl)-N-(3-hydroxy-1-(hydroxymethyl)-1,3-dimethyl-2,3-dihydro1H-inden-4-yl)-1H-pyrazole4-carboxamide
Note: GB HSE 2023

N-des-Me-1'-CH2OH-3'-OH-S2840

Rat

4-(3-(difluoromethyl)-1Hpyrazole-4-carboxamido)-1,3-dimethyl-2,3-dihydro1H-indene-1-carboxylic acid
Note: GB HSE 2023

N-des-Me-1'-COOH-S-2840

Rat

(R)-1,1,3-trimethyl-2,3-dihydro-1H-inden-4-amine
Note: GB HSE 2023

ATMI

Surface water; Sediment

3-(difluoromethyl)-1-methyl1H-pyrazole-4-carboxylic acid
Note: GB HSE 2023

DFPA

Surface water; Sediment; Plant

3-(difluoromethyl)-1Hpyrazole-4-carboxylic acid
Note: GB HSE 2023

N-des-Me-DFPA

Plant

3-(difluoromethyl)-1-methyl1H-pyrazole-4-carboxamide
Note: GB HSE 2023

DFPA-CONH2

Plant; Animal

(4-(3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamido)-1,3-dimethyl2,3-dihydro-1H-inden-1-yl)methyl hydrogen sulfate
Note: GB HSE 2023

1'-CH2OH-S-2840-sulfate

Hen

6-((4-(3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamido)-1,3-dimethyl2,3-dihydro-1H-inden-1-yl)methoxy)-3,4,5-trihydroxytetrahydro-2Hpyran-2-carboxylic acid
Note: GB HSE 2023

Glu-1'-CH2OH-S2840

Rat; Animal

ECOTOXICOLOGY

Terrestrial ecotoxicology

Property

Value

Source; quality score; and other information

Interpretation

Mammals - Acute oral LD₅₀ (mg kg⁻¹)

180

Rat

Moderate

Mammals - Short term dietary NOEL

(mg kg⁻¹)

(ppm diet)

Mammals - Chronic 21d NOAEL (mg kg⁻¹ bw d⁻¹)

Birds - Acute LD₅₀ (mg kg⁻¹)

> 2250

Colinus virginianus

Low

Birds - Short term dietary (LC₅₀/LD₅₀)

Birds - Chronic 21d NOEL (mg kg⁻¹ bw d⁻¹)

Earthworms - Acute 14 day LC₅₀ (mg kg⁻¹)

112.95

Eisenia foetida corr

Moderate

Earthworms - Chronic NOEC, reproduction (mg kg⁻¹)

6.25

Eisenia foetida

Moderate

Soil micro-organisms

Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect

Dose: 1.33 mg kg⁻¹ soil 28 days

Collembola

Acute LC₅₀ (mg kg⁻¹)

Chronic NOEC (mg kg⁻¹)

100

Folsomia candida

Non-target plants

>= 91

6 species
Vegetative vigour, ER₅₀
as g ha⁻¹

-
Emergence, ER₅₀
B5 6 species

Honeybees (Apis spp.)

Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

> 100

Apis mellifera

Low

Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

> 111.3

Apis mellifera

Low

Unknown mode acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Chronic

Notes

Bumblebees (Bombus spp.)

Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

> 100

Bombus spp.

Low

Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

> 95.1

Bombus spp.

Moderate

Mason bees (Osmia spp.)

Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Other bee species (1)

Acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg insect⁻¹)

Mode of exposure

Other bee species (2)

Acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg insect⁻¹)

Mode of exposure

Beneficial insects (Ladybirds)

Beneficial insects (Lacewings)

Beneficial insects (Parasitic wasps) Mortality, LR₅₀

49.1

Aphidius rhopalosiphi

Beneficial insects (Predatory mites) Mortality, LR₅₀

67.7

Typhlodromus pyri

Beneficial insects (Ground beetles)

Aquatic ecotoxicology

Property

Value

Source; quality score; and other information

Interpretation

Temperate Freshwater Fish - Acute 96 hour LC₅₀ (mg l⁻¹)

0.031

Oncorhynchus mykiss

High

Temperate Freshwater Fish - Chronic 21 day NOEC (mg l⁻¹)

Tropical Freshwater Fish - Acute 96 hour LC₅₀ (mg l⁻¹)

0.30

Danio rerio

Moderate

Temperate Freshwater Aquatic invertebrates - Acute 48 hour EC₅₀ (mg l⁻¹)

1.1

Daphnia magna

Moderate

Temperate Freshwater Aquatic invertebrates - Chronic 21 day NOEC (mg l⁻¹)

Tropical Freshwater Aquatic invertebrates - Acute 48 hour EC₅₀ (mg l⁻¹)

Aquatic crustaceans - Acute 96 hour LC₅₀ (mg l⁻¹)

Sediment dwelling organisms - Acute 96 hour LC₅₀ (mg l⁻¹)

Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l⁻¹)

Chironomus dilutus

Low

Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg⁻¹)

Aquatic plants - Acute 7 day EC₅₀, biomass (mg l⁻¹)

> 24.0

Lemna gibba

Low

Algae - Acute 72 hour EC₅₀, growth (mg l⁻¹)

6.4

Pseudokirchneriella subcapitata

Moderate

Algae - Chronic 96 hour NOEC, growth (mg l⁻¹)

Mesocosm study data

NOEAEC mg l⁻¹

Marine bivalves

HUMAN HEALTH AND PROTECTION

General

Property

Value

Source; quality score; and other information

Interpretation

Threshold of Toxicological Concern (Cramer Class)

High (class III)

Mammals - Acute oral LD₅₀ (mg kg⁻¹)

180

Rat

Moderate

Mammals - Dermal LD₅₀ (mg kg⁻¹ body weight)

2000

Rat

Mammals - Inhalation LC₅₀ (mg l⁻¹)

> 2.61

Rat

Other Mammal toxicity endpoints

ADI - Acceptable Daily Intake (mg kg⁻¹ bw day⁻¹)

0.06

Dog SF=100

ARfD - Acute Reference Dose (mg kg⁻¹ bw day⁻¹)

0.3

Rat SF=100

AAOEL - Acute Acceptable Operator Exposure Level (mg kg⁻¹ bw day⁻¹)

0.3

Rat SF=100

AOEL - Acceptable Operator Exposure Level - Systemic (mg kg⁻¹ bw day⁻¹)

0.06

Dog SF=100

Dermal penetration studies (%)

8.9-20.0

concentration dependant

Dangerous Substances Directive 76/464

Exposure Routes

Public

Minimal risk for proposed uses

Occupational

PPE/PPC recommended

MRLs

European

EU MRL pesticide database

Great Britain

GB MRL Register

Notes

Drinking Water Standards

Drinking Water MAC (μg l⁻¹)

Mammalian dose elimination route and rate

Rapid elimination ~69% in bile, ~27% urine within 3 days

Health issues

Specific human health issues

Carcinogen

Genotoxic

Endocrine disruptor

; ; ; ;

Reproduction / development effects

Acetyl cholinesterase inhibitor

Neurotoxicant

No data found

Respiratory tract irritant

Skin irritant

Skin sensitiser

No data found

Eye irritant

Phototoxicant

General human health issues

Possible liver and thyroid toxicant

Handling issues

Property

Value and interpretation

General

Not expected to autoignite; Not highly flammable
Not explosive or oxidising

CLP classification 2013

Health: H301

WHO Classification

Not listed (Not listed)

UN Number

Waste disposal & packaging

Shelf-life, storage, stability and reactivity

TRANSLATIONS

Language

Name

English

inpyrfluxam

French

German

Danish

Italian

Spanish

Greek

Polish

Swedish

Hungarian

Dutch

Norwegian

Record last updated:	09/01/2025
Contact:	aeru@herts.ac.uk
Please cite as:	Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242