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folpet
** folpel ** folpan ** phthaltan ** trichloromethylthiophthalimide ** Translations

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GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for folpet

Description: A protective fungicide used for broad spectrum control of fungal pathogens

Example pests controlled: Downy mildew; Powdery mildew; Leaf spot; Rose black spot; Apple scab; Rose mildew

Example applications: Fruits including apples, cherry, berries; Ornamentals including roses; Vegetables

Efficacy & activity: Wheat/Septoria=Low; Wheat/Rust=Low; Barley/Rhynchosporium=Low; Barley/Mildew=Low; Barley/Ramularia=Low

Availability status: Current

Introduction & key dates: 1952, first reported

EC Regulation 1107/2009 (repealing 91/414):
Status Approved
Dossier rapporteur/co-rapporteur Austria/Italy
Date inclusion expires 30/07/2019
EU Candidate for substitution (CfS) No
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: USA

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism -
Chemical formula C9H4Cl3NO2S
Canonical SMILES C1=CC=C2C(=C1)C(=O)N(C2=O)SC(Cl)(Cl)Cl
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) HKIOYBQGHSTUDB-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C9H4Cl3NO2S/c10-9(11,12)16-13-7(14)5-3-1-2-4-6(5)8(13)15/h1-4H
Structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Fungicide
Substance group Phthalimide
Minimum active substance purity 940 g/kg
Known relevant impurities -
Substance origin Synthetic
Mode of action Foliar applied with protective action. Acts by inhibiting normal cell division of many microorganisms. Multi-site activity.
CAS RN 133-07-3
EC number 205-088-6
CIPAC number 75
US EPA chemical code 081601
PubChem CID 8607
Molecular mass (g mol-1) 296.56
PIN (Preferred Identification Name) -
IUPAC name N-(trichloromethylthio)phthalimide
CAS name 2-((trichloromethyl)thio)-1H-isoindole-1,3(2H)-dione
Other status information -
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) M4
Examples of recorded resistance -
Physical state Colourless crystals
Related substances & organisms

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • Makhteshim Agan
  • AgroCare
  • India Pesticides Ltd.
  • Chevron
  • Stauffer
Example products using this active
  • Folpan 80 WG
  • Petal
  • Enofol
  • Faltex
  • Thiophal
  • Folpwel
UK LERAP status No UK approval for use as a pesticide under EC Regulation 1107/2009
Formulation and application details Often supplied as water dispersible granules or wettable powders.


ENVIRONMENTAL FATE

for folpet

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 0.8 A5 Low
Solubility - In organic solvents at 20oC (mg l-1) 34000 A5 - Acetone -
1400 A5 - n-Octanol -
3100 A5 - Methanol -
450 A5 - Heptane -
Melting point (oC) 178.5 A5 -
Boiling point (oC) Decomposes before boiling A5 -
Degradation point (oC) 184 A5 -
Flashpoint (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 1.05 X 1003 Calculated -
Log P 3.02 A5 High
Bulk density (g ml-1)/Specific gravity 1.72 A5 -
Dissociation constant (pKa) at 25oC Not applicable A5 -
Note: No dissociation
Vapour pressure at 20oC (mPa) 2.10 X 10-02 A5 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 8.00 X 10-03 A5 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 1.02 Calculated Low leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 3.53 X 10-03 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Low
Maximum UV-vis absorption L mol-1 cm-1 Neutral solution: 47100, 7900, 1780, 1720 at 223, 236, 295, 300nm; [Acidic solution: 52600, 8410, 1770, 1720 at 223, 237, 296, 301nm; [Basic solution: 19900, 11300, 7410, 1810, 1650, 1320 at 225, 238,247, 280, 289, 301nm A5 -
Surface tension (mN m-1) - - -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 4.7 A5 Non-persistent
DT50 (lab at 20oC) 4.7 A5 Non-persistent
DT50 (field) 3 A5 Non-persistent
DT90 (lab at 20oC) 5.4 A5 -
DT90 (field) - - -
DT50 modelling endpoint - - -
Note EU dossier lab studies DT50 range 0.2-4.3 days, DT90 range 0.7-12.8 days
Dissipation rate RL50 on plant matrix Value 10.7 R4 -
Note Published literature RL50 range 6.0-14.1 days, 2 field & undercover grown crops, various matrices, n=4
Dissipation rate RL50 on and in plant matrix Value - - -
Note -
Aqueous photolysis DT50 (days) at pH 7 Value Stable A5 -
Note Not a significant degradation route
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value 0.05 A5 Non-persistent
Note Rapid and pH sensitive: DT50 2.6 hours at pH 5, 1 minute at pH 9, all at 25 degC
Water-sediment DT50 (days) 0.02 A5 Fast
Water phase only DT50 (days) 0.02 A5 Fast

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - A3 Moderately mobile
Koc 304
Notes and range EU dossier worst case estimate; Other sources: 15.0 mL/g (DW3)
Freundlich Kf - - -
Kfoc -
1/n -
Notes and range -
pH sensitivity -

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
phthalimide This metabolite may cause environmental pollution, click here for further information Soil   0.649   Major fraction, Relevant
phthalic acid This metabolite may cause environmental pollution, click here for further information Soil   0.166   Major fraction, Not relevant
phthalamic acid This metabolite may cause environmental pollution, click here for further information Soil   0.167   Major fraction, Not relevant

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
trichlomethylsulfenic acid - Water/sediment (Hydrolysis) - -
tricloromethylmercaptan - Water/sediment (Hydrolysis) - -
thiophosgene - Soil; Water/sediment (Hydrolysis) - -
carbon oxysulfide - Water/sediment (Hydrolysis) - -
2-cyanobenzoic acid - Water 0.397 -
benzamide - Water 0.102 -


ECOTOXICOLOGY

for folpet

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 56 A5 Whole fish Low potential
CT50 (days) 0.6 -
Mammals - Acute oral LD50 (mg kg-1) > 2000 A5 Rat Low
Mammals - Short term dietary NOEL (mg kg-1) 44.5 A5 Rat High
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) > 2510 A5 Colinus virginianus Low
Birds - Short term dietary (LC50/LD50) > 1127 mg kg bw-1 day-1 A5 Colinus virginianus -
Fish - Acute 96 hour LC50 (mg l-1) 0.233 A5 Oncorhynchus mykiss Moderate
Fish - Chronic 21 day NOEC (mg l-1) - - -
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 0.68 A5 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 0.002 F3 Daphnia magna, LOEC High
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) 12.1 F3 Americamysis bahia Moderate
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) - - -
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) > 10 A5 Scenedemus subspicatus Low
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees Contact acute 48 hour LD50 (μg bee-1) > 200 A5 Low
Oral acute 48 hour LD50 (μg bee-1) > 236 A5 Low
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) > 500 A5 Eisenia foetida, corr Moderate
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) 5.18 A5 Eisenia foetida corr Moderate
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect 32.5
-75
Mortality
Parasitism
Dose: 2.0 kg ha-1
A5 Aphidius rhopalosiphi, adult
-
Other arthropod (2) LR50 g ha-1 - - -
% Effect 0
9.2
Mortality
Egg production
Dose: 5.25 kg ha-1
A5 Typhlodromus pyri
-
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: 15.93 kg ha-1
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for folpet

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) > 2000 A5 Rat Low
Mammals - Dermal LD50 (mg kg-1 body weight) > 2000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) 1.89 A5 Rat -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.1 A5 Dog, SF=100 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) 0.2 A5 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.1 A5 Rat, 90 day, SF=100 -
Dermal penetration studies (%) 10.0 A5 -
Dangerous Substances Directive 76/464 - - -
Exposure Limits - - -
Exposure Routes Public Negligible risk to bystanders
Occupational Potential risk to operators and other workers not utilising PPE/PPC
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) 0.1 EU Dir 89/778/EC limit; A5 -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

-

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

General human health issues USEPA - possible human carcinogen at high doses

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Prevent generation of dust
Not explosive
IMDG Transport Code is usually 9
CLP classification 2013 Health: H317, H319, H332, H351
Environment: H400
EC Risk Classification Click here to view information omn the EU risk phrases Carcinogen category 3: R40
Xn - Harmful: R20, R43
Xi - Irritant: R36
N - Dangerous for the environment: R50
EC Safety Classification Click here to view information omn the EU safety phrases S2, S36/37, S46, S61
WHO Classification U - Unlikely to present an acute hazard
US EPA Classification (formulation) IV - Caution - Not acutely toxic
UN Number Usually 3077
Waste disposal & packaging Click here for a description of UN packaging marks Packaging Group III (minor danger)


TRANSLATIONS

for folpet

Language Name
English folpet
French folpet
German Folpet
Danish folpet
Italian folpet
Spanish folpet
Greek folpet
Slovenian folpet
Polish folpet
Swedish folpet
Hungarian folpet
Dutch folpet

Record last updated: Thursday 23 August 2018
Contact: aeru@herts.ac.uk
© University of Hertfordshire