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isoproturon (Ref: HOE 16410)
** IPU ** ipuron ** CGA 18731 ** AE F016410 ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for isoproturon

Description: A herbicide for use, typically, in cereals to control annual grasses and many broad-leaved weeds

Example pests controlled: Annual grass weeds; Broad-leaved weeds

Example applications: Cereals including wheat, barley, rye; Rice-wheat cropping systems

Efficacy & activity: -

Availability status: Current

Introduction & key dates: 1971

EC Regulation 1107/2009 (repealing 91/414):
Status Not approved
Dossier rapporteur/co-rapporteur Germany
Date inclusion expires Expired
EU Candidate for substitution (CfS) -
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism None
Chemical formula C12H18N2O
Canonical SMILES CC(C)C1=CC=C(C=C1)NC(=O)N(C)C
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) PUIYMUZLKQOUOZ-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C12H18N2O/c1-9(2)10-5-7-11(8-6-10)13-12(15)14(3)4/h5-9H,1-4H3,(H,13,15)
Structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Herbicide
Substance group Urea
Minimum active substance purity 970 g/kg
Known relevant impurities EU dossier - None declared
Substance origin Synthetic
Mode of action Selective, systemic absorbed by roots and leaves. Inhibits photosynthesis (photosystem II).
CAS RN 34123-59-6
EC number 251-835-4
CIPAC number 336
US EPA chemical code -
PubChem CID 36679
Molecular mass (g mol-1) 206.28
PIN (Preferred Identification Name) -
IUPAC name 3-(4-isopropylphenyl)-1,1-dimethylurea
CAS name N,N-dimethyl-N'-(4-(1-methylethyl)phenyl)urea
Other status information WFD priority substance; restricted UK use; Potential groundwater contaminant
Relevant Environmental Water Quality Standards EU Directive 2008/105/EC EQS surface waters: annual average 0.3 ug/L; max measured 1.0 ug/L
UK Environment Agency non-statutory standard for the protection of aquatic life in fresh surface water and saltwater: 2 ug/L as annual average, 20 ug/L as max acceptable conc.
Non-statutory WHO drinking water guideline 0.009 mg/L
Herbicide Resistance Classification (HRAC) C2
Herbicide Resistance Classification (WSSA) 7
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance Alopecurus myosuroides
Phalaris minor
Physical state Colourless crystals
Related substances & organisms

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • AgriGuard
  • BASF
  • Bayer CropScience
  • DAPT
  • Makhteshim-Agan
  • Nufarm
  • Rotan CropScience
Example products using this active
  • Alpha IPU 500
  • Alpha Isoproturon
  • Ingot
  • Koala
  • Trump
  • Javelin
  • Javelin Gold
  • Protugan
  • Tolugan Extra
UK LERAP status Buffer probably required in UK - see product label
Formulation and application details Often supplied as a soluble concentrate that is mixed with water and used as a spray; New low dose formulations being considered for UK registration.


ENVIRONMENTAL FATE

for isoproturon

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 70.2 A5 Moderate
Solubility - In organic solvents at 20oC (mg l-1) 100 A5 - n-Heptane -
2000 A5 - Xylene -
30000 A5 - Acetone -
46000 A5 - 1,2-Dichloroethane -
Melting point (oC) 157.3 A5 -
Boiling point (oC) - - -
Degradation point (oC) - - -
Flashpoint (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 3.16 X 1002 Calculated -
Log P 2.5 A5 Low
Bulk density (g ml-1)/Specific gravity 1.17 A5 -
Dissociation constant (pKa) at 25oC Not applicable A5 -
Note: No dissociation
Vapour pressure at 20oC (mPa) 5.50 X 10-03 A5 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 1.46 X 10-05 A5 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 2.07 Calculated Transition state
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 4.86 X 10-02 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Low
Maximum UV-vis absorption L mol-1 cm-1 207.8nm = 32512, 241.5nm = 1972, 295nm = 550 A5 -
Surface tension (mN m-1) - - -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 12 A5 Non-persistent
DT50 (lab at 20oC) 12 A5 Non-persistent
DT50 (field) 23 A5 Non-persistent
DT90 (lab at 20oC) 39.2 A5 -
DT90 (field) 51 A5 -
DT50 modelling endpoint - - -
Note EU dossier lab studies DT50 range 7.2-18.2 days, DT90 = 23.8-111.1 days, field studies DT50 range 12-33 days, DT90 range 34-68 days
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value 4.5 R4 -
Note Published literature RL50 range 1.5-7.5 days, wheat, whole plant, n=2
Aqueous photolysis DT50 (days) at pH 7 Value 48 A5 Stable
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value 1560 A5 Very persistent
Note pH sensitive: DT50 1210 days at pH 5, 540 days at pH 9, all at 25 degC
Water-sediment DT50 (days) 149 A5 Slow
Water phase only DT50 (days) 40 A5 Stable

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - - -
Koc -
Notes and range -
Freundlich Kf 2.83 A5 Moderately mobile
Kfoc 122
1/n 0.8
Notes and range EU dossier Kf range 0.26-27.1 mL/g, Kfoc range 36-241 mL/g, 1/n range 0.66-0.94, Soils = 21; Literature mean: kf = 3.0 mL/g, Kfoc = 155 mL/g, 1/n = 1.02, Soils = 33
pH sensitivity No

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
desmethylisoproturon This metabolite may cause environmental pollution, click here for further information Soil   0.140   Major fraction, Relevant


ECOTOXICOLOGY

for isoproturon

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 177 R3 (Low risk LogP < 3 (A5)) Threshold for concern
CT50 (days) Not available -
Mammals - Acute oral LD50 (mg kg-1) 1826 A5 Rat Moderate
Mammals - Short term dietary NOEL (mg kg-1) - L3 Rat -
(ppm diet) 400 -
Birds - Acute LD50 (mg kg-1) 1401 A4 Unknown species Moderate
Birds - Short term dietary (LC50/LD50) > 5000 mg kg feed-1 A4 Unknown species -
Fish - Acute 96 hour LC50 (mg l-1) 18 A4 Unknown species Moderate
Fish - Chronic 21 day NOEC (mg l-1) 1 A5 Oncorhynchus mykiss Moderate
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 0.58 A4 Unknown species Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 0.12 A5 Daphnia magna Moderate
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) 0.031 A5 Lemna minor Moderate
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) 0.013 A5 Navicula pelliculosa Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) 0.052 Q2 Unknown species Moderate
Honeybees Contact acute 48 hour LD50 (μg bee-1) 200 A5 Low
Oral acute 48 hour LD50 (μg bee-1) 195 A5 Low
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) > 1000 A5 Eisenia foetida Low
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect 7
30
Mortality
Fertility
Dose: 25 kg ha-1
A4 Aphidius rhopalosiphi, adult
-
Other arthropod (2) LR50 g ha-1 - - -
% Effect 16
27
Mortality
Fertility
Dose: 25 kg ha-1
A5 Typhlodromus pyri, protonymph
-
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: 3.0 kg ha-1
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for isoproturon

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) 1826 A5 Rat Moderate
Mammals - Dermal LD50 (mg kg-1 body weight) > 2000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) 1.95 A5 Rat (aerosol) -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.015 A5 Rat, SF=200 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) None allocated A5 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.015 A4 Dog, 90 day, SF=200 -
Dermal penetration studies (%) 17 A5 -
Dangerous Substances Directive 76/464 - - -
Exposure Limits - - -
Exposure Routes Public No unacceptable risks to bystanders identified
Occupational No unacceptable risks to operators or other workers identified
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

General human health issues Endocrine issues - Pregnane X cellular receptor activation

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes IMDG Transport Code is usually 9
CLP classification 2013 Health: H351
Environment: H400, H410
EC Risk Classification Click here to view information omn the EU risk phrases Carcinogen category 3: R40
N - Dangerous for the environment: R50, R53
EC Safety Classification Click here to view information omn the EU safety phrases S2, S36/37, S60, S61
WHO Classification II - Moderately hazardous
US EPA Classification (formulation) No consensus across products or no products available - -
UN Number Usually 3077
Waste disposal & packaging Click here for a description of UN packaging marks Packaging Group III (minor danger)


TRANSLATIONS

for isoproturon

Language Name
English isoproturon
French isoproturon
German Isoproturon
Danish isoproturon
Italian isoproturon
Spanish isoproturon
Greek isoproturon
Slovenian izoproturon
Polish izoproturon
Swedish isoproturon
Hungarian izoproturon
Dutch isoproturon

Record last updated: Wednesday 31 October 2018
Contact: aeru@herts.ac.uk
© University of Hertfordshire