mancozeb ** manzeb ** Translations

Environmental Fate - Ecotoxicology - Human Health

GENERAL INFORMATION

Description: A fungicide for control of a wide range of pathogens including blights, mildews and scabs on potatoes and other crops

Introduction: 1961, first reported

EC Directive 1107/2009 (repealing 91/414):

Status	Annex 1
Dossier rapporteur/co-rapporteur	Italy
Date inclusion expires	30/06/2016

Approved for use () or known to be used () in the following European countries:

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also registered in: Australia, USA

General status:

Pesticide type	Fungicide
Substance group	Dithiocarbamate
Substance origin	Synthetic
Mode of action	Broad spectrum, non-systemic, contact with protective action, acts by distrupting lipid metabolism
CAS RN	8018-01-7 (formerly 8065-67-6)
EC number	006-076-00-1
CIPAC number	34
US EPA chemical code	014504
Chemical formula	(C4H6MnN2S4)x(Zn)y
SMILES	[Mn+2].[Zn+2].[S-]C(=S)NCCNC(=S)[S-].[S-]C(=S)NCCNC([S-])=S
International Chemical Identifier (InChI)	-
Structure diagram/image available?	Yes
Molecular mass (g mol-1)	271.3
IUPAC Name	manganese ethylenebis(dithiocarbamate) (polymeric) complex with zinc salt
CAS Name	[[2-[(dithiocarboxy)amino]ethyl]carbamodithioato]](2-)-kS,kS']manganese mixture with [[2-[(dithiocarboxy)amino]ethyl]carbamodithioato]](2-)-kS,kS']zinc
Other status information	Marine Pollutant
Herbicide Resistance Classification (HRAC)	Not applicable
Insecticide Resistance Classification (IRAC)	Not applicable
Fungicide Resistance Classification (FRAC)	M3
Physical state	Grey to yellow coloured powder
Related substances & organisms	sodium lignosulfonate benalaxyl benthiavalicarb chlorothalonil cymoxanil dimethomorph

Formulations:

Property	Value
Example manufacturers of products using this active	AgriGuard Certis Dow AgroSciences DuPont Headland Interfarm Nufarm Sipcam Syngenta
Example products using this active	Fubol Gold Dithane Dry Flowable Dithane 945 Karamate DryFlo Manzate 75WG Matilda WG Penncozeb
UK LERAP status	LERAP Category B (may vary across mixtures)
Formulation and application details	Often supplied as wettable granules and powders that are mixed with water and used as a spray.

ENVIRONMENTAL FATE

Property		Value	Source/Quality Score/Other Information	Interpretation
Solubility - In water at 20oC (mg l-1)		6.2	G4	Low
Solubility - In organic solvents at 20oC (mg l-1)		Insoluble	A4 - Most organic solvents	-
Melting Point (oC)		Decomposes before melting	A5	-
Boiling Point (oC)		Decomposes before boiling	A5	-
Degradation point (oC)		172	L3	-
Flashpoint (oC)		Not highly flammable	A5	-
Octanol-water partition coefficient at pH 7, 20oC	P	2.14 X 1001	Calculated	-
	Log P	1.33	A5	Low
Bulk density (g ml-1)/Specific gravity		1.98	A5	-
Dissociation constant (pKa) at 25oC		10.3	A5	-
		Note: Very weak acid
Vapour pressure at 25oC (mPa)		0.013	A5	Non-volatile
Henry's law constant at 25oC (Pa m3 mol-1)		5.90 X 10-04	A5	Non-volatile
Henry's law constant at 20oC (dimensionless)		1.76 X 10-10	Q2	Non-volatile
GUS leaching potential index		-1.00	Calculated	Low leachability
SCI-GROW groundwater index (µg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate	Value	2.84 X 10-06	Calculated	-
	Note	-
Potential for particle bound transport index		-	Calculated	Low
Maximum UV-vis absorption L mol-1 cm-1		-	-	-
Surface tension (mN m-1)		-	-	-

Degradation:

Property		Value	Source/Quality Score/Other Information	Interpretation
Soil degradation (days) (aerobic)	DT50 (typical)	0.1	A5	Non-persistent
	DT50 (lab at 20oC)	0.1	A5	Non-persistent
	DT50 (field)	18	H4	Non-persistent
	DT90 (lab at 20oC)	0.5	A5	-
	DT90 (field)	-	-	-
	Note	EU dossier lab studies DT50 range 1-3 hours, Dt90 range 2- 25 hours
Aqueous photolysis DT50 (days) at pH 7	Value	Stable	A3	Stable
	Note	Not a significant route of degradation
Aqueous hydrolysis DT50 (days) at 20oC and pH 7	Value	1.3	A4	Non-persistent
	Note	pH variable: DT50 2-36 hours at pH 5, 5.5-55 hours at pH 7, 15 hours at pH 9
Water-Sediment DT50 (days)		76	Q3	Moderately fast
Water phase only DT50 (days)		0.2	A5	Fast

Soil adsorption and mobility:

Property		Value	Source/Quality Score/Other Information	Interpretation
Linear	Kd	9.7	A5	Slightly mobile
	Koc	998
	Notes and range	EU dossier KD range 7.26-11.67 mL/g, Koc range 363-2334 mL/g, Soils=4
Freundlich	Kf	-	-	-
	Kfoc	-
	1/n	-
	Notes and range	-
pH sensitivity		No

Key metabolites:

Metabolite		Formation Medium	Estimated Maximum Occurrence Fraction	91/414 Relevancy
ethylenethiourea		Soil	0.031	Minor fraction, Relevant
ethyleneurea		Soil	0.085	Minor fraction, Relevant
ethylene bisisothiocyanate sulphide		Soil	0.082	Minor fraction, Relevant

Other known metabolites:

Metabolite name and reference	Aliases	Formation Medium / Rate	Estimated Maximum Occurrence Fraction	Metabolising Enzymes
ethylene thiuram disulphide	ETD	Soil	Very low	-

ECOTOXICOLOGY

Property		Value	Source/Quality Score/Other Information	Interpretation
Bio-concentration factor	BCF	3.2	Q2 EU dossier states low risk	Low potential
	CT50 (days)	Not available		-
Bioaccumulation potential		-	Calculated	Low
Mammals - Acute oral LD50 (mg kg-1)		> 5000	A5 Rat	Low
Mammals - Short term dietary NOEL	(mg kg-1)	-	-	-
	(ppm diet)	-		-
Birds - Acute LD50 (mg kg-1)		> 2000	A4 Median across species	Moderate
Birds - Short term dietary (LC50/LD50)		> 860 mg kg bw-1 day-1	A4 Colinus virginianus	-
Fish - Acute 96 hour LC50 (mg l-1)		0.074	A5 Oncorhynchus mykiss	High
Fish - Chronic 21 day NOEC (mg l-1)		0.0022	A4 Oncorhynchus mykiss, 34 day NOEC	-
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1)		0.073	A5 Daphnia magna	High
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1)		0.0073	A5 Daphnia magna	-
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1)		-	-	-
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1)		-	-	-
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1)		-	-	-
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1)		-	-	-
Aquatic plants - Acute 7 day EC50, biomass (mg l-1)		-	-	-
Algae - Acute 72 hour EC50, growth (mg l-1)		0.044	A5 Pseudokirchneriella subcapitata	Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1)		-	-	-
Honeybees - Acute 48 hour LD50 (µg bee-1)		140.6	A5 Oral	Low
Earthworms - Acute 14 day LC50 (mg kg-1)		> 299.1	A5 Eisenia foetida	Moderate
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1)		20.0	A5 Eisenia foetida	Moderate
Other soil macro-organisms - e.g. Collembola	LR50product ha EC50product ha NOECproduct ha % Effect	-	-	-
Other arthropod (1)	LR50 g ha-1	Harmful	Dose: 480 g ha-1 AA2 Typhlodromus pyri	Harmful
	% Effect	75	Long term effect Dose: 36 kg ha-1 A5 Typhlodromus pyri, adult	Moderately harmful
Other arthropod (2)	LR50 g ha-1	Harmless	Dose: 480 g ha-1 AA2 Chrysoperla carnea	Harmless
	% Effect	-0.4	Mortality Dose: 2.6 kg ha-1 A5 Aphidius rhopalosiphi	Harmless
Soil micro-organisms		Nitrogen mineralisation: No significant effect Carbon mineralisation: No significant effect	A5 Dose: 4.2 kg/ha	-
Mesocosm study data	NOEAEC mg l-1	0.032	A5 Invertebrates and phytoplankton	-
	NOEAEC mg l-1	-	-	-

HUMAN HEALTH AND PROTECTION

General:

Property		Value	Source/Quality Score/Other Information	Interpretation
Mammals - Acute oral LD50 (mg kg-1)		> 5000	A5 Rat	Low
Mammals - Dermal LD50 (mg kg-1 body weight)		> 2000	A5 Rat	-
Mammals - Inhalation LC50 (mg l-1)		> 5.14	A5 Rat	-
Other Mammal toxicity endpoints		-		-
ADI - Acceptable Daily Intake (mg kg-1bw day-1)		0.05	A5 Rat, SF=100	-
ARfD - Acute Reference Dose (mg kg-1bw day-1)		0.6	A5 Rat	-
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1)		0.035	A5	-
Dermal penetration studies (%)		0.11-0.24	A5 concentration dependant	-
Dangerous Substances Directive 76/464		List II	-	-
Exposure Limits		-	-	-
Exposure Routes	Public	-
	Occupational	-
Examples of European MRLs (mg kg-1)	Value	Currants, gooseberries, citrus and lettuce: 5.0; Tomatoes and pome fruit: 3.0; Apricots, nectarines, peaches, grapes, strawberries, barley grains and oat grains: 2.0; Brassicas, beans (with pods), peas (with pods), cherries, plums, rye grains and wheat grains: 1.0; Onions, garlic, cucumbers, melons (not watermelons), pumpkins, summer squash and celery: 0.5; Carrots: 0.2; Potatoes, beans (edible part) and peas (edible part): 0.1; Other vegetables, other fruit and other cereal grains: 0.05
	Note	[Current May 2007.] [Expressed as carbon disulphide.] For the EU pesticides database click here
Drinking Water MAC (µg l-1)		-	-	-

Health issues:

Carcinogen	Mutagen	Endocrine disrupter	Reproduction / development effects	Acetyl cholinesterase inhibitor	Neurotoxicant	Respiratory tract irritant	Skin irritant	Eye irritant
General human health issues		[May cause ovarian hyperthropy], [Possible thyroid toxicant]

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data

Handling issues:

Property		Value	Source/Quality Score/Other Information	Interpretation
General		[Not explosive], [IMDG Transport Code is usually 9]
EC Risk Classification		[Reproduction risk category 3: R63], [Xi - Irritant: R43], [N - Dangerous for the environment: R50]
EC Safety Classification		S2, S36/37, S46, S61
WHO Classification		U	-	Unlikely to present an acute hazard
US EPA Classification (formulation)		IV	-	Caution - Not acutely toxic
UN Number		Variable with product, usually 3077 or 3082
Waste disposal & packaging		[Usually Packaging Group III (minor danger)]

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