metiram (Ref: BAS 222F) ** carbatene ** metirame ** zinc metiram ** polyram ** FMC 9102 ** Translations

Environmental Fate - Ecotoxicology - Human Health

GENERAL INFORMATION

Description: A fungicide used to control a wide range of diseases including scab on top fruit, blight on potatoes and tomatoes, and downy mildew on many crops

Introduction: 1958, introduced Germany

EC Directive 1107/2009 (repealing 91/414):

Status	Annex 1
Dossier rapporteur/co-rapporteur	Italy
Date inclusion expires	30/06/2016

Approved for use () or known to be used () in the following European countries:

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also registered in: Australia

General status:

Pesticide type	Fungicide
Substance group	Dithiocarbamate
Substance origin	Synthetic
Mode of action	Broad spectrum, non-systemic with protective action
CAS RN	9006-42-2 / 9063-14-3
EC number	-
CIPAC number	478
US EPA chemical code	014601
Chemical formula	(C16H33N11S16Zn3)x
SMILES	[Zn+2].[S-]C(=S)NCCNC(=S)[S-]
International Chemical Identifier (InChI)	InChI=1/C4H8N2S4.H3N.Zn/c7-3(8)5-1-2-6-4(9)10;;/h1-2H2,(H2,5,7,8)(H2,6,9,10);1H3;/q;;+2/p-2
Structure diagram/image available?	Yes
Molecular mass (g mol-1)	(1088.6)x
IUPAC Name	zinc ammoniate ethylenebis(dithiocarbamate) - poly(ethylenethiuram disulfide)
CAS Name	metiram
Other status information	-
Herbicide Resistance Classification (HRAC)	Not applicable
Insecticide Resistance Classification (IRAC)	Not applicable
Fungicide Resistance Classification (FRAC)	M3
Physical state	Yellow powder
Related substances & organisms	-

Formulations:

Property	Value
Example manufacturers of products using this active	BASF
Example products using this active	-
UK LERAP status	None
Formulation and application details	-

ENVIRONMENTAL FATE

Property		Value	Source/Quality Score/Other Information	Interpretation
Solubility - In water at 20oC (mg l-1)		2	A5	Low
Solubility - In organic solvents at 20oC (mg l-1)		100	A3 - Methanol	-
		100	A3 - Acetone	-
		100	A3 - Toluene	-
		100	A3 - Ethyl acetate	-
Melting Point (oC)		156	A5	-
Boiling Point (oC)		Decomposes before boiling	A5	-
Degradation point (oC)		156	A5	-
Flashpoint (oC)		Not highly flammable	A5	-
Octanol-water partition coefficient at pH 7, 20oC	P	5.75 X 1001	Calculated	-
	Log P	1.76	A5	Low
Bulk density (g ml-1)/Specific gravity		1.86	A5	-
Dissociation constant (pKa) at 25oC		Not applicable	A5	-
		Note: No dissociation
Vapour pressure at 25oC (mPa)		0.01	A5	Non-volatile
Henry's law constant at 25oC (Pa m3 mol-1)		5.40 X 10-03	A5	Non-volatile
Henry's law constant at 20oC (dimensionless)		-	-	-
GUS leaching potential index		0.00	Calculated	Low leachability
SCI-GROW groundwater index (µg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate	Value	5.35 X 10-03	Calculated	-
	Note	Estimated concentrations of chemicals with Koc values greater than 9995 ml g-1 are beyond the scope of the regression data used in SCI-GROW development. If there are concerns for such chemicals, a higher tier groundwater exposure assessment should be considered, regardless of the concentration returned by SCI-GROW
Potential for particle bound transport index		-	Calculated	Low
Maximum UV-vis absorption L mol-1 cm-1		259nm = 64000, 281nm = 48000, 29 nm = 30000	A5	-
Surface tension (mN m-1)		-	-	-

Degradation:

Property		Value	Source/Quality Score/Other Information	Interpretation
Soil degradation (days) (aerobic)	DT50 (typical)	1	F3	Non-persistent
	DT50 (lab at 20oC)	1	A5	Non-persistent
	DT50 (field)	7	A3	Non-persistent
	DT90 (lab at 20oC)	2.5	A5	-
	DT90 (field)	14	A3	-
	Note	EU dossier lab studies DT50 range 0.5-19 days, DT90 range 1.8-3.2 days, Field studies DT50 ~7days, DT90 <14 days; Other sources: 20 days (DW4)
Aqueous photolysis DT50 (days) at pH 7	Value	0.3	A5	Fast
	Note	6.3 hours in continuous irradiation, 0.6 days central Europe scenario, March
Aqueous hydrolysis DT50 (days) at 20oC and pH 7	Value	0.7	A5	Non-persistent
	Note	pH sensitive: DT50 22.5 hours at pH 5, 17.4 hours at pH 7, 4.8 days at pH 9, all at 22 degC
Water-Sediment DT50 (days)		3.4	A5	Fast
Water phase only DT50 (days)		0.7	A5	Fast

Soil adsorption and mobility:

Property		Value	Source/Quality Score/Other Information	Interpretation
Linear	Kd	-	G3	Non-mobile
	Koc	500000
	Notes and range	-
Freundlich	Kf	-	-	-
	Kfoc	-
	1/n	-
	Notes and range	-
pH sensitivity		No

Key metabolites:

Metabolite		Formation Medium	Estimated Maximum Occurrence Fraction	91/414 Relevancy
ethylenethiourea		Soil	0.12	Major fraction, Relevant
ethylene bisisothiocyanate sulphide		Soil	0.57	Major fraction, Relevant
carbimid		Soil	0.135	Major fraction, Relevant

Other known metabolites:

Metabolite name and reference	Aliases	Formation Medium / Rate	Estimated Maximum Occurrence Fraction	Metabolising Enzymes
-	TDIT	Soil	0.135	-
-	hydantoin	Water	-	-

ECOTOXICOLOGY

Property		Value	Source/Quality Score/Other Information	Interpretation
Bio-concentration factor	BCF	3.2	Q3	Low potential
	CT50 (days)	Not available		-
Bioaccumulation potential		-	Calculated	Low
Mammals - Acute oral LD50 (mg kg-1)		> 5000	A5 Rat	Low
Mammals - Short term dietary NOEL	(mg kg-1)	> 50	G3 Rat	High
	(ppm diet)	-		-
Birds - Acute LD50 (mg kg-1)		> 2150	A5 Colinus virginianus	Low
Birds - Short term dietary (LC50/LD50)		853 mg kg bw-1 day-1	A5 Colinus virginianus	-
Fish - Acute 96 hour LC50 (mg l-1)		0.33	A5 Oncorhynchus mykiss	Moderate
Fish - Chronic 21 day NOEC (mg l-1)		0.022	A5 Oncorhynchus mykiss	-
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1)		0.77	A5 Daphnia magna	Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1)		0.0043	A5 Daphnia magna	-
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1)		-	-	-
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1)		-	-	-
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1)		-	-	-
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1)		-	-	-
Aquatic plants - Acute 7 day EC50, biomass (mg l-1)		-	-	-
Algae - Acute 72 hour EC50, growth (mg l-1)		0.063	A5 Pseudokirchneriella subcapitata	Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1)		-	-	-
Honeybees - Acute 48 hour LD50 (µg bee-1)		> 16	G3 Contact	Moderate
Earthworms - Acute 14 day LC50 (mg kg-1)		> 1000	A5	Moderate
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1)		-	-	-
Other soil macro-organisms - e.g. Collembola	LR50product ha EC50product ha NOECproduct ha % Effect	-	-	-
Other arthropod (1)	LR50 g ha-1	Harmless	HarmlessAA2 Aphidius rhopalosiphi	Harmless
	% Effect	14	Lethal Dose: 4 kg ha-1 A5 Aphidius rhopalosiphi, adult	Harmless
Other arthropod (2)	LR50 g ha-1	Harmful	AA2 Typhlodromus pyri	Harmful
	% Effect	100	Lethal Dose: 0.7 kg ha-1 A5 Typhlodromus pyri	Harmful
Soil micro-organisms		Nitrogen mineralisation: No long-term effect Carbon mineralisation: No long-term effect	A5 Dose: 48 kg/ha	-
Mesocosm study data	NOEAEC mg l-1	-	-	-
	NOEAEC mg l-1	-	-	-

HUMAN HEALTH AND PROTECTION

General:

Property		Value	Source/Quality Score/Other Information	Interpretation
Mammals - Acute oral LD50 (mg kg-1)		> 5000	A5 Rat	Low
Mammals - Dermal LD50 (mg kg-1 body weight)		> 2000	A5 Rat	-
Mammals - Inhalation LC50 (mg l-1)		> 5.7	A5 Rat	-
Other Mammal toxicity endpoints		-		-
ADI - Acceptable Daily Intake (mg kg-1bw day-1)		0.03	A5 Rat, SF=100	-
ARfD - Acute Reference Dose (mg kg-1bw day-1)		None allocated	A5	-
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1)		0.016	A5 Rat, SF=100	-
Dermal penetration studies (%)		-	-	-
Dangerous Substances Directive 76/464		List II	-	-
Exposure Limits		-	-	-
Exposure Routes	Public	-
	Occupational	-
Examples of European MRLs (mg kg-1)	Value	Lettuce, citrus, currants and gooseberries: 5.0; Tomatoes and pomes: 3.0; Apricots, nectarines, peaches, grapes, strawberries, barley grains and oat grains: 2.0; Brassicas, beans, peas, cherries, plums, rys grains and wheat grains: 1.0; Onions, garlic, cucumbers, melons (not watermelons), pumpkins, squash and celery: 0.5; Carrots: 0.2; Potatoes: 0.1; Other vegetables, other fruit and other cereal grains: 0.05
	Note	[Current May 2007.] [Limits expressed as carbon disulphide.] For the EU pesticides database click here
Drinking Water MAC (µg l-1)		-	-	-

Health issues:

Carcinogen	Mutagen	Endocrine disrupter	Reproduction / development effects	Acetyl cholinesterase inhibitor	Neurotoxicant	Respiratory tract irritant	Skin irritant	Eye irritant
			-
General human health issues		[Skin sensitiser]

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data

Handling issues:

Property		Value	Source/Quality Score/Other Information	Interpretation
General		[Not explosive]
EC Risk Classification		-
EC Safety Classification		-
WHO Classification		U	-	Unlikely to present an acute hazard
US EPA Classification (formulation)		IV	-	Caution - Not acutely toxic
UN Number		-
Waste disposal & packaging		-

TRANSLATIONS