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piperonyl butoxide (Ref: ENT 14250)
** PBO ** butacide ** butoxide ** Translations

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GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for piperonyl butoxide

Description: An unclassified synergist used in a wide variety of insecticides to provide enhanced performance of the active ingredient

Availability status: Unknown

Introduction & key dates: circa 1950

EC Regulation 1107/2009 (repealing 91/414):
Status None - not a ppp
Dossier rapporteur/co-rapporteur Not applicable
Date inclusion expires Not applicable
EU Candidate for substitution (CfS) -
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia, USA

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism -
Chemical formula C19H30O5
Canonical SMILES CCCCOCCOCCOCC1=CC2=C(C=C1CCC)OCO2
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) FIPWRIJSWJWJAI-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C19H30O5/c1-3-5-7-20-8-9-21-10-11-22-14-17-13-19-18(23-15-24-19)12-16(17)6-4-2/h12-13H,3-11,14-15H2,1-2H3
Structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Other substance, Veterinary substance
Other constituent type Performance enhancer, Synergist
Substance group Cyclic aromatic
Minimum active substance purity -
Known relevant impurities -
Substance origin Synthetic
Mode of action Blocks pests natural detoxification system. Synergist. P450-dependent monooxygenase inhibitor.
CAS RN 51-03-6
EC number 200-076-7
CIPAC number 33
US EPA chemical code 067501
PubChem CID -
Molecular mass (g mol-1) 338.44
PIN (Preferred Identification Name) -
IUPAC name 5-[2-(2-butoxyethoxy)ethoxymethyl]-6-propyl-1,3-benzodioxole
CAS name 5-((2-(2-butoxyethoxy)ethoxy)methyl)-6-propyl-1,3-benzodioxole
Other status information Listed on USA Toxic Release Inventory
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) 27A
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance Aedes aegypti
Culex pipiens
Musca domestica
Pectinophora gossypiella
Rhizopertha dominica
many others
Physical state Colourless to yellow oily liquid
Related substances & organisms -

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • AgroCare
  • Agropharm
  • Bayer
  • Cooper
Example products using this active
  • Pyrocide
  • Rotacide
  • Meteor-Plus
UK LERAP status Not applicable
Formulation and application details Available in a range of formulations including dusts, emulsifiable concentrates, foggers, paper coatings, pressurized sprays, wettable powders, shampoos and as impregnated collars.


ENVIRONMENTAL FATE

for piperonyl butoxide

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 14.3 L3 Low
Solubility - In organic solvents at 20oC (mg l-1) - - -
Melting point (oC) Not applicable L3 -
Boiling point (oC) - - -
Degradation point (oC) 164 E3 -
Flashpoint (oC) 179 E3 -
Octanol-water partition coefficient at pH 7, 20oC P 5.62 X 1004 Calculated -
Log P 4.75 L3 High
Bulk density (g ml-1)/Specific gravity 1.06 L3 -
Dissociation constant (pKa) at 25oC - - -
Note:
Vapour pressure at 20oC (mPa) 2.00 X 10-02 L3 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 2.30 X 10-06 L3 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index -1.06 Calculated Low leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 5.35 X 10-03 Calculated -
Note Estimated concentrations of chemicals with Koc values greater than 9995 ml g-1 are beyond the scope of the regression data used in SCI-GROW development. If there are concerns for such chemicals, a higher tier groundwater exposure assessment should be considered, regardless of the concentration returned by SCI-GROW
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Medium
Maximum UV-vis absorption L mol-1 cm-1 - - -
Surface tension (mN m-1) 50.39 E3 -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 13 K4 Non-persistent
DT50 (lab at 20oC) - - -
DT50 (field) - - -
DT90 (lab at 20oC) - - -
DT90 (field) - - -
DT50 modelling endpoint - - -
Note Best available data
Dissipation rate RL50 on plant matrix Value 14.3 R4 -
Note Published literature RL50 range 3.3-25.3 days, 2 field crops, various matrices, n=2
Dissipation rate RL50 on and in plant matrix Value - - -
Note -
Aqueous photolysis DT50 (days) at pH 7 Value - - -
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value 250 H3 Persistent
Note Stable pH 5 to pH 9 at 25 degC
Water-sediment DT50 (days) - - -
Water phase only DT50 (days) - - -

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - W3 Non-mobile
Koc 89125
Notes and range Other data: Koc range 399-830 mL/g (L3)
Freundlich Kf - - -
Kfoc -
1/n -
Notes and range -
pH sensitivity -


ECOTOXICOLOGY

for piperonyl butoxide

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 260 E3 Lepomis macrochinis Threshold for concern
CT50 (days) Not available -
Mammals - Acute oral LD50 (mg kg-1) > 7220 L3 Rat Low
Mammals - Short term dietary NOEL (mg kg-1) 30 L2 Rat, 2 year High
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) > 2250 L3 Colinus virginianus Low
Birds - Short term dietary (LC50/LD50) - - -
Fish - Acute 96 hour LC50 (mg l-1) 5.3 L3 Cyprinidae Moderate
Fish - Chronic 21 day NOEC (mg l-1) - - -
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 0.51 J4 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 0.12 F3 Daphnia magna, LOEC Moderate
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) - - -
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) 0.24 K3 Unknown species Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees Contact acute 48 hour LD50 (μg bee-1) 294 E3 Low
Oral acute 48 hour LD50 (μg bee-1) - - -
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) - - -
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect - - -
Other arthropod (2) LR50 g ha-1 - - -
% Effect - - -
Soil micro-organisms - - -
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for piperonyl butoxide

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) > 7220 L3 Rat Low
Mammals - Dermal LD50 (mg kg-1 body weight) > 1880 L3 Rabbit -
Mammals - Inhalation LC50 (mg l-1) > 5.9 L3 Rat -
Other Mammal toxicity endpoints Intraperitoneal LDLo = 1000 mg kg-1 V3 Mouse -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.2 JMPR 1995 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) None allocated JMPR 2002 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) - - -
Dermal penetration studies (%) - - -
Dangerous Substances Directive 76/464 - - -
Exposure Limits - - -
Exposure Routes Public -
Occupational -
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

General human health issues Possible liver toxicant
NB: Some sources dispute carcinogenicity
IARC Group 3 carcinogen; USEPA - possible human carcinogen

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive
IMDG Transport Code is usually 9
CLP classification 2013 -
EC Risk Classification Click here to view information omn the EU risk phrases Carcinogen category 3: R40
T - Toxic: R23, R24, R25
N - Dangerous for the environment: R50/53
EC Safety Classification Click here to view information omn the EU safety phrases S23, S26, S36, S37, S39, S45
WHO Classification U - Unlikely to present an acute hazard
US EPA Classification (formulation) IV - Caution - Not acutely toxic
UN Number 3082
Waste disposal & packaging Click here for a description of UN packaging marks Packaging Group III (minor danger)


TRANSLATIONS

for piperonyl butoxide

Language Name
English piperonyl butoxide
French pipéronyl butoxyde
German Piperonylbutoxid
Danish piperonylbutoxyd
Italian piperonil butossido
Spanish butoxido de piperonilo
Greek -
Slovenian piperonil butoksid
Polish piperonyl butoksydu
Swedish piperonylbutoxid
Hungarian -
Dutch -

Record last updated: Thursday 29 March 2018
Contact: aeru@herts.ac.uk
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