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propamocarb hydrochloride (Ref: SN 66752)
** propamocarb ** Translations

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GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for propamocarb hydrochloride

Description: A fungicide for specific control of Phycomycetes and effective against Phytophthora spp. and Pythium spp.

Example pests controlled: Late blight; Root rot; Damping off; Downy mildew (Bremia lactucae); Mildew

Example applications: Turf; Ornamentals; Tobacco; Vegetables; Potatoes; Strawberries; Cucumbers; Tomato; Lettuce

Efficacy & activity: -

Availability status: Current

Introduction & key dates: 1978, first reported

EC Regulation 1107/2009 (repealing 91/414):
Status Approved
Dossier rapporteur/co-rapporteur Portugal/Belgium
Date inclusion expires 31/07/2019
EU Candidate for substitution (CfS) No
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism -
Chemical formula C9H21ClN2O2
Canonical SMILES CCCOC(=O)NCCCN(C)C.Cl
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) MKIMSXGUTQTKJU-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C9H20N2O2.ClH/c1-4-8-13-9(12)10-6-5-7-11(2)3;/h4-8H2,1-3H3,(H,10,12);1H
Structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Fungicide
Substance group Carbamate
Minimum active substance purity 92-97%
Known relevant impurities EU dossier - None declared
Substance origin Synthetic
Mode of action Systemic, with protective action absorbed by roots and leaves and translocated. Lipid synthesis inhibitor.
CAS RN 25606-41-1
EC number 247-125-9
CIPAC number 399.601
US EPA chemical code 119302
PubChem CID 15575641
Molecular mass (g mol-1) 224.73
PIN (Preferred Identification Name) -
IUPAC name propyl 3-(dimethylamino)propylcarbamate hydrochloride
CAS name propyl (3-(dimethylamino)propyl)carbamate monohydrochloride
Other status information -
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) 28
Examples of recorded resistance -
Physical state Colourless crystals
Related substances & organisms

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • AgriGuard
  • Bayer CropScience
  • Fargro
  • Pan Agriculture
Example products using this active
  • Consento
  • Infinito
  • Merlin
  • Previcur N
UK LERAP status Buffer probably required in UK - see product label
Formulation and application details Often supplied as an aqueous solution.


ENVIRONMENTAL FATE

for propamocarb hydrochloride

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 1005000 A5 High
Solubility - In organic solvents at 20oC (mg l-1) 40 A5 - Toluene -
4800 A5 - Dichloromethane -
560000 A5 - Acetone -
4800 A5 - Ethyl acetate -
Melting point (oC) 64.2 A5 -
Boiling point (oC) Decomposes before boiling A5 -
Degradation point (oC) 150 A5 -
Flashpoint (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 5.01 X 10-02 Calculated -
Log P -1.3 A5 Low
Bulk density (g ml-1)/Specific gravity 1.16 A5 -
Dissociation constant (pKa) at 25oC 9.6 A5 -
Note: Weak acid
Vapour pressure at 20oC (mPa) 8.70 X 10-01 A3 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 8.50 X 10-09 A5 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 1.84 Calculated Transition state
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 6.09 X 10-02 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Low
Maximum UV-vis absorption L mol-1 cm-1 Absorption observed at 203nm and 217nm at pH 7, no absorbance >290nm A5 -
Surface tension (mN m-1) 71.98 A5 at 20oC -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 39.3 A5 Moderately persistent
DT50 (lab at 20oC) 39.3 A5 Moderately persistent
DT50 (field) 20 A4 Non-persistent
DT90 (lab at 20oC) 130.6 A5 -
DT90 (field) - - -
DT50 modelling endpoint - - -
Note EU dossier lab studies DT50 range 10.9-137 days in 9 soils, DT90 range 36.1-452.0 days, 8 soils; field studies DT50 range 17.4-23.7 days
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value 7.7 R4 -
Note Published literature RL50 range 1.3-22.7 days, 2 field crops, various matrices, n=4
Aqueous photolysis DT50 (days) at pH 7 Value Stable A5 -
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value Stable A5 -
Note Stable at pH 4 to pH 9, at 25 and 50 degC
Water-sediment DT50 (days) 17 A5 Fast
Water phase only DT50 (days) 12 A5 Moderately fast

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - - -
Koc -
Notes and range -
Freundlich Kf 18.7 A5 Slightly mobile
Kfoc 706
1/n 0.87
Notes and range EU dossier Kf range 1.29-77.20 mL/g, Kfoc range 124-2451 mL/g, 1/n range 0.77-0.90, Soils=5
pH sensitivity None, but adsorption may correlate to soil clay content

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
3-(3-dimethylaminopropyl)-4-hydroxy-4-methyloxazolidin-2-one - Animal - -
- hydroxypropyl-propamocarb Plant - -
- propamocarb-N-oxyde Plant - -
2-hydroxypropyl 3-(dimethylamino)propylcarbamate - Animal - -
propyl [3-(methylamino)propyl]carbamate - Animal - -
propyl-3-(dimethylamino)propylcarbamate-N-oxide - Animal - -


ECOTOXICOLOGY

for propamocarb hydrochloride

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 54 A5 Low potential
CT50 (days) Not available -
Mammals - Acute oral LD50 (mg kg-1) > 1330 A5 Rat Moderate
Mammals - Short term dietary NOEL (mg kg-1) 37 A5 Rat High
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) > 1842 A5 Anas platyrhynchos Moderate
Birds - Short term dietary (LC50/LD50) > 962 mg kg bw-1 day-1 A5 Anas platyrhynchos -
Fish - Acute 96 hour LC50 (mg l-1) > 99 A5 Oncorhynchus mykiss Moderate
Fish - Chronic 21 day NOEC (mg l-1) > 6.3 A4 Lepomis macrochirus, 32 day Moderate
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) > 100 A5 Daphnia magna Low
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 12.3 A5 Daphnia magna Low
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) > 18 A5 Lemna gibba Low
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) > 85 A5 Pseudokirchneriella subcapitata Low
Algae - Chronic 96 hour NOEC, growth (mg l-1) 22 Q2 Unknown species Low
Honeybees Contact acute 48 hour LD50 (μg bee-1) > 100 A5 Low
Oral acute 48 hour LD50 (μg bee-1) > 84 A5 Moderate
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) > 660 A5 Eisenia foetida Moderate
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) 362 A5 Eisenia foetida Low
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 500 EC50 (Other data: NOEL = 170 g ha-1)
A5 Aphidius rhopalosiphi, adult
-
% Effect - - -
Other arthropod (2) LR50 g ha-1 360 EC50 (Other data: LOEL = 360 g ha-1)
A5 Typhlodromus pyri, adult
-
% Effect - - -
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: 28/9 kg ha-1
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for propamocarb hydrochloride

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) > 1330 A5 Rat Moderate
Mammals - Dermal LD50 (mg kg-1 body weight) > 2000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) > 5.01 A5 Rat -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.29 A5 Rat, SF=100 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) 1 A5 Rat, SF=100 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.29 A5 Rat, SF=100 -
Dermal penetration studies (%) - - -
Dangerous Substances Directive 76/464 - - -
Exposure Limits - - -
Exposure Routes Public -
Occupational -
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

-

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

General human health issues Endocrine issues - Weak increase of aromatase activity and estrogen production

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive
CLP classification 2013 Health: H317
EC Risk Classification Click here to view information omn the EU risk phrases Xn - Harmful: R43
N - Dangerous for the environment: R52
EC Safety Classification Click here to view information omn the EU safety phrases S2, S24, S37, S46, S61
WHO Classification U - Unlikely to present an acute hazard
US EPA Classification (formulation) IV - Caution - Not acutely toxic
UN Number -
Waste disposal & packaging Click here for a description of UN packaging marks -


TRANSLATIONS

for propamocarb hydrochloride

Language Name
English propamocarb hydrochloride
French propamocarbe hydrochloride
German Propamocarb
Danish propamocarb
Italian propamocarb
Spanish propamocarb
Greek -
Slovenian propamokarb hidroklorid
Polish chlorowodorek propamokarbu
Swedish propamokarb hydroklorid
Hungarian propamokarb-HCl
Dutch propamocarb-hydrochloride

Record last updated: Friday 14 September 2018
Contact: aeru@herts.ac.uk
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