propoxur (Ref: OMS 33) |
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SUMMARY
Propoxur is a carbamate pesticide not approved for use in the EU. With a high aqueous solubilty, it has potential for being mobile in groundwaters although it is rarely reported. It is not highly volatile. In some instances it may persist in soil systems. It is highly toxic to humans if it is ingested but not other serious health issues have been identified. There are gaps in information relating to the toxicity of propoxur to biodiversity but based on information that is available it likely to be moderately to highly toxic. . GENERAL INFORMATION
for propoxur
Description: A insecticide and acaricide active against a wide range of pests especially those that cause damage via sucking and chewing. Also used for flea control on domestic pets.
Example pests controlled: Cockroaches; Flies; Mosquitoes; Fleas; Ticks; Aphids; Leaf hoppers
Example applications: Ornamentals; Lawns & turf; Glasshouse crops including tomatoes & cucumbers
Efficacy & activity: -
Availability status: Current
Introduction & key dates: 1959; first registered in the US in 1963.
EC Regulation 1107/2009 (repealing 91/414):
Status | Not approved |
Dossier rapporteur/co-rapporteur | Not applicable |
Date inclusion expires | Expired |
EU Candidate for substitution (CfS) | Not applicable |
Listed in EU database | Yes |
Approved for use () or known to be used (
) in the following European countries:
AT |
BE |
BG |
CY |
CZ |
DE |
DK |
EE |
EL |
ES |
FI |
FR |
HR |
HU |
IE |
IT |
LT |
LU |
LV |
MT |
NL |
PL |
PT |
RO |
SE |
SI |
SK |
UK |
Also used in: Australia, USA
Isomerism | - |
Chemical formula | C11H15NO3 |
Canonical SMILES | CC(C)OC1=CC=CC=C1OC(=O)NC |
Isomeric SMILES | No data |
International Chemical Identifier key (InChIKey) | ISRUGXGCCGIOQO-UHFFFAOYSA-N |
International Chemical Identifier (InChI) | InChI=1S/C11H15NO3/c1-8(2)14-9-6-4-5-7-10(9)15-11(13)12-3/h4-8H,1-3H3,(H,12,13) |
2D structure diagram/image available? | Yes |
Pesticide type | Insecticide, Acaricide, Veterinary substance | |||
Substance group | Carbamate | |||
Minimum active substance purity | - | |||
Known relevant impurities | - | |||
Substance origin | Synthetic | |||
Mode of action | Non-systemic with contact and stomach action. Acetylcholinesterase (AChE) inhibitor. | |||
CAS RN | 114-26-1 | |||
EC number | 204-043-8 | |||
CIPAC number | 80 | |||
US EPA chemical code | 047802 | |||
PubChem CID | 4944 | |||
Molecular mass (g mol-1) | 209.24 | |||
PIN (Preferred Identification Name) | - | |||
IUPAC name | 2-isopropoxyphenyl methylcarbamate | |||
CAS name | 2-(1-methylethoxy)phenyl methylcarbamate | |||
Other status information | Marine Pollutant | |||
Relevant Environmental Water Quality Standards | - | |||
Herbicide Resistance Classification (HRAC) | Not applicable | |||
Herbicide Resistance Classification (WSSA) | Not applicable | |||
Insecticide Resistance Classification (IRAC) | 1A | |||
Fungicide Resistance Classification (FRAC) | Not applicable | |||
Examples of recorded resistance | Aedes aegypti Amblyseius potentillae Anopheles albimanus Anopheles atroparvus Anopheles funestus many others |
|||
Physical state | White crystalline solid | |||
Related substances & organisms | - |
Formulations:
ENVIRONMENTAL FATE
for propoxur
Property ![]() |
Value | Source/Quality Score/Other Information ![]() |
Interpretation ![]() |
|
Linear | Kd | - | G3 | Mobile |
Koc | 30 | |||
Notes and range | - | |||
Freundlich | Kf | - | - | - |
Kfoc | - | |||
1/n | - | |||
Notes and range | - | |||
pH sensitivity | - |
Other known metabolites:
Metabolite name and reference | Aliases | Formation medium / Rate | Estimated maximum occurrence fraction | Metabolising enzymes |
2-(1-methylethoxy)phenol | - | Soil (Photolysis) | - | - |
dimethyl propoxus | - | Plant | 0.27-0.36 | - |
HUMAN HEALTH AND PROTECTION
for propoxur
General:
Property ![]() |
Value | Source/Quality Score/Other Information ![]() |
Interpretation ![]() |
|
Threshold of Toxicological Concern (Cramer Class) ![]() |
High (class III) | - | - | |
Mammals - Acute oral LD50 (mg kg-1) | ~ 50 | L3 Rat | High | |
Mammals - Dermal LD50 (mg kg-1 body weight) | > 5000 | L3 Rat | - | |
Mammals - Inhalation LC50 (mg l-1) | > 0.50 | E3 Rat | - | |
Other Mammal toxicity endpoints | Intraperitoneal LD50 = 30 mg kg-1 | V3 Rat | - | |
Intramuscular LD50 = 53 mg kg-1 | V3 Rat | - | ||
ADI - Acceptable Daily Intake (mg kg-1bw day-1) | 0.02 | JMPR 1989 | - | |
ARfD - Acute Reference Dose (mg kg-1bw day-1) | - | - | - | |
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) | - | - | - | |
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) | - | - | - | |
Dermal penetration studies (%) | - | - | - | |
Dangerous Substances Directive 76/464 | - | - | - | |
Exposure Limits | [UK LT TWA 8 hr: 0.5 mg/m3], [UK STEL 15 mins: 2 mg/m3] | UK EA QS database, 2018 | - | |
Exposure Routes | Public | - | ||
Occupational | - | |||
European MRLs | Click here for the EU MRL pesticide database | |||
Drinking Water Standards | - | - | - | |
Drinking Water MAC (μg l-1) | - | - | - |
Health issues:
Carcinogen | Mutagen | Endocrine disrupter | Reproduction / development effects | Cholinesterase inhibitor | Neurotoxicant | |||
Respiratory tract irritant | Skin irritant | Skin sensitiser | Eye irritant | Phototoxicant | ||||
- |
- |
- |
|
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General human health issues | Toxic USEPA - probable human carcinogen Endocrine issues - Weak estrogenic effect |
: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found
Handling issues:
Language | Name |
English | propoxur |
French | propoxur |
German | Propoxur |
Danish | propoxur |
Italian | propoxur |
Spanish | propoxur |
Greek | propoxur |
Slovenian | propoksur |
Polish | propoksur |
Swedish | - |
Hungarian | - |
Dutch | propoxur |
Record last updated: Friday 24 August 2018
Contact: aeru@herts.ac.uk
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