INTERNATIONAL UNION
   OF PURE AND APPLIED
   CHEMISTRY
contact
propoxur (Ref: OMS 33)
** arprocarb ** PHC ** propotox ** ENT 25671 ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

SUMMARY

Propoxur is a carbamate pesticide not approved for use in the EU. With a high aqueous solubilty, it has potential for being mobile in groundwaters although it is rarely reported. It is not highly volatile. In some instances it may persist in soil systems. It is highly toxic to humans if it is ingested but not other serious health issues have been identified. There are gaps in information relating to the toxicity of propoxur to biodiversity but based on information that is available it likely to be moderately to highly toxic. .

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for propoxur

Description: A insecticide and acaricide active against a wide range of pests especially those that cause damage via sucking and chewing. Also used for flea control on domestic pets.

Example pests controlled: Cockroaches; Flies; Mosquitoes; Fleas; Ticks; Aphids; Leaf hoppers

Example applications: Ornamentals; Lawns & turf; Glasshouse crops including tomatoes & cucumbers

Efficacy & activity: -

Availability status: Current

Introduction & key dates: 1959; first registered in the US in 1963.

EC Regulation 1107/2009 (repealing 91/414):
Status Not approved
Dossier rapporteur/co-rapporteur Not applicable
Date inclusion expires Expired
EU Candidate for substitution (CfS) Not applicable
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia, USA

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism -
Chemical formula C11H15NO3
Canonical SMILES CC(C)OC1=CC=CC=C1OC(=O)NC
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) ISRUGXGCCGIOQO-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C11H15NO3/c1-8(2)14-9-6-4-5-7-10(9)15-11(13)12-3/h4-8H,1-3H3,(H,12,13)
Structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Insecticide, Acaricide, Veterinary substance
Substance group Carbamate
Minimum active substance purity -
Known relevant impurities -
Substance origin Synthetic
Mode of action Non-systemic with contact and stomach action. Acetylcholinesterase (AChE) inhibitor.
CAS RN 114-26-1
EC number 204-043-8
CIPAC number 80
US EPA chemical code 047802
PubChem CID 4944
Molecular mass (g mol-1) 209.24
PIN (Preferred Identification Name) -
IUPAC name 2-isopropoxyphenyl methylcarbamate
CAS name 2-(1-methylethoxy)phenyl methylcarbamate
Other status information Marine Pollutant
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) 1A
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance Aedes aegypti
Amblyseius potentillae
Anopheles albimanus
Anopheles atroparvus
Anopheles funestus
many others
Physical state White crystalline solid
Related substances & organisms -

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • Bayer
  • Makhteshim-Agan
  • Mobay
Example products using this active
  • Unden
  • Rhoden
  • Baygon
  • Sendran
UK LERAP status No UK approval for use as a pesticide under EC Regulation 1107/2009
Formulation and application details Often supplied as emulsifiable concentrates, granules, dusts or wettable powders.


ENVIRONMENTAL FATE

for propoxur

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 1800 H4 High
Solubility - In organic solvents at 20oC (mg l-1) 200000 L3 - Isopropanol -
94000 L3 - Toluene -
1300 L3 - Hexane -
Melting point (oC) 90 E3 -
Boiling point (oC) Decomposes on distillation E3 -
Degradation point (oC) - - -
Flashpoint (oC) - - -
Octanol-water partition coefficient at pH 7, 20oC P 1.38 X 1000 Calculated -
Log P 0.14 G4 Low
Bulk density (g ml-1)/Specific gravity 1.18 L3 -
Dissociation constant (pKa) at 25oC - - -
Note:
Vapour pressure at 20oC (mPa) 1.3 E3 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 1.50 X 10-04 E3 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 3.73 Calculated High leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 6.36 X 10-01 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Medium
Maximum UV-vis absorption L mol-1 cm-1 - - -
Surface tension (mN m-1) - - -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 79 K4 Moderately persistent
DT50 (lab at 20oC) 30 Q2 Moderately persistent
DT50 (field) 28 L3 Non-persistent
DT90 (lab at 20oC) - - -
DT90 (field) - - -
DT50 modelling endpoint - - -
Note Best available data
Dissipation rate RL50 on plant matrix Value 0.65 R3 -
Note Leaves of ornamentals grown undercover, n=1
Dissipation rate RL50 on and in plant matrix Value 0.4 R3 -
Note Beans, leaves, n=1
Aqueous photolysis DT50 (days) at pH 7 Value 0.01 K4 Fast
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value 180 K3 Persistent
Note -
Water-sediment DT50 (days) 2 K4 Fast
Water phase only DT50 (days) - - -

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - G3 Mobile
Koc 30
Notes and range -
Freundlich Kf - - -
Kfoc -
1/n -
Notes and range -
pH sensitivity -

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
2-(1-methylethoxy)phenol - Soil (Photolysis) - -
dimethyl propoxus - Plant 0.27-0.36 -


ECOTOXICOLOGY

for propoxur

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) Low risk R3 Dapid aquatic degradation Low potential
CT50 (days) Not available -
Mammals - Acute oral LD50 (mg kg-1) ~ 50 L3 Rat High
Mammals - Short term dietary NOEL (mg kg-1) - L2 Rat, 2 year -
(ppm diet) 200 -
Birds - Acute LD50 (mg kg-1) 25.9 G4 Colinus virginianus High
Birds - Short term dietary (LC50/LD50) - - -
Fish - Acute 96 hour LC50 (mg l-1) 6.2 E3 Lepomis macrochirus Moderate
Fish - Chronic 21 day NOEC (mg l-1) - - -
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 0.15 E3 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) - - -
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) 38.1 F3 Chironomus riparius, 1 day Moderate
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) - - -
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) - - -
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees Contact acute 48 hour LD50 (μg bee-1) 0.112 F3 Apis mellifera, 24hr High
Oral acute 48 hour LD50 (μg bee-1) - - -
Unknown mode acute 48 hour LD50 (μg bee-1) > 1.35 F4 Moderate
Earthworms - Acute 14 day LC50 (mg kg-1) - - -
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect Harmful AA2 Chrysoperla carnea -
Other arthropod (2) LR50 g ha-1 - - -
% Effect - - -
Soil micro-organisms - - -
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for propoxur

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) ~ 50 L3 Rat High
Mammals - Dermal LD50 (mg kg-1 body weight) > 5000 L3 Rat -
Mammals - Inhalation LC50 (mg l-1) > 0.50 E3 Rat -
Other Mammal toxicity endpoints Intraperitoneal LD50 = 30 mg kg-1 V3 Rat -
Intramuscular LD50 = 53 mg kg-1 V3 Rat -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.02 JMPR 1989 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) - - -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) - - -
Dermal penetration studies (%) - - -
Dangerous Substances Directive 76/464 - - -
Exposure Limits [UK LT TWA 8 hr: 0.5 mg/m3], [UK STEL 15 mins: 2 mg/m3] UK EA QS database, 2018 -
Exposure Routes Public -
Occupational -
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

-

General human health issues Toxic
USEPA - probable human carcinogen
Endocrine issues - Weak estrogenic effect

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes No information available
CLP classification 2013 Human: H301
Environment: H400, H410
EC Risk Classification Click here to view information omn the EU risk phrases T - Toxic: R25
N - Dangerous for the environment: R50, R53
EC Safety Classification Click here to view information omn the EU safety phrases S2, S37, S45, S60, S61
WHO Classification II - Moderately hazardous
US EPA Classification (formulation) II - Warning - Moderately toxic
UN Number 2757
Waste disposal & packaging Click here for a description of UN packaging marks -


TRANSLATIONS

for propoxur

Language Name
English propoxur
French propoxur
German Propoxur
Danish propoxur
Italian propoxur
Spanish propoxur
Greek propoxur
Slovenian propoksur
Polish propoksur
Swedish -
Hungarian -
Dutch propoxur

Record last updated: Friday 24 August 2018
Contact: aeru@herts.ac.uk
© University of Hertfordshire