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proquinazid (Ref: DPX KQ926)
** IN KQ926 ** Translations

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GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for proquinazid

Description: A fungicide with the potential to control powdery mildew in a range of crops including cereals

Example pests controlled: Powdery mildew; Septoria leaf blotch; Glume blotch; Yellow rust; Brown rust; Eyespot; Ear disease complex

Example applications: Cereals including wheat, barley, oats, rye, triticale; Grapes

Efficacy & activity: Wheat/Mildew=High; Mildew=Moderate for protection, Low for eradication

Availability status: Current

Introduction & key dates: 2005

EC Regulation 1107/2009 (repealing 91/414):
Status Approved
Dossier rapporteur/co-rapporteur Sweden/Lithuania
Date inclusion expires 31/07/2022
EU Candidate for substitution (CfS) No
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism -
Chemical formula C14H17IN202
Canonical SMILES CCCN1C(=O)C2=C(C=CC(=C2)I)N=C1OCCC
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) FLVBXVXXXMLMOX-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C14H17IN2O2/c1-3-7-17-13(18)11-9-10(15)5-6-12(11)16-14(17)19-8-4-2/h5-6,9H,3-4,7-8H2,1-2H3
Structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Fungicide
Substance group Quinazolinone
Minimum active substance purity -
Known relevant impurities EU dossier - None declared
Substance origin Synthetic
Mode of action Preventative and curative activity. Translocates and inhibits appressoria development stopping infections. Signal transduction
CAS RN 189278-12-4
EC number -
CIPAC number 764
US EPA chemical code 044502
PubChem CID 11057771
Molecular mass (g mol-1) 372.2
PIN (Preferred Identification Name) -
IUPAC name 6-iodo-2-propoxy-3-propylquinazolin-4(3H)-one
CAS name 6-iodo-2-propoxy-3-propyl-4(3H)-quinazolinone
Other status information PAN listed Highly Hazardous Chemical
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) 13
Examples of recorded resistance -
Physical state White crystalline solid
Related substances & organisms -

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • DuPont
Example products using this active
  • Justice
  • Talius
  • Talendo
UK LERAP status Buffer probably required in UK - see product label
Formulation and application details Often supplied as an emulsifiable concentrate that is mixed with water and used as a spray.


ENVIRONMENTAL FATE

for proquinazid

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 0.93 A5 Low
Solubility - In organic solvents at 20oC (mg l-1) 250000 A5 - Acetone -
250000 A5 - Dichloromethane -
250000 A5 - Ethyl acetate -
136000 A5 - Methanol -
Melting point (oC) 62 A5 -
Boiling point (oC) Decomposes before boiling A5 -
Degradation point (oC) 367 A5 -
Flashpoint (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 3.16 X 1005 Calculated -
Log P 5.5 A5 High
Bulk density (g ml-1)/Specific gravity 1.57 A5 -
Dissociation constant (pKa) at 25oC Not applicable A5 -
Note: No dissociation
Vapour pressure at 20oC (mPa) 0.09 A5 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 3.00 X 10-02 A5 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index -0.19 Calculated Low leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 5.35 X 10-03 Calculated -
Note Estimated concentrations of chemicals with Koc values greater than 9995 ml g-1 are beyond the scope of the regression data used in SCI-GROW development. If there are concerns for such chemicals, a higher tier groundwater exposure assessment should be considered, regardless of the concentration returned by SCI-GROW
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated High
Maximum UV-vis absorption L mol-1 cm-1 Neutral, acid & basic media: 270nm = 16000, 325nm = 300 A5 -
Surface tension (mN m-1) 73.9 A5 at 19.8oC -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 45 L3 Moderately persistent
DT50 (lab at 20oC) 60 A5 Moderately persistent
DT50 (field) 30.5 A5 Moderately persistent
DT90 (lab at 20oC) 483 A5 -
DT90 (field) 100 A5 -
DT50 modelling endpoint - - -
Note EU dossier lab studies DT50 range 28-239 days 4 soils, DT90 range 131-1150 days, field studies DT50 range 5.5-70 days European soils, DT90 range 18-231 days
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value 1.0 R4 -
Note Published literature RL50 range 0.77-1.26 days, Grapes, various matrices, n=2
Aqueous photolysis DT50 (days) at pH 7 Value 0.03 A5 Fast
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value Stable A5 -
Note Stable pH 4 to pH 9 at 20 degC
Water-sediment DT50 (days) 70.5 A5 Moderately fast
Water phase only DT50 (days) 0.78 A5 Fast

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - - -
Koc -
Notes and range -
Freundlich Kf 194 A5 Non-mobile
Kfoc 12870
1/n 0.94
Notes and range EU dossier Kf range 107-295 mL/g, Kfoc range 9091-16769 mL/g, 1/n range 0.91-0.98, Soils=4
pH sensitivity No

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
2-propoxy-3-propylquinazolin-4(3H)-one (Ref: IN-MM671) This metabolite may cause environmental pollution, click here for further information Soil   0.65   Major fraction, Relevant
6-iodo-3-propylquinazoline-2,4(1H,3H)-dione (Ref: IN-MM986) Soil   0.02   Minor fraction, Relevant
3-propylquinazoline-2,4(1H,3H)-dione (Ref: IN-MM991) Soil   0.07   Minor fraction, Relevant

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
(Ref: IN-GJ515) - Rat (Faeces, Urinary) - -
(Ref: IN-MM991)
Note: Risk for groundwater
- a = Plant; b = Water (Hydrolysis, Photolysis); Soil (c = Aerobic, d = Anaerobic); Sediment c=0.07; d=0.01 -
(Ref: IN-MT884)
Note: Risk for groundwater
- Water (Photolysis, Hydrolysis) - -
(Ref: IN-MU210) - Plant; Animal (Urinary); Rat - -
(Ref: IN-MU715) - Rat (Faeces, Urinary) - -
(Ref: IN-MW397) - Poultry (Eggs) - -
(Ref: IN-MW398) - Poultry (Eggs) - -
(Ref: IN-MW977) - Plant - -
(Ref: IN-MY340) - Plant; Poultry (Eggs) - -
(Ref: IN-MY341) - Plant - -
(Ref: IN-NA251) - Animal; Poultry (Eggs) - -
(Ref: IN-NA252) - Animal - -
(Ref: IN-NB673) - Rat (Faeces, Urinary) - -


ECOTOXICOLOGY

for proquinazid

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 821 A5 Whole fish Threshold for concern
CT50 (days) Not available -
Mammals - Acute oral LD50 (mg kg-1) 4846 A5 Rat Low
Mammals - Short term dietary NOEL (mg kg-1) - - -
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) > 2250 A5 Colinus virginianus Low
Birds - Short term dietary (LC50/LD50) 1371 mg kg bw-1 day-1 A5 Colinus virginianus -
Fish - Acute 96 hour LC50 (mg l-1) 0.349 A5 Oncorhynchus mykiss Moderate
Fish - Chronic 21 day NOEC (mg l-1) 0.003 A4 Oncorhynchus mykiss, technical material High
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 0.287 A5 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 0.0018 A4 Daphnia magna, technical material High
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) 0.11 A5 Americamysis bahia Moderate
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) 0.456 A5 Chironomus riparius Moderate
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) > 0.2 A5 Lemna gibba Moderate
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) 0.684 A5 Pseudokirchneriella subcapitata Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees Contact acute 48 hour LD50 (μg bee-1) > 197 A5 Low
Oral acute 48 hour LD50 (μg bee-1) > 125 A5 Low
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) > 1000 A5 Eisenia foetida Low
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) 50.9 A5 Eisenia foetida, 56 days Moderate
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 131.4 A5 Aphidius rhopalosiphi -
% Effect - - -
Other arthropod (2) LR50 g ha-1 47.85 A5 Typhlodromus pyri -
% Effect - - -
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: 50 mg kg-1 soil
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for proquinazid

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) 4846 A5 Rat Low
Mammals - Dermal LD50 (mg kg-1 body weight) > 5000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) > 5.2 A5 Rat, 4 hr (nose only) -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.01 A3 proposed Rat, 2 year, SF=100 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) 0.2 A3 proposed Dog, SF=100 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.02 A3 proposed Rat, 90 day, SF=100 -
Dermal penetration studies (%) 2.0-12.0 A5 concentration dependent -
Dangerous Substances Directive 76/464 - - -
Exposure Limits - - -
Exposure Routes Public No unacceptable risks to bystanders identified
Occupational Risk of exposure acceptable under label recommendations for use for personal protection clothing and equipment
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) 0.1 EU Dir 89/778/EC limit; A5 Calc MAC=30.0 μg l-1 -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

-

-

-

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

-

General human health issues Formulation may be eye irritant
Possible liver and thyroid toxicant
May cause hormonal changes
USEPA - some evidence to suggest possible human carcinogen

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive or oxidising
IMDG Transport Code is usually 9
CLP classification 2013 Health: H351
Environment: H400, H410
EC Risk Classification Click here to view information omn the EU risk phrases Carcinogen category 3: R40
Xn - Harmful: R41
N - Dangerous for the environment: R50, R53
EC Safety Classification Click here to view information omn the EU safety phrases S35, S57
WHO Classification NL - Not listed
US EPA Classification (formulation) - -
UN Number Usually 3082
Waste disposal & packaging Click here for a description of UN packaging marks Packaging Group III (minor danger)


TRANSLATIONS

for proquinazid

Language Name
English proquinazid
French proquinazid technique
German Proquinazid
Danish proquinazid
Italian proquinazid
Spanish proquinazid
Greek -
Slovenian prokvinazid
Polish proquinazid
Swedish -
Hungarian -
Dutch -

Record last updated: Thursday 23 August 2018
Contact: aeru@herts.ac.uk
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