pyridaben (Ref: BAS 300l) ** piridabena ** NC 129 ** Translations

Environmental Fate - Ecotoxicology - Human Health

GENERAL INFORMATION

Description: An insecticide and acaricide affective against thrips, mites, aphids and leafhoppers

Introduction: 1988, first reported; 1990, first marketed Belgium

EC Directive 1107/2009 (repealing 91/414):

Status	Annex 1
Dossier rapporteur/co-rapporteur	Netherlands
Date inclusion expires	30/04/2021

Approved for use () or known to be used () in the following European countries:

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also registered in: Australia, Japan

General status:

Pesticide type	Insecticide, Acaricide
Substance group	Pyridazinone
Substance origin	Synthetic
Mode of action	Non-systemic with rapid knock down action and long residual activity
CAS RN	96489-71-3
EC number	405-700-3
CIPAC number	583
US EPA chemical code	-
Chemical formula	C19H25CIN2OS
SMILES	O=C2C(\Cl)=C(\SCc1ccc(cc1)C(C)(C)C)/C=N\N2C(C)(C)C
International Chemical Identifier (InChI)	InChI=1/C19H25ClN2OS/c1-18(2,3)14-9-7-13(8-10-14)12-24-15-11-21-22(19(4,5)6)17(23)16(15)20/h7-11H,12H2,1-6H3
Structure diagram/image available?	Yes
Molecular mass (g mol-1)	364.93
IUPAC Name	2-tert-butyl-5-(4-tert-butylbenzylthio)-4-chloropyridazin-3(2H)-one
CAS Name	4-chloro-2-(1,1-dimethylethyl)-5-[[[4-(1,1-dimethylethyl)phenyl]methyl]thio]-3(2H)-pyridazinone
Other status information	-
Herbicide Resistance Classification (HRAC)	Not applicable
Insecticide Resistance Classification (IRAC)	21
Fungicide Resistance Classification (FRAC)	Not applicable
Physical state	White crystals
Related substances & organisms	-

Formulations:

Property	Value
Example manufacturers of products using this active	Nissan Chemicals
Example products using this active	Nexter Pro Sanmite 75WP Pyramite
UK LERAP status	No UK approval for use or outside scope
Formulation and application details	Usually supplied as a wettable powder and suspension concentrates that are mixed with water and applied as a spray.

ENVIRONMENTAL FATE

Property		Value	Source/Quality Score/Other Information	Interpretation
Solubility - In water at 20oC (mg l-1)		0.022	A5	Low
Solubility - In organic solvents at 20oC (mg l-1)		333000	A5 - Acetone	-
		345000	A5 - Xylene	-
		49400	A5 - Methanol	-
		14100	A5 - n-Hexane	-
Melting Point (oC)		109.4	A5	-
Boiling Point (oC)		Decomposes before boiling	A5	-
Degradation point (oC)		200	A4	-
Flashpoint (oC)		Not highly flammable	A5	-
Octanol-water partition coefficient at pH 7, 20oC	P	2.34 X 1006	Calculated	-
	Log P	6.37	A5	High
Bulk density (g ml-1)/Specific gravity		1.2	L3	-
Dissociation constant (pKa) at 25oC		Not applicable	A5	-
		Note: No dissociation
Vapour pressure at 25oC (mPa)		0.001	A2	Non-volatile
Henry's law constant at 25oC (Pa m3 mol-1)		0.3	A2	Moderately volatile
Henry's law constant at 20oC (dimensionless)		3.13 X 10-03	K3	Volatile
GUS leaching potential index		-1.43	Calculated	Low leachability
SCI-GROW groundwater index (µg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate	Value	5.35 X 10-03	Calculated	-
	Note	Estimated concentrations of chemicals with Koc values greater than 9995 ml g-1 are beyond the scope of the regression data used in SCI-GROW development. If there are concerns for such chemicals, a higher tier groundwater exposure assessment should be considered, regardless of the concentration returned by SCI-GROW
Potential for particle bound transport index		-	Calculated	High
Maximum UV-vis absorption L mol-1 cm-1		Neutral solution 296.5nm = 11746, 236.2nm = 21102, 223.4nm = 23221; [Acidic solution: 296.9nm = 11785, 236.3nm= 21142, 223.3nm = 23327; [Basic solution 296.6nm = 11724, 236.3nm = 21015, 223.3nm = 23037	A5	-
Surface tension (mN m-1)		Not applicable	A5 Low aqueous solubility	-

Degradation:

Property		Value	Source/Quality Score/Other Information	Interpretation
Soil degradation (days) (aerobic)	DT50 (typical)	55	K4	Moderately persistent
	DT50 (lab at 20oC)	106	A5	Persistent
	DT50 (field)	29	A5	Non-persistent
	DT90 (lab at 20oC)	1520	A3	-
	DT90 (field)	188	A5	-
	Note	EU dossier lab studies DT50 range 50-199 days, DT90 range 241-4522 days; field study DT50 range 5-128 days, DT90 range 98-424 days; Other sources: DT50 86 days (DW4)
Aqueous photolysis DT50 (days) at pH 7	Value	0.005	A5	Fast
	Note	Rapid
Aqueous hydrolysis DT50 (days) at 20oC and pH 7	Value	Stable	A5	Very persistent
	Note	Stable pH 5 to pH 9 at 25 degC
Water-Sediment DT50 (days)		17.5	A5	Fast
Water phase only DT50 (days)		1.18	A5	Moderately fast

Soil adsorption and mobility:

Property		Value	Source/Quality Score/Other Information	Interpretation
Linear	Kd	-	-	-
	Koc	-
	Notes and range	-
Freundlich	Kf	276	A5	Non-mobile
	Kfoc	66503
	1/n	0.95
	Notes and range	EU dossier kf range 108-445 mL/g, Kfoc range 34858-87918 mL/g, 1/n range 0.90-1.28, Soils=4
pH sensitivity		No

Key metabolites:

Metabolite		Formation Medium	Estimated Maximum Occurrence Fraction	91/414 Relevancy
2-tert-butyl-5-(4-(1-carboxy-1-methylethyl) benzylthio)4-chloropyridazin-3 (2H)-one		Soil	0.085	Minor fraction, Relevant
2-tert-butyl-4-chloropyridazin-3(2H)-one-5-sulfonic acid		Soil	0.076	Minor fraction, Relevant

Other known metabolites:

Metabolite name and reference	Aliases	Formation Medium / Rate	Estimated Maximum Occurrence Fraction	Metabolising Enzymes
2-tert-butyl-4-chloro-5-[4-(1,1-dimethyl-2-hydroxyethyl)benzylthio]-chloropyridazin-3 (2H)-one	PB-9	-	-	-

ECOTOXICOLOGY

Property		Value	Source/Quality Score/Other Information	Interpretation
Bio-concentration factor	BCF	48	A5	Low potential
	CT50 (days)	0.8		-
Bioaccumulation potential		-	Calculated	Low
Mammals - Acute oral LD50 (mg kg-1)		161	A5 Rat	Moderate
Mammals - Short term dietary NOEL	(mg kg-1)	-	-	-
	(ppm diet)	-		-
Birds - Acute LD50 (mg kg-1)		> 2250	A5 Colinus virginianus	Low
Birds - Short term dietary (LC50/LD50)		> 4298 mg kg bw-1 day-1	A5 Colinus virginianus	-
Fish - Acute 96 hour LC50 (mg l-1)		0.0007	A5 Oncorhynchus mykiss	High
Fish - Chronic 21 day NOEC (mg l-1)		-	-	-
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1)		0.001	A5 Daphnia magna	High
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1)		0.000086	A5 Daphnia magna	-
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1)		0.00054	F3 Americamysis bahia	High
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1)		-	-	-
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1)		-	-	-
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1)		-	-	-
Aquatic plants - Acute 7 day EC50, biomass (mg l-1)		0.016	F3 Lemna gibba	Moderate
Algae - Acute 72 hour EC50, growth (mg l-1)		0.017	A5 Pseudokirchneriella subcapitata	Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1)		-	-	-
Honeybees - Acute 48 hour LD50 (µg bee-1)		0.024	A5 Contact	High
Earthworms - Acute 14 day LC50 (mg kg-1)		19	A5 Eisenia foetida, corr	Moderate
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1)		0.29	A5 Eisenia foetida	Moderate
Other soil macro-organisms - e.g. Collembola	LR50product ha EC50product ha NOECproduct ha % Effect	3.28	A5 Folsomia candida, 28 day NOEC mg kg-1	-
Other arthropod (1)	LR50 g ha-1	<47	48 hour A5 Aphidius rhopalosiphi, adult	Harmless at 1 kg ha-1
	% Effect	-	-	-
Other arthropod (2)	LR50 g ha-1	<47	7 day A5 Typhlodromus pyri protonymph	Harmless at 1 kg ha-1
	% Effect	-	-	-
Soil micro-organisms		-	-	-
Mesocosm study data	NOEAEC mg l-1	-	-	-
	NOEAEC mg l-1	-	-	-

HUMAN HEALTH AND PROTECTION

General:

Property		Value	Source/Quality Score/Other Information	Interpretation
Mammals - Acute oral LD50 (mg kg-1)		161	A5 Rat	Moderate
Mammals - Dermal LD50 (mg kg-1 body weight)		> 2000	A5 Rat	-
Mammals - Inhalation LC50 (mg l-1)		0.62	A5 Rat	-
Other Mammal toxicity endpoints		-		-
ADI - Acceptable Daily Intake (mg kg-1bw day-1)		0.01	A3 Rat, SF=100	-
ARfD - Acute Reference Dose (mg kg-1bw day-1)		0.05	A3 Rabbit, SF=100	-
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1)		0.005	A3 Rat, SF=10	-
Dermal penetration studies (%)		0.4-1.2	A5 concentration dependant	-
Dangerous Substances Directive 76/464		-	-	-
Exposure Limits		-	-	-
Exposure Routes	Public	[Risk to bystanders if they enter greenhouses after spraying]
	Occupational	[No unacceptable risks to operators or other workers identified utilising PPE/PPC]
Examples of European MRLs (mg kg-1)	Value	Orange: 0.2; Tomato: 0.1
	Note	[A5 EU dossier proposals] For the EU pesticides database click here
Drinking Water MAC (µg l-1)		0.1	EU Dir 89/778/EC limit; Calc MAC=30 µg/l; A5	-

Health issues:

Carcinogen	Mutagen	Endocrine disrupter	Reproduction / development effects	Acetyl cholinesterase inhibitor	Neurotoxicant	Respiratory tract irritant	Skin irritant	Eye irritant
	-	-
General human health issues		[Moderately toxic]

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data

Handling issues:

Property		Value	Source/Quality Score/Other Information	Interpretation
General		[Not explosive or oxidising], [IMDG Transport Code is usually 6.1]
EC Risk Classification		[T - Toxic: R23/25], [N - Dangerous for the environment: R50, R53]
EC Safety Classification		S1/2, S36/37, S45, S60, S61
WHO Classification		II	-	Moderately hazardous
US EPA Classification (formulation)		I	-	Danger - Highly toxic
UN Number		Usually 3077
Waste disposal & packaging		[Usually Packaging Group II (medium danger)]

TRANSLATIONS