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quinoxyfen (Ref: DE 795)
** quinoline ** Translations

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GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for quinoxyfen

Description: A fungicide used mainly to control powdery mildew in cereals and other crops

Example pests controlled: Powdery mildew

Example applications: Cereals; Grapes; Curcubits; Mangoes; Tomato

Efficacy & activity: Wheat/Mildew=Low; Mildew=Low for protection, no data for eradication

Availability status: Current

Introduction & key dates: 1996, Europe

EC Regulation 1107/2009 (repealing 91/414):
Status Approved
Dossier rapporteur/co-rapporteur UK/Austria
Date inclusion expires 30/04/2019
EU Candidate for substitution (CfS) Yes - two 'Persistent-Bioaccumulative-Toxic' criteria
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia, Chile, USA

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism -
Chemical formula C15H8Cl2FNO
Canonical SMILES C1=CC(=CC=C1OC2=C3C(=CC(=CC3=NC=C2)Cl)Cl)F
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) WRPIRSINYZBGPK-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C15H8Cl2FNO/c16-9-7-12(17)15-13(8-9)19-6-5-14(15)20-11-3-1-10(18)2-4-11/h1-8H
Structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Fungicide
Substance group Quinoline
Minimum active substance purity 99.7%
Known relevant impurities EU 2003 dossier - 4,5,7-trichloroquinoline
Substance origin Synthetic
Mode of action Systemic with protective properties, translocates and inhibits appressoria development stopping infections. Signal transduction
CAS RN 124495-18-7
EC number -
CIPAC number 566
US EPA chemical code 055459
PubChem CID 3391107
Molecular mass (g mol-1) 308.13
PIN (Preferred Identification Name) 5,7-dichloro-4-(4-fluorophenoxy)quinoline
IUPAC name 5,7-dichloro-4-quinolyl 4-fluorophenyl ether
CAS name 5,7-dichloro-4-(4-fluorophenoxy)quinoline
Other status information -
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) 13
Examples of recorded resistance -
Physical state Off-white solid
Related substances & organisms

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • Dow AgroSciences
Example products using this active
  • Apres
  • Excelsior
  • Fortress
  • Orka
  • Legend
  • proxima
UK LERAP status Buffer probably required in UK - see product label
Formulation and application details Often supplied as a soluble concentrate that is mixed with water and used as a spray.


ENVIRONMENTAL FATE

for quinoxyfen

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 0.047 A5 Low
Solubility - In organic solvents at 20oC (mg l-1) 9640 A5 - Hexane -
21500 A5 - Methanol -
272000 A5 - Toluene -
116000 A5 - Acetone -
Melting point (oC) 103 A5 -
Boiling point (oC) - - -
Degradation point (oC) - - -
Flashpoint (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 1.26 X 1005 Calculated -
Log P 5.1 A5 High
Bulk density (g ml-1)/Specific gravity 1.56 A5 -
Dissociation constant (pKa) at 25oC Not applicable A5 -
Note: No dissociation
Vapour pressure at 20oC (mPa) 0.012 A5 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 3.08 X 10-02 A5 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index -0.90 Calculated Low leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 5.35 X 10-03 Calculated -
Note Estimated concentrations of chemicals with Koc values greater than 9995 ml g-1 are beyond the scope of the regression data used in SCI-GROW development. If there are concerns for such chemicals, a higher tier groundwater exposure assessment should be considered, regardless of the concentration returned by SCI-GROW
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated High
Maximum UV-vis absorption L mol-1 cm-1 Maxima at 298nm A5 -
Surface tension (mN m-1) - - -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 308 A5 Persistent
DT50 (lab at 20oC) 308 A5 Persistent
DT50 (field) 169.3 A5 Persistent
DT90 (lab at 20oC) - - -
DT90 (field) 2270 A5 -
DT50 modelling endpoint - - -
Note EU 2017 lab studies DT50 range 110-560 days, Soils = 12, Field studies DT50 range 14.7-588 days, DT90 range 391 - >10,000 days, Soils =10; EU 2003 dossier Lab studies DT50 range 224-508 days, field study DT50 range 13-190 days (EU), DT90 range 380-750 days
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value 7.2 R3 -
Note Grape berries, n=1
Aqueous photolysis DT50 (days) at pH 7 Value 0.8 A5 Fast
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value Stable A5 -
Note pH and temperature sensitive: DT50 75 days at pH 5 and 25 degC, 7 days at pH 5 and 50 degC, stable pH 7 and pH 9
Water-sediment DT50 (days) 127 A5 Slow
Water phase only DT50 (days) 5 A5 Moderately fast

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - - -
Koc -
Notes and range -
Freundlich Kf - A4 Non-mobile
Kfoc 22929
1/n -
Notes and range EU Dossier Kfoc range 18339 28897 mL/g
pH sensitivity -

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
3-hydroxy-quinoxyfen (Ref: 3-OH DE-795) This metabolite may cause environmental pollution, click here for further information Soil   0.270   Major fraction; Not significant

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
5,7-dichloro-4-(4-fluorophenoxy)quinoline-N-oxide DE-795 n-oxide; quinoxyfen n-oxide - - -
4-fluorophenol - Animal; Plamt - -
5,7-dichloro-4-hydroxyquinoline
Note: Minor metabolite
DCHQ Soils (acidic) 0.064 -
2-chloro-10-fluoro[1]benzopyrano[2,3,4-de-quinoline CFBPQ Water (Photolysis) - -
5,7-dichloro-4-(4-fluorophenoxy)-2-oxo-quinoline 2-oxo DE-795; 2-oxoquinoxyfen Plant; Soil (Aerobic) - -


ECOTOXICOLOGY

for quinoxyfen

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 5040 A5 High potential
CT50 (days) Not available -
Mammals - Acute oral LD50 (mg kg-1) > 5000 A5 Rat Low
Mammals - Short term dietary NOEL (mg kg-1) - L3 Rat -
(ppm diet) > 10 -
Birds - Acute LD50 (mg kg-1) > 2250 A5 Colinus virginianus Low
Birds - Short term dietary (LC50/LD50) > 5620 mg kg feed-1 A5 Colinus virginianus -
Fish - Acute 96 hour LC50 (mg l-1) 0.27 A5 Oncorhynchus mykiss Moderate
Fish - Chronic 21 day NOEC (mg l-1) 0.014 A5 Oncorhynchus mykiss Moderate
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 0.08 A5 Daphnia magna High
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 0.028 A5 Daphnia magna Moderate
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) 0.128 A5 Chironomus riparius, emergence Moderate
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) 0.548 A5 Chironomus riparius Moderate
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) 1.85 F4 Lemna gibba Moderate
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) 0.027 A4 Raphidocelis subcapitata, 120 hour Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) 0.026 Q2 Unknown species Moderate
Honeybees Contact acute 48 hour LD50 (μg bee-1) > 100 A5 Low
Oral acute 48 hour LD50 (μg bee-1) > 100 A5 Low
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) > 923 A5 Eisenia foetida Moderate
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) 2.67 A5 Eisenia foetida Moderate
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect 63
-85
Mortality
Parasitism
Dose: Not stated
A4 Aphidius rhopalosiphi, adult
-
Other arthropod (2) LR50 g ha-1 - - -
% Effect -93.3 Beneficial capacity
Dose: Not stated
A4 Typhlodromus pyri, adult
-
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: 5.3 mg kg-1 soil
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for quinoxyfen

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) > 5000 A5 Rat Low
Mammals - Dermal LD50 (mg kg-1 body weight) > 2000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) 2.38 A5 Rat -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.2 A5 Dog, SF=100 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) None allocated A5 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.14 A4 Dog, 1 year, SF=100 -
Dermal penetration studies (%) 10.0 A5 -
Dangerous Substances Directive 76/464 - - -
Exposure Limits - - -
Exposure Routes Public No unacceptable risks to bystanders identified
Occupational No unacceptable risks to operators or other workers identified
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

-

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

General human health issues Possible liver, kidney and blood toxicant

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive or oxidising
IMDG Transport Code is usually 9
CLP classification 2013 Health: H317
Environment: H400, H410
EC Risk Classification Click here to view information omn the EU risk phrases Xn - Harmful: R43
N - Dangerous for the environment: R50, R53
EC Safety Classification Click here to view information omn the EU safety phrases S2, S24, S37, S46, S60, S61
WHO Classification U - Unlikely to present an acute hazard
US EPA Classification (formulation) No consensus across products or no products available - -
UN Number 3082
Waste disposal & packaging Click here for a description of UN packaging marks Packaging Group III (minor danger)


TRANSLATIONS

for quinoxyfen

Language Name
English quinoxyfen
French quinoxyfen
German Quinoxyfen
Danish quinoxyfen
Italian quinoxifen
Spanish quinoxifen
Greek quinoxyfen
Slovenian kinoxifen
Polish quinoxyfen
Swedish -
Hungarian quinoxifen
Dutch quinoxyfen

Record last updated: Monday 02 July 2018
Contact: aeru@herts.ac.uk
© University of Hertfordshire