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simazine (Ref: G 27692)
** permazine ** symazine ** taphazine ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for simazine

Description: A soil-acting herbicide with used to control most germinating annual grasses and broad-leaved weeds. Has also been used to control algae in ponds and fish hatcheries.

Example pests controlled: Ivyleaved speedwell; Rocket; Shepherd's purse; Dead nettles; Goosefoot; Bindweed; Suppresses volunteer cereals

Example applications: Fruit including berries, currants, apples, pears; Hops; Almonds; Vines; Canola; Chickpeas; Beans; Lupins

Efficacy & activity: -

Availability status: Current

Introduction & key dates: circa 1960

EC Regulation 1107/2009 (repealing 91/414):

Status Not approved
Dossier rapporteur/co-rapporteur UK
Date inclusion expires Not applicable
EU Candidate for substitution (CfS) -
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia, USA

Chemical structure: Click here for further information on the general chemical status information used on this site

Isomerism -
Chemical formula C7H12ClN5
Canonical SMILES CCNC1=NC(=NC(=N1)Cl)NCC
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) ODCWYMIRDDJXKW-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C7H12ClN5/c1-3-9-6-11-5(8)12-7(13-6)10-4-2/h3-4H2,1-2H3,(H2,9,10,11,12,13)
2D structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site

Pesticide type Herbicide
Substance group Triazine
Minimum active substance purity -
Known relevant impurities -
Substance origin Synthetic
Mode of action Selective, systemic, absorbed through roots and foliage and translocated. Inhibits photosynthesis (photosystem II).
CAS RN 122-34-9
EC number 204-535-2
CIPAC number 22
US EPA chemical code 080807
PubChem CID 5216
Molecular mass (g mol-1) 201.66
PIN (Preferred Identification Name) 6-chloro-N2,N4-diethyl-1,3,5-triazine-2,4-diamine
IUPAC name 6-chloro-N2,N4-diethyl-1,3,5-triazine-2,4-diamine
CAS name 6-chloro-N,N'-diethyl-1,3,5-triazine-2,4-diamine
Other status information WFD priority substance; Potential groundwater and surface water contaminant; Chemical subject to PIC regulations
Relevant Environmental Water Quality Standards EU Directive 2008/105/EC EQS surface waters: annual average 1.0 ug/L; max measured 4.0 ug/L
UK stutory standard for the protection of aquatic life: freshwater and salt water annual average 2 ug/L
Herbicide Resistance Classification (HRAC) C1
Herbicide Resistance Classification (WSSA) 5
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance Amaranthus albus
Amaranthus blitoides
Physical state Colourless to white solid
Related substances & organisms -

Formulations:

Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • Loveland Chemicals
  • Makhteshim Agan
  • Syngenta
Example products using this active
  • Sanazine
  • Simanex
  • Amizina
  • Eagrow
  • Derby
UK LERAP status No UK approval for use as a pesticide under EC Regulation 1107/2009
Formulation and application details Available in a range of formulations including wettable powders, water dispersible granules, liquids and granules.


ENVIRONMENTAL FATE

for simazine

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 5 B5 Low
Solubility - In organic solvents at 20oC (mg l-1) 570 L3 - Ethanol -
1500 L3 - Acetone -
130 L3 - Toluene -
3.1 L3 - n-Hexane -
Melting point (oC) Decomposes before melting L3 -
Boiling point (oC) Decomposes before boiling L3 -
Degradation point (oC) 226 L3 -
Flashpoint (oC) Not expected to self ignite; Not highly flammable L3 -
Octanol-water partition coefficient at pH 7, 20oC P 2.00 X 1002 Calculated -
Log P 2.3 B5 Low
Bulk density (g ml-1)/Specific gravity 1.3 B5 -
Dissociation constant (pKa) at 25oC 1.62 L3 -
Note: Very weak base
Vapour pressure at 20oC (mPa) 0.00081 B5 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 5.60 X 10-05 L3 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 2.00 Calculated Transition state
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 7.96 X 10-02 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Medium
Maximum UV-vis absorption L mol-1 cm-1 - - -
Surface tension (mN m-1) - - -

Degradation:

Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 60 DW4 Moderately persistent
DT50 (lab at 20oC) - - -
DT50 (field) 90 B4 Moderately persistent
DT90 (lab at 20oC) - - -
DT90 (field) - - -
DT50 modelling endpoint - - -
Note Other sources: DT50 27-102 days (R3), 91 days at 25 DegC (R4)
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value - - -
Note -
Aqueous photolysis DT50 (days) at pH 7 Value 1.9 K4 Moderately fast
Note Unstable in UV light
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value 96 B4 Moderately persistent
Note Stable under normal environmental conditions, hydrolysis does occur in strong acid and alkai solutions
Water-sediment DT50 (days) 33 Q2 Moderately fast
Water phase only DT50 (days) 46 K4 Stable

Soil adsorption and mobility:

Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - G3 Moderately mobile
Koc 130
Notes and range Other sources: Log Koc 2.14 at 25 Deg C (R3), 2.11 (R3)
Freundlich Kf 15.88 R4 Slightly mobile
Kfoc 750
1/n 0.76
Notes and range Kf range 4.59-20.6 mL/g, Kfoc range 124-1585 mL/g, 1/n range 0.33-0.89, Soils=3
pH sensitivity -

Key metabolites:

Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
6-deisopropyl atrazine (Ref: G-28279) Soil   -   -
2-hydroxy-4,6-bis(ethlyamino)-S-triazine Soil   -   -


ECOTOXICOLOGY

for simazine

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 221 F3 Threshold for concern
CT50 (days) Not available -
Mammals - Acute oral LD50 (mg kg-1) > 5000 B4 Rat Low
Mammals - Short term dietary NOEL (mg kg-1) 6.9 B5 Rat High
(ppm diet) 200 -
Birds - Acute LD50 (mg kg-1) 4640 B5 Anas platyrhynchos Low
Birds - Short term dietary (LC50/LD50) - - -
Fish - Acute 96 hour LC50 (mg l-1) 90 B5 Lepomis macrochirus Moderate
Fish - Chronic 21 day NOEC (mg l-1) 0.7 P3 Unknown species Moderate
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 1.1 B5 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 2.5 F3 Daphnia magna, LOEC Moderate
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) 0.3 F3 Lemna gibba Moderate
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) 0.04 B5 Scenedemus subspicatus Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) 0.6 Q2 Unknown species Moderate
Honeybees (Apis spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) 97 B3 Moderate
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Unknown mode acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Bumblebees (Bombus spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
-
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
-
Mason bees (Osmia spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Other pollinators (1) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Other pollinators (2) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Earthworms - Acute 14 day LC50 (mg kg-1) 1000 B5 Eisenia foetida Moderate
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect Harmless Dose: 1125 g ha-1
AA3 Typhlodromus pyri
-
Other arthropod (2) LR50 g ha-1 - - -
% Effect Harmless Dose: 1125 g ha-1
AA3 Chrysoperla carnea
-
Soil micro-organisms - - -
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for simazine

General:

Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) > 5000 B4 Rat Low
Mammals - Dermal LD50 (mg kg-1 body weight) > 2000 L3 Rat -
Mammals - Inhalation LC50 (mg l-1) 5.5 L3 Rat -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.005 UK ACP 1999 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) - - -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.05 UK ACP 1999 -
Dermal penetration studies (%) - - -
Dangerous Substances Directive 76/464 List II - -
Exposure Routes Public -
Occupational -
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards Non-statutory WHO drinking water guideline 0.002 mg/L UK EA QS database, 2018 -
Drinking Water MAC (μg l-1) - - -

Health issues:

Carcinogen Genotoxic Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

A3; B3; C3; D0; E3

-

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

General human health issues May cause dermatitis
May cause tremor, convulsions, paralysis, cyanosis, slowed respiration and diarrhea
Endocrine issues - Induction of aromatase activity, increase of estrogen production
Key: Genotoxicity
A: Chromosome aberration (EFSA database)
B: DNA damage/repair (EFSA database)
C: Gene mutation (EFSA database)
D: Genome mutation (EFSA database)
E: Unspecified genotoxicity type (miscellaneous data source)
0: No data
1: Positive
2: Mixed/ambiguous results
3: Negative
Key: Other
: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:

Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Prevent generation of dust
IMDG Transport Code is usually 9
CLP classification 2013 Health: H351
Environment: H400, H410
EC Risk Classification Click here to view information omn the EU risk phrases Carcinogen category 3: R40
N - Dangerous for the environment: R50, R53
EC Safety Classification Click here to view information omn the EU safety phrases S2, S36/37, S46, S60, S61
WHO Classification U - Unlikely to present an acute hazard
UN Number Usually 3077
Waste disposal & packaging Click here for a description of UN packaging marks Packaging Group III (minor danger)


TRANSLATIONS

for simazine

Language Name
English simazine
French simazine
German Simazin
Danish simazin
Italian simazina
Spanish simazina
Greek simazine
Slovenian simazin
Polish symazyna
Swedish -
Hungarian -
Dutch simazine

Record last updated: Friday 25 May 2018
Contact: aeru@herts.ac.uk
© University of Hertfordshire