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thiabendazole (Ref: MK 360)
** tiabendazole ** TBZ ** tebuzate ** Translations

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GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for thiabendazole

Description: A mainly post-harvest fungicide used to control a wide range of diseases for fruit and other crops

Example pests controlled: Aspergillus; Botrytis; Cladosporium; Fusarium spp. including pod & stem blight, smut; damping-off, seedling blight, dwarf bunt, scab

Example applications: Fruit including apples, pears, citrus; Seed potatoes; Peas & chickpeas; Lentils; Cereals including wheat, barley, oats, rye, triticale, field corn; Popcorn; Sweetcorn

Efficacy & activity: -

Availability status: Current

Introduction & key dates: 1961, discovered; 1964, first reported

EC Regulation 1107/2009 (repealing 91/414):
Status Approved
Dossier rapporteur/co-rapporteur Spain/Netherlands
Date inclusion expires 30/03/2032
EU Candidate for substitution (CfS) No
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism -
Chemical formula C10H7N3S
Canonical SMILES C1=CC=C2C(=C1)NC(=N2)C3=CSC=N3
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) WJCNZQLZVWNLKY-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C10H7N3S/c1-2-4-8-7(3-1)12-10(13-8)9-5-14-6-11-9/h1-6H,(H,12,13)
Structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Fungicide, Veterinary substance
Substance group Benzimidazole
Minimum active substance purity 985 g/kg
Known relevant impurities EU dossier - None declared
Substance origin Synthetic
Mode of action Systemic with curative and protective action. Acts by compromising the cytoskeleton through a selective interaction with -tubulin.
CAS RN 148-79-8
EC number 205-725-8
CIPAC number 323
US EPA chemical code 060101
PubChem CID 5430
Molecular mass (g mol-1) 201.25
PIN (Preferred Identification Name) 2-(1,3-thiazol-4-yl)-1H-1,3-benzimidazole
IUPAC name 2-(thiazol-4-yl)benzimidazole
CAS name 2-(4-thiazolyl)-1H-benzimidazole
Other status information -
Relevant Environmental Water Quality Standards UK Environment Agency non-statutory standard for the protection of freshwater and saltwater aquatic life 5 ug/L as annual average, 50 ug/L as max acceptable conc]
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) 1
Examples of recorded resistance -
Physical state Colourless to yellow-white powder
Related substances & organisms

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • AgriGuard
  • Merial
  • Syngenta
Example products using this active
  • Hykeep
  • Storite
  • Tezate 220 SL
  • Tecto
  • Tobaz
UK LERAP status None (may vary with mixtures)
Formulation and application details Formulations include dry powders, soluble liquids and suspension concentrates.


ENVIRONMENTAL FATE

for thiabendazole

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 30 A5 Low
Solubility - In organic solvents at 20oC (mg l-1) 10 A5 - n-Heptane -
130 A5 - Xylene -
8230 A5 - Methanol -
2430 A5 - Acetone -
Melting point (oC) 297 A5 -
Boiling point (oC) - - -
Degradation point (oC) - - -
Flashpoint (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 2.45 X 1002 Calculated -
Log P 2.39 A5 Low
Bulk density (g ml-1)/Specific gravity 1.4 A5 -
Dissociation constant (pKa) at 25oC 4.73 A5 -
Note: pKa(2) 12.00
Vapour pressure at 20oC (mPa) 5.30 X 10-04 A5 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 3.70 X 10-06 A5 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 2.04 Calculated Transition state
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 8.92 X 10-02 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated High
Maximum UV-vis absorption L mol-1 cm-1 Neutral: 234nm=15201, 242nm=15436, 299nm=23213, 312nm=16438; [Acidic: 244nm=11554, 303nm=25775, 316nm=16920; [Basic: 234nm=16013, 300nm=19700 A5 -
Surface tension (mN m-1) 72.7 A5 -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 500 A2 Very persistent
DT50 (lab at 20oC) 1000 A2 Very persistent
DT50 (field) 724 A2 Very persistent
DT90 (lab at 20oC) 1000 A2 -
DT90 (field) - - -
DT50 modelling endpoint - - -
Note EU dossier 2001
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value - - -
Note -
Aqueous photolysis DT50 (days) at pH 7 Value 1.2 A5 Moderately fast
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value 203 A5 Persistent
Note Stable pH 5 to pH 9
Water-sediment DT50 (days) 4 A5 Fast
Water phase only DT50 (days) 1.6 A5 Moderately fast

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd 56 A5 Slightly mobile
Koc 3983
Notes and range EU dossier 2014 Kd range 26-120 mL/g; Koc range 1200-11000 mL/g, Soils=6; Other data: Koc ~ 2500 mL/g (DW3)
Freundlich Kf 35.5 A5 Slightly mobile
Kfoc 2091
1/n 0.79
Notes and range EU dossier 2014 Kf range 13-100 mL/g, Kfoc range 580-3921 mL/g, 1/n range 0.72-0.90, Soils =5
pH sensitivity No

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
5-hydroxythiabendazole NOA415696 Animal - -
benzimidazole-2-carboxamide - Water - -
benzimidazole-2-carboxylic acid - - - -
1,2-dihydro-3-hydroxy-quinoxaline - - - -


ECOTOXICOLOGY

for thiabendazole

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 96.5 A5 Low potential
CT50 (days) Not available -
Mammals - Acute oral LD50 (mg kg-1) > 5000 A5 Rat Low
Mammals - Short term dietary NOEL (mg kg-1) > 10 A5 Rat High
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) > 2250 A5 Colinus virginianus Low
Birds - Short term dietary (LC50/LD50) > 5620 mg kg feed-1 A5 Colinus virginianus -
Fish - Acute 96 hour LC50 (mg l-1) 0.55 A5 Oncorhynchus mykiss Moderate
Fish - Chronic 21 day NOEC (mg l-1) 0.012 A5 Oncorhynchus mykiss Moderate
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 0.81 A5 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 0.042 A5 Daphnia magna Moderate
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) 0.34 F3 Americamysis bahia Moderate
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) 2.0 A5 Chironomus riparius Moderate
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) 3.0 A5 Chironomus riparius Moderate
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) - - -
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) 9.0 C4 Raphidocelis subcapitata Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) 3.2 A4 Unknown species Low
Honeybees Contact acute 48 hour LD50 (μg bee-1) > 34 A5 Moderate
Oral acute 48 hour LD50 (μg bee-1) > 4.0 A5 Moderate
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) > 1000 A5 Eisenia foetida Low
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) 4.2 A5 Eisenia foetida Moderate
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 1800 >
A5 Typhlodromus pyri
-
% Effect 0
62
Mortality
Fecundity
Dose: 1.8 kg ha-1
A5 Aphidius rhopalosiphi
-
Other arthropod (2) LR50 g ha-1 1800 >
A5 Typhlodromus pyri
-
% Effect 3
5
Mortality
Fecundity
Dose: 1.8 kg ha-1
A5 Typhlodromus pyri
-
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: 9 mg kg-1 soil
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for thiabendazole

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) > 5000 A5 Rat Low
Mammals - Dermal LD50 (mg kg-1 body weight) > 5000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) > 0.53 A5 Rat -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.1 A5 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) None allocated A5 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.1 A5 -
Dermal penetration studies (%) 0.15-1.84% A5 concentration dependent -
Dangerous Substances Directive 76/464 - - -
Exposure Limits - - -
Exposure Routes Public No unacceptable risks to bystanders identified
Occupational No unacceptable risks to operators or other workers identified
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

-

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

General human health issues Possible thyroid, liver, spleen and kidney toxicant
USEPA - possible human carcinogen at high doses

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive or oxidising
IMDG Transport Code is usually 9
CLP classification 2013 Environment: H400, H410
EC Risk Classification Click here to view information omn the EU risk phrases N - Dangerous for the environment: R50, R53
EC Safety Classification Click here to view information omn the EU safety phrases S60, S61
WHO Classification III - Slightly hazardous
US EPA Classification (formulation) III - Caution - Slightly toxic
UN Number Variable with product, usually 3077 or 3082
Waste disposal & packaging Click here for a description of UN packaging marks Packaging Group III (minor danger)


TRANSLATIONS

for thiabendazole

Language Name
English thiabendazole
French thiabendazole
German Thiabendazol
Danish E 233, thiabendazole
Italian tiabendazolo
Spanish tiabendazol
Greek thiabendazol
Slovenian tiabendazol
Polish tiabendazol
Swedish tiabendazol
Hungarian thiabendazole
Dutch thiabendazool

Record last updated: Wednesday 31 October 2018
Contact: aeru@herts.ac.uk
© University of Hertfordshire